• Molecules and Cells
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• 제38권6호
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• pp.518-527
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• 2015

Controlled release of medications remains the most convenient way to deliver drugs. In this study, we precipitated gold nanoparticles with quercetin. We loaded gold-quercetin into poly(DL-lactide-co-glycolide) nanoparticles (NQ) and tested the biological activity of NQ on HepG2 hepatocarcinoma cells to acquire the sustained release property. We determined by circular dichroism spectroscopy that NQ effectively caused conformational changes in DNA and modulated different proteins related to epigenetic modifications and c ell cycle control. The mitochondrial membrane potential (MMP), reactive oxygen species (ROS), cell cycle, apoptosis, DNA damage, and caspase 3 activity were analyzed by flow cytometry, and the expression profiles of different anti- and pro-apoptotic as well as epigenetic signals were studied by immunoblotting. A cytotoxicity assay indicated that NQ preferentially killed cancer cells, compared to normal cells. NQ interacted with HepG2 cell DNA and reduced histone deacetylases to control cell proliferation and arrest the cell cycle at the sub-G stage. Activities of cell cycle-related proteins, such as $p21^{WAF}$, cdk1, and pAkt, were modulated. NQ induced apoptosis in HepG2 cells by activating p53-ROS crosstalk and induces epigenetic modifications leading to inhibited proliferation and cell cycle arrest.

• Steel and Composite Structures
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• 제33권6호
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• pp.777-792
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• 2019

This paper presents a new efficient approach to estimate the S-N type fatigue life assessment curve for S550 high strength steels under low-cycle actions at -60℃. The proposed approach combines a single set of monotonic tension test and one set of fatigue tests to determine the key material damage parameters in the continuum damage mechanics framework. The experimental program in this study examines both the material response under low-cycle actions. The microstructural mechanisms revealed by the Scanning Electron Microscopy (SEM) at the low temperature, furthermore, characterizes the effect due to different strain ratios and low temperature on the low-cycle fatigue life of S550 steels. Anchored on the experimental results, this study validates the S-N curve determined from the proposed approach. The S-N type curve determined from one set of fatigue tests and one set of monotonic tension tests estimates the fatigue life of all specimens under different strain ratios satisfactorily.

• 한국수소및신에너지학회논문집
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• 제6권1호
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• pp.35-41
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• 1995

The MmNi-based alloy electrode was studied for use as a negative electrode in Ni-MH battery. Alloys with $MmNi_5-_xM_x$(M=Co,Al,Mn) composition were synthesized, and their electrode charateristics of activation rate, temperature dependence, electrode capacity and cycle life were investigated. With increasing Al content and decreasing Mn content in the alloys, the discharge capacity increased while the cycle life decreased. As x in $MmNi_5-_xM_x$ increased from 1.5 to 2.0, decreasing the Ni content, the discharge capacity, the low temperature property and the rate capability decreased. However its cycle life was improved. Increasing Co content resulted in a prolonged cycle life and decrease of high rate discharge capacity. It can be concluded that the most promising alloy in view of discharge capacity and cycle life is $MmNi_{3.5}Co_{0.7}Al_{0.5}Mn_{0.3}$.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제7권12호
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• pp.3118-3134
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• 2013

This paper deliberates for a multimedia transmission scheme combining multiple description coding (MDC) and network coding (NC). Our goal is to take advantage from the property of MDC to provide quantized and compressed independent and identically distributed (iid) descriptions and also from the benefit of network coding, which uses network resources efficiently to recover lost data in the network. Recently, p-cycle NC has been introduced to recover and protect any lost or distorted descriptions at the receiver part exactly without need of retransmission. So far, MDC have not been explored using this type of NC. Compressed and coded descriptions are transmitted through the network where p-cycle NC is applied. P-cycle based algorithm is proposed for single and multiple descriptions lost. Results show that in the fixed bit rate, the PSNR (Peak Signal to Noise Ratio) of our reconstructed image and also subjective evaluation is improved significantly compared to previous work which is averaging method joint with MDC in order to conceal lost descriptions.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1997년도 추계학술대회 논문집
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• pp.275-278
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• 1997

