• 대한상한금궤의학회지
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• v.10 no.1
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• pp.57-67
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• 2018

Objective : This case report presents the effect of Daecheongryong-tang on Impulse Control Disorder. The patient was diagnosed with Taeyang-byung based on Shanghanlun provisions. Methods : According to Shanghanlun six meridian patterns diagnostic system, we diagnosed the patient as Taeyang-byung and she has been suffering from impulse control disorder. The patient was treated with Daecheongryong-tang. And it was provided for 60 days.The changing symptom was estimated by Global Assessment of Functioning and Visual Analogue Scale. Results : After the treatment, the patient's functioning got better from 65 to 85 on GAF. And the degree of pain was reduced from 10 to 2 on VAS. Conclusions :This case study shows an effectiveness of using Daecheongryong-tang according to Diagnostic system based on Shanghanlun provisions on Impulse Control Disorder.

• Journal of Korean Medical classics
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• v.32 no.1
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• pp.171-189
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• 2019

Objectives : This study analyzes herbs combinations and primary virtues that constitute the prescriptions of Gyeji-tang, Mahwang-tang, and Daecheongryong-tang to effectively analyze medication preparations described in "Shanghanlun" using database, and test the results of the data structure and effectiveness of queries. Methods : This study enters "Sanghanjapbyeongronyeonggudaeseong" as the original text into the database, and even uses one provision as independent knowledge by dividing provisions in accordance with the content. Results : Five tables and 12 queries were created and used for data input and analysis. Using the types of Herbs included in the prescriptions, this study manages to search for the same or supplemented prescriptions, and the primary virtues of the prescriptions were collected and compared. Conclusions : Subject to the combination of herbs and pathology for the prescriptions described in "Shanghanlun" utilizing the database, this study found relevant texts and combinations of herbs and pathologies, and using this, the time required for theoretical research between prescriptions could be shortened.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.6
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• pp.650-656
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• 2014

The purpose of this study is to investigate the effect of 2 Kobangs. Daecheongryong-tang and Samhwangsasim-tang on to two psoriasis patients each. The improvement of the skin condition was observed by Psoriasis Area and Severity Index (PASI) score. The patient treated with Daecheongryong-tang showed significant improvement after the patient's state of sweating improved and the PASI score of the patient reduced from 17.6 to 1.8 after five months of treatment. The patient treated with Samhwangsasim-tang showed gradual improvement after the patient's defecation was improved and the PASI score of the patient reduced from 27.3 to 3.6 after three months of treatment. According to the results, we obtained clinically positive effects from 2 Kobangs applied on 2 psoriasis cases respectively. Although there were few reports on psoriasis treated with Kobang, we can suggest effective treatment on psoriasis.

• The Journal of Internal Korean Medicine
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• v.27 no.1
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• pp.92-101
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• 2006

Objectives : This study was done with intend to investigate whether two oriental medical prescriptions, daecheongryong-tang (DCRT) and prescription A (P-A) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. Methods : Confluent HTSE cells were metabolically radiolabeled with $^3H$-glucosamine for 24 hrs and chased for 30 min in the presence of DCRT or P-A to assess the effect of each agent on $^3H$-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of DCRT and P-A on contractility of isolated tracheal smooth muscle were investigated. Results were as follows : 1. DCRT significantly inhibited mucin release from cultured HTSE cells, with significant cytotoxicity. 2. P-A significantly increased mucin release from cultured HTSE cells, with significant cytotoxicity. 3. DCRT inhibited Ach-induced contraction of isolated tracheal smooth muscle. 4. P-A also inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusion: Results suggest that DCRT and P-A have regulating effects on mucin secretion from goblet cells. Further investigation is needed, because of the value in finding novel agents to this purpose, and these oriental medical prescriptions have potential for this role.

