• Archives of Pharmacal Research
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• v.29 no.11
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• pp.977-983
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• 2006

The objective was to devise an animal model of myocardial infarction (MI) against which cardioprotective drugs might be tested. We describe the effects of nimesulide, a COX experience with development and validation of such a model. The rabbit was chosen in preference to rodents because its heart and cardiac circulation more closely resemble those of human. Thus, the cardiovascular system of anaesthetized male rabbits, 1 to 1.5 kg (n=11), was stressed by a single bolus intravenous injection of isoprenaline (ISP), 65 mg/kg. The effects of the injection were followed for sixteen days and were evaluated in four ways: 1) measurements of creatinine kinase isozyme and troponin-I (TPI) in serum 2) Electrocardiographic (ECG) changes (ST elevation and Q wave development) 3) Cardiac histopathology observed in tissue sections of the isolated of the heart. The histopathological analysis showed that rabbit heart on 2nd day after ISP injection showed changes of coagulation necrosis. Day 4 total coagulation with the loss of nuclear and striation associated with heavy interstitial infiltrate of neutrophils was found. Day 8 after infarction showed collagen deposition with capillary channels in between the remaining islands of myocytes in the infarcted area. On the 16th day scarring was complete. Coronary perfusion rates (CPR) and heart rate (HR) of the infarcted and nimesulide (a COX-2 inhibitor) treated rabbits displayed significant improvement (n=11) on each corresponding day after infarction as compared to the infarcted and saline treated rabbits (P<0.05). All four indices revealed similarities with effects commonly associated with MI in humans.

• Journal of Electrical Engineering and Technology
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• v.13 no.5
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• pp.1886-1900
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• 2018

This paper proposes a confronting feedback control structure and controllers for positive output elementary super lift Luo converters (POESLLCs) working in discontinuous conduction mode (DCM). The POESLLC offers the merits like high voltage transfer gain, good efficiency, and minimized coil current and capacitor voltage ripples. The POESLLC working in DCM holds the value of not having right half pole zero (RHPZ) in their control to output transfer function unlike continuous conduction mode (CCM). Also the DCM bestows superlative dynamic response, eliminates the reverse recovery troubles of diode and retains the stability. The proposed control structure involves two controllers respectively to control the voltage (outer) loop and the current (inner) loop to confront the time-varying ON/OFF characteristics of variable structured systems (VSSs) like POESLLC. This study involves two different combination of feedback controllers viz. the proportional integral controller (PIC) plus sliding mode controller (SMC) and the fuzzy logic controller (FLC) plus SMC. The state space averaging modeling of POESLLC in DCM is reviewed first, then design of PIC, FLC and SMC are detailed. The performance of developed controller combinations is studied at different working states of the POESLLC system by MATLAB-Simulink implementation. Further the experimental corroboration is done through implementation of the developed controllers in PIC 16F877A processor. The prototype uses IRF250 MOSFET, IR2110 driver and UF5408 diodes. The results reassured the proficiency of designed FLC plus SMC combination over its counterpart PIC plus SMC.

• International Journal of Computer Science & Network Security
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• v.21 no.12
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• pp.235-247
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• 2021

Today, the cloud computing has become a major demand of many organizations. The major reason behind this expansion is due to its cloud's sharing infrastructure with higher computing efficiency, lower cost and higher fle3xibility. But, still the security is being a hurdle that blocks the success of the cloud computing platform. Therefore, a novel Multi-tenant Decentralized Information Flow Control (MT-DIFC) model is introduced in this research work. The proposed system will encapsulate four types of entities: (1) The central authority (CA), (2) The encryption proxy (EP), (3) Cloud server CS and (4) Multi-tenant Cloud virtual machines. Our contribution resides within the encryption proxy (EP). Initially, the trust level of all the users within each of the cloud is computed using the proposed two-stage trust computational model, wherein the user is categorized bas primary and secondary users. The primary and secondary users vary based on the application and data owner's preference. Based on the computed trust level, the access privilege is provided to the cloud users. In EP, the cipher text information flow security strategy is implemented using the blowfish encryption model. For the data encryption as well as decryption, the key generation is the crucial as well as the challenging part. In this research work, a new optimal key generation is carried out within the blowfish encryption Algorithm. In the blowfish encryption Algorithm, both the data encryption as well as decryption is accomplishment using the newly proposed optimal key. The proposed optimal key has been selected using a new Self Improved Cat and Mouse Based Optimizer (SI-CMBO), which has been an advanced version of the standard Cat and Mouse Based Optimizer. The proposed model is validated in terms of encryption time, decryption time, KPA attacks as well.

