• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.9
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• pp.1200-1206
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• 2006

The purpose of this study was to investigate the relation between NEAP (net rate of endogenous noncarbonic acid production) from dietary potassium and protein intakes, and bone mineral density and urinary deoxypyridinoline (DPD) in Korean women. The subjects were 276 women aged $18\sim81$, and they were asked about general characteristics and nutrient intake using 24-hr recall method. Also, their bone mineral density of spine and femoral neck were measured using DEXA. Urinary DPD analysis was done in 106 postmenopausal women. The average energy, protein and potassium intake were 1503.0 kcal, 57.7 g and 60.8 mEq, respectively. Mean NEAP [54.5$\times${protein intake (g)/potassium intake (mEq)}-10.2] was 44.6. NEAP showed a significantly negative correlation with spine bone mineral density of the subjects after controlling for confounding factors (age, height and weight) (p<0.05). The lowest quartile of protein intake had the highest spine bone mineral density after controlling for confounding factors (p<0.05). There was no significant correlation between urinary DPD and calculated NEAP. These results provided positive relation between a ratio of lower protein to higher potassium dietary intake and bone mineral density.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.181-182
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• 2008

In this paper, an cost-effective system architecture is proposed to implement digital predistortion scheme for linearizing the PA amplifing TDD wideband signal. To make digital predistorted signal for compensating nonlinearity of PA, a dedicated ADC and a frequency-down converter are necessary. Proposed scheme is based on the TDD feature that the RF receiver frontend is idle state during the downlink signal processing time and utilize them to make the digital predistorted signal for PA.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.1
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• pp.14-23
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• 2020

This study was conducted to evaluate the efficacy of Cheongawongagam on osteoporosis rat. A total of 35 rats were divided into seven groups; Normal control(SD-Nr), experimental control group(OVX-CTL), positive control group(OVX-17β-E2) and herb extracts group[Eucommia ulmoides(OVX-EU-E), Juglandis semen(OVX-JR-SE), Acanthopanax senticosus(OVX-AS-E) extract and Cheongawongagam extracts(OVX-JAEG-E)]. All control group, and herb extracts group were ovariectomized. After the 3 weeks recovery period, herb extract group were orally administered 200 mg / kg of the EU-E, JR-SE, AS-E and JAEG-E for 12 weeks. In the OVX-CTL, 17β-estradiol(E2) was administered subcutaneously on the back of the rats at a dose of 0.03 ug/sc. Their body weight, serum total cholesterol, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Leukotriene B4 (LTB4), calcium (Ca), estradiol, osteocalcin, and deoxypyridinoline (DPD) concentration were measured. Also, we investigated mRNA expression of inflammatory cytokine, MMP-2, MMP-9, and bone tissue. As a result, total cholesterol was significantly decreased in the OVX-AS-E and OVX-JAEG-E. ALP was significantly increased and osteocalcin, DPD was significantly decreased in OVX-JAEG-E. The expression of inflammatory mediators (TNF-α, IL-1β, LTB4, COX-2, NOS-2), inflammatory cytokines IL-1β and MMP-9 mRNA were significantly decreased in OVX-JAEG-E. Histologic examination of the femur showed that bone mineral density, and bone mass were increased and bone marrow were decreased in the OVX-JAEG-E group. The above experiment shows that cheongawongagam extract were effective in the prevention and treatment of osteoporosis.

• Nutrition Research and Practice
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• v.11 no.3
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• pp.223-231
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• 2017

BACKGROUND/OBJECTIVES: Soy isoflavones are expected to improve menopausal symptoms and osteoporosis in women. However, their efficacy is still inconclusive, and there was limited data for postmenopausal women in South Korea. We examined the effects of soy isoflavones on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women. SUBJECTS/METHODS: A randomized, double-blind study design was used. Eighty-seven participants who had undergone natural menopause were randomly administered either 70 mg/day isoflavones (n = 43) or placebo (n = 41) for 12 weeks. We assessed the Kupperman index for climacteric symptoms and the menopause-specific quality of life (MENQOL) questionnaire for quality of the life. Biomarkers of bone metabolism were also measured in serum bone-specific alkaline phosphatase (BALP), osteocalcin (OC), N- and C-terminal cross-linking telopeptides of type Ι collagen (NTx, CTx), and urine-deoxypyridinolin (u-DPD). RESULTS: Scores of the Kupperman index were decreased in both the isoflavones group ($-7.0{\pm}15.8$, P = 0.0074) and placebo group ($-6.3{\pm}14.6$, P = 0.0064) during the intervention, but no significant difference was noted between the groups. Regarding the bone formation markers, the level of serum BALP increased by $6.3{\pm}4.1%$ (P = 0.004) and OC increased by $9.3{\pm}6.2%$ (P < 0.001), meanwhile those of the placebo were not changed. For the bone resorption markers, NTx, CTx, and u-DPD were not significantly different in either group. MENQOL was significant decreased in the isoflavone group ($-0.6{\pm}0.5$) and placebo group ($-0.6{\pm}0.4$), with a significant difference between groups (P = 0.0228). CONCLUSIONS: Our study suggests that 70 mg isoflavones supplement has beneficial effects on bone formation markers; however, it showed no benefit compared to the placebo on climacteric symptoms or quality of life.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.11
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• pp.596-602
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• 2016

