• Earthquakes and Structures
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• v.5 no.1
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• pp.23-48
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• 2013

In this study, the effect of flexibility of superstructures and nonlinear characteristics of LRB (Lead Rubber Bearing) isolator on inelastic response of base isolated structures is investigated. To demonstrate the intensity of damage in superstructures, demand response modification factor without the consideration of damping reduction factor, demand RI, is used and the N2 method is applied to compute this factor. To evaluate the influence of superstructure flexibility on inelastic response of base isolated structures, different steel intermediate moment resisting frames with different heights have been investigated. In lead rubber bearing, the rubber provides flexibility and the lead is the source of damping; variations of aforementioned characteristics are also investigated on inelastic response of superstructures. It is observed that an increase in height of superstructure leads to higher value of demand RI till 4-story frame but afterward this factor remains constant; in other words, an increase in height until 4-story frame causes more damage in the superstructure but after that superstructure's damage is equal to the 4-story frame's. The results demonstrate that the low value of second stiffness (rubber stiffness in LRBs) tends to show a significant decrease in demand RI. Increase in value of characteristic strength (yield strength of the lead in LRBs) leads to decrease in the demand RI.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2023.04a
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• pp.54-54
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• 2023

Nypa fruticans Wurmb (N. fruticans) is a plant that belongs to Araceae and N. fruticans is mainly found in tropical mangrove systems. The parts (leaves, stems, and roots) of N. fruticans are traditionally used for asthma, sore throat, and liver disease. N. fruticans contains flavonoids and polyphenols, which are substances that have inhibitory effects on cancer and oxidant. In previous studies, some pharmaceutical effects of N. fruticans on melanogenesis and inflammation have been reported. The present study is conducted to investigate the effect of the ethyl acetate fraction of N. fruticans (ENF) on oxidative DNA damage and UVB-induced DNA damage. DNA damage response (DDR) pathway is important in research on cancer, apoptosis, and so on. DDR pathways are considered a crucial factor affecting the alleviation of cellular damage. ENF could reduce oxidative DNA damage derived from reactive oxygen species by the Fenton reaction. Also, ENF reduced the intensity of intracellular ROS in the live cell image by DCFDA assay. UVB is known to cause skin and cellular damage, then finally contribute to causing the formation of tumors. As for the strategies of reducing DNA damage by UVB, inhibition of p53, H2AX, and Chk2 can be important indexes to protect the human body from DNA damage. As a result of confirming the protective effect of ENF for UVB damage, MMPs significantly decreased, and the expression of apoptosis-related factors tended to decrease. In conclusion, ENF can provide protective effects against double-stranded DNA break (DSB) caused by oxidative DNA damage and UVB-induced DNA damage. These results are considered to be closely related to the protective effect against radicals based on catechin, epicatechin, and isoquercitrin contained in ENF. Based on these results, it is thought that additional mechanism studies for inhibiting cell damage are needed.

• Korean Security Journal
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• no.14
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• pp.261-283
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• 2007

In recent studies for explaining the causation of crime fear shows interest and effort in studies attempting microscopical individual level and macroscopical local level of sex, age, economic level, crime damage level and etc. However, in this study, it is considered that interest and analysis of individual on characteristics of these local level may has its difference depends on crime damage experience in the past, fragility precision of crime damage and interest on crime relating information and processed positive analysis on characteristics of individual and relation of crime fear on individual level before making an attempt of connecting microscopical level and macroscopical level. Therefore, the purpose of this study is on positive verification of how people feel about crime fear depends on individual's characteristic and also how much effect would they receive. As the result of this study, it is shown that first, population statistical characteristics that crime damage experience is statistically meaningful of its difference of each group are age, status of marriage, final education status and residential area and for the fragility precision of crime damage was sex and status of marriage and for the interest about the crime relating information has meaningful difference statistically of each group depends on sex, age, final education status, income of the house and location of residential area. Second, after processing correlation analysis on individual characteristic primary factor and crime fear, the result of 3 primary factor independent variable all shows statistically meaningful correlation with crime fear and especially fragility primary factor on crime damage showed the most high correlation with crime fear. Lastly, fragility of crime damage, interest on crime information and crime damage experience has effected as characteristics of individual and especially fragility of crime damage which the person thought to be the most fragility on crime damage out of these individual characteristic primary factor showed to have the most effecting primary factor.

