• Title/Summary/Keyword: D8/17

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Determination of metabolites of prostanozol in human urine by LC/ESI/MS and GC/TOF-MS (LC/ESI/MS와 GC/TOF-MS를 이용한 인체뇨시료에서의 Prostanozol 대사체 검출)

  • Yum, Tae-Woo;Paeng, Ki-Jung;Kim, Yun-Je
    • Analytical Science and Technology
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    • v.24 no.3
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    • pp.173-182
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    • 2011
  • This research examined prostanozol and its metabolites in urine of women who took the medicine (prostanozol). Prostanozol and its metabolites were successfully separated and detected by using LC/ESI/MS and GC/TOF-MS. Mass spectrum of LC/ESI/MS estimated molecular weight of Prostanozol and its metabolites and that of GC/TOF-MS verified them. For M1, carbon number 17 of Prostanozol substituted to a keto group and it is called 17-keto-Prostanozol. M2 turned out to be hydroxy-17-keto-Prostanozol. It came from substitution of one hydroxyl group of pyrazole nucleus and A-ring of M1. Substitution of one hydroxyl group of B-ring or C-ring became M3, hydroxy-17-keto-Prostanozol. M4 was found to be a hydroxy-17-keto-Prostsnozol transposed from one hydroxyl group to a D-ring. M5 has a hydroxyl group of carbon number 17. One hydroxyl group is substituted from B-ring or C-ring and it is assumed to be hydroxy-17-hydroxy-Prostanozol. M6 was turned out to be dihydroxy-17-keto-Prostanozol transposed from one hydroxyl group to pyrazole nucleus or A-ring and to B-ring or C-ring. Like M6, M7 has a keto group at carbon number 17 and was identified as dihydroxy-17-keto-Prostanozol. M7 has one hydroxyl group at pyrazole nucleus or A-ring and also at D-ring. At last M8 was found to be dihydroxy-17-hydroxy-Prostanozol. Pyrazole nucleus or A-ring has got one hydroxyl group and other rings were substituted to another hydroxyl group. From above, M5, M7 and M8 were verified as new metabolites that were not discovered yet. Prostanozol and all of the 8 metabolites formed glucuronic conjugates as a result of conjugation reaction test in human body. Some of 8 metabolites were excreted without forming conjugates. Particularly M6 and M7 were excreted as sulfate conjugates.

Disk Sector Antenna fed by CPW for UWB Communications (UWB 통신용 CPW 급전 디스크 섹터 안테나)

  • Lim, Jung-Hyun;Lee, Min-Soo;Yang, Doo-Yeong
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.2
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    • pp.303-312
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    • 2009
  • In this paper, we design and fabricate a disk sector antenna fed by CPW fur UWB communications. Also, we insert a rectangular slit on the arc-edge of the disk sector antenna. Then, the antenna has the directivity of E-면. In order to design the antenna, the input impedance is matched with the feed line of $50{\Omega}$ as varying the physical antenna parameters, which are the radius, the flare angle of disk sector, the length of ground, and the length of ground comer near by feed tine. Dimension of the antenna designed for UWB communication is $72mm{\times}26mm$ and bandwidth through computer simulation is $3{\sim}13GHz$. From the measured results, the bandwidth is $1.98{\sim}11GHz$. Return loss and gain of the fabricated antenna are -50.38dB, 1.34dBi at 3.5GHz, -12.27dB, 3.35dBi at 5.5GHz, -23.2dB, 3.8dBi at 8GHz and -16.17dB, 5.2dBi at 10GHz, respectively.

Quad-Band RF CMOS Power Amplifier for Wireless Communications (무선 통신을 위한 Quad-band RF CMOS 전력증폭기)

  • Lee, Milim;Yang, Junhyuk;Park, Changkun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.23 no.7
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    • pp.807-815
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    • 2019
  • In this paper, we design a power amplifier to support quad-band in wireless communication devices using RF CMOS 180-nm process. The proposed power amplifier consists of low-band 0.9, 1.8, and 2.4 GHz and high-band 5 GHz. We proposed a structure that can support each input matching network without using a switch. For maximum linear output power, the output matching network was designed for impedance conversion to the power matching point. The fabricated quad-band power amplifier was verified using modulation signals. The long-term evolution(LTE) 10 MHz modulated signal was used for 0.9 and 1.8 GHz, and the measured output power is 23.55 and 24.23 dBm, respectively. The LTE 20 MHz modulated signal was used for 1.8 GHz, and the measured output power is 22.24 dBm. The wireless local area network(WLAN) 802.11n modulated signal was used for 2.4 GHz and 5.0 GHz. We obtain maximum linear output power of 20.58 dBm at 2.4 GHz and 17.7 dBm at 5.0 GHz.

