• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.25 no.12
• /
• pp.1914-1919
• /
• 2021

With the development of advanced industries, research on image processing hardware is essential, and timing verification at the gate level is required for actual chip operation. For FPGA-based verification, DDR3 memory interface was previously applied. But recently, as the FPGA specification has improved, DDR4 memory is used. In this case, when a previously used memory interface is applied, the timing mismatch of signals may occur and thus cannot be used. This is due to the difference in performance between CPU and memory. In this paper, the problem is solved through state optimization of the existing interface system FSM. In this process, data read speed is doubled through AXI Data Width modification. For actual case analysis, ZC706 using DDR3 memory and ZCU106 using DDR4 memory among Xilinx's SoC boards are used.

• Journal of the Korean Society of Radiology
• /
• v.1 no.1
• /
• pp.25-30
• /
• 2007

ROC(Receiver Operating Characteristic)curve is the method that estimate detected insignificant signal from the human's sense of sight, it has been raised excellent results. In this study, we evaluate image quality and equipment character by obtaining a chest image from CR(Computed Radiography) and DDR(Direct Digital radiography) using the human chest phantom, The parameter of exposure for obtaining chest image was 120 kVp/3.2 mAs and the SID(Source to Image Distance) was 180cm. The images were obtained by CR(AGFA MD 4.0 General plate, JAPAN) and DDR(HOLOGIC nDirect Ray, USA). Using some pieces of Aluminum and stone for expressing regions, then attached them on the heart, lung and thoracic vertebrae of the phantom. 29 persons hold radiology degrees were participated in ROC analysis. As a result of the ROC analysis, TPF(true positive fraction) and FPF(false positive fraction) of DDR and CR are 0.552 and 0.474 and 0.629 and 0.405, respectively. By using the results, the ROC curve of CR has higher image quality than DDR. According to the theory, DDR has the higher image quality than CR in chest X-ray image. But, CR has the higher image quality than DDR. quality of DDR inserted the enhance board. The results confirmed that image post-processing is important element decipherment of clinical.

• Molecules and Cells
• /
• v.41 no.2
• /
• pp.93-102
• /
• 2018

Discoidin domain receptor 1 (DDR1) is involved in tumorigenesis and angiogenesis. However, its role in lymphangiogenesis has been unknown. Here, we tested whether downregulation of DDR1 expression by miR-199a/b can suppress lymphangiogenesis. We also aimed to identify miRNA target site(s) in the 3' untranslated region (UTR) of DDR1. Transfection with miR-199a/b-5p mimics reduced expression of DDR1 and tube formation in primary human dermal lymphatic endothelial cells, whereas miR-199a/b-5p inhibitors showed the opposite effects. Critically, injection of miR-199a/b-5p mimics suppressed DDR1 expression and lymphangiogenesis in a corneal alkali-burn rat model. The three well-conserved seed matched sites for miR-199a/b-5p in the DDR1 3'-UTR were targeted, and miRNA binding to at least two sites was required for DDR1 inhibition. Our data suggest that DDR1 promotes enhanced lymphangiogenesis during eye injury, and miR-199a/b-5p suppresses this activity by inhibiting DDR1 expression. Thus, this miRNA may be useful for the treatment of lymphangiogenesis-related eye diseases.

• Journal of information and communication convergence engineering
• /
• v.7 no.2
• /
• pp.203-208
• /
• 2009

Recently, improved capabilities of the mobile device is represented in a demand for same level services with the desktop device services but the service that is developed for desktop device is not compatible with mobile devices. To fulfill these demands, it is needed to provide services with considering features of mobile devices. This means that CP(Contents Provider) must do contents transformation in order to make suitable contents on mobile device. For managing some information that is required to do contents transformation, we need the DDR(Device Description Repository) which can store and search a variety of device information to grasp the constraints on the mobile device as compared with desktop devices. Also, defining standard API is required to offer a service regardless of platforms. Hereupon W3C(World Wide Web Consortium) introduced DDR Simple API. However that specifies the limited functions of DDR, which is inevitable to be added for more precise search services. In this paper, we expanded DDR Simple API and implemented DDR that supports DDL(Device Description Language) conversion and storing and searching device information.

• Journal of Radiation Industry
• /
• v.4 no.3
• /
• pp.289-295
• /
• 2010

The bacterium Deinococcus radiodurans is one of the most resistant organisms to the effects of ionizing radiation and other DNA-damaging agents. In this study, distributions of 10 ddr (DNA damage response) genes were investigated in 8 species of Deinococcus by polymerase chain reaction (PCR). We have compared the sequences of ddr genes of D. radiodurans, D. geothermalis and D. deserti, and selected primers which are suitable for the detection of ddr in different species of Deinococcus. A sequence homology search and PCR assay showed that ddrO, which encodes a global regulator of the radiation-desiccation response, was most well conserved in the Deinococcus lineage.

• Journal of IKEEE
• /
• v.21 no.4
• /
• pp.416-419
• /
• 2017

In this paper, we propose a new digital delay-locked loop (DLL) for high-speed DDR3/DDR4 SDRAMs. The proposed digital DLL adopts a fine delay line using phase interpolation to eliminate the jitter increase problem due to the boundary switching problem. In addition, the proposed digital DLL utilizes a new gradual search algorithm to eliminate the harmonic lock problem. The proposed digital DLL is designed with a 1.1 V, 38-nm CMOS DRAM process and has a frequency operating range of 0.25-2.0 GHz. It has a peak-to-peak jitter of 1.1 ps at 2.0 GHz and has a power consumption of about 13 mW.

