• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.703-712
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• 2016

Monoclonal antibodies with specific antigens have been widely used as targeted therapy for cancer. Hep88 mAb is a monoclonal antibody which shows specific binding with anti-cancer effects against the HepG2 cell line. However, its mechanisms of action are still not completely understood. We examined cell cycling and apoptosis by flow cytometry and mRNA expression of factors involved in apoptosis and paraptosis in Hep88 mAb-treated HepG2 cells by real-time PCR. The cell-cycle analysis demonstrated that growth-inhibitory activity was associated with G2/M cell cycle arrest. Hep88 mAb induced a significant increase in apoptotic cell populations in a dose- and time-dependent manner. The mRNA expression results also suggested that the process triggered by Hep88 mAb involved up-regulation of tumor suppressor p53, pro-apoptotic Bax, Cathepsin B, Caspase-3 and Caspase-9, with a decrease of anti-apoptotic Bcl-2 - thus confirming paraptosis and apoptosis programmed cell death. These findings represent new insights into the molecular mechanisms underlying the anti-cancer properties of Hep88 mAb in liver cancer cells.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.12
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• pp.98-106
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• 2013

The duty-cycle synchronization among mobile sensor nodes with energy-harvesting is very important. The nodes should keep their duty-cycle same to others as much as possible because they have to cooperate each other and to consume energy efficiently. The distribution of node position in network affects not only node connectivity but also the active time of synchronized nodes, and it relates to network life-time finally. In this paper, we introduce a network topology change algorithm (TCA) for energy-harvesting mobile sensor networks based on self-synchronized duty-cycling. The algorithm tries to change a network topology into a balanced topology where the mobile sensor nodes are unified according to the density of the number of nodes. For TCA, both fluid flow algorithm and flock dispersion algorithm are proposed and they are evaluated through the simulation in agent based modeling language. TCA is applied to the energy-harvesting mobile sensor networks to improve the synchronization of duty-cycle and to reduce the variation of energy consumption among nodes.

• Journal of Korean Society of Transportation
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• v.28 no.4
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• pp.97-106
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• 2010

Environmental issues resulting from climate change and energy crises have become global issues, and cycling has gained greater popularity for sustainable transportation. Though many cities are trying to build bicycle roads, it is not easy to implement bicycle roads because there is little available space for bicycle facilities. Therefore, road diets have become more popular in Korea. However, there has been no intensive research to date of their impacts. The purpose of this research is to evaluate the effects of road diets and construction of bike lanes. Every benefit, including energy benefit, environmental benefit, and health benefit is considered, while only time savings benefit has been considered in previous studies. The benefit analysis for the Seoul metropolitan area as a case study shows that road diets have a (1) time saving benefit for only five percent of the mode share and (2) enough total benefit even if bicycle mode share is less than two percent.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.9 no.5
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• pp.59-66
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• 2010

Korea have experienced a very rapid increase in police-reported collisions between bicycle and motor vehicles over the past decade. Even though cycling accidents are increasing, efforts to make urban areas more accomodating to cyclists are seldom formed. Clearance intervals(including both the yellow change and all-red clearance intervals) at signalized intersections that are of inadequate lengths for bicycles may cause accidents. Data on bicycling speed, acceleration and deceleration were tested and analyzed on the flat. Using the results of the analysis and based on the AASHTO's equation of the bicycle clearance interval, a methodology is got for calculation safe clearance intervals for bicycle riders. The clearance interval call for bicycles will be larger or same than for vehicles because of the speed, acceleration and deceleration difference. Adequate bicycle speed, acceleration and deceleration for korean bicycle users is presented in this paper. It is hoped that traffic engineers to provide safe intersection clearance time for bicycles use the results of this paper.

• Journal of KIISE:Software and Applications
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• v.41 no.8
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• pp.586-597
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• 2014

The next generation mobile computing technology is recently attracting attention that smartphone and wearable device imbedded with various sensors are being deployed in the world. Existing activity and posture recognition research can be divided into two different ways considering feature of one's movement. While activity recognition focuses on catching distinct pattern according to continuous movement, posture recognition focuses on sudden change of posture and body orientation. There is a lack of research constructing a system mixing two separate patterns which could be applied in real world. In this paper, we propose a method to use both smartphone and wearable device to recognize activity and posture in the same time. To use smartphone and wearable sensor data together, we designed a pre-processing method and constructed recognition model mixing signal vector magnitude and orientation pattern features of vertical and horizontal. We considered cycling, fast/slow walking and running activities, and postures such as standing, sitting, and laying down. We confirmed the performance and validity by experiment, and proved the feasibility in real world.

• Journal of Industrial Convergence
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• v.19 no.1
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• pp.137-146
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• 2021

In This study investigated the effects of various intensity cycling exercise on body composition, blood lipids and fat metabolism in obese middle-aged women. 17 people obesity middle - aged women aged 35 to 55 years were divided into 3 groups: 5 people in the low intensity group, 6 people in the medium intensity group, and 6 people in the high intensity group. The object of this study was to compare the effect of cycle exercise performed between 20 ~ 50 minutes per a day,1 3 day times per week on the body composition, lipid profile and lipid metabolism of obesity middle - aged women. There was not substantial difference in body construction between groups. in blood lipid changes, there was a substantial difference in glucose between groups, There was not substantial difference between groups in the change of fat metabolism. In addition, there was not substantial difference in the interaction effect between time and time × group. It is expected that the results of this study will be used as basic data for related field.

