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http://dx.doi.org/10.14374/HFS.2014.22.1.113

Comparison of Pakistani and Chinese Ephedra Herba-Containing Gangjihwan in the Improvement Effects of Nonalcoholic Fatty Liver Disease in a High Fat Diet-Fed NAFLD Mouse Model  

Jo, Ju Heum (Woosim Korean Medicine Clinic)
Jang, Du Hyon (Chungnam Korean Medicine Clinic)
Jung, Yang Sam (Jungyangsam Korean Medicine Clinic)
Kim, Jong Hoon (Neungin Korean Medicine Clinic)
Kim, Byeong Chul (Goryo Korean Medicine Clinic)
Seok, Hoa Jun (Soojung Korean Medicine Clinic)
Yoo, Jae Sang (Bonghwang Korean Medicine Clinic)
Ku, Ja Ryong (Soricheong Luck Korean Medicine Clinic)
Yoon, Ki Hyeon (Dept. of Formula Sciences and Research Institute of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Roh, Jong Seong (Dept. of Formula Sciences and Research Institute of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Ahn, Ye Ji (Dept. of Formula Sciences and Research Institute of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Lee, Won Kyung (Dept. of Formula Sciences and Research Institute of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Yoon, Michung (Dept. of Life Sciences, Mok-Won University)
Shin, Soon Shik (Dept. of Formula Sciences and Research Institute of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Publication Information
Herbal Formula Science / v.22, no.1, 2014 , pp. 113-122 More about this Journal
Abstract
Objectives : This study investigated the improvement effects of Pakistani (DF-a) and Chinese Ephedra herba-containing Gangjihwan (DF-b) on nonalcoholic fatty liver disease in a high fat diet-induced obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into five groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and atorvastatin, DF-a, and DF-b groups given a high fat diet with atorvastatin (10 mg/kg), DF-a (80 mg/kg), and DF-b (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, blood lipid markers, ALT concentrations, liver weight and histology were examined. Results : 1. Body weight gain was significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control. The extent of decreases was eminent in DF-a group. 2. Circulating concentrations of total cholesterol and LDL-cholesterol were significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control. The decreases were most effective in atorvastatin group. 3. Liver weights were decreased in DF-a, DF-b, and atorvastatin groups compared with control. In particular, liver weight was significantly reduced in DF-b group. 4. Hepatic lipid accumulation was significantly decreased in DF-a, DF-b, and atorvastatin groups compared with control, and the magnitude of which was most effective in DF-b group. 5. Circulating ALT concentrations were decreased in DF-a, DF-b, and atorvastatin groups compared with control, but ALS levels were significantly reduced only in DF-b group. Conclusions : In conclusion, these results suggest that DF-a and DF-b decrease body weight gain, improve blood lipid metabolism, and reduce liver weight and hepatic lipid accumulation, contributing to the improvement of nonalcoholic fatty liver disease. In addition, these effects were similar between Pakistani and Chinese Ephedra herba-containing Gangjihwan.
Keywords
Gangjihwan; DF-a; DF-b; nonalcoholic fatty liver disease; cholesterol;
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