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http://dx.doi.org/10.9799/ksfan.2021.34.2.146

Anti-Inflammatory Effects of Polysaccharides Isolated from Tremella fuciformis Mycelium on Dextran Sulfate Sodium-Induced Colitis Model  

Yoo, Sun Hee (Dept. of Convergence Technology, Graduate School of Venture, Hoseo University)
Kang, Soon Ah (Dept. of Convergence Technology, Graduate School of Venture, Hoseo University)
Publication Information
The Korean Journal of Food And Nutrition / v.34, no.2, 2021 , pp. 146-155 More about this Journal
Abstract
This study observed the anti-inflammatory effect of the polysaccharide derived from the mycelium of Tremella fuciformis in mice with colitis induced with dextran sulfate sodium (DSS). The experimental groups were normal, DSS, DSS-TFL50, DSS-TFH100, and suflasalazine. Body weights, colon lengths, and organ weights were measured, and the plasma level of pro-inflammatory cytokine and mRNA and protein expression in colon tissue were analyzed. Body weight loss, a symptom of DSS-induced colitis, was suppressed by DSS-TF and the speed of weight recovery proceeded rapidly. In addition, DSS-TF showed a significant inhibitory effect on the decrease of colon length typically caused by colon damage. TNF-α, IL-6 and IL-1β cytokine levels in plasma were reduced in DSS-TF and positive control groups. TNF-α, COX-2 and IL-1β mRNA expression in colon tissue were inhibited in DSS-TF and positive control, and it was significantly different from that of the DSS group. The protein expression of inflammation-related genes (IL-6, TNF-α and COX-2) in the colon tissue was significantly increased by DSS compared to that of the normal group, but by DSS-TFL50, DSS-TFH100 and sulfasalarin decreased. In conclusion, the polysaccharide derived from the mycelium of Tremella fuciformis showed the anti-inflammatory effect on DSS-induced colitis in mice.
Keywords
anti-inflammatory effect; polysaccharides; Tremella fuciformis; DSS-induced colitis;
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