• Asia pacific journal of information systems
• /
• v.4 no.1
• /
• pp.139-168
• /
• 1994

Many researchers and practitioners have paid much attention to identifying some critical factors for the successful implementation of the TPS, EDP and MIS. However, not much effort have been focused on the implementation issues of DSS which is different from TPS or MIS in terms of the scope of the system, evaluation criteria, decision types served, and level of users. Because of these differences, implemention of DSS should be planned and approached from different aspects of TPS, EDP and MIS. A conceptual model includes four characteristics as independent variables and three dependent variables such as system usage, user's satisfaction, and user's attitude. This paper is to empirically prove the usefulness of the model and to identify a model for the successful implementation of DSS in Korea. It will provide a better understanding of the variables associated with the successful DSS implementation.

• Smart Structures and Systems
• /
• v.26 no.4
• /
• pp.533-544
• /
• 2020

Effective bridge maintenance reduces bridge operation costs and extends its service life. The possibility of storing bridge life-cycle data in a 3D parametric model of the bridge through Bridge Information Modeling (BrIM) provides new opportunities to enhance current practices of bridge maintenance management. This study develops a Decision Support System (DSS), namely BrDSS, which employs BrIM and an efficient optimization model for bridge maintenance planning. The BrIM model in BrDSS extracts basic data of elements required for the optimization process and visualizes the inspection data and the optimization results to the user to help in decision makings. In the optimization module of the DSS, the specifically formulated Genetic Algorithm (GA) eliminates the chances of producing infeasible solutions for faster convergence. The practicality of the presented DSS was explored by utilizing the DSS in the maintenance planning of a bridge under operation in the southwest of Iran.

• Korean Management Science Review
• /
• v.18 no.2
• /
• pp.39-60
• /
• 2001

This Paper deals with a collaborative decision making procedure of web-based DSS for supply chain management (SCM). The seemingly autonomous DSS dedicated to each of mutually exclusive prob1em domains forms a communication network and cooperates each other for better SCM decision making. We a1so propose a hub-spoke information sharing model for the DSS network. In the hub-spoke model, an information hub at the center facilitates information exchange between DSS\\`s and controls the conversations defined by the series of XML messages between agents of DSS. A product ordering scenario where supply decision is triggered upon customer order is used to demonstrate the SCM decision procedure through a collaboration of the web-based DSS.

• Biomedical Science Letters
• /
• v.20 no.4
• /
• pp.227-236
• /
• 2014

Ulcerative colitis (UC) is a serious gastrointestinal tract disease characterized by recurrent chronic inflammation and mucosal damage of the gastrointestinal tract. The conventional therapies of choice are anti-inflammatory agents, steroids and anti-TNF-${\alpha}$ therapy. However, inherent limitations in these therapies have steered many UC patients to supplement existing therapies with alternative medicinal products. In the current study, we tested the efficacy of Gingko bilola extract (EGb 761) in abating colonic inflammation in a DSS-induced murine model of colitis. C57BL/6 mice were administered 2% DSS in the drinking water for 7 days, then regular water for 7 days, and then 2% DSS for an additional 7 days. EGb 761 (1 mg/dose) was oral gavaged daily for the duration of the experiment. At the termination of the experiment, mice treated with EGb+DSS showed higher body weight, lower spleen weight and longer colon length compared to mice treated with DSS alone. HE-stained colon tissues also exhibited less histologic inflammation in mice treated with EGb+DSS mice compared to mice treated with DSS alone. The serum levels inflammatory cytokines, KC and TNF-${\alpha}$, were also decreased in mice treated with EGb+DSS compared to mice treated with DSS alone. Finally, addition of EGb 761 to TNF-${\alpha}$ treated colonic cell line (HT29/c1) decreased secretion of IL-8 in vitro. These results collectively suggest that EGb 761 abates induction of colitis in DSS-induced model of colitis in mice.

• IMMUNE NETWORK
• /
• v.11 no.6
• /
• pp.416-419
• /
• 2011

Dextran sodium sulfate (DSS) is a widely used chemical model for inflammatory bowel disease (IBD). It is thought that imbalances in the T helper (Th) cell subsets contribute to IBD. Recent studies suggest that the acute DSS-colitis model is polarized toward a Th1/Th17 profile based on RT-PCR analysis of colonic tissues. In the current study we determined whether colonic Th cells from DSS-colitis mice were skewed toward the Th17 profile. Mice were treated with 5% DSS for 7 days and colonic T cells isolated and examined for production of IFN-${\gamma}$ (Th1 cell), IL-4 (Th2 cell) and IL-17 (Th17 cell) by intracellular flow cytometry. We found that the percentage of colonic Th17 cells were similar to non-treated controls but the percentage of Th1 cells were elevated in DSS-colitis mice. These results suggest that in the acute DSS-colitis model the colonic Th cells exhibit a Th1 profile and not a Th17 profile.