A study of the sidelobe supprion in an acousto-optic wavelength tunable filter utilizing a SAW-guide directional coupler (방향성 결합구조의 음향파 도파로를 이용한 음향광학형 파장가변 광 필터의 부모드 억제에 관한 연구)

  • 임경훈;정홍식
    • Korean Journal of Optics and Photonics
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    • v.11 no.6
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    • pp.423-428
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    • 2000
  • We have demonstrated a -8 dB additional reduction in the intensity sidelobe of an apodized-interaction-strength guide-wave acousto-optic filter with a center passband of 1551.6 nm. Acoustic-intensity weighting was achieved by launching a surface acoustic wave (SAW) beam in a straight acoustic waveguide, and gradually transferring this SAW intensity to the active device, and back out, by evanescent-wave coupling across a 50 !lm barrier over a 19 rom interaction length. The intensity sidelobe was -4.27 dB for an unapodized filter with abmpt onset and cutoff of the interaction, but sidelobes were reduced to at most -12.68 dB for a SAW intensity with raised-cosine weighting. The RF driving power was 17.78 mW. A linear tuning rate of 8.86 nmIMHz and a spectral width of -1.7 nm were demonstrated. rated.

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Development of Combinational 2-Way Isohybrid for GSM1900 Base Station (GSM1900 기지국용 일체형 2-Way Isohybrid의 개발)

  • Park, Noh-Joon;Jung, Seung-Woo;Kang, Young-Jin;Choi, U-Sung
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.11 no.8
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    • pp.1415-1423
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    • 2007
  • Total efficiency of transmitter system was improved by developing combinational 2-Way Isohybrid for GSM1900 base station in this paper. The size of product was decreased and the characteristics were stabilized. The isohybrid transmitter combiner of chip coupler type and hybrid coupler type were designed and fabricated. Insertion loss for chip coupler type isohybrid was $3.17\;dB{\sim}3.47\;dB$. On the other hand, insertion loss for hybrid coupler type was $3.17\;dB{\sim}3.42\;dB$. Isolations between ANT and port were $24.23\;dB{\sim}29.98\;dB$ in case of chip coupler type Isohybrid and were $26.28\;dB{\sim}36.91\;dB$ in case of hybrid coupler type, respectively.

Effect of Water Management after Fertilizer Application on Fate and Efficiency of Applied Nitrogen (시식 후 물관리 방법이 실소의 동태 및 이용효율에 미치는 영향)

  • 이변우;명을재;최관호
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.40 no.2
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    • pp.157-166
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    • 1995
  • The fate and use efficiency of applied nitrogen were evaluated in a pot experiment with different fertilizers and water management practices during 30days after fertilizer application. N-P-K compound fertilizers, 13-10-1l(F-l) for upland Crop use and 15-10-10(F-3) for rice Crop use, and mixed fertilizer, 21-17-17(F-2) for basal dressing in rice were used. Fertilizers corresponding to 1.8g N were mixed thoroughly with the whole volume of sandy loam soil in a pot. The pots were flooded upto 3cm above soil surface for O(0dF), 10(10dF), 20(20dF), and 30(30dF) days after fertilizer application and all the treatments were flooded continuously from 30 days after fertilizer application. During the flooding period water percolation rate was adjusted to 2.5mm/day. Rice seedlings were transplanted 40 days after fertilizer application. The pH of infiltrated water increased with increasing duration of flooding. The pH of F-2 was higher than those of F-1 and F-3 between which there were no differences. The applied nitrogen remained 23% in F-1, 29% in F-2, and 29.1 % in F-3, and 45.0% in 0dF, 26.6% in 10dF, 24.8% in 20dF, and 20.3% in 30dF as inorganic nitrogen at 63 days after fertilizer application. Nitrogen losses by leaching amounted to 51.3%, 32.1% and 48.1% of applied nitrogen in F-1, F-2 and F-3, respectively. Nitrogen leaching losses increased with increasing duration of flood- ing, amounting to 25.7%, 29.8%, 32.7%, and 35.8% in 0dF, 10dF, 20dF and 30dF, respectively. Gaseous loss of applied nitrogen was greatest in F-2, followed by F-1 and F-3. Total loss of nitrogen due to gaseous volatilization and leaching was greatest in F -1, followed by F -2 and F-3, and were greater in the treatments with longer flooding after fertilizer application. Nitrogen recovery by rice shoot until 72 days after transplanting were 23.2%, 24.7% and 27.4% of applied nitrogen in F-1, F-2 and F-3, respectively and 34.1%, 25.5%, 21.1%, and 21.2% in 0dF, 10dF, 20dF and 30dF, respectively.