We investigated effectness of sort and volume of conductive agent to charge/discharge capacity of LiMn$_2$O$_4$. LiMn$_2$O$_4$is prepared by reacting stoichiometric mixture of LiOH . $H_2O$ and MnO$_2$(mole ratio 1 : 2) and heating at 80$0^{\circ}C$ for 24h, 36h, 48h, 60h and 72h. All LiMn$_2$O$_4$cathode active materials show spinel structure. Cathode active materials calcined at 80$0^{\circ}C$ for 36h, charge/discharge characteristics and cycle stability have remarkable advantages. Used that super-s-black and 20wt% as conductive agent in LiMn$_2$O$_4$, it is excellent than property of cathode used Acetylene black or mixture of Super-s-black and acetylene black at charge/discharge capacity and cycle stability. Also, specific efficiency of cathode is excellent as over 98% and that of first cycle is excellent as 92%.

• 한국윤활학회:학술대회논문집
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• 한국윤활학회 1998년도 제28회 추계학술대회
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• pp.91-99
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• 1998

A correlation between the low-cycle fatigue life and the scuffing-failure life is demonstrated using the plastic strain in boundary lubricated sliding. Loadings proportional to hardness with three different lubricated conditions were used to evaluate the plastic strain. As the results of scuffing tests using vacuum pump oils in nitrogen gas, plastic strain shows 0.0062, and In the mineral oils and commercial engine oils in air, plastic strain show 0.0042 and 0.00092. Those are very useful to describe quantitatively the real lubricated sliding conditions, and are very effective to find the relation between the low-cycle fatigue life and the scuffing life.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1999년도 가을 학술발표회 논문집
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• pp.249-256
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• 1999

This study is intended to propose a systematic procedure for the development of the reliability-based seismic safety and cost-effective Performance criteria for design and upgrading of long span PC bridges. In the paper, a set of cost function models for life cycle cost analysis of bridges is proposed. The total life cycle cost functions consist of initial cost and direct/indirect damage costs considering repair/replacement costs, human losses and property damage costs, road user costs, and indirect regional economic losses. The damage costs are successfully expressed in terms of Park-Ang median global damage indices and damage probabilities. The proposed approach is successfully applied to model bridges in both regions of a moderate seismicity area like Seoul, Korea and a high one like Tokyo, Japan. It may be expected that the proposed approach can be effectively utilized for the development of cost-effective performance criteria for design and upgrading of various types of bridges as well as long span PC bridges.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 춘계학술대회논문집
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• pp.202-209
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• 2007

Vehicle body frame stiffness affects the dynamic and static characteristics. Vehicle frame structural performance is greatly affected by crossmember and joint design. While the structural characteristics of these joints vary widely, there is no known tool currently in use that quickly predicts joint stiffness early in design cycle. This paper presents the joint design factors affecting on low frequency vibration. The joint factors are joint panel thickness, section property, flange width and weld point space. To study the effect on vehicle low frequency vibration, case studies for these factors are performed. And Sensitivity analysis for section property is performed. The result can present design guide for high-stiffness vehicle.

• Fibers and Polymers
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• 제4권4호
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• pp.151-155
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• 2003

The abrasion behavior of three kinds of warp knitted fabrics, which are normally used for upper sole of footwear, was evaluated. We measured the changes of mechanical and structural properties of each sample as abrasion cycle increased. Each sample showed similar trends in compression and surface properties but there were significant differences in abrasion rate among the samples. The mechanical properties showed remarkable differences with directions. The frictional coefficient (MIU) of fabric surface increased at the beginning of abrasion and decreased as abrasion cycles increased. The weight and thickness of the fabric linearly decreased with abrasion cycles. The surface roughness (SMD) and the compressional resilience (RC) decreased as abrasion cycles increased while compressional energy (WC) increased.

• 한국CDE학회논문집
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• 제13권5호
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• pp.352-361
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• 2008

Architectural design work depends on information made from earlier phases such as feasibility study, planning, and conceptual design. This design guideline information includes design objectives, requirements, and constraints made by decision-making, and has great influence on various works of latter phases of design process. Despite of this cognition, however, the lack of design guideline information management still remains as one among the critical issues in design area. Design tools with design guideline information do not also address the issue of interoperability throughout the life-cycle of buildings. The purpose of this research is to propose a method for design guideline information management by using the IFC technology and IFC Property set (Pset) extension mechanism. The method comprises defining and mapping the practically used design guideline items and extensible IFC data model, and includes the management of relationships that exist between design guideline information and design model in the IFC data model.