• PNF and Movement
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• v.17 no.1
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• pp.47-56
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• 2019

Purpose: This study investigated the effects of neck pattern of proprioceptive neuromuscular facilitation (PNF) on balance and walking ability in patients with chronic stroke. Methods: Fourteen participants with chronic stroke were randomly assigned to vestibular rehabilitation and then divided into two groups: the neck pattern group or treadmill group. Each group underwent 20 sessions (20 minutes/day, five days/week, for four weeks). Patients were assessed with the Berg balance scale (BBS) and gait parameters (gait speed, cadence, step length, and double-limb support period) using a GAITRite system. Results: Vestibular rehabilitation for the neck pattern group and the treadmill group showed significant intragroup improvement on the BBS and in terms of gait speed, cadence, step length, and double-limb support period (p < 0.05). Vestibular rehabilitation was more effective for the neck pattern group than for the treadmill group in terms of the BBS (p = 0.00; 95% CI, 1.49-5.94), gait speed (p = 0.01; 95% CI, 0.05-0.16), cadence (p = 0.02; 95% CI, 0.54-4.99), and step length (p = 0.00, 95% CI, 1.55-4.62). Conclusion: This study used the neck pattern of PNF for vestibular rehabilitation in patients with chronic stroke. The results showed significant improvement in the patients' balance and walking ability. Therefore, the neck pattern of PNF for vestibular stimulation may be more effective than treadmill training to improve balance and walking ability in patients with chronic stroke.

• Journal of The Korea Institute of Healthcare Architecture
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• v.9 no.2
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• pp.25-36
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• 2003

The purpose of this study is to trace the historical background and to describe the architectural issues of the healthcare facilities in 1876~1945 years. Between 1876~1895 yr, the first western hospital "Jejung-Won" was built in Seoul by the Korean Gov. with the help of the American Missionary Dr. Allen. The special clinic for curing smallpox, Udu-Kuk was built nationally and the hospitals for infection disease were built in the same periods. In the next stage 1896~1905, 1905~1910 yr, there were many type of facilities such as military hospital, oriental medicine hospital, public hospital for poor people, clinic or hospital for Mission. After being conquered by Japan in 1910~1945, the Japan Healthcare System was directly transferred into Korean system and the healthcare facilities was built by japanese architect. At that time, the Japan healthcare system had been constructed after following the modern European healthcare system. Most healthcare facilities in the age of Japanese imperialist was handed over to the Korean Government in 1950~1960 yr after world war II.

• Nuclear Engineering and Technology
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• v.41 no.1
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• pp.125-134
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• 2009

This paper presents details on a tube inspection robotic system and a positioning method of the robot for a steam generator (SG) in nuclear power plants (NPPs). The robotic system is separated into three parts for easy handling, which reduces the radiation exposure during installation. The system has a supporting leg to increase the rigidity of the robot base. Since there are several thousands of tubes to be inspected inside a SG, it is very important to position the tool of the robot at the right tubes even if the robot base is positioned inaccurately during the installation. In order to obtain absolute accuracy of a position, the robot kinematics was mathematically modeled with the modified DH(Denavit-Hartenberg) model and calibrated on site using tube holes as calibration points. To tune the PID gains of a commercial motor driver systematically, the time delay control (TDC) based gain tuning method was adopted. To verify the performance of the robotic system, experiments on a Framatomes 51B Model type SG mockup were undertaken.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.299-300
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• 1998