Potassium iodide (KI) TRO sensor for measuring total residual oxidant which is an index for disinfection and neutralization in ballast water has been constructed. The results of UV absorption wavelength and absorbance test in various TRO concentrations show high linear correlation ($r^2=0.9825$) at 350 nm wavelengths and it can be possible to visualize numerical value of TRO concentration (0.1~7.0 mg/L). The result of comparison test according to TRO concentration between the KI based TRO sensor system and the DPD based TRO sensor system showed identical trend. Overall results indicated that the KI TRO sensing system could be applied for continuous TRO concentration measurement in ballast water treatment system.

• Nutrition Research and Practice
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• v.1 no.4
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• pp.305-312
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• 2007

A group of 101 women, aged 40-65 years consisted of 48 premenopausal subjects and 53 postmenopausal ones living in Daegu and Gyeongbuk area in Korea were evaluated with their general characteristics, lifestyle factors, nutrient and phytoestrogen intakes, blood and urinary indices concerning antioxidant status and bone metabolism. Body mass index (BMI), waist hip ratio (WHR) and systolic blood pressure (SBP) of the postmenopausal women were significantly higher (23.8, 0.86, and 126.9 mmHg, respectively) than those of the premenopausal women (22.6, 0.82, and 115.9 mmHg; respectively). Nutrient intakes of the postmenopausal and premenopausal groups were not different except lower fat intake and higher dietary fiber and iron intakes in the postmenopausal group. Daily total phytoestrogen intake was significantly higher in the postmenopausal group (48.54 mg) than the premenopausal (31.41 mg) and was resulted mostly from higher intakes of daidzein and genistein from soy and soy products (45.42 mg vs 28.91 mg). Serum genistein level and excretion of enterolactone, major lignan metabolite, were not very different between the two groups. Serum retinal and ${\alpha}$- tocopherol levels were higher in the postmenopausal group but TBARS levels were not different between the two groups. Serum osteocalcin (7.18 ng/mL) and urinary deoxypyridinoline (7.15 nmol/mmol creatinine), in the postmenopausal group were significantly higher than those in the premenopausal group (4.80 ng/mL, 5.95 nmol/mmol creatinine). Urinary excretion of enterolactone was positively correlated with serum osetocalcin in premenopausal women and serum genistein negatively correlated with the urinary DPD in postmenopausal women. Dietary phytoestrogen intake was negatively correlated with serum level of TBARS in all subjects. It is concluded that the effect of total phytoestrogen intake is beneficial on body antioxidant status in all middle-aged women regardless of menopause but the effect on bone metabolism appears different by the type of the phytoestrogen and the menopausal state.

• International Journal of Contents
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• v.11 no.1
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• pp.62-68
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• 2015

Many severe earthquakes have occurred along the main fault lines in the world. In recent years, there has been a high incidence of small- and large-scale earthquakes in our country. These occurrences of earthquakes have become increasingly serious, owing to a degrading earth environment. An earthquake, in general, causes far more serious damages like disruptions in electricity or gas facilities, and fire disasters from its annexed effects than by its vibrations or the shock itself. In this paper, we present a countermeasure and its necessity in safeguarding against fire disasters in regional heritage villages such as "Asan Oeam," "Jeonju Hanok," and "Andong Hahoe." A more systematic and effective strategy for prevention systems against severe fire disasters is proposed after performing various related investigations and analyses of existing domestic and international systems. We investigated the existing fire security systems and their historical records with the tendency of earthquake occurrences in these three folk villages. In this proposal, we present a strategic approach for safeguarding against fire damages in our regional heritage villages derived from ICT (information communication technology)-based DPD (disaster prevention design), after examining the laws and regulations of fire-prevention strategies in Japan, America, and Europe.

• Journal of the Korean Chemical Society
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• v.56 no.4
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• pp.431-439
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• 2012

Dissipative particle dynamics (DPD) was carried out to study the nucleation and crystal growth process of $CeO_2$ nanoparticles in different alcohol aqueous solutions. The results showed that the nucleation and crystal growth process of $CeO_2$ can be classified into three stages: nuclei growth, crystal stabilization and crystal aggregation except the initial induction stage, which could be reproduced by collecting simulation results after different simulation time. Properly selecting the sizes of $CeO_2$ and water bead was crucial in the simulation system. The influence of alcohol type and content in solutions, and precipitation temperature on the particle dimension were investigated in detail and compared with the experimental results. The consistency between simulation results and experimental data verify that the simulation can reproduce the macroscopic particle aggregation process. The effect of solvent on the nucleation and crystal growth of $CeO_2$ nanoparticles are different at three stages and can not be simply described by Derjaguin-Landau-Verwey-Overbeek (DLVO) theory or nucleation thermodynamics theory. Our work demonstrated that DPD methods can be applied to study nanoparticle forming process.