• Proceedings of the KSR Conference
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• 2002.10b
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• pp.1065-1073
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• 2002

A new damage identification technique using static displacement data is developed to assess the structural integrity of bridge structures. In the conventional damage assessment techniques using dynamic response, it is usually difficult to obtain a significant natural frequencies variation from the measured data because the natural frequencies variation is intrinsically not sensitive to the damage of a bridge. In this proposed identification method, the stiffness reduction of the bridges can be estimated using the static displacement data measured periodically and a specific loading test is not required. The static displacement data due to the dead load of the bridge structure can be measured by devices such as a laser displacement sensor. In this study, structural damage is represented by the reduction in the elastic modulus of the element. The damage factor of the element is introduced to estimate the stiffness reduction of the bridge under consideration. Finally, the proposed algorithm is verified using various numerical simulation and compared with other damage identification method. Also, the effect of noise and number of damaged elements on the identification are investigated. The results show that the proposed algorithm is efficient for damage identification of the bridges.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2006.04a
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• pp.914-921
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• 2006

To describe the effect of the numerous and various oriented microcracks on the compressive and tensile concrete behaviors, the directional nonlocality is defined. The plasticity model using multiple failure criteria is developed for RC planar members in tension-compression. The crack damages are defined in the pre-determined reference orientations, and then the total crack damage is calculated by integrating multi-oriented crack damages. To describe the effect of directional nonlocality on the anisotropic tensile damage, based on the existing test results, the nonlocal damage factor is defined in each reference orientation. The reduced compressive strength in the cracked concrete is defined by the multi-oriented crack damages defined as excluding the tensile normal plastic strain from the compressive equivalent plastic strain. The proposed model is implemented to finite element analysis, and it is verified by comparisons with various existing panel test results.

• Korean Journal of Plant Resources
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• v.23 no.2
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• pp.172-178
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• 2010

This study was carried out to investigate abiotic and biotic environmental factors affecting homoharringtonine (HHT) contents of Cephalotaxus koreana, whereby, to provide basic information of high value-added industry production of HHT as a promising anti-cancer agent. For correlation between abiotic environmental factors (soil moisture, soil pH, habitat density and temperature) and HHT contents, the contents were highly correlated with soil moisture (0.77) and soil pH (-0.68). For multiple regression analysis of relationship between abiotic environmental factors (soil moisture and soil pH) and HHT contents, soil moisture appeared to be strongly affecting the contents relatively due to being significant at only its regression coefficient ($26.48^{***}$). For the effect of biotic environmental factors (damage index) affecting HHT contents, the contents was quadratic with equation of $H=278.23+1242D-398.87D^2$, also, damage index had strong effect on the contents. Finally, for the result of the most influencing an environmental factor on HHT contents, both damage index and soil moisture were suitable in second polynomial regression, also, damage index ($R^2=0.73^{***}$) was turned out to be more influencing factor than soil moisture ($R^2=0.67^{**}$) on HHT contents relatively. Therefore, we predict that HHT contents in the trees of Cephalotaxus koreana is produced as a chemical defense mechanism triggered by a stress-related damage of fungi or insects.

