• 한국ITS학회 논문지
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• 제10권5호
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• pp.23-35
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• 2011

광폭의 도로에서는 횡단거리가 길어 보행자의 녹색시간이 길게 할당된다. 부도로의 교통량이 적을 때에도 보행자의 최소녹색시간으로 인해 일정시간 이상의 녹색신호시간을 보장해 주어야 하기 때문에 신호주기가 길어지고 주도로의 g/C 비율이 감소하게 되어 교차로 전체의 지체가 증가되는 문제점이 발생한다. 이 같은 문제점을 개선하기 위해 2단 횡단보도의 설치 효과를 차량 측면과 보행자 측면으로 나누어 분석하였다. 차량당 제어지체를 TRANSYT-7F와 VISSIM을 활용하여 산출하였고 그 결과 2단 횡단보도의 차량당 제어지체가 일반 횡단보도에 비해 최소 14.9%에서 최대 85.6% 감소하는 것으로 나타났다. 보행자 측면에서는 해석적 방법으로 두 횡단보도의 보행자 평균 횡단시간을 비교하였으며, 또한 VISSIM을 통한 평균 보행자지체를 산출하여 비교분석하였다. 해석적 방법으로 보행자 평균 횡단시간을 산출한 결과, 두 횡단보도의 큰 차이는 없는 것으로 분석되었다. VISSIM을 활용하여 보행자 지체시간을 산출한 결과, 일반 횡단보도에 비해 2단 횡단보도의 평균 보행자 지체가 13.4%~22.3%까지 감소하는 것으로 분석되었다. 따라서 교통 및 기하조건이 연구결과와 유사한 경우에는 일반 횡단보도에 비해 2단 횡단보도가 차량 및 보행자측면에서 효과적으로 사용될 수 있을 것으로 사료된다.

• 전기전자학회논문지
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• 제22권3호
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• pp.638-644
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• 2018

본 논문에서는 플라스틱 Scintillator와 NaI(TI) 검출기를 이용하여 움직이는 차량 적재물에 존재하는 다수의 방사선원 위치를 3차원으로 판별하는 측정시스템을 제안한다. 제안하는 시스템은 방사선량 측정용 플라스틱 Scintillator, 2채널 펄스 카운터, 핵종 분석용 NaI(TI) 검출기 및 1채널 MCA Board 등으로 구성된다. 방사선원 위치판별 알고리즘은 방사선량의 거리의 자승에 반비례한 특성($1/r^2$)과 장치와의 각도(${\theta}$)에 따른 보상을 통해 계산된 방사선원의 CPS 값의 비율을 SVM 분류를 통하여 방사선원의 위치(X, Y)를 구할 수 있다. (Z) 좌표 값은 단위 시간당 움직이는 대상체의 속도에 따라 정해지게 되며 이는 단위주기당 백그라운드 스펙트럼을 제외한 순수 핵종의 스펙트럼을 분석한 후 핵종 유무 판별을 진행한 뒤 해당 핵종의 위치를 판별하게 된다. 본 논문에서 제안한 시스템의 위치 판별 실험 결과 ${\pm}1m$ 이내의 국제표준오차를 나타내었다. 따라서 본 논문에서 제안한 시스템의 유효성이 입증되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.6159-6164
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• 2013

Background: Phytochemical compounds are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. The purpose of this study was to investigate the potential effcts of thymoquinone, caffeic acid phenylester (CAPE) and resveratrol on inflammatory markers, oxidative stress parameters, mRNA expression levels of proteins and survival of lung cancer cells in Vitro. Materials and Methods: The A549 cell line was treated with benzo(a)pyrene, benzo(a)pyrene plus caffeic acid phenylester (CAPE), benzo(a)pyrene plus resveratrol (RES), and benzo(a)pyrene plus thymoquinone (TQ). Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and anti-apoptotic proteins and cell viability were assessed and results were compared among study groups. Results: TQ treatment up-regulated Bax and down-regulated Bcl2 proteins and increased the Bax/Bcl2 ratio. CAPE and TQ also up-regulated Bax expression. RES and TQ down-regulated the expression of Bcl-2. All three agents decreased the expression of cyclin D and increased the expression of p21. However, the most significant up-regulation of p21 expression was observed in TQ treated cells. CAPE, RES and TQ up-regulated TRAIL receptor 1 and 2 expression. RES and TQ down-regulated the expression of NF-kappa B and IKK1. Viability of CAPE, RES and TQ treated cells was found to be significantly decreased when compared with the control group (p=0.004). Conclusions: Our results revealed up-regulation of the key upstream signaling factors, which ultimately cause increase in their regulatory p53 levels affecting the induction of G2/M cell cycle arrest and apoptosis. Overall these results provide mechanistic insights for understanding the molecular basis and utility of the anti-tumor activity of TQ, RES and CAPE.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.769-773
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• 2014

