Anticancer Effects of Thymoquinone, Caffeic Acid Phenethyl Ester and Resveratrol on A549 Non-small Cell Lung Cancer Cells Exposed to Benzo(a)pyrene |
Ulasli, Sevinc Sarinc
(Department of Pulmonary Diseases, Faculty of Medicine, Afyon Kocatepe University)
Celik, Sefa (Department of Medical Biochemistry, Faculty of Medicine, Afyon Kocatepe University) Gunay, Ersin (Department of Pulmonary Diseases, Faculty of Medicine, Afyon Kocatepe University) Ozdemir, Mehmet (Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Afyon Kocatepe University) Hazman, Omer (Department of Chemistry, Faculty of Science and Arts, Afyon Kocatepe University) Ozyurek, Arzu (Department of Chemistry, Faculty of Science and Arts, Afyon Kocatepe University) Koyuncu, Tulay (Department of Pulmonary Diseases, Faculty of Medicine, Afyon Kocatepe University) Unlu, Mehmet (Department of Pulmonary Diseases, Faculty of Medicine, Afyon Kocatepe University) |
1 | Bradford MM (1976). A rapid and sensitive for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding. Anal Biochem, 72, 248-54. DOI ScienceOn |
2 | Attoub S, Sperandio O, Raza H, et al (2013). Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo. Fundam Clin Pharmacol, 27, 557-69. DOI ScienceOn |
3 | Bae S, Lee EM, Cha HJ, et al (2011). Resveratrol alters microRNA expression profiles in A549 human non-small cell lung cancer cells. Mol Cells, 32, 243-9. DOI ScienceOn |
4 | Binkova B, Giguere Y, Rossner P Jr, Dostal M, Sram RJ (2000). The effect of dibenzo[a,1]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: the induction of DNA adducts, expression of p53 and p21 (WAF1) proteins and cell cycle distribution. Mutat Res, 471, 57-70. DOI ScienceOn |
5 | Brugarolas J, Chandrasekaran C, Gordon JI, et al (1995). Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature, 377, 552-7. DOI ScienceOn |
6 | Buetler E, Dubon O, Kelly, BM (1963). Improved method for the determination of blood glutathione. J Lab Clin Med, 61, 882-8. |
7 | Chellappan SS, Giordano A, Fisher PB (1998). Role of cyclin dependent kinases and their inhibitors in cellular differentiation and development. Curr Top Microbiol Immunol, 227, 57-103. |
8 | Cheng EH, Wei MC, Weiler S, et al (2001). Bcl-2, Bcl-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell, 8, 705-11. DOI ScienceOn |
9 | Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A (1996). Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol, 16, 4673-82. |
10 | Chen MF, Wu CT, Chen YJ, Keng PC, Chen WC (2004). Cell killing and radiosensitization by caffeic acid phenethyl ester (CAPE) in lung cancer cells. J Radiat Res, 45, 253-60. DOI ScienceOn |
11 | Connelly L, Barham W, Onishko HM, et al (2011). Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene, 30, 1402-12. DOI ScienceOn |
12 | Cotgreave IA, Gerdes RG (1998). Recent trends in glutathione biochemistry-glutathione-protein interactions: a molecular link between oxidative stres and cell proliferation? Biochem Biophys Res Commun, 242, 1-9. DOI ScienceOn |
13 | Devesa SS, Bray F, Vizcaino AP, Parkin DM (2005). International lung cancer trends by histologic type: male:female diff erences diminishing and adenocarcinoma rates rising. Int J Cancer, 117, 294-9. DOI ScienceOn |
14 | Eom SY, Yim DH, Moon SI, et al (2013). Polycyclic aromatic hydrocarbon-induced oxidative stress, antioxidant capacity, and the risk of lung cancer: a pilot nested case-control study. Anticancer Res, 33, 3089-97. |
15 | Erel O (2004). A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem, 37, 277-85. DOI ScienceOn |
16 | Goldstraw P, Ball D, Jett JR, et al (2011). Non-small-cell lung cancer. Lancet, 78, 1727-40. |
17 | Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. DOI |
18 | Erel O (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38, 1103-11. DOI ScienceOn |
19 | Esen C, Alkan BA, Kirnap M, et al (2012). The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index. J Periodontol, 83, 773-9. DOI ScienceOn |
20 | Gartel AL, Tyner AL (2002). The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther, 1, 639-49. |
21 | Kaspin LC, Baird WM (1996). Anti-benzo[a]pyrene-7,8-diol-9,10- epoxide treatment increases levels of proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7. Polycyclic Arom Comp, 10, 299-306. DOI ScienceOn |
22 | Khan A, Vaibhav K, Javed H , et al (2012). Attenuation of Ab-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress. Mol Cell Biochem, 369, 55-65. DOI ScienceOn |
23 | Kode A, Rajendrasozhan S, Caito S, et al (2008). Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol, 294, 478-88. |