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Correlation between the Salmonella seroprevalence on farms and the isolation rate from slaughtered pigs and antimicrobial resistance from the isolates (양돈장 살모넬라 혈청 양성율과 도축돈 살모넬라균 분리율의 상관관계 및 분리 균주의 항생제 내성)

  • Kim, Kyung-Eon;An, Jong-Min;Yang, Byung-Hun;Park, Yeong-Hee;Park, Mi-Young;Jung, Joon-Yong
    • Korean Journal of Veterinary Service
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    • v.37 no.4
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    • pp.233-240
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    • 2014
  • Salmonella spp. are one of the most common bacteria that causes heavy losses in swine industry and have implications for public health. In this study, the correlation between Salmonella seroprev-alence on farms and the isolation rate from slaughtered pigs was analyzed and the antimicrobial resistance of the isolated Salmonella spp. was investigated. A total of 3,001 serum samples for ELISA were collected from 17 farms during two consecutive years (2012-2013). The mean values of ELISA OD% for each 8 age groups were as follows; gilt 27.83 (n=472), sow 23.75 (n=367), 150 days (d) of pig 16.53 (n=278), 130 d 11.87 (n=366), 100 d 9.46 (n=378), 20 d 9.17 (n=394), 70 d 6.56 (n=382), 40 d 3.72 (n=364). From July 2013 to January 2014, a total of 53 (8.0%) Salmonella strains were isolated from 665 slaughtered pigs shipped from those 17 farms. The mean values of ELISA OD% for each age groups serum samples that were collected in the second half of 2013 showed a positive correlation at 100 d (0.61, P<0.05), 130 d (0.45, P<0.1) with the isolation rate of Salmonella spp. in the slaughtered pigs. All the isolates were identified by a real-time PCR and tested for antimicrobial susceptibility. As a result, the predominant serovar was S. Typhimurium (52.8%) and there were 15 strains showing their own antimicrobial resistance pattern. All strains were susceptible to amoxicillin, cefepime, ciprofloxacin and some of them were resistant to streptomycin and tetracycline (60%), ampicillin (53.3%), chloramphenicol (33.3%), respectively.

Effect of $17{\beta}$-Estradiol and 1,25-Dihydroxyvitamin $D_3$ on Interleukin-6 Production of Periodontal Ligament Cells (($17{\beta}$-Estradiol 및 1,25-Dihydroxyvitamin $D_3$가 치주인대 세포의 Interleukin-6의 생성에 미치는 영향)

  • Kwak, Wall-Ah;Choi, Bong-Kyu;Lee, Hyun-Jung;Yoo, Yun-Jung
    • Journal of Periodontal and Implant Science
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    • v.29 no.3
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    • pp.645-654
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    • 1999
  • Interleukin-6(IL-6) stimulate osteoclast differentiation. $17{\beta}$-estradiol, 1,25-dihydroxyvitamin $D_3$(1,25-$(OH)_2D_3$) and interleukin-$1{\beta}$ inhibit or stimulate osteoclast differentiation by decreasing or increasing the synthesis of interleukin-6(IL-6) from stromal/osteoblastic cells, respectively. Periodontal ligament(PDL) cells reside between the alveolar bone and the cementum and have osteoblastic characteristics. To estimate the effect of $17{\beta}$-estradiol and 1,25$(OH)_2D_3$ on IL-6 production of PDL cells, PDL cells were treated with $17{\beta}$-estradiol or 1,25-$(OH)_2D_3$ in the absence or the presence of IL-$1{\beta}$. The concentration of IL-6 produced form PDL cells was determined by enzym linked immunosorbent assay(ELISA). In unstimulated PDL cells, we detected constitutive production of IL-6 at 1st and 2nd day. IL-$1{\beta}$ increased IL-6 synthesis at 1st day and 2nd day. $17{\beta}$-estradiol had no significant effect on the secretion of this cytokine, either constitutively or after stimulation with IL- $1{\beta}$(0.05 ng/ml). 1,25-$(OH)_2D_3$($10^{-8}M$) decreased not only constitutive IL-6 production but also IL-$1{\beta}$-induced IL-6 production at 2nd day. These results suggest that 1,25-$(OH)_2D_3$ may control IL-$1{\beta}$-induced osteoclast differentiation by decreasing IL-$1{\beta}$-induced IL-6 secretion of PDL cells.

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Serially Concatenated Neural Linear Transversal Equalizer/Turbo Code Detection for High Density Nonlinear Magnetic Storage Channels (고밀도 비선형 자기 저장 채널을 위한 신경망 등화기와 터보 코드의 연접 데이터 복호 방법)

  • Lee, Jun;Lee, Jae-Jin
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.25 no.11B
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    • pp.1879-1883
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    • 2000
  • 디지털 자기 기록 저장기기에서 채널 밀도가 증가하면 심각한 인접심볼 간섭과 비선형 왜곡이 야기된다. 본 논문에서는 심각한 비선형 인접심볼 간섭과 비선형 왜곡을 극복하기 위한 방법으로 기존의 등화기 대신 NLTE(neural linear transversal equalizer)를 등화기로 사용하고 검출기로는 터보 코드를 사용한 NLTE/TC 구조를 제안한다. 채널 밀도 S=2.5에서 부분 삭제가 0.7 정도 존재할 때, 코드율이 8/9일 때는 $10^{-5}$의 비트 에러율을 18dB 이후에서 만족하며, 코드율이 16/17일 때는 20dB 이후에서 만족함을 알 수 있었다. 채널 밀도 S=3에서 부분 삭제가 0.6 정도 존재할 때 코드율이 8/9일 때는 $10^{-5}$의 비트 에러율을 22dB 이후에서 만족하고, 코드율이 16/17일 때는 24dB 이후에서 만족함을 확인할 수 있었다.

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