• Journal of Radiation Protection and Research
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• v.41 no.3
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• pp.206-210
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• 2016

Background: Ionizing radiation causes cellular damage and death through the direct damage and/or indirectly the production of ROS, which induces oxidative stress. This study was designed to evaluate the in vivo radioprotective effects of a bio-active material coated fabric (BMCF) against ${\gamma}$-irradiation-induced cellular damage in Sprague-Dawley (SD) rats. Materials and Methods: Healthy male SD rats wore bio-active material coated (concentrations in 10% and 30%) fabric for 7 days after 3 Gy of ${\gamma}$-irradiation. Radioprotective effects were evaluated by performing various biochemical assays including spleen and thymus index, WBC count, hepatic damage marker enzymes [aspartate transaminase (AST) and alanine transaminase (ALT)] in plasma, liver antioxidant enzymes, and mitochondrial activity in muscle. Results and Discussions: Exposure to ${\gamma}$-irradiation resulted in hepatocellular and immune systemic damage. Gamma-irradiation induced decreases in antioxidant enzymes. However, wearing the BMCF-30% decreased significantly AST and ALT activities in plasma. Furthermore, wearing the BMCF-30% increased SOD (superoxide dismutase) and mitochondrial activity. Conclusion: These results suggest that wearing BMCF offers effective radioprotection against ${\gamma}$-irradiation-induced cellular damage in SD rats.

• Journal of Korea Water Resources Association
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• v.44 no.1
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• pp.1-8
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• 2011

This paper addresses the correlation between the flood damage cost and recovery cost. National data (15 regions) for 20 years, panel data, has been analyzed for this test. Model specification of panel data analysis depends on the characteristics of data set and "fixed" or "random" effects model can be used. The results are represented in both models. As we expected all independent variables show positive relationship with recovery cost, except for the number of death and suffers. The damage of public facilities, such as rivers and road are the major factors on the damage and recovery cost, which means that flood damage can not be decreased without decreasing damages of public facilities from floods. Especially, the recovery cost is always higher than the damage cost and investment for flood control. Unlikely, government investment for flood control is the highest and recovery cost is the always lower than da mage cost andinvestment in Japan. Which means that proper investment can reduce economic damage cost of flood and recovery cost.

• The Korea Journal of Herbology
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• v.22 no.1
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• pp.103-110
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• 2007

Objectives : This study was performed to prove the preventive effect of water extracts from Artemisiae Iwayomogi Herba on hyperlipiderma and liver damage induced alcohol. Methods : Except for the normal group, we fed rat on 25% alcohol for 55 days. And Artemisiae Iwayomogi Herba extract was administrated for the same period. We measured the serum component in rat's blood. body weight and weight of liver. Result : At first, we observed preventive effects of Artemisiae Iwayomogi Herba on hyperlipiderma induced by alcohol. Artemisiae Iwayomogi Herba group showed significant decrease of total cholesterol and triglyceride in comparison with those of the control group. Artemisiae Iwayomogi Herba group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. At second, we observed preventive effects of Artemisiae Iwayomogi Herba on liver damage induced by alcohol. Artemisiae Iwayomogi Herba group showed significant decrease of GOT, ALP and LDH in comparison with those of the control group. Artemisiae Iwayomogi Herba group showed significant increase of liver weight in comparison with those of the control group. Conclusion : Reviewing these experimental results, it appears that water extracts from Artemisiae Iwayomogi Herba have pharmaceutical preventive efficacy on hyperlipiderma and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of Artemisiae Iwayomogi Herba.

• Computers and Concrete
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• v.1 no.2
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• pp.169-188
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• 2004

A coupled damage-viscoplasticity model is presented for the analysis of localisation and size effects. On one hand, viscosity helps to avoid mesh sensitivity because of the introduction of a length scale in the model and, on the other hand, enables to represent size effects. Size effects were analysed by means of three-point bending tests. Correlation between the fracture energy parameter measured experimentally and the density fracture energy modelling parameter is discussed. It has been shown that the dependence of nominal strength and fracture energy on size is determined by the ligament length in comparison with the width of the fracture process zone.

• Journal of Nutrition and Health
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• v.37 no.6
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• pp.440-447
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• 2004

In this study the in vitro protective effects of several antioxidant vitamins (vitamin C, $\alpha$-tocopherol, $\beta$-carotene), fruits and vegetables (strawberry, tangerine, orange and 100％ orange juice, carrot juice), on the levels of isolated human lymphocyte DNA damage was measured using Comet assay. Comet assay has been used widely to assess the level of the DNA damage in the individual cells. Lymphocytes were pre-treated for 30 minutes with antioxidant vitamins (10, 50, 100, 500 $\mu$M) or fruits$.$vegetables (10, 100, 500, 1000 $\mu$g/ml), an4 then oxidatively challenged with 100 $\mu$M $H_2O$$_2$ for 5 min at 4$^{\circ}C$. The protective effect of antioxidant vitamins against DNA damage at a concentration of 50 $\mu$M were 50％ in vitamin C, 32％ in $\alpha$-tocopherol, whereas, fJ-carotene showed a 55％ protection at a dose as low as 10 $\mu$M. The inhibitory effects of DNA damage by strawberry, tangerine, orange, orange juices, carrot juices were 50 - 60％ with wide ranges of doses. The results of the present study indicate that most the antioxidant vitamins and fruits$.$vegetables juices produced a significant reduction in oxidative DNA damage.