Fangchinoline (Fan) inhibits cell proliferation and induces apoptosis in several cancer cell lines. The effects of Fan on cell growth and proliferation in breast cancer cells remain to be elucidated. Here, we show that Fan inhibited cell proliferation in the MDA-MB-231 breast cancer cell line through suppression of the AKT/Gsk-3beta/cyclin D1 signaling pathway. Furthermore, Fan induced apoptosis by increasing the expression of Bax (relative to Bcl-2), active caspase 3 and cytochrome-c. Fan significantly inhibited cell proliferation of MDA-MB-231 cells in a concentration and time dependent manner as determined by MTT assay. Flow cytometry analysis demonstrated that Fan treatment of MDA-MB-231 cells resulted in cell cycle arrest at the G1 phase, which correlated with apparent downregulation of both mRNA and protein levels of both PCNA and cyclin D1. Further analysis demonstrated that Fan decreased the phosphorylation of AKT and GSK-3beta. In addition, Fan up-regulated active caspase3, cytochrome-c protein levels and the ratio of Bax/Bcl-2, accompanied by apoptosis. Taken together, these results suggest that Fan is a potential natural product for the treatment of breast cancer.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.48-54
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• 2020

과학기술의 급속한 발전 속도와 군용부품시장의 축소 등이 원인이 되어 부품단종이 증가하고 있다. 부품단종은 무기체계 총수명주기비용이 증가시키며 군 전투력 등에 큰 문제를 일으킬 수 있다. 따라서 부품단종으로 발생하는 대응비용을 절감하기 위해서는 사전 관리가 중요하며 사전관리 근간을 마련하기 위해 단종관련 정보를 관련자들이 공유할 수 있는 데이터베이스 구축이 되어야 한다. 효율적으로 데이터베이스를 관리하기 위해서는 주요 관리 항목을 선정하여 지속적으로 업무를 수행하는 것이 필요하다. 본 연구의 목적은 부품단종 관리 시스템에서 주요한 관리 항목을 도출하는 데 있다. 방위사업청 매뉴얼과 SD-22 등을 바탕으로 관리 항목을 선정하여 주요 관리항목을 AHP(Analytic Hierarchy Process) 기법을 통해서 분석하였다. 부품단종에 따른 영향성, 부품단종 확률, 부품단종 대응비용의 3가지 기준에 의해 관련된 세부 항목 15개로 계층화하였으며 9점 척도로 설문한 항목에 대해 각각의 가중치를 산출하였다. AHP 설문조사는 부품 관리 전문가 25명을 대상으로 실시하였고, AHP 설문결과 일관성비율이 0.1 초과인 것을 제외하였다. 그 결과 부품단종관리를 위한 유용한 항목을 도출할 수 있었으며 이에 대한 결과 해석 및 향후 발전방향을 제시하였다.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.248-258
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• 2020

본 연구에서는 해외 선진국의 유지관리 체계를 벤치마킹하여 시설물의 생애주기 차원에서 종합적 자산 관리개념을 고려한 유지관리 기술 분류체계를 제안하였다. 이를 위하여 비교사례 연구 기법을 적용하였으며, 국내·외 유지관리 제도, 정의, 기술 분류체계 등을 비교·분석하였다. 비교사례 분석을 위하여 유지관리 비용 집행 비율이 높은 미국, 영국, 일본을 대상 국가로 선정하였고, 해당 국가들의 유지관리 체계를 분석하였다. 다음으로, 국내 유지관리 관련 법에 내포되어있는 인프라 유지관리 기술의 분류 및 정의에 대하여 분석하였다. 그 결과 해외 선진국들은 유지관리 기술의 효과에 따라 유지보수와 개선을 명확하게 분류하고, 예방적 유지관리 활동 중심의 체계를 구성하고 있었다. 반면, 우리나라의 시설물 유지관리 기술은 그 분류 및 정의가 명확하게 구분되지 않고 아직도 사후 대응적 구조 중심으로 이루어져 있어 개선이 필요한 것으로 나타났다. 비교사례연구 결과를 토대로 제안한 분류체계는 유지관리, 유지보수, 성능개선의 개념을 정립하고, 예방적 유지보수와 대응적 유지보수를 명확하게 구분하였다. 결과적으로 제안된 기술 분류체계는 자산관리관점에서 선제적 유지관리 활동과 합리적인 유지관리 예산 분배를 위한 기초연구로서의 활용도가 높을 것으로 기대된다.

