• Journal of Life Science
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• v.23 no.7
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• pp.904-912
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• 2013

This study aimed to evaluate the protective effect of cordycepin-increased Cordyceps militaris strain on carbon tetrachloride ($CCl_4$)-induced hepatotoxicity and oxidative stress in rats. Male Sprague-Dawley rats were randomly divided into five groups (n=6) based on six dietary categories: normal (N), $CCl_4$ control (C), $CCl_4$ plus Paecilomyces japonica (CPJ) (3%, w/w), $CCl_4$ plus C. militaris (CCM) (3%, w/w), and $CCl_4$ plus cordycepin-increased C. militaris ($CCM{\alpha}$) (3%, w/w). The activities of the liver marker enzymes ALT, AST, and LDH and the levels of lipid peroxidation were increased in the $CCl_4$-treated groups, but these parameters were significantly decreased in the $CCM{\alpha}$ group. The TBARS content in the liver homogenate, microsome, and mitochondrial fractions of the C group was significantly elevated compared with the N group. However, in the $CCl_4$-treated groups, $CCM{\alpha}$ group was significantly lowered in the TBARS levels of hepatic homogenate and microsomal fractions. The C group showed a significant decrease in the levels of plasma and hepatic glutathione, whereas they were significantly increased in the $CCM{\alpha}$ group. Accordingly, cordycepin-increased C. militaris may be an ideal animal model for studying hepatoprotective effects.

• Molecules and Cells
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• v.43 no.7
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• pp.619-631
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• 2020

In this study, we describe a novel function of TNNC1 (Troponin C1, Slow Skeletal and Cardiac Type), a component of actin-bound troponin, as a tumor suppressor of lung adenocarcinoma (LUAD). First, the expression of TNNC1 was strongly down-regulated in cancer tissues compared to matched normal lung tissues, and down-regulation of TNNC1 was shown to be strongly correlated with increased mortality among LUAD patients. Interestingly, TNNC1 expression was enhanced by suppression of KRAS, and ectopic expression of TNNC1 in turn inhibited KRAS^G12D-mediated anchorage independent growth of NIH3T3 cells. Consistently, activation of KRAS pathway in LUAD patients was shown to be strongly correlated with down-regulation of TNNC1. In addition, ectopic expression of TNNC1 inhibited colony formation of multiple LUAD cell lines and induced DNA damage, cell cycle arrest and ultimately apoptosis. We further examined potential correlations between expression levels of TNNC1 and various clinical parameters and found that low-level expression is significantly associated with invasiveness of the tumor. Indeed, RNA interference-mediated down-regulation of TNNC1 led to significant enhancement of invasiveness in vitro. Collectively, our data indicate that TNNC1 has a novel function as a tumor suppressor and is targeted for down-regulation by KRAS pathway during the carcinogenesis of LUAD.

• Spatial Information Research
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• v.21 no.6
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• pp.43-55
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• 2013

Recently, the research to visualize and to reproduce evacuation situations such as terrorism, the disaster and fire indoor space has been come into the spotlight and designing a model for interior space and reliable analysis through safety evaluation of the life is required. Therefore, this paper aims to develop simulation model which is able to suggest evacuation route guidance and safety analysis by considering the major risk factor of fire in actual building. First of all, we designed 3D-based fire and evacuation model at a subway station building in Incheon and performed fire risk analysis through thermal parameters on the basis of interior materials supplied by Incheon Transit Corporation. In order to evaluate safety of a life, ASET (Available Safe Egress Time), which is the time for occupants to endure without damage, and RSET (Required Safe Egress Time) are calculated through evacuation simulation by Fire Dynamics Simulator. Finally, we can come to the conclusion that a more realistic safety assessment is carried out through indoor space model based on 3-dimension building information and simulation analysis applied by safety guideline for measurement of fire and evacuation risk.

