• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.2
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• pp.73-79
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• 2002

The NO emissions at the exhaust manifo1d were investigated with a fast NO analyzer to investigate the cycle-by-cycle variations on NO emissions level and the dependence of NO emissions on combustion. The measurement was performed with a part load condition with respect to the mixture ratios and the changes in loads at 1800rpm. The averaged values were obtained during 200 cycles. We found that there is characteristic pattern in 70 emissions from exhaust port and it was possible to set a representative value with the data sampled during specific period. As the load increased, the characteristics of NO emissions were more dependent on combustion pressures. It was also analyzed that the correlation between combustion pressures and NO emissions for different equivalence ratios tends to increase as the mixture goes leaner, Furthermore, this correlation for the lean mixture near the lean limit seemed to be kept.

• Journal of Hydrogen and New Energy
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• v.13 no.3
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• pp.233-241
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• 2002

To achieve hydrogen power system with high performance and stable operation, the COVimep of hydrogen fueled engine with direct injection was evaluated with the change of engine speed, injection timing, air-fuel equivalence ratio and spark timing. And the cause of cycle variation was analyzed by using coefficient of variation in combustion period defined in this study. the results showed that the cycle variation of hydrogen fueled engine is mainly dependent on the early combustion period.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.7 no.3
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• pp.488-500
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• 1995

An air-cooled ammonia/water GAX(Generator-Absorber heat eXchange) absorption cooling cycle is proposed and its performance is numerically evaluated. It is shown that the performance of the system is greatly dependent on the quality of the refrigerant leaving the evaporator. For any refrigerant concentration in the investigated range(99.1~99.9% ammonia), the cycle COP(coefficient of performance) reaches the highest value, when some amount(about 7%) of refrigerant evaporates in the refrigerant heat exchanger. Among temperature differences in various heat exchangers, the temperature difference between GAX-absorber and the GAX-generator shows the greatest effect on the system performance, whereas pressure losses cause no significant decrease in COP. The system COP increases almost linearly with increasing evaporator temperature, decreasing absorber temperature or decreasing condenser temperature. If both absorber and condenser temperature increase simultaneously, the decrease in the COP becomes larger.

• Journal of the Korean Society for Railway
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• v.8 no.6 s.31
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• pp.581-585
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• 2005

In this study, the environmental impacts of a bogie in the electric motor unit(EMU) were evaluated quantitatively using simplified life cycle assessment(S_LCA). Target was the bogie and life cycle inventory(LCI) database for the bogie was established. The software used for simplified LCA was PASS. Environmental impacts with the parts of the bogie were dependent on their weight significantly. Among impact categories, abiotic resource depletion(ARD) and global warming(GW) were shown dominantly. Global warming was occurred mainly due to the emission of CO₂released from energy consumption and abiotic resource depletion was caused mostly by the consumption of iron ore for the manufacturing of steel. Therefore, the environmental impacts of the bogie could be reduced by the light-weighting of EMU and the improvement of energy efficiency.

• The Korea Journal of Herbology
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• v.21 no.1
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• pp.33-42
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• 2006

Objectives : The purpose of this study was to investigate the anticancer effects of Bodusan (BDS) on SNU-1 cells, a human gastric cancer cell line. Methods : To study the cytotoxic effect of BDS on SNU-1 cells, the cells were treated with various concentrations of BDS and then cell viability was determined by XTT reduction method and trypan blue exclusion assay. The typical signs of apoptosis, was examined by western blot analysis. BDS-induced MAPK activation was also examined by Western blot for phosphorylated ERK and p38. Results : BDS reduced proliferation of SNU-1 cells in a dose-dependent manner and decreased procaspase 3 level in a dose-dependent manner and induced the clevage of PARP at concentration > 500 ${\mu}g/ml$. BDS also triggered the mitochondrial apoptotic signaling by increasing the release of cytochrome C from mitochondria to cytosol and reducing the level of anti-apoptotic Bcl-2. BDS significantly decreased ERK phosphorylation and increased p38 phosphorylation in a dose-dependent manner. Futhermore, BDS treatment up-regulated p53 and p21waf expression in a dose-dependent manner. Conclusion : BDS-induced apoptosis is MAP kinase-dependent apoptoric pathway and arrested SNU-1 cells at the G0/G1 of cell cycle. These results suggest that BDS is potentially useful as a chemotherapeutic agent in human gastric cancer.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.1
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• pp.183-189
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• 2003

