• Title/Summary/Keyword: DAVIS

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Screening of Anticancer Potential of Celecoxib and its Derivatives (셀레콕시브 및 그 합성유도체들의 항암활성 스크리닝)

  • Park, Jeong-Ran;Kang, Jin-Hyoung;Kuh, Hyo-Jeong;Noh, Ji-Young;Ryu, Hyung-Chul;Park, Sang-Wook;Ko, Dong-Hyun;Cho, Il-Hwan;Lee, Joo-Y.;Hwang, Daniel-H.;Kim, In-Kyung
    • Journal of Pharmaceutical Investigation
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    • v.33 no.2
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    • pp.105-112
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    • 2003
  • Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at $1\;{\mu}M$ after 24 hr exposure. Forty ${\mu}M$ and $50\;{\mu}M$ of ce1ecoxib induced $G_1$ arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.

Designing Passive-Type Radar Reflector for Small Ship

  • Yim, Jeong-Bin;Kim, Woo-Suk;Ahn, Yoeng-Sub;Park, Sung-Hyeon;Jung, Jung-Sik;Lee, Kyu-Dong
    • Proceedings of KOSOMES biannual meeting
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    • 2003.05a
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    • pp.125-134
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    • 2003
  • This paper describes on the design of Passive-type Radar Reflector for small Ship (PRR-S) based on the newly revised 2000 SOLAS regulations. The design idea, adopted in the study, is to hold PRR-S in the proper ‘catch rain’ position to avoid fluctuations of Radar Cross Section (RCS) due to ship's heeling. The PRR-S consists of octahedral-type radar reflector with circular plates and three-axis gimbaled stabilizer with weight on the bottom of outer gimbal ring. Performance test for the PRR is carried out in an anechoic chamber. The test results show that the reflected radar signal from PRR-S is more uniformly distributed than the reference model (Davis Echomaster).

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Usability Test of Website Navigation by Using Spatial Metaphor Concept (공간메타포 개념을 이용한 웹 사이트 네비게이션의 사용성 평가)

  • 이건창;정남호;홍노경
    • Journal of Intelligence and Information Systems
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    • v.10 no.1
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    • pp.93-107
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    • 2004
  • This study is concerned with proposing a new construct named "spatial metaphor" in the field of user interface design for web. Recently, web has been recognized as an important vehicle of delivering messages and information to customers. Since both hyperlink and multimedia technology are crucial part of web, its user interface requires a new approach to enhance user's acceptance of web. In this sense, we introduced a new concept named "spatial metaphor" instead of hierarchical menus. As a theoretical basis, Davis (1986)'s TAM(Technology Acceptance Model) was used to test the statistical validity of the proposed spatial metaphor. For test web site, we developed a prototype designed by using atomic-web system and spatial metaphor. By using the prototype, we built a web-based questionnaire system so that respondents can use it directly before answering the questionnaire. To prove its statistical validity, we collected valid questionnaires and tested with LISREL. In this way, statistical validity of our proposed approach was proven.approach was proven.

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A Exploratory Study of Confidential Document Circulation System Design (기밀문서 유통체계 설계에 관한 탐색적 연구)

  • Chang, Hang-Bae;Kim, Heung-Gook
    • Journal of Advanced Navigation Technology
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    • v.15 no.3
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    • pp.462-470
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    • 2011
  • Since, Davis(1991) has proposed the TAM(Technology Acceptance Model) through a literature review of informatization promotion, which insists that a user conveniency is judged by the degree of effectiveness caused by IT, the advancement of IT such as the Internet, e-mail, electronic data exchange, and groupware have brought into various changes in ordinary corporations and public institutions. However, with the right function, the advancement of IT has provided various benefits including additional reverse functions. Based on an integrated environment of business process, unauthorized user could access to information and a management of information becomes more difficult than before due to informatization of critical information. Furthermore, external hacking or information leakage by insider becomes easier owing to advancement in communication technology. This study has tried to develop a specified management procedure and implementation method for confidential documents.