Recently the development of medical modality like as MRI, 3D US, DR etc is very active. Therefore it is more required not only the enhancement of quality in medical service but the improvement of medical system based on quantization, minimization, and optimization of high speed. Especially, as the changing into the digital modality system, it gets to start using ASIC(Application Specific Integrated Circuit) to realize one board system. It requires the implementation of hardware debugging and effective speedy algorithm with more speed and accuracy in order to support and replace existing device. If objected image could be linked to high speed process board with special interface and pre-processed using FPGA, it can be used in real time image processing and protocol of HIS(Hospital Information System). This study can support the basic circuit design of medical image board which is able to realize image processing basically using digitalized medical image, and to interface between existing device and image board containing image processing algorithm.

• The Pure and Applied Mathematics
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• v.27 no.3
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• pp.137-155
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• 2020

Redundancy is commonly employed to improve system reliability. In most situations, components in the standby configurations are assumed statistically similar but independent. In many realistic models, all parts in standby are not treated as identical as they have different failure possibilities. The operational structure of the system has subsystem-1 with five identical components working under 2-out-of-5: G; policy, and the subsystem-2 has two units and functioning under 1-out-of-2: G; policy. Failure rates of units of subsystems are constant and assumed to follow an exponential distribution. Computed results give a new aspect to the scientific community to adopt multi-dimension repair in the form of the copula.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.54 no.2
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• pp.97-103
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• 2005

Most car navigation systems(CNS) estimate the vehicle's location using global positioning system(GPS) or dead reckoning(DR) system. However, the estimated location has undesirable errors because of various noise sources such as unpredictable GPS noises. As a result, the measured position is not lying on the road, although the vehicle is known to be restricted on the road network. The purpose of map matching is to locate the vehicle's position on the road network where the vehicle is most likely to be positioned. In this paper, we analyze some general map matching algorithms first. Then, we propose a map matching method using compensation vectors to improve the performance of map matching. The proposed method calculates a compensation vector from the discrepancy between a measured position and an estimated position. The compensation vector and a newly measured position are to be used to determine the next estimation. To show the performance improvement of the map matching using compensation vectors, the real time map matching experiments are performed. The real road experiments demonstrate the effectiveness and applicability of the proposed map matching.

• Earthquakes and Structures
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• v.3 no.5
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• pp.749-766
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• 2012

Structural control through integration of passive damping devices within the building structure has been increasingly implemented internationally in the last years and has proven to be a most promising strategy for earthquake safety. In the present paper an alternative configuration of an innovative energy dissipation mechanism that consists of slender tension only bracing members with closed loop and a hysteretic damper is investigated in its dynamic behavior. The implementation of the adaptable dual control system, ADCS, in frame structures enables a dual function of the component members, leading to two practically uncoupled systems, i.e., the primary frame, responsible for the normal vertical and horizontal forces and the closed bracing-damper mechanism, for the earthquake forces and the necessary energy dissipation. Three representative international earthquake motions of differing frequency contents, duration and peak ground acceleration have been considered for the numerical verification of the effectiveness and properties of the SDOF systems with the proposed ADCS-configuration. The control mechanism may result in significant energy dissipation, when the geometrical and mechanical properties, i.e., stiffness and yield force of the integrated damper, are predefined. An optimum damper ratio, DR, defined as the ratio of the stiffness to the yield force of the hysteretic damper, is proposed to be used along with the stiffness factor of the damper's- to the primary frame's stiffness, in order for the control mechanism to achieve high energy dissipation and at the same time to prevent any increase of the system's maximum base shear and relative displacements. The results are summarized in a preliminary design methodology for ADCS.