• JSTS:Journal of Semiconductor Technology and Science
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• v.7 no.3
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• pp.196-208
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• 2007

An analytical model is proposed for an optically controlled Metal Semiconductor Field Effect Transistor (MESFET), known as Optical Field Effect Transistor (OPFET) considering the diffusion fabrication process. The electrical parameters such as threshold voltage, drain-source current, gate capacitances and switching response have been determined for the dark and various illuminated conditions. The Photovoltaic effect due to photogenerated carriers under illumination is shown to modulate the channel cross-section, which in turn significantly changes the threshold voltage, drainsource current, the gate capacitances and the device switching speed. The threshold voltage $V_T$ is reduced under optical illumination condition, which leads the device to change the device property from enhancement mode to depletion mode depending on photon impurity flux density. The resulting I-V characteristics show that the drain-source current IDS for different gate-source voltage $V_{gs}$ is significantly increased with optical illumination for photon flux densities of ${\Phi}=10^{15}\;and\;10^{17}/cm^2s$ compared to the dark condition. Further more, the drain-source current as a function of drain-source voltage $V_{DS}$ is evaluated to find the I-V characteristics for various pinch-off voltages $V_P$ for optimization of impurity flux density $Q_{Diff}$ by diffusion process. The resulting I-V characteristics also show that the diffusion process introduces less process-induced damage compared to ion implantation, which suffers from current reduction due to a large number of defects introduced by the ion implantation process. Further the results show significant increase in gate-source capacitance $C_{gs}$ and gate-drain capacitance $C_{gd}$ for optical illuminations, where the photo-induced voltage has a significant role on gate capacitances. The switching time ${\tau}$ of the OPFET device is computed for dark and illumination conditions. The switching time ${\tau}$ is greatly reduced by optical illumination and is also a function of device active layer thickness and corresponding impurity flux density $Q_{Diff}$. Thus it is shown that the diffusion process shows great potential for improvement of optoelectronic devices in quantum efficiency and other performance areas.

• Journal of the Korea Concrete Institute
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• v.22 no.1
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• pp.19-27
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• 2010

Aging and severe environments are major causes of damage in reinforced concrete (RC) structures such as buildings and bridges. Deterioration such as concrete cracks, corrosion of steel, and deformation of structural members can significantly degrade the structural performance and safety. Therefore, effective and easy-to-use methods are desired for repairing and strengthening such concrete structures. Various methods for strengthening and rehabilitation of RC structures have been developed in the past several decades. Recently, FRP composite materials have emerged as a cost-effective alternative to the conventional materials for repairing, strengthening, and retrofitting deteriorating/deficient concrete structures, by externally bonding FRP laminates to concrete structural members. The main purpose of this study is to investigate the effectiveness of adaptive neuro-fuzzy inference system (ANFIS) in predicting behavior of circular type concrete column retrofitted with FRP. To construct training and testing dataset, experiment results for the specimens which have different retrofit profile are used. Retrofit ratio, strength of existing concrete, thickness, number of layer, stiffness, ultimate strength of fiber and size of specimens are selected as input parameters to predict strength, strain, and stiffness of post-yielding modulus. These proposed ANFIS models show reliable increased accuracy in predicting constitutive properties of concrete retrofitted by FRP, compared to the constitutive models suggested by other researchers.

• Journal of the Korea Concrete Institute
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• v.23 no.1
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• pp.109-120
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• 2011

This paper presents an experimental study results on the crack control of flexure-dominant reinforced concrete beams repaired with strain-hardening cement composite (SHCC). Five RC beams were fabricated and tested until failure. One unrepaired RC beam was a control specimen (CBN) and remaining four speciemens were repaired with SHCC materials. The test parameters included two types of SHCC matrix ductility and two types of repair method (patching and layering). Test results demonstrated that RC beams repaired with SHCC showed no concrete crushing or spalling until final failure, but numerous hair cracks were observed. The control specimen CBN failed due to crushing. It is important to note that SHCC matrix can improve crack-damage mitigation and flexural behavior of RC beams such as flexural strength, post peak ductility, and energy dissipation capacity. In the perspective of crack width, crack widths in RC beams repaired with SHCC had far smaller crack width than the control specimen CBN under the same deflection. Especially, the specimens repaired with SHCC of PVA0.75%+PE0.75% showed a high durability and ductility. The crack width indicates the residual capacity of the beam since SHCC matrix can delay residual capacity degradation of the RC beams.

