• Title/Summary/Keyword: DES[2]

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Chemical Constituents from Solenostemma argel and their Cholinesterase Inhibitory Activity

  • Demmak, Rym Gouta;Bordage, Simon;Bensegueni, Abederrahmane;Boutaghane, Naima;Hennebelle, Thierry;Mokrani, El Hassen;Sahpaz, Sevser
    • Natural Product Sciences
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    • v.25 no.2
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    • pp.115-121
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    • 2019
  • Alzheimer's disease is a chronic neurodegenerative disorder with no curative treatment. The commercially available drugs, which target acetylcholinesterase, are not satisfactory. The aim of this study was to investigate the cholinesterase inhibitory activity of Solenostemma argel aerial part. Eight compounds were isolated and identified by NMR: kaempferol-3-O-glucopyranoside (1), kaempferol (2), kaempferol-3-glucopyranosyl($1{\rightarrow}6$)rhamnopyranose (3) p-hydroxybenzoic acid (4), dehydrovomifoliol (5), 14,15-dihydroxypregn-4-ene-3,20-dione (6), 14,15-dihydroxy-pregn-4-ene-3,20-dione-$15{\beta}$-D-glucopyranoside (7) and solargin I (8). Two of them (compounds 2 and 3) could inhibit over 50 % of butyrylcholinesterase activity at $100{\mu}M$. Compound (2) displayed the highest inhibitory effect against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with a slight selectivity towards the latter. Molecular docking studies supported the in vitro results and revealed that (2) had made several hydrogen and ${\pi}-{\pi}$ stacking interactions which could explain the compound potency to inhibit AChE and BChE.

Multi-Round CPA on Hardware DES Implementation (하드웨어 DES에 적용한 다중라운드 CPA 분석)

  • Kim, Min-Ku;Han, Dong-Guk;Yi, Ok-Yeon
    • Journal of the Institute of Electronics Engineers of Korea CI
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    • v.49 no.3
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    • pp.74-80
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    • 2012
  • Recently at SCIS2011, Nakatsu et. al. proposed multi-round Correlation Power Analysis(CPA) on Hardware Advanced Encryption Standard(AES) to improve the performance of CPA with limited number of traces. In this paper, we propose, Multi-Round CPA to retrieve master key using CPA of 1round and 2round on Hardware DES. From the simulation result for the proposed attack method, we could extract 56-bit master key using the 300 power traces of Hardware DES in DPA contes. And it was proved that we can search more master key using multi-round CPA than using single round CPA in limited environments.

Numerical Simulation of the Flow Around the SUBOFF Submarine Model Using a DES Method (DES법을 이용한 SUBOFF 잠수함 모델 주위 유동 수치해석 연구)

  • Suh, Sung-Bu;Park, Il-Ryong
    • Journal of the Society of Naval Architects of Korea
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    • v.58 no.2
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    • pp.73-83
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    • 2021
  • In this study, the numerical investigation of the flow around the SUBOFF submarine model is performed by using the Detached Eddy Simulation (DES) method which is developed based on the SST k-ω turbulence model. At the DES analysis level, complex vortical flows around the submarine model are caused mainly by the vortices due to the appendages and their interactions with the flows from the hull boundary layer and other appendages. The complexity and scale of the vortical flow obtained from the numerical simulations are highly dependent on the grid. The computed local flow properties of the submarine model are compared with the available experimental data showing a good agreement. The DES analysis more reasonably estimates the physical phenomena inherent in the experimental result in a low radius of the propeller plane where vortical flows smaller than the RANS scale are dominant.

Promotive Effects of Several Synthetic Hormones Using Short-Term Carcinogen Screening Method (단기 발암성 검색법을 이용한 축산식품에 잔류할 수 있는 합성홀몬의 발암촉진효과에 대한 연구)

