• 대한화학회지
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• 제28권1호
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• pp.26-33
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• 1984

HF와 DF 혼합계내에서 일어나는 다음 두 진동-진동 에너지 이동 반응의 속도상수$(k_{vv})$를 n=2~5에 대해 300~800K 온도 범위에서 이론적으로 계산하였다. HF(v=n) + DF(v=0) ${\to}$ HF(v=n-l) + DF(v=l) + ${\Delta}E$(a) DF(v=n) + HF(v=0) ${\to}$ DF(v=n-l) + HF(v=l) + ${\Delta}E$(b) 이용한 충돌모형은 수소결합에너지를 분자간 상호작용의 주축으로 삼는 loosely-held, non-rigid dimer model이었고, 계산법으로는 반고전적 방법을 사용하였다. 계산 결과 반응(a)에 대한 속도상수가 반응(b)에 대한 속도상수 보다 훨씬 HF-DF 혼합계 내에서는 진동에너지가 HF에서 DF로 이동함이, 또한 반응(a)에 대한 속도 상수는 온도가 높아질 수록 감소하고, 진동 양자수가 커질 수록 증가하는 반면에, 반응 (b)에 대한 속도 상수는 온도 의존성과 양자수 의존성에 있어서 대체로 이와 반대의 경향을 보임을 밝혔으며, 이 계산 결과는 주로 에너지 차 ${\Delta}E$의 부호와 크기로써 설명될 수 있음을 보였다.

• 대한한의학방제학회지
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• 제22권1호
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• pp.113-122
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• 2014

Objectives : This study investigated the improvement effects of Pakistani (DF-a) and Chinese Ephedra herba-containing Gangjihwan (DF-b) on nonalcoholic fatty liver disease in a high fat diet-induced obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into five groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and atorvastatin, DF-a, and DF-b groups given a high fat diet with atorvastatin (10 mg/kg), DF-a (80 mg/kg), and DF-b (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, blood lipid markers, ALT concentrations, liver weight and histology were examined. Results : 1. Body weight gain was significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control. The extent of decreases was eminent in DF-a group. 2. Circulating concentrations of total cholesterol and LDL-cholesterol were significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control. The decreases were most effective in atorvastatin group. 3. Liver weights were decreased in DF-a, DF-b, and atorvastatin groups compared with control. In particular, liver weight was significantly reduced in DF-b group. 4. Hepatic lipid accumulation was significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control, and the magnitude of which was most effective in DF-b group. 5. Circulating ALT concentrations were decreased in DF-a, DF-b, and atorvastatin groups compared with control, but ALS levels were significantly reduced only in DF-b group. Conclusions : In conclusion, these results suggest that DF-a and DF-b decrease body weight gain, improve blood lipid metabolism, and reduce liver weight and hepatic lipid accumulation, contributing to the improvement of nonalcoholic fatty liver disease. In addition, these effects were similar between Pakistani and Chinese Ephedra herba-containing Gangjihwan.

• 대한한의학방제학회지
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• 제22권2호
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• pp.63-76
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• 2014

Objectives : This study investigated the improvement effects of Pakistani (DF-a) and Chinese Ephedra herba-containing Gangjihwan (DF-b) on obesity in a high fat diet-fed obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into four groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-a and DF-b groups given a high fat diet with DF-a (80 mg/kg), and DF-b (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : 1. Body weight gain and fat mass were significantly decreased in DF-a and DF-b groups compared with control. The extent of decreases was eminent in DF-a group. 2. Feeding efficiency ratio and circulating leptin concentration were significantly decreased in DF-a and DF-b groups compared with control, whereas circulating adiponectin concentration was increased in DF-a and DF-b groups compared with control. 3. Consistent with their effects on body weight gain and fat mass, circulating concentrations of triglyceride, glucose and insulin were decreased in DF-a and DF-b groups compared with control. 4. The size of adipocytes were decreased by DF-a and DF-b compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF-a and DF-b decreased the number of large adipocytes. 5. Consistent with their effects on body weight gain, liver fibrosis was reduced in DF-a and DF-b groups compared with control. Conclusions : In conclusion, these results suggest that DF-a and DF-b not only decrease feeding efficiency ratio, plasma leptin concentration, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF-a and DF-b also inhibit liver fibrosis. In addition, these effects were similar between Pakistani Ephedra herba and Chinese Ephedra herba-containing Gangjihwan.

