• Title/Summary/Keyword: DIM

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Effects of Indole Oligomers Induced from Indole-3-carbinol on the Growth of MCF-7 Breast Cancer Cells

  • Kang, Kap-Suk;Leonard F. Bjeldanes
    • Preventive Nutrition and Food Science
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    • v.3 no.2
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    • pp.163-168
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    • 1998
  • Inhibitory effect of indole oligomers induced from indole-3-carbinol(I3C) on the growth of breast cancer cells was studied. We gernerated the reaction mixtures (RXM) at ambient temperature by treating a stirred aqueous solution of I3C (typeically 0.25ml) at a concentration of 12 $\mu$mol/ml) with hydrochloric acid (typically 28$\mu$l of a 1 mmol/ml solution). RXM was fractionated by the column chromatography. The fractions with similar UV-pattern were further fractionated by HPLC and 3.3'-diindoylmethane (DIM) and other indole oligomers were identified. I3C, RXM, and it derived indole compounds were added to MCF-7 cells and cultured in the presence of 10-7M estradiol for 7 days. the growth-inhibitory effect of I3C and DIM on the growth of MCF-7 cell was very strong. The synthetic DIM also revealed antiproliferative effect on MCF-7 cel. The fractions containing high DIM content (77%), were most effective in inhibiting MCF-7 cell growth induced by estradiol. With these results, we suggest that I3C and DIM might have anticarcinogenic effect on the breast cancer.

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Forensic Classification of Median Filtering by Hough Transform of Digital Image (디지털 영상의 허프 변환에 의한 미디언 필터링 포렌식 분류)

  • RHEE, Kang Hyeon
    • Journal of the Institute of Electronics and Information Engineers
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    • v.54 no.5
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    • pp.42-47
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    • 2017
  • In the distribution of digital image, the median filtering is used for a forgery. This paper proposed the algorithm of a image forensics detection for the classification of median filtering. For the solution of this grave problem, the feature vector is composed of 42-Dim. The detected quantity 32, 64 and 128 of forgery image edges, respectively, which are processed by the Hough transform, then it extracted from the start-end point coordinates of the Hough Lines. Also, the Hough Peaks of the Angle-Distance plane are extracted. Subsequently, both of the feature vectors are composed of the proposed scheme. The defined 42-Dim. feature vector is trained in SVM (Support Vector Machine) classifier for the MF classification of the forged images. The experimental results of the proposed MF detection algorithm is compared between the 10-Dim. MFR and the 686-Dim. SPAM. It confirmed that the MF forensic classification ratio of the evaluated performance is 99% above with the whole test image types: the unaltered, the average filtering ($3{\times}3$), the JPEG (QF=90 and 70)) compression, the Gaussian filtered ($3{\times}3$ and $5{\times}5$) images, respectively.

Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells

  • Lee, Geum-A;Choi, Kyung-Chul;Hwang, Kyung-A
    • Biomolecules & Therapeutics
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    • v.26 no.5
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    • pp.503-511
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    • 2018
  • Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3'-diindolylmethane (DIM) are phytoestrogens that play chemopreventive roles in the inhibition of carcinogenesis and cancer progression. In this study, the influence of TCS, BPA, Kaem, and DIM on proliferation and apoptotic abilities of VM7Luc4E2 breast cancer cells were examined. MTT assay revealed that TCS ($0.1-10{\mu}M$), BPA ($0.1-10{\mu}M$) and E2 ($0.01-0.0001{\mu}M$) induced significant cell proliferation of VM7Luc4E2 cells, which was restored to the control (0.1% DMSO) by co-treatment with Kaem ($30{\mu}M$) or DIM ($15{\mu}M$). Reactive oxygen species (ROS) production assays showed that TCS and BPA inhibited ROS production of VM7Luc4E2 cells similar to E2, but that co-treatment with Kaem or DIM on VM7Luc4E2 cells induced increased ROS production. Based on these results, the effects of TCS, BPA, Kaem, and DIM on protein expression of apoptosis and ROS production-related markers such as Bax and Bcl-xl, as well as endoplasmic reticulum (ER) stress-related markers such as $eIF2{\alpha}$ and CHOP were investigated by Western blot assay. The results revealed that TCS, and BPA induced anti-apoptosis by reducing ROS production and ER stress. However, Kaem and DIM effectively inhibited TCS and BPA-induced anti-apoptotic processes in VM7Luc4E2 cells. Overall, TCS and BPA were revealed to be distinct xenoestrogens that enhanced proliferation and anti-apoptosis, while Kaem and DIM were identified as natural chemopreventive compounds that effectively inhibited breast cancer cell proliferation and increased anti-apoptosis induced by TCS and BPA.

