• Journal of Sensor Science and Technology
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• v.19 no.5
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• pp.361-368
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• 2010

ACROSS device, which is composed of an implantable microphone, a signal processor, and a vibrating transducer, is a fullyimplantable middle ear hearing device(F-IMEHD) for the recovery of patients with hearing loss. And since a microphone is implanted under skin and tissue at the temporal bones, the amplitude of the sound wave is attenuated by absorption and scattering. And the vibrating transducer attached to the ossicular chain caused also the different displacement from characteristic of the stapes. For the gain control of auditory signals, most of implantable hearing devices with the digital audio signal processor still apply to fitting rules of conventional hearing aid without regard to the effect of the implanted microphone and the vibrating transducer. So it should be taken into account the effect of the implantable microphone and the vibrating transducer to use the conventional audio fitting rule. The aim of this study was to measure gain characteristics caused by the implanted microphone and the vibrating transducer attached to the ossicle chains for the gain compensation of ACROSS device. Differential floating mass transducers (DFMT) of ACROSS device were clipped on four cadaver temporal bones. And after placing the DFMT on them, displacements of the ossicle chain with the DFMT operated by 1 $mA_{peak}$ current was measured using laser Doppler vibrometer. And the sensitivity of microphones under the sampled pig skin and the skin of 3 rat back were measured by stimulus of pure tones in frequency from 0.1 to 8.9 kHz. And we confirmed that the microphone implanted under skin showed poorer frequency response in the acoustic high-frequency band than it in the low- to mid- frequency band, and the resonant frequency of the stapes vibration was changed by attaching the DFMT on the incus, the displacement of the DFMT driven with 1 $mA_{rms}$ was higher by the amount of about 20 dB than that of cadaver's stapes driven by the sound presssure of 94 dB SPL in resonance frequency range.

• Journal of Korean Society of Transportation
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• v.21 no.4
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• pp.133-144
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• 2003

The current procedure of estimating accident reduction benefit shows fixed accident rates for each level of roads without considering the various characteristics of roadway geometries, and traffics. In this study, in order to solve the problems mentioned in the above, models were developed considering the characteristics of roadway alignments and traffic characteristics. The developed models can be used to estimate the accident rates on new or improved roads, In this study, only urban highways were included as a beginning stage. First of all. factors influencing accident rates were selected. Those factors such as traffic volumes. number of signalized intersections, the number of connecting roads, number of pedestrian traffic signals, existence of median barrier, and the number of road lane are also selected based upon the obtainability at the planning stage of roads. The relationship between the selected factors and accident rates shows strong correlation statistically. In this study, roads were classified into 4 groups based on number of lanes, level of roads and the existence of median barriers. The regression analysis had been performed for each group with actual data associated with traffic, roads. and accidents. The developed regression models were verified with another data set. In this study, in order to develop the proposed models, only data on a limited area were used. In order to represent whole area of the country with the developed models. the models should be re-analyzed with vast data.

• Journal of Korean Society of Transportation
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• v.30 no.2
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• pp.67-78
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• 2012

The current traffic regulations in Korea stipulate that traffic should keep to the right according to the Road Traffic Act; thus, customarily, the 'seat-on-the-left' system has been maintained. However, an increased number of 'seat-on-the-right' vehicles are being imported via a variety of routes from foreign countries, especially from Japan. According to the data from July 2004, 1,343 cargo vehicles and 593 passenger vehicles (for diplomats, etc.) were currently being driven on domestic road. As these 'seat-on-the-right' vehicles are not compatible with the domestic transportation system of driving on the right side of the road, there is a high risk of accidents. Experiments show that such system-driver mismatch causes longer operation time for directional signals, higher error frequency in yielding due to additional mental adjustments for 'seat-on-the-right' vehicle drivers. These are, therefore, influential factors which can lead to possible accidents. Furthermore, when the experiments test the visual range during overtaking maneuvers, the visual range of the drivers in the 'seat-on-the-left' vehicle was 2.95 meters as opposed to 1.7 meters for the drivers in the 'seat-on-the-right' vehicle. (In the experiment, the drivers were instructed to look at the paper cup 10 meters away from the back of drivers' seat.) The results demonstrate that it is necessary to have additional safety measures be implemented for the 'seat-on-the-right' vehicles.