• 대한상한금궤의학회지
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• v.15 no.1
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• pp.131-148
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• 2023

Objective : We Explored the meaning of the 厥逆 in Gangpyeong-Shanghanlun through two cases. Methods : We analyzed the original form of 厥逆 and the contexts in Shanghanlun. At the same time, we analyzed 2 clinical cases treated with 大靑龍湯 (Daecheongryong-tang) according to the newly deduced definition of 厥逆. Results : 厥逆 can be interpreted as 'Being indulged and indigestive'. We analyzed the cases and found that both cases were related to eating disorder even though their chief complaints were different. We also found that 大靑龍湯 was effective for both bulimia nervosa and anorexia nervosa. Conclusions : 厥逆 is symptoms of reflux in human body such as, gastroesophageal reflux disease, as a result of concentration or indulgence. We analyzed the two cases with DSM-5 and found that the two cases also can be diagnosed with eating disorder along with the provision (38條, 大靑龍湯). We found out the possibility of correlation between eating disorder and 38條, however, more advanced clinical studies are needed in the future.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.3
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• pp.92-105
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• 2010

Objectives: The purpose of this study is to investigate the effects of Daecheongryong-tang (DCRT) on the adipogenesis in 3T3-L1 preadipocytes. Methods: 3T3-L1 preadipocytes were differentiated with adipogenic reagents by incubating for 2 days in the absence or presence of DCRT ranging 0.25 and 2%. The effect of DCRT on adipogenesis was examined by Oil red O staining, and the protein, RNA, and RT-PCR were measured. Results: Our results showed that DCRT decreased the TG content by ORO staining. To elucidate the mechanism of the effects of DCRT on lowering TG content in 3T3-L1 adipocytes, we examined the DCRT modulate expressions of transcription factors to induce adipogenesis and adipogenic genes which is related to the regulation of accumulation of lipids. As a result, the expression of SREBP1, C/$EBP{\beta}$, C/$EBP{\delta}$, C/$EBP{\alpha}$, and $PPAR{\gamma}$ genes, which induce the adipose differentiation and adipose-specific aP2, adipsin, LPL, CD36, TGF-${\beta}$ and adiponectin genes which regulates fat formations, were decreased. In addition, DCRT reduced the expression of iNOS and IL-6 in 3T3-L1 adipocytes, resulting in inflammation. Conclusions: DCRT could regulate transcript factor related to induction of adipose differentiation, inhibit the accumulation of lipids and expression of the adipogenic genes.

• The Korea Journal of Herbology
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• v.38 no.4
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• pp.1-9
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• 2023

Objectives : This study aimed to convert into weight the dosages of flower of Daphne canescens and leaf of Phyllostachys nigra var. henonsis, whose daily dosages are likened to an object in 《Treatise on Cold Damage Diseases》. This study also aimed to understand their implications along with the previously studied gypsium and rhubarb. Methods : After reviewing documents, the dosages were converted into weight, confirmed by experiment, and their implications were considered. Results : A chicken-egg-volume of flowers of Daphne canescens is one Ryang(6.5 g) and two handfuls of leaves of Phyllostachys nigra var. henonsis is four Ryang(13 g). Each item was only used once in a decoction. Their dosages were expressed in weight respectively in 《Supplement to the Essential Prescriptions Worth a Thousand Gold》 and 《Bohenggyuljangbuyongyakbubyo》. Gypsium dosage was expressed in weight except in Daecheongryong-tang as chicken-egg-volume(16 Ryang). To liken a dosage to an object is an exception, as in the three cases above; for precision and convenience it is recommended that dosages be expressed in weight, in which case all three items fell into one of eight categories from one Ryang to 16 Ryang. Rhubarb was measured in weight, but only when using the 12-hour leaching method, four Ryang of rhubarb was cut into of 5-6 wide-go-stone-sized pieces and two Ryang into 5-6 go-stone-sized pieces. Conclusions : To liken a dosage to an object is only an exception and lacks precision and convenience; therefore dosages ended up expressed in weight, count, or volume.