Analysis of Pre-service Elementary Teachers' Reflection on Their Science Teaching in Terms of Productive Reflection (생산적 반성의 관점에서 분석한 초등 예비교사의 과학 수업 반성의 특징)

  • Yoon, Hye-Gyoung
    • Journal of The Korean Association For Science Education
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    • v.32 no.4
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    • pp.703-716
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    • 2012
  • Frequently, pre-service elementary teachers are asked to write reflective journals on their teaching during teacher education program. However, writing reflective journals can not guarantee pre-service teachers to learn from their experience. In this study, 44 reflective journals of pre-service elementary teachers on their science teaching were analyzed in terms of 'productive reflection', a concept suggested by Davis (2006). Productive reflection may help teachers' effective learning by considering interrelationships among aspects of teaching including learners and learning, subject matter knowledge, assessment, and instruction. The result showed what aspects of teaching were included, emphasized, and integrated in the pre-service elementary teachers' reflective journals. Implications for teacher education would be discussed.

Soluble Proteins Analysis of Class Cephalopoda in the Yellow Sea(I) (황해산 두족류의 가용성 단백질에 대한 연구 (I))

  • 허회권
    • Journal of Aquaculture
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    • v.10 no.3
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    • pp.301-310
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    • 1997
  • To investigate a possibility of the species genetic relationship for the soluble proteins analysis on the class Cephalopoda in the Yellow Sea, the isolate eye, muscle and liver proteins from five species (Sepia esculenta, Sepiella japonica, Loligo chinensis, Loligo beka and Octopus minor) were analysed using different electrophoretic techniques (Davis-polyacrylamide gel electrophoresis, SDS-PAGE, exponential gradient SDS-PAGE, thin-layer isoelectro-focusing and two-dimensional PAGE). The average molecular weight of the soluble eye and muscle proteins was estimated at 35-50 KDa, separated b the exponential gradient SDS-PAGE. It was corresponds to that of electrophoretic patterns by t재 dimensional PAGE. By which the thin layer IEF, the target proteins showed a reasonable specificity based on their isoelectric points (pI) 7.5-8.5.

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A Study on the Formative Characteristics on Hollywood Actresses' makeup - Focused on from 1920s to 2000s - (할리우드 여배우의 메이크업 조형특성 연구 - 1920년대부터 2000년대까지 -)

  • Kim, Eun-Sil;Bae, Soo-Jeong
    • Journal of Fashion Business
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    • v.15 no.5
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    • pp.195-219
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    • 2011
  • The purpose of the study is to analyze Hollywood actresses' makeup in formative characteristics and see the transition of the change for the usage as the fundamental materials to develop the future makeup field academy with the focus focused from 1920s to 2000s when the cosmetic industry began in earnest. The content of the study is to see the transition of the change by analyzing makeup of each era in formative aspect after seeing the transition of the makeup change in the social background by classifying by 10 years from 1920s to 2000s with related literature as the center in the theoretical background. The method of the study is to analyze makeup in formative aspect with total 180 pieces of pictures selected by two experts among their photos by selecting four actresses by each era and analyze Hollywood actresses' advertisement pictures which can be called as beauty icons at that time. Analysis frame to analyze the formativeness established new classification frame based on theories of Marian L. Davis, Marilyn Revell Delong, and Kang to analyze line, shape, texture, and decoration, and researcher's analysis frame was prepared based Munsell's color circle, tone analysis of P.C.C.S color system, and Kang's makeup color name to analyze colors. The result of the study is like below. Generally 20s and 30s highlighted line of eyebrows, 40s naturalness, 50s and 60s highlighted eye makeup, and from 70s makeup was focused on health, in 80s colorful makeup was boom, and 90s and 2000s has shown characteristics focused on texture of face.

A Study on the Effects of the Use Intention of Service Robots by Potential Customers (소비자의 지능형 서비스로봇 이용의도에 관한 연구)

  • Park, Nam-Gue;Suh, Sang-Hyuk;Kim, Myeong-Suk
    • Journal of Digital Convergence
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    • v.11 no.3
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    • pp.165-173
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    • 2013
  • The purpose of this study was to investigate the effects of customer's innovation and usefulness on the use intention of Service Robots by potential customers. Based on Davis(1989)'s Technology Acceptance Model, this study formulated three hypotheses, which were about relationships between customer's innovation, usefulness, and use intention of Service Robots. For this study, structured questionnaires were used and data were collected from the 171 people in Seoul and Cheonan. To test three hypotheses, collected data were analyzed using hierarchical regression technique. The results showed that customer's innovation has no influence on usefulness, whereas customer's innovation and usefulness have effects on use intention.