  • 임윤규;강경선;이영순
    • Journal of Food Hygiene and Safety
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    • v.5 no.4
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    • pp.179-186
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    • 1990
  • This study was performed for assessing carcinogenicity of several synthetic hormones; Diethylstilbesterol (DES), 17-ethinylestradiol ($EE_2$) and Bovine somatotrophin (BST). Six weeks old F344 rats were divided into five groups and given an intraperitoneally injection of 200 mg of diethylnitrosamine (DENA). At two week after beginnig of experiment, DES, $EE_2$, BST. Phenobarbital were administered to group 1, 2, 3 and 4 respectively, group 4 is positive control and group 5 is negative control. At the same time, all groups received a single i.p. injection of D-galactosamine at a dose of 300 mg/kg and underwent 2/3 partial hepatectomy at week 5. All rats were sacrificed at the end of week 8 for assessment of liver lesion development. The liver was processed for immunohistochmical staining for GST-P and quantitatively analyzed by image analyzer. It was concluded that two synthetic estrogen hormones (DES, $EE_2$) was different significantly (p < 0.01) but BST was not different as compared with control group. Therefore, we thought that DES, $EE_2$ was promoting effects and BST was not in rat hepatocarcinogenesis.

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Simultaneous Spectrometric Determination of Caffeic Acid, Gallic Acid, and Quercetin in Some Aromatic Herbs, Using Chemometric Tools

  • Kachbi, Abdelmalek;Abdelfettah-Kara, Dalila;Benamor, Mohamed;Senhadji-Kebiche, Ounissa
    • Journal of the Korean Chemical Society
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    • v.65 no.4
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    • pp.254-259
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    • 2021
  • The purpose of this work is the development of a method for an effective, less expensive, rapid, and simultaneous determination of three phenolic compounds (caffeic acid, gallic acid, and quercetin) widely present in food resources and known for their antioxidant powers. The method relies on partial least squares (PLS) calibration of UV-visible spectroscopic data. This model was applied to simultaneously determine, the concentrations of caffeic acid (CA), gallic acid (GA), and quercetin (Q) in six herb infusion extracts: basil, chive, laurel, mint, parsley, and thyme. A wavelength range (250-400) nm, and an experimental calibration matrix with 21 samples of ternary mixtures composed of CA (6.0-21.0 mg/L), GA (10.0-35.2 mg/L), and Q (6.4-17.5 mg/L) were chosen. Spectroscopic data were mean-centered before calibration. Two latent variables were determined using the contiguous block cross-validation procedure after calculating the root mean square error cross-validation RMSECV. Other statistic parameters: RMSEP, R2, and Recovery (%) were used to determine the predictive ability of the model. The results obtained demonstrated that UV-visible spectrometry and PLS regression were successfully applied to simultaneously quantify the three phenolic compounds in synthetic ternary mixtures. Moreover, the concentrations of CA, GA and Q in herb infusion extracts were easily predicted and found to be 3.918-18.055, 9.014-23.825, and 9.040-13.350 mg/g of dry sample, respectively.

Etude sur les mesures des costumes nationaux de $cor{\acute{e}}e$ (한복(韓服)의 치수에 대(對)한 연구(硏究))

  • Go, Bok-Nam
    • Journal of the Korean Society of Costume
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    • v.1
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    • pp.59-65
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    • 1977
  • Les modes des costumes naitonaux de $cor{\acute{e}}e$ est plus simple que celle du Occident. mais les facons, sur les quelles les mesures fondamentalement agissent, ont des $varit{\acute{e}}s$ selon les personnes qui se les habillent: masculines, $f{\acute{e}}m$ nines, jeunes, vieilles. Le but de cette ${\acute{e}}tude$ est, par l'anayse statistique des mesures, $d'{\acute{e}}tablir$ comment sont les $vari{\acute{e}}t{\acute{e}}s$. Les $r{\acute{e}}sultats$ de ce travail peuveut $\hat{e}tre$ $r{\acute{e}}sum{\acute{e}}s$ ainsi: 1. Plus $\grave{a}g{\acute{e}}s$ sont les personnes, plue larges et longues les Cheo-go-ri (vestes). 2. A propos des longeur des vestes, on les $g{\acute{e}}n{\acute{e}}ralement$ $consid{\acute{e}}re$ comme les $donn{\acute{e}}es$ principalement $subondonn{\acute{e}}es$ aux tailles des personnes $habill{\acute{e}}es$. mais a mon travail, le tour do poitrine peut-$\hat{e}tre$ le plus relatis en ce problemes. [parce que le coefficient $conr{\acute{e}}ratif$ ayant rapponts au tour de poitrine (r=0.512) est plus haut que celui qui est relatif a la taille (r=0.436).