• Asian-Australasian Journal of Animal Sciences
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• 제33권1호
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• pp.166-176
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• 2020

Objective: An experiment was conducted to determine the effects of L-arginine (L-Arg) and N-carbamoylglutamic acid (NCG) on the growth, metabolism, immunity and community of cecal bacterial flora of weanling and young rabbits. Methods: Eighteen normal-grade male weanling Japanese White rabbits (JWR) were selected and randomly divided into 6 groups with or without L-Arg and NCG supplementation. The whole feeding process was divided into weanling stage (day 37 to 65) and young stage (day 66 to 85). The effects of L-Arg and NCG on the growth, metabolism, immunity and development of the ileum and jejunum were compared via nutrient metabolism experiments and histological assessment. The different communities of cecal bacterial flora affected by L-Arg and NCG were assessed using high-throughput sequencing technology and bioinformatics analysis. Results: The addition of L-Arg and NCG enhanced the growth of weanling and young rabbit by increasing the nitrogen metabolism, protein efficiency ratio, and biological value, as well as feed intake and daily weight gain. Both L-Arg and NCG increased the concentration of immunoglobulin A (IgA), IgM, and IgG. NCG was superior to L-Arg in promoting intestinal villus development by increasing villus height, villus height/crypt depth index, and reducing the crypt depth. The effects of L-Arg and NCG on the cecal bacterial flora were mainly concentrated in different genera, including Parabacteroides, Roseburia, dgA-11_gut_group, Alistipes, Bacteroides, and Ruminococcaceae_UCG-005. These bacteria function mainly in amino acid transport and metabolism, energy production and conversion, lipid transport and metabolism, recombination and repair, cell cycle control, cell division, and cell motility. Conclusion: L-Arg and NCG can promote the growth and immunity of weanling and young JWR, as well as effecting the jejunum and ileum villi. L-Arg and NCG have different effects in the promotion of nutrient utilization, relieving inflammation and enhancing adaptability through regulating microbial community.

• 한국정보시스템학회지:정보시스템연구
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• 제27권1호
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• pp.171-191
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• 2018

Purpose Corporate technology leakage is not only monetary loss, but also has a negative impact on the corporate image and further deteriorates sustainable growth. In particular, since SMEs are highly dependent on core technologies compared to large corporations, loss of technology leakage threatens corporate survival. Therefore, it is important for SMEs to "prevent and protect technology leakage". With the recent development of data analysis technology and the opening of public data, it has become possible to discover and proactively detect companies with a high probability of technology leakage based on actual company data. In this study, we try to construct profiles of enterprises with and without technology leakage experience through profiling analysis using data mining techniques. Furthermore, based on this, we propose a classification model that distinguishes companies that are likely to leak technology. Design/methodology/approach This study tries to develop the empirical model for prevention and protection of technology leakage through profiling method which analyzes each SME from the viewpoint of individual. Based on the previous research, we tried to classify many characteristics of SMEs into six categories and to identify the factors influencing the technology leakage of SMEs from the enterprise point of view. Specifically, we divided the 29 SME characteristics into the following six categories: 'firm characteristics', 'organizational characteristics', 'technical characteristics', 'relational characteristics', 'financial characteristics', and 'enterprise core competencies'. Each characteristic was extracted from the questionnaire data of 'Survey of Small and Medium Enterprises Technology' carried out annually by the Government of the Republic of Korea. Since the number of SMEs with experience of technology leakage in questionnaire data was significantly smaller than the other, we made a 1: 1 correspondence with each sample through mixed sampling. We conducted profiling of companies with and without technology leakage experience using decision-tree technique for research data, and derived meaningful variables that can distinguish the two. Then, empirical model for prevention and protection of technology leakage was developed through discriminant analysis and logistic regression analysis. Findings Profiling analysis shows that technology novelty, enterprise technology group, number of intellectual property registrations, product life cycle, technology development infrastructure level(absence of dedicated organization), enterprise core competency(design) and enterprise core competency(process design) help us find SME's technology leakage. We developed the two empirical model for prevention and protection of technology leakage in SMEs using discriminant analysis and logistic regression analysis, and each hit ratio is 65%(discriminant analysis) and 67%(logistic regression analysis).