Quantifying the 2022 Extreme Drought Using Global Grid-Based Satellite Rainfall Products (전지구 강수관측위성 기반 격자형 강우자료를 활용한 2022년 국내 가뭄 분석)

  • Mun, Young-Sik;Nam, Won-Ho;Jeon, Min-Gi;Lee, Kwang-Ya;Do, Jong-Won;Isaya Kisekka
    • Journal of The Korean Society of Agricultural Engineers
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    • v.66 no.4
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    • pp.41-50
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    • 2024
  • Precipitation is an important component of the hydrological cycle and a key input parameter for many applications in hydrology, climatology, meteorology, and weather forecasting research. Grid-based satellite rainfall products with wide spatial coverage and easy accessibility are well recognized as a supplement to ground-based observations for various hydrological applications. The error properties of satellite rainfall products vary as a function of rainfall intensity, climate region, altitude, and land surface conditions. Therefore, this study aims to evaluate the commonly used new global grid-based satellite rainfall product, Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS), using data collected at different spatial and temporal scales. Additionally, in this study, grid-based CHIRPS satellite precipitation data were used to evaluate the 2022 extreme drought. CHIRPS provides high-resolution precipitation data at 5 km and offers reliable global data through the correction of ground-based observations. A frequency analysis was performed to determine the precipitation deficit in 2022. As a result of comparing droughts in 2015, 2017, and 2022, it was found that May 2022 had a drought frequency of more than 500 years. The 1-month SPI in May 2022 indicated a severe drought with an average value of -1.8, while the 3-month SPI showed a moderate drought with an average value of 0.6. The extreme drought experienced in South Korea in 2022 was evident in the 1-month SPI. Both CHIRPS precipitation data and observations from weather stations depicted similar trends. Based on these results, it is concluded that CHIRPS can be used as fundamental data for drought evaluation and monitoring in unmeasured areas of precipitation.

The Factors Affecting Attitudes Toward HSDPA Service and Intention to Use: A Cross-Cultural Comparison between Asia and Europe (대영향(对影响)HSDPA복무적태도화사용의도적인소적연구(服务的态度和使用意图的因素的研究): 재아주화구주지간적(在亚洲和欧洲之间的)-개과문화비교(个跨文化比较))

