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http://dx.doi.org/10.14374/HFS.2014.22.2.063

Comparison of Pakistani Ephedra Herba and Chinese Ephedra Herba Containing Gangjihwan in the Improvement Effects of Weight Loss in a High Fat Diet-Fed Obese Mice  

Kim, Byeong Chul (Goryo Korean Medicine Clinic)
Seok, Hoa Jun (Soojung Korean Medicine Clinic)
Yoo, Jae Sang (Bonghwang Korean Medicine Clinic)
Ku, Ja Ryong (Soricheong Luck Korean Medicine Clinic)
Yoon, Ki Hyeon (Dept. of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Jo, Ju Heum (Woosim Korean Medicine Clinic)
Jang, Du Hyon (Chungnam Korean Medicine Clinic)
Jung, Yang Sam (Jungyangsam Korean Medicine Clinic)
Kim, Jong Hoon (Neungin Korean Medicine Clinic)
Ahn, Ye Ji (Dept. of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Woo, Sangee (Division of Medical Engineering and Health Management, Mok-Won University)
Yoon, Miso (Division of Medical Engineering and Health Management, Mok-Won University)
Shin, Soon Shik (Dept. of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
Publication Information
Herbal Formula Science / v.22, no.2, 2014 , pp. 63-76 More about this Journal
Abstract
Objectives : This study investigated the improvement effects of Pakistani (DF-a) and Chinese Ephedra herba-containing Gangjihwan (DF-b) on obesity in a high fat diet-fed obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into four groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-a and DF-b groups given a high fat diet with DF-a (80 mg/kg), and DF-b (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : 1. Body weight gain and fat mass were significantly decreased in DF-a and DF-b groups compared with control. The extent of decreases was eminent in DF-a group. 2. Feeding efficiency ratio and circulating leptin concentration were significantly decreased in DF-a and DF-b groups compared with control, whereas circulating adiponectin concentration was increased in DF-a and DF-b groups compared with control. 3. Consistent with their effects on body weight gain and fat mass, circulating concentrations of triglyceride, glucose and insulin were decreased in DF-a and DF-b groups compared with control. 4. The size of adipocytes were decreased by DF-a and DF-b compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF-a and DF-b decreased the number of large adipocytes. 5. Consistent with their effects on body weight gain, liver fibrosis was reduced in DF-a and DF-b groups compared with control. Conclusions : In conclusion, these results suggest that DF-a and DF-b not only decrease feeding efficiency ratio, plasma leptin concentration, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF-a and DF-b also inhibit liver fibrosis. In addition, these effects were similar between Pakistani Ephedra herba and Chinese Ephedra herba-containing Gangjihwan.
Keywords
Gangjihwan; Pakistani ephedra herba; Chinese ephedra herba; obesity; triglyceride;
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