• Structural Engineering and Mechanics
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• v.65 no.1
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• pp.43-51
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• 2018

Structural modal parameters i.e. natural frequencies, damping ratios and mode shapes are dynamic features obtained either by measuring the vibration responses of a structure or by means of finite elements models. Over the past two decades, modal parameters have been used to detect damage in structures by observing its variations over time. However, such variations can also be caused by environmental factors such as humidity, wind and, more importantly, temperature. In so doing, the use of modal parameters as damage indicators can be seriously compromised if these effects are not properly tackled. Many researchers around the world have found numerous methods to mitigate the influence of such environmental factors from modal parameters and many advanced damage indicators have been developed and proposed to improve the reliability of structural health monitoring. In this paper, several vibration tests are performed on a simply supported steel beam subjected to different damage scenarios and temperature conditions, aiming to describe the variation in modal parameters due to temperature changes. Moreover, four statistical methodologies are proposed to identify damage. Results show a slightly linear decrease in the modal parameters due to temperature increase, although it is not possible to establish an empirical equation to describe this tendency.

• The Journal of Korean Medicine
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• v.25 no.1
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• pp.117-128
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• 2004

Objectives : This research was performed to investigate effect of Samul-tang-gamibang against focal cerebral ischemic damage after middle cerebral artery occlusion(MCAO). Methods : This research was used rats which were against focal cerebral ischemic damage by MCAO. It was used Zea Longa's theory and Belayev's methods to give rise to focal cerebral ischemic damage by MCAO. After 7days later, we drew out the brain and then had frozen and dyeing it and we had taken a picture to measure of the damaged area in each brain section. We determined the Neurological Index and tested the Foot-fault test and Roatated test to appraise the fall of motion ability result from cerebral ischemic damage. Results : The results of the experiment are as follows. 1. Samul-tang-gamibang reduced infarct size of sample group compared to control group at 7 day after MCAO. 2. Samul-tang-gamibang reduced infarct volume of sample group compared to control group at 7 day after MCAO. 3. Samul-tang-gamibang reduced foot-fault index of sample group compared to control group at 5,7 day after MCAO. Conclusions : Samul-tang-gamibang has protective effects against ischemic brain damage and had significant reduced infarct size and infarct volume of Rt-MCAO.

• Proceedings of the KSME Conference
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• 2001.11a
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• pp.204-209
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• 2001

In this research, the effects of fiber stacking sequence on damage behaviors of FML(Fiber Metal Laminates) subject to indentation loading. SOP (Singly Oriented Ply) FML and angle ply FML were fabricated to study fiber orientation effects and angle ply effects. FML were fabricated by using 1050 aluminum laminate and carbon/epoxy prepreg. To increase adhesive bonding strength, Al laminate was etched using FPL methods. The static indentation test were conducted by using UTM(5ton, Shimadzu) under the 2side clamped conditions. During the tests, load and displacement curve and crack initiation and propagation behaviors were investigated. As fiber orientation angle increases, the crack initiation load of SOP FML increases because the stiffness induced by fiber orientation is increased. The penetration load of SOP FML is influenced by the deformation tendency and boundary conditions. However, the macro-crack of angle ply FML was initiated by fiber breakage of lower ply because angle plies in Angle ply FML prevents the crack growth and consolidation. The Angle ply FML has a critical cross-angle which prevent crack growth and consolidation. Damage behavior of Angle ply FML is changed around the critical cross-angle.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.21 no.1
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• pp.70-82
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• 2008

Objective : The purpose of this study is to examine the effects of Baickbujasan(BB) on the skin damage and depigmentation. Method : The inhibition of tyrosinase activity, melanogenesis and cell viability in cultured B16 melanoma cells were measured. In order to test effects of reduction of melanogenesis, B16 F-10 mouse melanoma stem line was employed to extract melanin from cultured cell, where BB was added or not, and was dissolved in alkali for colorimetric analysis. Also, in order to test skin alteration in C57BL/6 after UV irradiation, the animals were grouped into a UV urradiation group and UV irradiation after BB application group. Dopa oxidase tissue staining was excuted to invesitage the change in the distribution of active melanin cell. The distribution of active melanin cell in inner skin of iNOS after damage from UVB irradiation and the manifestation condition of P53 which takes part in natural death of keratinocyte were examined. Result : The results indicate that BB has significant effects on tyrosinase activity, and melanogenesis in vivo test. BB seems to reduce C57BL/6, external dermatological damage, for instance, erythematous papule, eczema, loss of keratinocyte, reduction in pus, and relieves dermatological damages. Conclusion : BB can be applied externally for UV protection and depigmentation.

• Smart Structures and Systems
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• v.17 no.6
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• pp.859-880
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• 2016

This study aims to establish an effective methodology for the detection of instant damages occurred in cable-stayed bridges with the measurements of cable vibration and structural temperatures. A transfer coefficient for the daily temperature variation and another for the long-term temperature variation are firstly determined to eliminate the environmental temperature effects from the cable force variation. Several thresholds corresponding to different levels of exceedance probability are then obtained to decide four upper criteria and four lower criteria for damage detection. With these criteria, the monitoring data for three stay cables of Ai-Lan Bridge are analyzed and compared to verify the proposed damage detection methodology. The simulated results to consider various damage scenarios unambiguously indicate that the damages with cable force changes larger than ${\pm}1%$ can be confidently detected. As for the required time to detect damage, it is found that the cases with ${\pm}2%$ of cable force change can be discovered in no more than 6 hours and those with ${\pm}1.5%$ of cable force change can be identified in at most 9 hours. This methodology is also investigated for more lightly monitored cases where only the air temperature measurement is available. Under such circumstances, the damages with cable force changes larger than ${\pm}1.5%$ can be detected within 12 hours. Even though not exhaustively reflecting the environmental temperature effects on the cable force variation, both the effective temperature and the air temperature can be considered as valid indices to eliminate these effects at high and low monitoring costs.