• 한국통신학회논문지
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• 제25권10B호
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• pp.1732-1743
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• 2000

In this paper a fixed-delay trellis search with decision feedback (FDTrS/DF) for high-density DVD systems (4.7-15GB) is proposed and implemented with FPGA. The proposed FDTrS/DF is derived by transforming the binary tree search structure into trellis search structure implying that FDTrS/DF performs better than the singnal detection techniques based on tree search structure such as FDTS/DF and SSD/DF. Advantages of FDTrS/DF are significant reductions in hardware complexity due to the unique structure of FDTrS composed of only one trellis stage requiring no traceback procedure usually implemented in the Viterbi detector. Also in this paper the PDFS/DF and SSD/DF orginally proposed for high-density magnetic recording systems are modified for the DVD system and compared with the proposed FDTrS/DF. In order to increase speed in the FPGA implementation the pipelining technique and absolute branch metric (instead of square branch metric) are applied. The proposed FDTrS/DF is shown to provide the best performance among various signal detection techniques such as PRML, DFE, FDTS/DF and SSD/DF even with a small hardware complexity.

• 한국가금학회지
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• 제50권4호
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• pp.283-291
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• 2023

지방산 결합 단백질(FABP)은 LCFA 수송, 지질 합성, 저장을 용이하게 하고, 염증을 포함한 다양한 경로에 영향을 미치는 신호 분자로 작용한다. 특히 FABP4는 혈관 및 심장관련 질환과 관련이 있으며, 대식세포 매개 염증 반응에서 역할을 한다. 이전의 연구들은 FABP4를 지방 생성을 위한 대표적인 바이오 마커일 뿐만 아니라, 면역 반응과도 상관관계가 있는 것으로 확인하였다. 본 연구는 톨-유사 수용체 3(TLR3) 활성화에 의한 닭 FABP4(chFABP4) 유전자의조절을 조사하고 chFABP4 전사 조절에 관여하는 신호 경로를 결정하는 것을 목표로 한다. 우리는 TLR3 자극 DF-1 세포에서 chFABP4의 전사 조절을 분석하였다. 결과는 TLR3 리간드인 폴리이노신-폴리시티딜산(PIC)으로 자극 시 chFABP4가 상향 조절되었음을 보여주었다. 특히 chFABP4 전사는 NF-κB 신호 경로에서 독립적으로 조절되었다. p38 억제에서 상향 조절되어 p38 신호 경로가 TLR3 활성화 DF-1 세포 내에서 chFABP4 전사를 억제할 수 있음을 보여주었다. 이와는 대조적으로, JNK 신호 경로 억제에서는 chFABP4 발현이 하향 조절되었으며, 이는 대식세포의 연구 결과와 일치하며, TLR3 활성화에 반응하여 DF-1 세포에서 chFABP4 전사를 위한 JNK 신호 전달 경로의 긍정적인 조절을 시사한다. MEK 경로 억제는 NF-κB 신호 전달과 유사한 조절을 초래하였다. 이러한 결과는 각 MAPK가 TLR3 활성화에 반응하여 DF-1 세포에서 chFABP4의 전사 조절에 차별적으로 기여함을 시사한다.

• 재활간호학회지
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• 제8권1호
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• pp.38-49
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• 2005

Purpose: The purpose of this study was to examine the cognitive function in NIDDM patients. Method: The data were collected at MI OPD in C University hospital. with Digit Span Forward & Backward, Trail Making Test-A, Trail Making Test-B, and MMSE. Result: There were significant differences in DF, DB, TMT-A, and TMT-B according to gender, and in TMT-A according to living with spouse and comorbidity. There were significant differences in DF, DB, TMT-A, TMT-B, and MMSE according to monthly income, and in DF, TMT-A, and TMT-B according to hypertensive state. But, there was no difference in cognitive function score according to diabetes-related complication and diabetes treatment modality. There was a significant positive correlation between duration of NIDDM and TMT-A(r=.215, p=.025). The global cognition score was explained 42.1% of varient by age, duration of education, monthly income, and hypertensive state. Conclusion: As above results showed, among age, duration of education, monthly income, and hypertensive state, prevented and managed hypertensive state which is modifiable factor may reduce or delay cognitive function impairment in NIDDM patients. And DF & DB, TMT-A & B could be more utilized as useful cognitive function measurements because those tests reflected cognitive function in NIDDM patients better than MMSE.