• Journal of Korean Medicine Rehabilitation
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• v.25 no.2
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• pp.51-64
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• 2015

Objectives This study was carried out to investigate the effects of Gyejigabuja-tang extracts on the Monosodium iodoacetate (MIA) induced osteoarthritis in rats. Methods Osteoarthritis was induced by injection of MIA into knee joint cavity of rats. Rats are divided into 4 groups (normal, control, positive comparison group, GBT group, each n=5). Normal group was injected by normal saline into knee joint cavity only. Control group was induced for osteoarthritis by MIA and oral medicated with distilled water. Positive comparison group was injected with MIA and taken Joins tablet 25 mg/kg. GBT group was injected with MIA and taken Gyejigabuja-tang extracts 300 mg/kg. Positive comparison group and GBT group were oral medicated for each substance once a day for 4 weeks. ALT, AST and creatinine were evaluated for hepatotoxicity and nephrotoxicity. Hind paw weight bearing ability was examined and inflammatory cytokines (IL-$1{\beta}$, IL-6, TNF-${\alpha}$), $PGE_2$, $LTB_4$, osteocalcin and deoxypyridinoline (DPD) within serum were analysed. Knee joint structures were observed by Hematoxylin & Eosin (H&E), Safranin-O staining method. Results 1. Function of liver and kidney was not affected. 2. Hind paw weight bearing ability was significantly improved. 3. IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ in experimental group were significantly decreased compared with control group. 4. $PGE_2$, $LTB_4$, Osteocalcin and DPD in experimental group were decreased compared with control group. 5. In histopathologic observation, injury on synovial membrane and cartilage of experimental group was lesser than control group (H&E, Safranin-O staining). Conclusions Based on these results, it can be suggested that Gyejigabuja-tang has anti-inflammation effects on the MIA-induced osteoarthritis in rats.

• 대한근관절건강학회:학술대회논문집
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• 2002.11a
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• pp.238-246
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• 2002

최근 경제의 발전과 의학의 발달로 인하여 인간의 수명은 점차 연장됨에 따라, 노인인구도 급격히 증가하고 있다. 40세 이상 여성 인구도 8.998천명으로 전체 여성의 38%를 차지하며 이는 매년 증가할 것이다. 그리하여 전체 인구에 대한 폐경 여성의 점유율도 급격히 증가하고 있다. 폐경 이후 $5{\sim}10$년 동안 매년 $2{\sim}4%$씩 골농도가 감소하고 있기 때문에 폐경기 여성을 위협하는 주요 질환 중 하나가 골다공증이다. 하지만 골다공증은 뚜렷한 자각증상이 없어 골 기형 및 골절이 발생하기 전에는 조기발견이 어렵다. 골다공증은 모든 중년 여성의 건강문제이므로 지역사회에서 골절 발생 위험율을 줄일 수 있도록 골다공증 예방을 위한 건강관리가 필요하다. 본 연구의 목적은 지역사회에서 적용할 수 있는 골다공증 예방 프로그램을 개발하여 그 효과를 검정한 후 지역사회 중년 여성 건강증진 프로그램으로 활용코저 함에 있다. 골다공증 예방 프로그램은 운동과 교육으로 구성하였으며, 12주 동안 점핑 동작 위주의 에어로빅과 스텝퍼 운동과 근력강화운동(최대 심박수의 $70%{\sim}80%$, $70{\sim}80$분, 3회/주)을 병행하여 실시하였고, 교육은 운동과 칼슘 섭취의 중요성을 건강 신념 이론에 근거하여 자기 효능감을 증대시키는 교육을 하여 지속적인 운동 실천과 칼슘식이 섭취를 하도록 하였다. 대상자는 서울시 일개 보건소에서 골감소증으로 진단받은 폐경 여성으로 실험군 19명과 대조군 19명이었다. 골다공증 예방 프로그램의 효과는 골밀도, DPD ratio, osteocalcin, 일일 평균 칼슘섭취량, 일일 열량 소모량, 배근력, 최대 산소 섭취량, 제지방량과 건강신념 변수로 측정하였다. 수집된 자료는 PC SPSS 8.0 프로그램을 이용하여 대상자의 일반적 특성은 실수와 백분율로 실험군과 대조군의 동질성 검사는 t-test, $x^2-test$ 및 Fisher exact test를 이용하였고, 두 집단 간 결과변수들의 중재 전후의 차이는 t-test로 분석하였다. 연구 결과는 다음과 같다. 1) $L_{2-4}$ 골밀도는 실험군이 대조군에 비하여 유의하게 높았다. 2) DPD ratio와 osteocalcin은 두 집단간 유의한 차이가 없었다. 3) 배근력은 실험군에서 대조군보다 유의하게 증가하였으나, 제지방량과 최대 산소 섭취량은 유의한 차이가 없었다.