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.4
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• pp.244-254
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• 2009

This paper describes a remote system to monitor the circadian behavioral patterns of elders who live alone. The proposed system was designed and implemented to provide more conveniently and reliably the required functionalities of a remote monitoring system for elders based on the development of first phase prototype[2]. The developed system is composed of an in-house sensing system and a server system. The in-house sensing system is a set of wireless sensor nodes which have pyroelectric infrared (PIR) sensor to detect a motion of elder. Each sensing node sends its detection signal to a home gateway via wireless link. The home gateway stores the received signals into a remote database. The server system is composed of a database server and a web server, which provides web-based monitoring system to caregivers (friends, family and social workers) for more cost effective intelligent care service. The improved second phase system can provide 'automatic diagnosis', 'going out detection', and enhanced user interface functionalities. We have evaluated the first and second phase monitoring systems from real field experiments of 3/4 months continuous operation with installation of 9/15 elders' houses, respectively. The experimental results show the promising possibilities to estimate the behavioral patterns and the current status of elder even though the simplicity of sensing capability.

• Applied Chemistry for Engineering
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• v.32 no.4
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• pp.461-466
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• 2021

In this article, a portable and cost-effective voltammetric biosensor with nanoparticles was developed for the measurements of heterogeneous nuclear ribonucleoprotein A1 protein (hnRNP A1) biomarker which can potentially be used for lung cancer diagnosis. Gold nanoparticles were first electrodeposited onto screen printed carbon electrode (SPCE) followed by immobilizing a single stranded DNA aptamer specific to hnRNP A1 onto the electrode surface. Ethanolamine was also used when immobilizing DNA aptamer on the surface to prevent signals from non-specific adsorption events. Sequential injection of hnRNP A1 biomarker and anti-hnRNP A1 conjugated with alkaline phosphatase (ALP) onto the aptamer chip surface allows to form the sandwich complex of DNA aptamer/hnRNP A1/ALP-anti-hnRNP A1 on the electrode surface which further reacted with 4-aminophenyl phosphate (APP). The electrocatalytic reaction of the enzyme, ALP, and the substrate, APP, resulting in the oxidative current response changes at -0.05 and -0.17 V (vs. Ag/AgCl) against the hnRNP A1 concentration was measured using cyclic and differential pulse voltammetry, respectively. The Au nanoparticles-integrated voltammetric biosensor was applied to analyze human normal serum solutions possibly suggesting potential applicability for lung cancer diagnosis.

• Journal of Food Hygiene and Safety
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• v.35 no.6
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• pp.535-543
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• 2020

In addition to the ubiquitous roles of cellular RNA in genetic regulations, gene expression and phenotypic variations in response to environmental cues and chemotactic signals, the regulatory roles of a new type of RNA called extracellular RNAs (exRNAs) are an up-and-coming area of research interest. exRNA is transported outside the cell through membrane blebs known as membrane vesicles or extracellular vesicles (EVs). EV formation is predominant and conserved among all microbial forms, including prokaryotes, eukaryotes, and archaea. This review will focus on the three major topics concerning bacterially derived exRNAs, i.e., 1) the discovery of exRNA and influence of extraneous RNA over bacterial gene regulations, 2) the known secretion mechanism for the release of exRNA, and 3) the possible applications that can be devised with these exRNA secreted by different gram-negative and gram-positive bacteria. Further, this review will also provide an opinion on exRNA- and EV-derived applications such as the species-specific exRNA markers for diagnostics and the possible roles of exRNA in probiotics and the epigenetic regulations of the gut microbiome.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.8 no.6
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• pp.957-966
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• 2018