• The Korean Journal of Physiology and Pharmacology
• /
• v.26 no.6
• /
• pp.427-438
• /
• 2022

Pyroptosis, a form of cell death associated with inflammation, is known to be involved in diabetic nephropathy (DN), and discoid domain receptor 1 (DDR1), an inflammatory regulatory protein, is reported to be associated with diabetes. However, the mechanism underlying DDR1 regulation and pyroptosis in DN remains unknown. We aimed to investigate the effect of DDR1 on renal tubular epithelial cell pyroptosis and the mechanism underlying DN. In this study, we used high glucose (HG)-treated HK-2 cells and rats with a single intraperitoneal injection of streptozotocin as DN models. Subsequently, the expression of pyroptosis-related proteins (cleaved caspase-1, GSDMD-N, Interleukin-1β [IL-1β], and interleukin-18 [IL-18]), DDR1, phosphorylated NF-κB (p-NF-κB), and NLR family pyrin domain-containing 3 (NLRP3) inflammasomes were determined through Western blotting. IL-1β and IL-18 levels were determined using ELISA. The rate of pyroptosis was assessed by propidium iodide (PI) staining. The results revealed upregulated expression of pyroptosisrelated proteins and increased concentration of IL-1β and IL-18, accompanied by DDR1, p-NF-κB, and NLRP3 upregulation in DN rat kidney tissues and HG-treated HK-2 cells. Moreover, DDR1 knockdown in the background of HG treatment resulted in inhibited expression of pyroptosis-related proteins and attenuation of IL-1β and IL-18 production and PI-positive cell frequency via the NF-κB/NLRP3 pathway in HK-2 cells. However, NLRP3 overexpression reversed the effect of DDR1 knockdown on pyroptosis. In conclusion, we demonstrated that DDR1 may be associated with pyroptosis, and DDR1 knockdown inhibited HG-induced renal tubular epithelial cell pyroptosis. The NF-κB/NLRP3 pathway is probably involved in the underlying mechanism of these findings.

• Journal of the Microelectronics and Packaging Society
• /
• v.19 no.4
• /
• pp.45-50
• /
• 2012

A family of multi-die DRAM packages was developed that incorporate the full functionality of an SODIMM into a single package. Using a common ball assignment analogous to the edge connector of an SODIMM, a broad range of memory types and assembly structures are supported in this new package. In particular DDR3U, LPDDR3 and DDR4RS are all supported. The center-bonded DRAM use face-down wirebond assembly, while the peripherybonded LPDDR3 use the face-up configuration. Flip chip assembly as well as TSV stacked memory is also supported in this new technology. For the center-bonded devices (DDR3, DDR4 and LPDDR3 ${\times}16$ die) and for the face up wirebonded ${\times}32$ LPDDR3 devices, a simple manufacturing flow is used: all die are placed on the strip in a single machine insertion and are sourced from a single wafer. Wirebonding is also a single insertion operation: all die on a strip are wirebonded at the same time. Because the locations of the power signals is unchanged for these different types of memories, a single consolidated set of test hardware can be used for testing and burn-in for all three memory types.

• Nutrition Research and Practice
• /
• v.9 no.1
• /
• pp.99-105
• /
• 2015

BACKGROUND/OBJECTIVES: Compelling evidence indicates that consumption of trans-fatty acids (TFA) is associated with a wide range of diseases. However, few validated tools for TFA intake assessment are available in Korea. We aimed to validate a food frequency questionnaire (FFQ) estimating usual intake of TFA in Korean adults. MATERIALS/METHODS: Eighty-two healthy adults completed an FFQ with a 3-day diet record (3DDR), and 58 completed a second FFQ at a 1-month interval. To assess the reproducibility of the FFQ, we compared estimated TFA intakes from each FFQ. To assess the validity, we compared estimates from the FFQ with those from the 3DDR. RESULTS: The FFQ was reproducible (Spearman r = 0.71) and provided modest correlations with the 3DDR (Spearman r = 0.38). After adjustment for total energy intake, the correlations increased (r = 0.45). Measurement-error correction also de-attenuated the correlations (r = 0.57). When quintiles of the FFQ and 3DDR were joint-classified, 9% on average were misclassified into extreme quintiles. CONCLUSIONS: Our findings suggest that the developed FFQ is reproducible and reasonably valid in categorizing individuals according to TFA intakes among healthy young and middle aged adults in Korea.

• Journal of Advanced Navigation Technology
• /
• v.15 no.6
• /
• pp.1104-1110
• /
• 2011

The conventional semiconductor equipment has adopted SRAM module as the test pattern memory, which has a simple design and does not require refreshing. However, SRAM has its disadvantages as it takes up more space as its capacity becomes larger, making it difficult to meet the requirements of large memories and compact size. if DRAM is adopted as the semiconductor inspection equipment, it takes up less space and costs less than SRAM. However, DRAM is also disadvantageous because it requires the memory cell refresh, which is not suitable for the semiconductor examination equipments that require correct timing. Therefore, In this paper, we will proposed an algorithm for punctuality guarantee of memory-free inspection equipment using DDR2 SDRAM. And we will Developed memory controller using punctuality guarantee algorithm. As the results, show that when we adopt the DDR2 SDRAM, we can get the benefits of saving 13.5 times and 5.3 times in cost and space, respectively, compared to the SRAM.