• KCI Concrete Journal
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• v.13 no.2
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• pp.26-32
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• 2001

A simple expected damage cost model is developed and a systematic approach to evaluate the economic effects of seismic hazards to reinforced concrete structures is presented. An expected damage cost function during a specific lifetime is modeled by a Poisson's process with uniform continuous cash flow assumption. It is possible that the proposed method can decouple the damage cost effect from random earthquake events. Thus, expected damage cost function can be formulated as a combination of three independent terms; a present worth factor of Poisson's process, a damage cost interpolation function and a mean occurrence rate of earthquake intensity. The validity of the proposed method is demonstrated by a comparative study of LCC evaluations with the previous study.

• Journal of the Korean Geotechnical Society
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• v.21 no.5
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• pp.153-161
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• 2005

A series of installation damage tests and creep tests are performed to assess the combined effect of installation damage and creep deformation far the long-term design strength of geogrid reinforcement. Three types of geogrids are used to investigate the influence of the geogrid types. From the experimental results, it is shown that installation damage and creep deformation of geogrids significantly depends on the polymer types of the geogrids and the larger the installation damage, the more the combined effect of installation damage and creep deformation. In addition, The results of this study show that the tensile strength reduction factor, RF, considering the combined effect between installation damage and creep deformation is less than that calculated by the current design practice which calculates the long-term design strength of geogrids damaged during installation by multiplying two partial safety factors, $RF_{ID}$ and $RF_{CR}$.

• Korean Journal of Clinical Laboratory Science
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• v.52 no.4
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• pp.389-397
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• 2020

Microglial cells function as major immune cells in the brain, playing an important role in the protection and damage of neurons. BV2 microglia, activated by drug stimulation, secrete inflammatory cytokines by activating the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway and are involved in neuroinflammatory and immune responses. The overactivation of microglia by stimuli can cause neuronal damage, leading to brain disease. Noni, a natural product, reduces the activity of microglia to prevent neuronal damage and is a potential natural medicine because it exerts excellent regeneration and anti-inflammatory effects on damaged cells. In this study, when noni was used to treat BV2 cells stimulated by the anti-cancer drug doxorubicin, it reduced the release of pro-inflammatory cytokines from BV2. On the other hand, neuronal damage is a side effect of doxorubicin. Therefore, the cytokines released from doxorubicin-stimulated BV2 cells treated with noni had a positive effect on the neuronal viability compared to those released from doxorubicin-stimulated BV2 cells not treated with Noni. Thus, Noni increases neuronal viability. These results suggest that noni inhibits the release of cytokines by regulating the nuclear factor kappa-light-chain-enhancer of the activated B cells pathway of BV2, thereby inhibiting neuronal damage.

• Steel and Composite Structures
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• v.25 no.1
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• pp.79-92
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• 2017

Initial damage to a stud due to corrosion, fatigue, unexpected overloading, a weld defect or other factors could degrade the shear capacity of the stud. Based on typical push-out tests, a FEM model and theoretical formulations were proposed in this study. Six specimens with the same geometric dimensions were tested to investigate the effect of the damage degree and location on the static behavior and shear capacity of stud shear connectors. The test results indicated that a reduction of up to 36.6% and 62.9% of the section area of the shank could result in a dropping rate of 7.9% and 57.2%, respectively, compared to the standard specimen shear capacity. Numerical analysis was performed to simulate the push-out test and validated against test results. A parametrical study was performed to further investigate the damage degree and location on the shear capacity of studs based on the proposed numerical model. It was demonstrated that the shear capacity was not sensitive to the damage degree when the damage section was located at 0.5d, where d is the shank diameter, from the stud root, even if the stud had a significant reduction in area. Finally, a theoretical formula with a reduction factor K was proposed to consider the reduction of the shear capacity due to the presence of initial damage. Calculating K was accomplished in two ways: a linear relationship and a square relationship with the damage degree corresponding to the shear capacity dominated by the section area and the nominal diameter of the damaged stud. This coefficient was applied using Eurocode 4, AASHTO LRFD (2014) and GB50017-2003 (2003) and compared with the test results found in the literature. It was found that the proposed method produced good predictions of the shear capacity of stud shear connectors with initial damage.