• 한국통신학회논문지
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• 제36권8C호
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• pp.516-521
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• 2011

이 논문에서는 심각한 다중경로 페이딩 왜곡과 충격성 잡음을 극복하기 위해 결정궤환 구조를 갖추고 오차의 영확률을 최대화하는 비선형 알고리듬(MZEP-DF)를 제안하였다. 제안된 MZEP-DF 알고리듬은 충격성 잡음에 강인성을 보였고 궤환구조 영역에서 잔여 심볼간 간섭을 제거하는 능력을 보였다. 기존 LMS 알고리듬이 정상상태 오차 전력에 대해 -3 dB 이하로 수렴하지 못했던 심각한 다중경로 페이딩과 충격성 잡음 환경에 대해 제안한 알고리듬은 선형 MZEP 알고리듬과 비교하였을 때, 10 dB 이상 성능향상을 보였다.

• BMB Reports
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• 제39권6호
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• pp.788-793
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• 2006

Bacterial DNA containing immunostimulatory CpG motifs can stimulate antigen-presenting cells to express co-stimulatory molecules and to produce various cytokines in vivo and in vitro. In this study, we fragmented macromolecular E.coli genomic DNA with DNase I, and analyzed the ability of the resulting DNA fragments to induce the NF-${\kappa}B$ activation and humoral immune response. Furthermore, using computational analysis and luciferase assay for synthetic ODNs based on the sequence of the immunostimulatory DNA fragments (DF-ODNs), an active component of DF-ODNs sequences was investigated. Experimental results demonstrated that DF-ODN is optimal for the NF-${\kappa}B$-responsive promoter activation in the mouse macrophage cell line and the humoral immune response in vivo. In agreement with the activity of the DF-ODNs processed by DNase I, a synthetic ODN based on the DF-ODN sequences is potent at inducing IL-12 mRNA expression in primary dendritic cells. These results suggest that the discovery and characterization of a highly active natural CpG-ODN may be achieved by the analyses of bacterial DNA fragments generated by a nuclease activity.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2019년도 춘계학술대회
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• pp.254-256
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• 2019

소수체 GF(p)와 이진체 $GF(2^m)$ 상의 다중 타원곡선을 지원하는 듀얼 필드 ECC (DF-ECC) 프로세서를 설계하였다. DF-ECC 프로세서의 저면적 설와 다양한 타원곡선의 지원이 가능하도록 워드 기반 몽고메리 곱셈 알고리듬을 적용한 유한체 곱셈기를 저면적으로 설계하였으며, 페르마의 소정리(Fermat's little theorem)를 유한체 곱셈기에 적용하여 유한체 나눗셈을 구현하였다. 설계된 DF-ECC 프로세서는 스칼라 곱셈과 점 연산, 그리고 모듈러 연산 기능을 가져 다양한 공개키 암호 프로토콜에 응용이 가능하며, 유한체 및 모듈러 연산에 적용되는 파라미터를 내부 연산으로 생성하여 다양한 표준의 타원곡선을 지원하도록 하였다. 설계된 DF-ECC는 FPGA 구현을 하드웨어 동작을 검증하였으며, 0.18-um CMOS 셀 라이브러리로 합성한 결과 22,262 GEs (gate equivalences)와 11 kbit RAM으로 구현되었으며, 최대 100 MHz의 동작 주파수를 갖는다. 설계된 DF-ECC 프로세서의 연산성능은 B-163 Koblitz 타원곡선의 경우 스칼라 곱셈 연산에 885,044 클록 사이클이 소요되며, B-571 슈도랜덤 타원곡선의 스칼라 곱셈에는 25,040,625 사이클이 소요된다.

• 한국수학교육학회지시리즈B:순수및응용수학
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• 제1권1호
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• pp.19-24
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• 1994

Let P be a probability measure on the real line with Lebesque-density f. The usual estimator of the distribution function (≡df) of P for the sample $\chi$$_1$,…, $\chi$$\_$n/ is the empirical df: F$\_$n/(t)=(equation omitted). But this estimator does not take into account the smoothness of F, that is, the existence of a density f. Therefore, one should expect that an estimator which is better adapted to this situation beats the empirical df with respect to a reasonable measure of performance.(omitted)