• Journal of Powder Materials
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• v.28 no.6
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• pp.462-469
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• 2021

Tin/graphite composites are prepared as anode materials for Li-ion batteries using a dry ball-milling process. The main experimental variables in this work are the ball milling time (0-8 h) and composition ratio (tin:graphite=5:95, 15:85, and 30:70 w/w) of graphite and tin powder. For comparison, a tin/graphite composite is prepared using wet ball milling. The morphology and structure of the different tin/graphite composites are investigated using X-ray diffraction, Raman spectroscopy, energy-dispersive X-ray spectroscopy, and scanning and transmission electron microscopy. The electrochemical properties of the samples are also examined. The optimal dry ball milling time for the uniform mixing of graphite and tin is 6 h in a graphite-30wt.%Sn sample. The electrode prepared from the composite that is dry-ball-milled for 6 h exhibits the best cycle performance (discharge capacity after 50^th cycle: 308 mAh/g and capacity retention: 46%). The discharge capacity after the 50^th cycle is approximately 112 mAh/g, higher than that when the electrode is composed of only graphite (196 mAh/g after 50^th cycle). This result indicates that it is possible to manufacture a tin/graphite composite anode material that can effectively buffer the volume change that occurs during cycling, even using a simple dry ball-milling process.

• Journal of the Korean Society for Marine Environment & Energy
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• v.12 no.4
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• pp.248-254
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• 2009

Budgets of fresh water, salt, DIP and DIN in the Youngsan river estuary were estimated seasonally in order to clarify the characteristics of material cycling and flux of nutrients with a simple box model. Inflow volumes of freshwater into system was approximately $36.481{\times}10^6{\sim}663.634{\times}10^6m^3/month$ and existing water mass of freshwater in system calculated by salt budget was approximately $2.515{\times}10^6{\sim}5.812{\times}10^6m^3$. Mean residence time of freshwater was calculated to be about 0.26~2.03 day. water exchange $1,248{\times}10^6{\sim}9,489{\times}10^6m^3/month$ assumed with salinity between estuary and adjacent ocean. Inflow mass of DIN and DIN were approximately 76.63~1,149.91 ton/month and 2.91~61.22 ton/month, respectively. Residence times of DIP and DIN were calculated to be 0.45~1.10 day and 0.28~1.92 day, respectively. The ratio of water residence time versus DIP, DIN residence time was calculated that freshwater residence time was longer than DIP, DIN residence time except for summer season. Thus, We assume that circulation of Nutrients in the system will happen rapidly except for summer season. Specially DIP in Winter could assume to outer input source existence because of seawater inflow in system and high DIP concentration in open sea.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.24 no.3
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• pp.99-105
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• 2014

$LiCoO_2$ thin film have received attention as cathodes of thin-film microbatteries. In this study, $LiCoO_2$ thin films were synthesized on Au substrates by sol-gel spin coating method and electrochemical properties were investigated under annealing temperature and time. The phycochemical properties of $LiCoO_2$ thin film were investigated by X-ray diffraction, scaning electron microscopy and atomic force microscopy. The electrochemical properties were characterized using galvanostatic charging/discharging cycling tests. From X-ray diffraction, as-grown films annealed at $550^{\circ}C$ and $750^{\circ}C$ are presumed to be spinel structure and a single phase of the layered-rock-salt, respectively. The RMS roughness and grain size of the films which annealed at $750^{\circ}C$ has similar values for annealing time 10 and 30 min, while for annealing time 120 min surface roughness, grain size increase and pore appearance were observed. The first discharge capacity of $LiCoO_2$ thin films annealed at $750^{\circ}C$ for 10, 30 and 120 min is about 54.5, 56.8 and $51.87{\mu}Ah/cm^2{\mu}m$, respectively. Corresponding capacity retention at 50th cycle is 97.25, 76.69, 77.19%.

• Wind and Structures
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• v.12 no.4
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• pp.383-400
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• 2009

Low rise building roofs can be subjected to large fluctuating pressures during a tropical cyclone resulting in fatigue failure of cladding. Following the damage to housing in Tropical Cyclone Tracy in Darwin, Australia, the Darwin Area Building Manual (DABM) cyclic loading test criteria, that loaded the cladding for 10000 cycles oscillating from zero to a permissible stress design pressure, and the Experimental Building Station TR440 test of 10200 load cycles which increased in steps to the permissible stress design pressure, were developed for assessing building elements susceptible to low cycle fatigue failure. Recently the 'Low-High-Low' (L-H-L) cyclic test for metal roofing was introduced into the Building Code of Australia (2007). Following advances in wind tunnel data acquisition and full-scale wind loading simulators, this paper presents a comparison of wind-induced cladding damage, from a "design" cyclone proposed by Jancauskas, et al. (1994), with current test criteria developed by Mahendran (1995). Wind tunnel data were used to generate the external and net pressure time histories on the roof of a low-rise building during the passage of the "design" cyclone. The peak pressures generated at the windward roof corner for a tributary area representative of a cladding fastener are underestimated by the Australian/New Zealand Wind Actions Standard. The "design" cyclone, with increasing and decreasing wind speeds combined with changes in wind direction, generated increasing then decreasing pressures in a manner similar to that specified in the L-H-L test. However, the L-H-L test underestimated the magnitude and number of large load cycles, but overestimated the number of cycles in the mid ranges. Cladding elements subjected to the L-H-L test showed greater fatigue damage than when experiencing a five hour "design" cyclone containing higher peak pressures. It is evident that the increased fatigue damage was due to the L-H-L test having a large number of load cycles cycling from zero load (R=0) in contrast to that produced during the cyclone.