• Journal of Nutrition and Health
• /
• v.37 no.6
• /
• pp.431-439
• /
• 2004

Scutellariae Radix (Scu.), one of the immune-regulatory substances, is recognized to play the role in the metabolic process of inflammation, allergy and immunity. It has been traditionally used in the Oriental medicine to treat inflammatory bowel diseases (IBD). The purpose of this study was to evaluate the effects of water extracts of Scutellariae Radix on the spleen lymphocyte immune function in the Balb/c female mice treated with dextran sodium sulfate (DSS) to induce colitis. Water extract of Scutellariae Radix (100 mg/kg) and sulfasalazine (50 mg/kg) were administrated orally for 2 weeks of experimental period. Mice were divided into three experimental groups randomly: DSS group (5％ DSS was ad libitum for 5 days) as control group, DSS ＋ Scu. (water extracts of Scutellariae Radix for 2 weeks after 5％ DSS was ad libitum for 5 days) as experimental group, and DSS ＋ Sulfasalazine group (Sulfasalazine for 2 weeks after 5％ DSS was ad libitum for 5 days) as positive control group. Levels of Ig A, Ig E, CD4$^{＋}$, CD8$^{＋}$, TNF-$\alpha$ and other cytokines were measured. Treatment of DSS for 5 days induced bowel inflammation and the treatment with Scu. water exteract and sulfasalazine significantly recovered the damage. The length of intestine of DSS group was significantly shorter than that of other groups. The serum and fecal concentration of Ig A of SS ＋ Scu group was higher than those of DSS group. The contents of CD4$^{＋}$ T cells was higher in the DSS ＋ Scu. group than the other groups and CD8$^{＋}$ T cells was the lowest in DSS ＋ Sulfasalazine group. The Ig A level of cultured supernatant of spleen lymphocyte was the highest, while the Ig E level was the lowest in SS ＋ Scu group. The concentration of TNF-$\alpha$, cytokine secreted from the Th1 cell in the supernatant spleen lymphocyte, was the highest in the DSS group and the lowest in the DSS ＋ Scu. group. The concentration of IFN-${\gamma}$ and ll...-12 was lower in the DSS ＋ Scu. group than those of the other groups. The concentration of IL-4 in the supernatant of spleen lymphocyte was the lowest in the DSS ＋ Scu. group but IL-10 was not significantly different. Based on these findings, water extract of Scutellariae Radix exhibited the inhibitory effect via IL-4 production thereby inhibited the production of Ig E and strengthened immune system, and alleviated injury in DSS- induced colitis mice model.

• The Korean Journal of Food And Nutrition
• /
• v.34 no.2
• /
• pp.146-155
• /
• 2021

This study observed the anti-inflammatory effect of the polysaccharide derived from the mycelium of Tremella fuciformis in mice with colitis induced with dextran sulfate sodium (DSS). The experimental groups were normal, DSS, DSS-TFL50, DSS-TFH100, and suflasalazine. Body weights, colon lengths, and organ weights were measured, and the plasma level of pro-inflammatory cytokine and mRNA and protein expression in colon tissue were analyzed. Body weight loss, a symptom of DSS-induced colitis, was suppressed by DSS-TF and the speed of weight recovery proceeded rapidly. In addition, DSS-TF showed a significant inhibitory effect on the decrease of colon length typically caused by colon damage. TNF-α, IL-6 and IL-1β cytokine levels in plasma were reduced in DSS-TF and positive control groups. TNF-α, COX-2 and IL-1β mRNA expression in colon tissue were inhibited in DSS-TF and positive control, and it was significantly different from that of the DSS group. The protein expression of inflammation-related genes (IL-6, TNF-α and COX-2) in the colon tissue was significantly increased by DSS compared to that of the normal group, but by DSS-TFL50, DSS-TFH100 and sulfasalarin decreased. In conclusion, the polysaccharide derived from the mycelium of Tremella fuciformis showed the anti-inflammatory effect on DSS-induced colitis in mice.

• Journal of Construction Engineering and Project Management
• /
• v.7 no.3
• /
• pp.1-14
• /
• 2017

Delay claim should actually be supported by a set of proper information so that the contractors could prove their validity. The so-called information should be able to clarify the relationship between delay events and how they impact on the whole project. Therefore, exploiting an integrated system by people who are involved in construction business would certainly prove helpful. In the present study, delay analysis methods have been investigated along with selecting a relatively comprehensive method which has been modified, and eventually, a novel model and its required modules have been proposed for evaluating delay claims. The suggested integrated model is formed to identify delayed events, to classify delays, to measure the impacts of delays on the project scheduling, and finally to estimate the damages which were caused by those so-called delays. A decision support system (DSS) model which is related to the integrated system is actually extracted from Iran's general contract conditions, that is, 4311 magazine (equivalent to red FIDIC book). It is then programmed and coded by C# program. This DSS model can be used as an input of Easy Plan program. In addition, at the end of this research, the coded DSS has been used along with the so-called program so that a modified and developed model could be generated.

• Journal of Korea Society of Industrial Information Systems
• /
• v.12 no.4
• /
• pp.41-54
• /
• 2007

To make most out of Order Review/Release(ORR) models, they are to be analyzed and classified according to their prospective users' requirements. To this end, we discuss ORR functions and so-called "ORR paradox", and propose an ORR model classification scheme named "COMPACT(COMplexity-imPACT) Matrix". Under the scheme, the complexity and impact levels of each ORR model are rated one after another in order to position it across the matrix. We explore the process and present the results, insisting that a DSS should suggest ORR models to its users on the complexity-impact basis.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.42 no.5
• /
• pp.103-113
• /
• 2000

A decision support system DSS-WQMRA (Decision Support System-Water Quality Management in Rural Area) was developed to help regional planners for the water quality management in a rural basin. The integrated model DSS-WQMRA, written in JAVA, includes four subsystems such as a GIS, a database, water quality simulation models and a decision model. In the system, the GIS deals with landuse and the location of pollutant sources. The database manages each data and supplies input data for various water quality simulation models. the water quality simulation model is composed of the GWLF( Generalized Watershed Loading Function), PCLM(Pollutant Loading Calculation Module) and the WASP5 model. The decision model based on mixed integer programming is designed to determine optimal costs and thus allow the selection of managemental practices to meet the water quality criteria. The methodology was tested with an example application in the Bokha River Basin, Kyunggi Province in Korea. It was proved that the integrated model DSS-WQMRA could be very useful for water quality management including the non-point source pollution in rural areas.