• 한국재료학회지
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• 제20권12호
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• pp.669-675
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• 2010

One of the greatest challenges for our society is providing powerful electrochemical energy conversion and storage devices. Rechargeable lithium-ion batteries and fuel cells are among the most promising candidates in terms of energy and power density. As the starting material, $TiCl_4{\cdot}YCl_3$ solution and dispersing agent (HCP) were mixed and synthesized using ammonia as the precipitation agent, in order to prepare the nano size Y doped spherical $TiO_2$ precursor. Then, the $Li_4Ti_5O_{12}$ was synthesized using solid state reaction method through the stoichiometric mixture of Y doped spherical $TiO_2$ precursor and LiOH. The Ti mole increased the concentration of the spherical particle size due to the addition of HPC with a similar particle size distribution in a well in which $Li_4Ti_5O_{12}$ spherical particles could be obtained. The optimal synthesis conditions and the molar ratio of the Ti 0.05 mol reaction at $50^{\circ}C$ for 30 minutes and at $850^{\circ}C$ for 6 hours heat treatment time were optimized. $Li_4Ti_5O_{12}$ was prepared by the above conditions as a working electrode after generating the Coin cell; then, electrochemical properties were evaluated when the voltage range of 1.5V was flat, the initial capacity was 141 mAh/g, and cycle retention rate was 86%; also, redox reactions between 1.5 and 1.7V, which arose from the insertion and deintercalation of 0.005 mole of Y doping is not a case of doping because the C-rate characteristics were significantly better.

• 대한한의학회지
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• 제31권1호
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• pp.138-152
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• 2010

Objective: Yikgeebohyul-tang (Yiqib$\check{u}$xu$\grave{e}$-t$\bar{a}$ng) is one of the representative prescriptions for invigoration of vitality and nourishing of the blood. This study was carried out to investigate the effects of Yikgeebohyul-tang (Yiqib$\check{u}$xu$\grave{e}$-t$\bar{a}$ng) on hair regrowth and cytokine changes in a shaving model of C57BL6 mice. Method: Five-week-old mice were acclimated for 1 week at a temperature between $21-23^{\circ}C{\acute{E}}$, 40-60% relative humidity, and 12h of a light/dark cycle before beginning of the experiment. There were two groups including normal saline (control) and a positive control of oral intake of Yikgeebohyul-tang (Yiqib$\check{u}$xu$\grave{e}$-t$\bar{a}$ng) extract (sample) in 18 female mice. The test compounds were topically treated once a day over 14 days. The hair regrowth was photographically and histologically determined during the experimental period of 14 days. Revelation of TGF-${\beta}1$ and EGF were also determined using immunohistochemistry. In addition to that, IFN-$\gamma$, IL-4 and IL-10 were determined in serum. Results: Hair regrowth in the sample group was promoted earlier and faster than the control group, as shown by concentrations of hairs and thick-hair ratio in the sample group. TGF-${\beta}1$ was not revealed in either control or sample group. EGF was strongly positive in out root sheath of some thick hair of the sample group. Serum IFN-$\gamma$ was significantly decreased in the sample group compared with the control group at 7 experimental days. However, it was not significantly decreased at 14 experimental days. Serum IL-4 was significantly increased in the sample group compared with the control group at 7 experimental days. However, it was not significantly decreased at 14 experimental days. Serum IL-10 was decreased in the sample group compared with the control group, but with no real statistical significance. Conclusion: These results suggest that Yikgeebohyul-tang (Yiqib$\check{u}$xu$\grave{e}$-t$\bar{a}$ng) has hair growth promoting activity and it can be used for treatment of alopecia. Also, these effects relate to EGF revelation of hair roots, a decrease in serum IFN-$\gamma$, and an increase of serum IL-4.