24 | Komiya T, Hosono Y, Hirashima T, et al (1997). p21 expression as a predictor for favorable prognosis in squamous cell carcinoma of the lung. Clin Cancer Res, 3, 1831-5. |
25 | Kubota T, Uemura Y, Kobayashi M, Taguchi H (2003). Combined effects of resveratrol and paclitaxel on lung cancer cells. Anticancer Res, 23, 4039-46. |
26 | Lozano R, Naghavi M, Foreman K, et al (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 380, 2095-128. DOI ScienceOn |
27 | Luch A, Kudla K, Seidel A, et al (1999). The level of DNA modification by (C)-syn- (11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l] pyrene determined the effect on the proteins p53 and p21WAF1 in human mammary carcinoma cell line MCF-7. Carcinogenesis, 20, 859-65. DOI ScienceOn |
28 | Li Y, Zhang S, Geng JX, Hu XY (2013). Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C. Asian Pac J Cancer Prev, 14, 4599-602. 과학기술학회마을 DOI ScienceOn |
29 | Lin HP, Kuo LK, Chuu CP (2012). Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells. Phytother Res, 26, 122-6. DOI ScienceOn |
30 | Malhotra A, Nair P, Dhawan DK (2011). Curcumin and resveratrol synergistically stimulate p21 and regulate cox-2 by maintaining adequate zinc levels during lung carcinogenesis. Eur J Cancer Prev, 20, 411-6. DOI ScienceOn |
31 | Miranda KM, Espey MG, Wink DA (2001). A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide, 5, 62-71. DOI ScienceOn |
32 | Natarajan K, Singh S, Burke TR Jr, Grunberger D, Aggarwal BB (1996). Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA, 93, 9090-5. DOI ScienceOn |
33 | Orsolic N, Sver L, Terzic S, Basic I (2005). Peroral application of water-soluble derivative of propolis (WSDP) and its related polyphenolic compounds and their influence on immunological and antitumour activity. Vet Res Commun, 29, 575-93. DOI |
34 | Niklinski J, Niklinska W, Laudanski J, Chyczewska E, Chyczewski L (2001). Prognostic molecular markers in non-small cell lung carcinoma. Lung Cancer, 2, 53-8. |
35 | Ramet M, Castren K, Jarvinen K, et al (1995). p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. Carcinogenesis, 16, 2117-24. DOI ScienceOn |
36 | Orsolic N, Knezevic AH, Sver L, Terzic S, Basic I (2004). Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds. J Ethnopharmacol, 94, 307-15. DOI ScienceOn |
37 | Randhawa MA, Alghamdi MS (2011). Anticancer activity of nigella saliva (Black Seed): a review. Am J Chin Med, 39, 1075-91. DOI ScienceOn |
38 | Rosell R, Bivona TG, Karachaliou N (2013). Genetics and biomarkers in personalisation of lung cancer treatment Lancet, 382, 720-31. DOI ScienceOn |
39 | Sethi G, Ahn KS, Aggarwal BB (2008). Targeting nuclear factor-_B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res, 6, 1059-70. DOI ScienceOn |
40 | Shigeoka Y, Igishi T, Matsumoto S, et al (2004). Sulindac sulfide and caffeic acid phenethyl ester suppress the motility of lung adenocarcinoma cells promoted by transforming growth factor-beta through Akt inhibition. J Cancer Res Clin Oncol, 130, 146-52. DOI |
41 | Woo CC, Kumar AP, Sethi G, Tan KH (2012). Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol, 83, 443-51. DOI ScienceOn |
42 | Shoji T, Tanaka F, Takata T, et al (2002). Clinical significance of p21 expression in non-small-cell lung carcinoma. J Clin Oncol, 20, 3865-71. DOI ScienceOn |
43 | Yoshioka T, Kawada K, Shimada T, Mori M (1979). Lipid peroxidation in maternal and cord blood and protective mechanisms against activated-oxygen toxicity in the blood. Am J Obstet Gynecol, 135, 372-5. |
44 | Tampioa M, Loikkanena J, Myllynenb P, Mertanena A, Vahakangasa KH (2008). Benzo(a)pyrene increases phosphorylation of p53 at serine 392 in relation to p53 induction and cell death in MCF-7 cells. Toxicol Lett, 178, 152-9. DOI ScienceOn |
45 | Zhang W, Wang X, Chen T (2011). Resveratrol induces mitochondria-mediated AIF and to a lesser extent caspase-9-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells. Mol Cell Biochem, 354, 29-37. DOI ScienceOn |
46 | Zhou YT, Li K, Tian H (2013). Effects of vinorelbine on cisplatin resistance reversal in human lung cancer A549/DPP cells. Asian Pac J Cancer Prev, 14, 4635-9. 과학기술학회마을 DOI ScienceOn |
47 | Yin HT, Tian QZ, Guan L, et al (2013). In vitro and in vivo evaluation of the antitumor efficiency of resveratrol against lung cancer. Asian Pac J Cancer Prev, 14, 1703-6. 과학기술학회마을 DOI ScienceOn |
48 | Chen Z, Jin K, Gao L, et al (2010). Anti-tumor effects of bakuchiol, an analogue of resveratrol, on human lung adenocarcinoma A549 cell line. Eur J Pharmacol, 643, 170-9. DOI ScienceOn |
49 | Pfeifer GP, Denissenko MF, Olivier M, et al (2002). Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene, 21, 7435-51. DOI ScienceOn |