Platycodi Radix, the root of Platycodon grandiflorum, commonly known as Doraji, is used as a traditional oriental medicine. Extracts from the roots of P. grandiflorum have been reported to have wide ranging health benefits. We investigated the effects of an aqueous extract from the roots of P. grandiflorum (AEPG) on the cell proliferation of human lung carcinoma A549 cells in order to understand its anti-proliferative mechanism. AEPG treatment resulted in the inhibition of cell proliferation in a concentration-dependent manner. This anti-proliferative effect of A549 cells by AEPG treatment was associated with morphological changes such as membrane shrinking, cell rounding up and inhibition of cell migration. DNA flow cytometric histograms showed that populations of both Sand G2/M phase of the cell cycle were increased by AEPG treatment in a concentration-dependent manner. AEPG treatment induced a marked accumulation of tumor suppressor p53 and a concomitant induction of cyclin-dependent kinase (Cdk) inhibitor p21 and p27. In addition, SSS treatment resulted in down-regulation of Cdk2 and Cdk4 expression. The present results indicated that AEPG-induced inhibition of lung cancer cell proliferation is associated with the blockage of S to G2/M phase progression the induction of apoptosis. Taken together, these findings suggest that P. grandiflorum has strong potential for development as an agent for prevention against human lung cancer.

• Journal of Life Science
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• v.23 no.6
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• pp.832-837
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• 2013

In this study, it was investigated the possible mechanisms by which glutamine deprivation exerts its anti-proliferative action in cultured human prostate carcinoma PC3 cells. Glutamine deprivation resulted in inhibition of growth and G2/M arrest of the cell cycle in a time-dependent manner without apoptosis induction, as determined by MTT assay, DAPI staining and flow cytometry analyses. The induction of G2/M arrest by glutamine deprivation was associated with the inhibition of expression of Cdc2, cyclin A and cyclin B1, and up-regulation of the expression of cyclin-dependent kinase (Cdk) inhibitor p21(WAF1/CIP1) in both transcriptional and translational levels. Moreover, glutamine deprivation increased the phosphorylation of checkpoint kinase (Chk)1 and Chk2; however, the levels of Cdc25C phosphorylation were decreased in response to glutamine deprivation in a time-dependent manner. Our data provide a first biochemical evidence that glutamine deprivation suppresses cell viability through G2/M phase arrest without induction of apoptosis in PC3 cells.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.101-109
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• 2004

Spatholobus suberectus belonging the family Leguminosae has been used for promoting blood circulation, removing blood stasis, tonifying the blood, relaxing tendons, stopping internal bleeding and eliminating dampness in oriental traditional medicine. This study investigates whether the water extracts of S. suberectus induce apoptotic cell death in Jurkat T-acute lymphoblastic leukemia (ALL) cells. Jurkat cells were increased inhibitions of cell viability in a concentration-dependent manner by S. suberectus, as measured by cell morphology. The capability of S. suberectus to induce apoptosis was associated with proteolytic cleavage of specific target protein such as poly (ADP­ribose)polymerase protein suggesting the possible involvement of caspases. The purpose of the present study is also to investigate the effect of S. suberectus on cell cycle progression. G1 checkpoin related gene products tested (cyclin D1, cyclin dependent kinase 4, retinoblastoma, E2Fl) were decreased in their protein levels in a dose-dependent manners after treatment of the extract. These results indicate that the increase of apoptotic cell death by S. suberectus may be due to the inhibition of cell cycle progression in wild type p53-lacking Jurkat cells.

• The Korean Journal of Financial Studies
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• v.2 no.1
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• pp.145-158
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• 1995

According to recent empirical studies, there is a systematic pattern in temporal behaviors of asset returns, and that systematic pattern is related to the business cycle. I propose a model which captures this evidence. This is done by considering a state dependent preference structure where state dependency is related to the business cycle. In this setting, the three main puzzles(i.e., the volatility puzzle, the equity premium puzzle, mean reversion) are understood as interrelated behaviors.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.114-114
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• 2003