Cell Cycle Arrest of Human Lung Carcinoma A549 Cells by an Aqueous Extract from the Roots of Platycodon grandiflorum
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Kang Rak Won
(Department of Internal Medicine, Oriental Medicine, Dongeui University)
Lee Jae Hun (Biochemistry, Oriental Medicine, Dongeui University) Kam Cheol Woo (Department of Internal Medicine, Oriental Medicine, Dongeui University) Choi Byung Tae (Anatomy, College of Oriental Medicine and Research Institute of Oriental Medicine, Dongeui University) Choi Yung Hyun (Biochemistry, Oriental Medicine, Dongeui University) Park Dong Il (Department of Internal Medicine, Oriental Medicine, Dongeui University) |
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WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
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2 |
Functional analysis of the transforming growth factor <TEX>${\beta}$</TEX> responsive elements in the WAF/Cip1/p21 promoter.
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Regulation of p21WAF1/CIP1 expression by p53-independent pathways.
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Histone deacetylase inhibitor activates the p21/WAF1/Cip1 gene promoter through the Sp1 sites.
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p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells.
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6 |
Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.
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p21 is a component of active cell cycle kinases.
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DOI ScienceOn |
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Involvement of p21(Wafl/Cipl) and its cleavage by DEVD-caspase during apoptosis of colorectal cancer cells induced by butyrate.
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Premature p34cdc2 activation required for apoptosis.
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Apoptosis. The role of the endonuclease.
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Multiple pathways to apoptosis.
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Apoptosis and the cell cycle.
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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.
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14 |
Cyelin-dependent regulation of G1 in mammalian fibroblasts.
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15 |
Effect of Platycodon grandiflorum DC extract on the growth of cancer cell lines
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16 |
Immune pharmacological studies on platicodi radix(Ⅱ). Antitumor activity of inulin from platicodi radix.
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17 |
Apoptotic Cell Death of Human Lung Carcinoma A549 Cells by an Aqueous Extract from the Roots of Platycodon grandiflorum.
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18 |
Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells.
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19 |
Resveratrol and quercetin inhibit angiogenesis in vitro.
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20 |
Research technics for the cell cycle study
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21 |
D-type cyclin-dependent kinase activity in mammalian cells.
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22 |
Formation and activation of a cyclin E-cdk2 complex during the Gl phase of the human cell cycle.
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23 |
Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
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24 |
Role for cyclin A in the dependence of mitosis on completion of DNA replication.
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25 |
Inhibition of prostaglandin E2 production by platycodin D isolated from the root of Platycodon grandiflorum.
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26 |
Antitumor and immunomodulatory activities of the Platycodon grandiflorum cultivated for more than 20 years.
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27 |
WAF1, a potential mediator of p53 tumor suppression.
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28 |
Cdk inhibitors: on the threshold of checkpoints and development.
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29 |
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
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30 |
Principles of CDK regulation.
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31 |
p21 is a universal inhibitor of cyclin kinases.
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32 |
Pharmacological activities of crude platycodin.
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33 |
The retinoblastoma protein and cell cycle control.
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34 |
The Pezcoller lecture : cancer cell cycles revisited.
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35 |
Pharmacological studies on Platycodon grandiflorum A. DC.
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36 |
Studies on antiinflammatory effect of Japanese Oriental medicines (kampo medicines) used to treat inflammatory diseases.
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37 |
A comparative study on commercial, botanical gardens and wild samples of the roots of Platycodon grandiflorum by HPLC analysis.
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38 |
Pharmaceutical substances of Platycodon grandiflorum (jacquin) A. De Candolle.
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39 |
Aging enhances G(1) phase in the colonic mucosa of rats.
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40 |
Regulation of cyclin D1 by calpain protease.
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