A Study on the Mapping Method of IEEE 11073 DIM/HL7 v3 RIM for Smart health-care (스마트폰 헬스케어를 위한 IEEE 11073 DIM/HL7 v3 RIM 매핑 방법에 대한 연구)

  • Kim, Jong-Pan;Jeon, Jae-Hwan;Oh, Am-Suk
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2012.05a
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    • pp.842-845
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    • 2012
  • 의료기기는 헬스케어 서비스를 위한 필수요소로 최근 의료와 관련된 스마트폰 애플리케이션의 증가와 함께 스마트폰과 연결되는 의료기기를 활용한 스마트 헬스케어가 대두되고 있다. 이러한 스마트 헬스케어는 현재 ISO/IEEE 11073 표준을 통해 의료기기와 게이트웨이를 연결하여 임상정보를 전송하고 게이트웨이는 HL7 CDA 표준 문서를 통해 전자 건강 기록 및 개인 건강 기록 시스템, 임상 워크플로우 및 임상 의사 결정 지원 시스템과 같은 유형의 의료 서비스 시스템과 연동하는 솔루션이다. ISO/IEEE 11073은 DIM(Domain Information Model)이라는 정보 모델을 기반으로 하며 HL7 v3인 CDA는 RIM(Reference Information Model)이 있기 때문에 상이한 인터페이스간의 매핑 매커니즘을 필요로 한다. 이에 본 논문에서는 스마트폰 환경에서 의료 응용 애플리케이션에서의 효율적인 의료기기 데이터 운용을 위해 RMIM(Refined Message Information Model) 기반의 IEEE 11073 DIM/HL7 v3 RIM 표준 인터페이스 변환 방법을 제안한다.

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Effect of Time of Initiating Dietary Fat Supplementation on Performance and Reproduction of Early Lactation Dairy Cows

  • Son, J.;Larson, L.L.;Grant, R.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.13 no.2
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    • pp.182-187
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    • 2000
  • Forty-two Holstein cows (21 multiparous) were assigned by calving date and parity to three dietary sequences to evaluate the effect of time of initiating fat supplementation to diets on lactation and reproductive performance. The dietary sequences were: 1) control, no supplemental fat from 1 to 98 days in milk (DIM) ; 2) control diet from 1 to 28 DIM then 3% supplemental fat (calcium salts of long-chain fatty acids) from 29 to 98 DIM; or 3) 3% supplemental fat from 1 to 98 DIM. Feeding supplemental fat did not enhance mean milk and 4% fat corrected milk (FCM) yields, but efficiency of FCM production was higher for cows fed supplemental fat. Milk fat percentage was unchanged whereas milk protein percentage was depressed with fat supplementation. Feeding supplemental fat reduced DMI and energy balance but there were no differences among treatments on time to resumption of ovarian cyclicity or conception rate to first service. Concentrations of progesterone during the first two ovulatory cycles tended to be greater in the fat-supplemented groups. Feeding supplemental fat starting at either parturition or 29 DIM increased efficiency of FCM production, but did not greatly enhance reproductive performance.

On the Metric Dimension of Corona Product of a Graph with K1

  • Mohsen Jannesari
    • Kyungpook Mathematical Journal
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    • v.63 no.1
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    • pp.123-129
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    • 2023
  • For an ordered set W = {w1, w2, . . . , wk} of vertices and a vertex v in a connected graph G, the k-vector r(v|W) = (d(v, w1), d(v, w2), . . . , d(v, wk)) is called the metric representation of v with respect to W, where d(x, y) is the distance between the vertices x and y. A set W is called a resolving set for G if distinct vertices of G have distinct metric representations with respect to W. The minimum cardinality of a resolving set for G is its metric dimension dim(G), and a resolving set of minimum cardinality is a basis of G. The corona product, G ⊙ H of graphs G and H is obtained by taking one copy of G and n(G) copies of H, and by joining each vertex of the ith copy of H to the ith vertex of G. In this paper, we obtain bounds for dim(G ⊙ K1), characterize all graphs G with dim(G ⊙ K1) = dim(G), and prove that dim(G ⊙ K1) = n - 1 if and only if G is the complete graph Kn or the star graph K1,n-1.