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Growth Characteristics and Ingredient Analysis According to the Transplanting Date and Distance of Dendranthema (L.). (감국 정식시기와 거리에 따른 생육특성과 성분 분석)

  • Jung, J.H.;Park, N.B.
    • Journal of Practical Agriculture & Fisheries Research
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    • v.22 no.1
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    • pp.65-77
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    • 2020
  • In order to industrialize of Dendranthema indicum (L.) DesMoul., which is a lot of commercially available and is synonymous with chrysanthemum tea, in the autumn of 2018, Dendranthema indicum (L.) DesMoul. seeds were collected from its own native region, and the seeds were germinated after refrigerated storage. Young seedlings were subjected to experiments in February, March, and April in the open field to examine the effects on the harvesting of leaves by distance and the growth of leaves and stems. The results of analyzing the components by collecting the leaves+stem after collecting the flower of Dendranthema indicum (L.) DesMoul. are as follows. 1. When D. indicum (L.) DesMoul. seedlings were planted according to the transplanting date, the number of flowers was 17.1 in the transplanting date in April. The diameter of the flower was 2.9cm, 16ea, 6.5~6.6g in the fresh weight, and the dry weight of the case was 1.1~1.2g. The leaves were 46~47ea in March and April in the planted area, 5.2~5.3cm in leaf length and 3.5~3.6cm in leaf width. 2. When planted D. indicum (L.) DesMoul. seedlings according to transplanting distance, the number of flowers was 16.2 when planted at 20×20cm intervals and, 16.8~17.1 at 30×30~50×50cm intervals. The diameter of the flower was 2.7~2.8cm, the number of petals was 8, the length of the petal was 0.8 cm, and fresh weight was 6.5~6.6g per flower. Leaves had the largest number of 47 of 30×30cm and 40×40cm, and leaf length appeared at the longest 6.2cm in the 50×50cm treatment area, but 5.2cm in the other treatment areas. 3. The extraction yield of D. indicum (L.) DesMoul. leaves+stems was 7.93%, and the extraction solvent colors were light green at 50, 60% and green at 70, 80, 90, 100%. The extraction yield of D. indicum (L.) DesMoul. flowers was 7.58%, the color of the extraction solvent was light yellow at 50, 60 and 70%, yellow at 80 and 90%, and dark yellow at 100%. 4. We confirmed 11 kinds of ingredients such as in D. indicum (L.) DesMoul. flowers are gallic acid, 4-hydroxy benzoic acid, methyl gallate, 4-hydroxy-3-methoxy benzoic, caffeic acid, salicylic acid, p-coumaric acid, sinapic acid, naringin, 4-melthoxyben, flavone. The content was 29.200-36.900ppm. 5. The components contained in the D. indicum (L.) DesMoul. leaf+stem, salicylic acid appeared at 6,129.526ppm, and the next 4-methoxyben was 1,966.714ppm. It was methyl gallate 8.197ppm, 4-hydroxy-3-methoxy benzoic 6.994ppm, caffeic acid 5.566ppm, flavone 4.522ppm, p-coumaric acid 3.787ppm, gallic acid 1.893ppm that appeared in the content below 10ppm.

The Effect of Chitosan on Hydroxyapatite Precipitation

  • Hatim, Zineb;Bakasse, Mina;Kheribech, Abdelmoula;Abida, Fatima;Bourouisse, Abderrahim
    • Proceedings of the Korean Powder Metallurgy Institute Conference
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    • 2006.09a
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    • pp.484-485
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    • 2006
  • The process of coprecipitation of biocomposite hydroxyapatite/chitosan from aqueous solution at low temperature in alkali environnement was examined. We have shown that initially we have the formation of amorphous octocalcium phosphates $(Ca_8(HPO_4)(PO_4)_5,\;nH_2O:\;OCP)$ and the transferring from OCP to amorphous calcium phosphate $(Ca_9(PO_4)_3,\;nH_2O:\;TCP)$, and then from TCP to calcium-deficient hydroxyapatite $(Ca_{10-X}\;(HPO_4)_X(PO_4)_{6-x}(OH)_{2-X}\;:\;ACP)$ and hydroxyapatite $(Ca_{10}(PO_4)_6(OH)_2\;:\;HAP)$. The transformation of ACP to HAP was inhibited in the presence of chitosan. The result suggests that there is an affinity binding between ACP and chitosan and subsequently blocking the active growth site of ACP.

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