Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
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Effects of Wearing Bio-active Material Coated Fabric against γ-irradiation-induced Cellular Damage in Sprague-Dawley Rats

  • Received : 2016.08.04
  • Accepted : 2016.09.22
  • Published : 2016.09.30
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Abstract

Background: Ionizing radiation causes cellular damage and death through the direct damage and/or indirectly the production of ROS, which induces oxidative stress. This study was designed to evaluate the in vivo radioprotective effects of a bio-active material coated fabric (BMCF) against ${\gamma}$-irradiation-induced cellular damage in Sprague-Dawley (SD) rats. Materials and Methods: Healthy male SD rats wore bio-active material coated (concentrations in 10% and 30%) fabric for 7 days after 3 Gy of ${\gamma}$-irradiation. Radioprotective effects were evaluated by performing various biochemical assays including spleen and thymus index, WBC count, hepatic damage marker enzymes [aspartate transaminase (AST) and alanine transaminase (ALT)] in plasma, liver antioxidant enzymes, and mitochondrial activity in muscle. Results and Discussions: Exposure to ${\gamma}$-irradiation resulted in hepatocellular and immune systemic damage. Gamma-irradiation induced decreases in antioxidant enzymes. However, wearing the BMCF-30% decreased significantly AST and ALT activities in plasma. Furthermore, wearing the BMCF-30% increased SOD (superoxide dismutase) and mitochondrial activity. Conclusion: These results suggest that wearing BMCF offers effective radioprotection against ${\gamma}$-irradiation-induced cellular damage in SD rats.

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References

  1. Dyer CS, Lei F, Clucas SN, Smart DF, Shea MA. Solar particle enhancements of single event effect rates at aircraft altitude. IEEE Tran. Nucl. Sci. 2003;50:2038-2045. https://doi.org/10.1109/TNS.2003.821375
  2. Kato H, Onda Y, Teramage M. Depth distribution of 137Cs, 134Cs, and 131I in soil profile after Fujushima Daiichi Nuclear Power Plant Accident. J. Environ. Radioact. 2011;111:59-64.
  3. Jeong C, Oh H, Lee J, Jo S, Park S. Analysis of dose by items according to act on safety control of radiation around living environment. J. Korea Soc. Radiol. 2013;7(6):377-381. https://doi.org/10.7742/jksr.2013.7.6.377
  4. Hall EJ, Giaccia AJ. Radiobiology for the radiologist. 6th Ed. New York NY. Lippincott Williams and Wilkins. 2006;5-15.
  5. Fan WC, Drumm CR, Roeske SB, Scrivner GJ. Shielding considerations for satellite microelectronics. IEEE Trans. Nucl. Sci. 1996;43(6):2790-2796. https://doi.org/10.1109/23.556868
  6. Lee MS, Kim HJ, Song J, Park KW, Moon SR. Effects of multifunctional fabric on cardiac autonomic tone and psychological state. Int. J. Neurosci. 2004;114:923-931. https://doi.org/10.1080/00207450490461297
  7. Lee DH, et al. Improvement characteristics of bio-active materials coated fabric on rat muscular mitochondria. Korean J. Physiol. Pharmcol. 2015;19:283-289. https://doi.org/10.4196/kjpp.2015.19.3.283
  8. Janssen AJ, Trijbels FJ, Sengers RC, Smeitink JA, van den Heuvel LP, Winties LT, Stoltenborg-Hogenkamp BJ, Rodenburg RJ. Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts. Clin. Chem. 2007;53:729-734. https://doi.org/10.1373/clinchem.2006.078873
  9. Zhao H, Wang Z, Ma F, Yang Xin, Cheng C, Yao L. Protective effect of anthocyanin from Lonicera Caerulea var. edulis on radiation- induced damage in mice. Int. J. Mol. Sci. 2012;13:11773-11782. https://doi.org/10.3390/ijms130911773
  10. Sallie R, Tredger JM, Willam R. Drugs and the liver. Biopharm. Drug Dispos. 1991;12: 251-259. https://doi.org/10.1002/bdd.2510120403
  11. Samarth RM, Kumar A. Radioprotection of Swiss albino mice by plant extract Menthe piperita (Linn.). J. Radiat. Res. 2003;44:101-109. https://doi.org/10.1269/jrr.44.101
  12. Mikinory K, Taketoshi A, Koichi N, Osamu I. Regulation of cell survival and death signaling induced by oxidative stress. J. Clin. Biochem. Nutr. 2008;43:51-57. https://doi.org/10.3164/jcbn.2008045
  13. Webster EW. Experiments with medium-Z materials for shielding against low-energy x rays. Radiology. 1966;84:146.
  14. Yaffe M, Mawdsley GE, Lilley M, Servant R, Reh G. Composite materials for x-ray protection. Health Phys. 1991;60(5):661-664. https://doi.org/10.1097/00004032-199105000-00004