Recently, the demand for remote patient monitoring based on IoT has been increased due to aging population and an increase in single-person household. A non-contact biological signal measurement system using multiple IR-UWB radars for remote patient monitoring is proposed in this paper. To reduce error signals, a multilayer Subtraction algorithm is applied because when the background subtraction algorithm was applied to the biological signal processing, errors occurred such as voltage noise and staircase phenomenon. Therefore, a multilayer background subtraction algorithm is applied to reduce error occurrence. The multilayer background subtraction algorithm extracts the signal by calculating the amount of change between the previous clutter and the current clutter. In this study, the SVD algorithm is used. We applied the improved multilayer background subtraction algorithm to biological signal measurement and computed the respiration rate through Fast Fourier Transform (FFT). To verify the proposed system using IR-UWB radars and multilayer background subtraction algorithm, the respiration rate was measured. The validity of this study was verified by obtaining a precision of 97.36% as a result of a control experiment with Neulog's attachment type breathing apparatus. The implemented algorithm improves the inconvenience of the existing contact wearable method.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.7 no.2
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• pp.401-408
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• 2017

GNSS(Global Navigation Satellite System) is positioning and navigation system using satellites. Accurate positioning is possible in all regions of the world using satellite signals. In Korea, GPS was introduced in the late 1980s. GPS is used in research and work in various fields such as navigation, surveying, and GIS. Since 1995, NGII(National Geographic Information Institute) has installed and operated CORS(Continuously Operating Reference Station) for the practical use of GNSS surveying, RINEX download and VRS(Virtual Reference Station) service was provided for precise positioning. Demand for these services is explosively increasing in the field of surveying. Therefore, there is a need for research to provide good service. In this study, status of national surveying infra structure was researched focused on CORS and its services. As a results, current status of CORS and service were presented. Users of VRS service has increased greatly. In order to provide stable service and advanced surveying, it is necessary to continuously upgrade services such as providing services for various GNSS satellites and securing stability through server redundancy in the data center.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.36 no.3
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• pp.155-163
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• 2023

Real-time monitoring technology is critical for ensuring the safety and reliability of nuclear power plant structures. However, the current seismic monitoring system has limited system identification capabilities such as modal parameter estimation. To obtain global behavior data and dynamic characteristics, multiple sensors must be optimally placed. Although several studies on optimal sensor placement have been conducted, they have primarily focused on civil and mechanical structures. Nuclear power plant structures require robust signals, even at low signal-to-noise ratios, and the robustness of each mode must be assessed separately. This is because the mode contributions of nuclear power plant containment buildings are concentrated in low-order modes. Therefore, this study proposes an optimal sensor placement methodology that can evaluate robustness against noise and the effects of each mode. Indicators, such as auto modal assurance criterion (MAC), cross MAC, and mode shape distribution by node were analyzed, and the suitability of the methodology was verified through numerical analysis.

• Animal Bioscience
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• v.35 no.10
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• pp.1461-1478
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• 2022

The maintenance of poultry gut health is complex depending on the intricate balance among diet, the commensal microbiota, and the mucosa, including the gut epithelium and the superimposing mucus layer. Changes in microflora composition and abundance can confer beneficial or detrimental effects on fowl. Antibiotics have devastating impacts on altering the landscape of gut microbiota, which further leads to antibiotic resistance or spread the pathogenic populations. By eliciting the landscape of gut microbiota, strategies should be made to break down the regulatory signals of pathogenic bacteria. The optional strategy of conferring dietary fibers (DFs) can be used to counterbalance the gut microbiota. DFs are the non-starch carbohydrates indigestible by host endogenous enzymes but can be fermented by symbiotic microbiota to produce short-chain fatty acids (SCFAs). This is one of the primary modes through which the gut microbiota interacts and communicate with the host. The majority of SCFAs are produced in the large intestine (particularly in the caecum), where they are taken up by the enterocytes or transported through portal vein circulation into the bloodstream. Recent shreds of evidence have elucidated that SCFAs affect the gut and modulate the tissues and organs either by activating G-protein-coupled receptors or affecting epigenetic modifications in the genome through inducing histone acetylase activities and inhibiting histone deacetylases. Thus, in this way, SCFAs vastly influence poultry health by promoting energy regulation, mucosal integrity, immune homeostasis, and immune maturation. In this review article, we will focus on DFs, which directly interact with gut microbes and lead to the production of SCFAs. Further, we will discuss the current molecular mechanisms of how SCFAs are generated, transported, and modulated the pro-and anti-inflammatory immune responses against pathogens and host physiology and gut health.