  • Jung, Hae-Sung;Shin, Jong-Kuk;Park, Min-Sook;Jung, Hong-Seob;Hooley, Graham;Lee, Nick;Kwak, Hyok-Jin;Kim, Sung-Hyun
    • Journal of Global Scholars of Marketing Science
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    • v.19 no.4
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    • pp.11-23
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    • 2009
  • HSDPA (High-Speed Downlink Packet Access) is a 3.5-generation asynchronous mobile communications service based on the third generation of W-CDMA. In Korea, it is mainly provided in through videophone service. Because of the diffusion of more powerful and diversified services, along with steep advances in mobile communications technology, consumers demand a wide range of choices. However, because of the variety of technologies, which tend to overflow the market regardless of consumer preferences, consumers feel increasingly confused. Therefore, we should not adopt strategies that focus only on developing new technology on the assumption that new technologies are next-generation projects. Instead, we should understand the process by which consumers accept new forms of technology and devise schemes to lower market entry barriers through strategies that enable developers to understand and provide what consumers really want. In the Technology Acceptance Model (TAM), perceived usefulness and perceived ease of use are suggested as the most important factors affecting the attitudes of people adopting new technologies (Davis, 1989; Taylor and Todd, 1995; Venkatesh, 2000; Lee et al., 2004). Perceived usefulness is the degree to which a person believes that a particular technology will enhance his or her job performance. Perceived ease of use is the degree of subjective belief that using a particular technology will require little physical and mental effort (Davis, 1989; Morris and Dillon, 1997; Venkatesh, 2000). Perceived pleasure and perceived usefulness have been shown to clearly affect attitudes toward accepting technology (Davis et al., 1992). For example, pleasure in online shopping has been shown to positively impact consumers' attitudes toward online sellers (Eighmey and McCord, 1998; Mathwick, 2002; Jarvenpaa and Todd, 1997). The perceived risk of customers is a subjective risk, which is distinguished from an objective probabilistic risk. Perceived risk includes a psychological risk that consumers perceive when they choose brands, stores, and methods of purchase to obtain a particular item. The ability of an enterprise to revolutionize products depends on the effective acquisition of knowledge about new products (Bierly and Chakrabarti, 1996; Rothwell and Dodgson, 1991). Knowledge acquisition is the ability of a company to perceive the value of novelty and technology of the outside (Cohen and Levinthal, 1990), to evaluate the outside technology that has newly appeared (Arora and Gambaradella, 1994), and to predict the future evolution of technology accurately (Cohen and Levinthal, 1990). Consumer innovativeness is the degree to which an individual adopts innovation earlier than others in the social system (Lee, Ahn, and Ha, 2001; Gatignon and Robertson, 1985). That is, it shows how fast and how easily consumers adopt new ideas. Innovativeness is regarded as important because it has a significant effect on whether consumers adopt new products and on how fast they accept new products (Midgley and Dowling, 1978; Foxall, 1988; Hirschman, 1980). We conducted cross-national comparative research using the TAM model, which empirically verified the relationship between the factors that affect attitudes - perceived usefulness, ease of use, perceived pleasure, perceived risk, innovativeness, and perceived level of knowledge management - and attitudes toward HSDPA service. We also verified the relationship between attitudes and usage intention for the purpose of developing more effective methods of management for HSDPA service providers. For this research, 346 questionnaires were distributed among 350 students in the Republic of Korea. Because 26 of the returned questionnaires were inconsistent or had missing data, 320 questionnaires were used in the hypothesis tests. In UK, 192 of the total 200 questionnaires were retrieved, and two incomplete ones were discarded, bringing the total to 190 questionnaires used for statistical analysis. The results of the overall model analysis are as follows: Republic of Korea x2=333.27(p=0.0), NFI=0.88, NNFI=0.88, CFI=0.91, IFI=0.91, RMR=0.054, GFI=0.90, AGFI=0.84, UK x2=176.57(p=0.0), NFI=0.88, NNFI=0.90, CFI=0.93, IFI=0.93, RMR=0.062, GFI=0.90, AGFI=0.84. From the results of the hypothesis tests of Korean consumers about the relationship between factors that affect intention to use HSDPA services and attitudes, we can conclude that perceived usefulness, ease of use, pleasure, a high level of knowledge management, and innovativeness promote positive attitudes toward HSDPA mobile phones. However, ease of use and perceived pleasure did not have a direct effect on intention to use HSDPA service. This may have resulted from the fact that the use of video phones is not necessary for everyday life yet. Moreover, it has been shown that attitudes toward HSDPA video phones are directly correlated with usage intention, which means that perceived usefulness, ease of use, pleasure, a high level of knowledge management, and innovativeness. These relationships form the basis of the intention to buy, contributing to a situation in which consumers decide to choose carefully. A summary of the results of the hypothesis tests of European consumers revealed that perceived usefulness, pleasure, risk, and the level of knowledge management are factors that affect the formation of attitudes, while ease of use and innovativeness do not have an effect on attitudes. In particular, with regard to the effect value, perceived usefulness has the largest effect on attitudes, followed by pleasure and knowledge management. On the contrary, perceived risk has a smaller effect on attitudes. In the Asian model, ease of use and perceived pleasure were found not to have a direct effect on intention to use. However, because attitudes generally affect the intention to use, perceived usefulness, pleasure, risk, and knowledge management may be considered key factors in attitude development from which usage intention arises. In conclusion, perceived usefulness, pleasure, and the level of knowledge management have an effect on attitude formation in both Asian and European consumers, and such attitudes shape these consumers' intention to use. Furthermore, the hypotheses that ease of use and perceived pleasure affect usage intention are rejected. However, ease of use, perceived risk, and innovativeness showed different results. Perceived risk had no effect on attitude formation among Asians, while ease of use and innovativeness had no effect on attitudes among Europeans.

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