• Journal of the korean academy of Pediatric Dentistry
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• v.27 no.4
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• pp.558-563
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• 2000

The lasers have been used in dentistry for more than 30 years and the application of lasers for drilling dental hard tissue has been investigated since the early developement of lasers. Recently, the Er:YAG laser was invented for hard tissue ablation. The Er:YAG laser, having a wavelength of 2.94um, is highly absorbed in both water and hydroxiapatite, leading to a very effective material for hard tissue removal by bursting off the solid tissue component that is, enamel and dentin are removed by the Er :YAG laser by water vaporization and microexplosion, without any melting of inorganic tissues. Therefore, the Er:YAG laser produced round craters with well defined margins and the surrounding tissues had no cracks and no charring. When used for cavity preparation, pulpal damage should not occur if hear buildup is minimized by careful selection of exposure parameters and by use of a water spray. The present study demonstrated that the Er:YAG laser cut the tooth substance adequately for composite resin restoration, without having undesirable side effects such as harmful effects on the pulp, discoloration or cracking etc. Also, the child patients were well cooperative during laser treatment mainly because of little noise, lesser vibration and minimal pain compared to conventional means of cavity preparation.

• Korean Chemical Engineering Research
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• v.49 no.4
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• pp.423-431
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• 2011

Recentincreasing awareness of the environmental damage caused by the $CO_2$ emission of fossil fuelsstimulated the interest in alternative and renewable sources of energy. Fuel cell is a representative example of hydrogen energy utilization. In this study, Molten Carbonate Fuel Cell system is simulated by using $Aspen^{TM}$. Stack model is consisted of equilibrium reaction equations using $ACM^{TM}$(Aspen Custom Modeler). Balance of process of fuel cell system is developed in Aspen $Plus^{TM}$ and simulated at steady-state. Analysis of performance of the system is carried out by using sensitivity analysis tool with main operating parameters such as current density, S/C ratio, and fuel utilization and recycle ratio.In Aspen $Dynamics^{TM}$, dynamics of MCFC system is simulated with PID control loops. From the simulation, we proposed operation range which generated maximum power and efficiency in MCFC power plant.

• Korean Journal of Environment and Ecology
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• v.23 no.3
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• pp.258-271
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• 2009

Various environmental parameters change and ecological succession often lead to decline of Pinus densiflora forest in Seoul. Due to decline of it, we proposed the ecological management for conserving and improving from decrease of its dominant area on there. We analysed the P. densiflora forest's classification and suggested its ecological management that based on relation to competition between dominant species in the upper tree layer, the presence of competitive species in shrub layer and vegetation management standard. The Pinus densiflora forest types has been classified 6 types by ecological characteristics. The results from categorized its types are following as; 1) Pinus densiflora pure forest type; edaphic climax Pinus densiflora forest(26.1%), Pinus densiflora pure forest(21.5%). 2) the forest of Pinus densiflora and other species that compete with each other type; Pinus densiflora-Quercus mongolica forest(28.0%), Pinus densiflora-Pinus rigida forest(13.1%), Pinus densiflora-Quercus acutissima(4.2%). We conclude that the results in these kind of 4 types; Pinus densiflora pure forest type where possible to maintain the forest by edaphic climax, human trampling damage, vegetation management(e.x. remove the competition species, shrub layers management etc.) are mainly need to negative management. Whereas, the others 4 types; Pinus densiflora and other species(Quercus variabilis, foreign species, naturalized species etc.) that compete with each other types are need to positive management such as manage the same niche competition species, shrub layers management, remove the foreign species, naturalized species etc.. In these kinds of ecological management are very necessary to maintain Pinus densiflora forest.

• Geomechanics and Engineering
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• v.21 no.1
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• pp.23-33
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• 2020

An advancing cutting roof for gob-side entry retaining with no-pillar mining under specific geological conditions is more conducive to the safe and efficient production in a coalmine. This method is being promoted for use in a large number of coalmines because it has many advantages compared to the retaining method with an artificial filling wall as the gateway side filling body. In order to observe the inner structure of the gateway cutting roof and understand its stability mechanism, an equivalent material simulation experiment for a coalmine with complex geological conditions was carried out in this study. The results show that a "self-stabilization bearing structure" equilibrium model was found after the cutting roof caving when the cut line deviation angle was unequal to zero and the cut height was greater than the mining height, and the caving roof rock was hard without damage. The model showed that its stability was mainly controlled by two key blocks. Furthermore, in order to determine the optimal parameters of the cut height and the cut line deviation angle for the cutting roof of the retaining gateway, an in-depth analysis with theoretical mechanics and mine rock mechanics of the model was performed, and the relationship between the roof balance control force and the cut height and cut line deviation angle was solved. It was found that the selection of the values of the cut height and the cut line deviation angle had to conform to a certain principle that it should not only utilize the support force provided by the coal wall and the contact surface of the two key blocks but also prevent the failure of the coal wall and the contact surface.