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INDUCTION OF MITOCHONDRIAL DNA DELETION BY IONIZING RADIATION IN HUMAN LUNG FIBROBLAST IMR-90 CELLS

  • Eom, Hyeon-Soo;Jung, U-Hee;Park, Hae-Ran;Jo, Sung-Kee
    • Journal of Radiation Protection and Research
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    • v.34 no.2
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    • pp.49-54
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    • 2009
  • Mitochondrial DNA (mtDNA) deletion is a well-known marker for oxidative stress and aging and also contributes to their unfavorable effects in cultured cells and animal tissues. This study was conducted to investigate the effect of ionizing radiation (IR) on mtDNA deletion and the involvement of reactive oxygen species (ROS) in this process in human lung fibroblast (IMR-90) cells. Young IMR-90 cells at population doubling (PD) 39 were irradiated with $^{137}Cs$ $\gamma$-rays and the intracellular ROS level was determined by 2',7'-dichlorofluorescein diacetate (DCFH-DA) and mtDNA common deletion (4977bp) was detected by nested PCR. Old cells at PD 55 and $H_2O_2$-treated young cells were compared as the positive control. IR increased the intracellular ROS level and mtDNA 4977 bp deletion in IMR-90 cells dose-dependently. The increases of ROS level and mtDNA deletion were also observed in old cells and $H_2O_2$-treated young cells. To confirm the increased ROS level is essential for mtDNA deletion in irradiated cells, the effects of N-acetylcysteine (NAC) on IRinduced ROS and mtDNA deletion were examined. 5 mM NAC significantly attenuated the IR-induced ROS increase and mtDNA deletion. These results suggest that IR induces the mtDNA deletion and this process is mediated by ROS in IMR-90 cells.

A study on predictive factors of Elderly Suicidal Ideation (노인의 자살생각 예측요인)

  • Oh, Yun-Jung;Kim, Hyang-Dong
    • Journal of Convergence for Information Technology
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    • v.8 no.2
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    • pp.1-9
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    • 2018
  • This study describes predictive factors for elderly suicidal ideation by analyzing the survey data from 359 people who were over 65 years old in Daegu, Korea. The mean score of social support(3.35), self-esteem(3.38), depression(8.64) and suicidal ideation(1.65) of elderly residence. Social support, self-esteem and suicidal ideation had negative correlation. Depression and suicidal ideation had positive correlation. Suicidal ideation was significantly different according to age, education, spouse, living arrangement, type of medical guarantee, pocket money, past job, leisure(time), health status, number of chronic disease, smoking. Others support, self-esteem, pocket money, education, age were influencing factors of suicidal ideation(48.2%). Among them, 41.8% of others support was.

A Theoretical Comparative Study of Human Resource Security Based on Korean and Int'l Information Security Management Systems (국내·외 정보보호 관리체계기반의 인적보안의 이론적 비교연구)

  • Rha, Hyeon-Dae;Chung, Hyun-soo
    • Journal of Convergence Society for SMB
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    • v.6 no.3
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    • pp.13-19
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    • 2016
  • In various ICBM (IoT, Bigdata, Cloud, Mobile) IT convergence environments, IT technologies have been evolved, new information security threats have been occurred. As information security incidents in major public agencies, financial institutions and companies occurred, it was emphasized that the importance of human security was disclosed. Thus, implementing of information security management system could protect hacks and security breaches and respond quickly to accidents so it minimized the sized of loss. In this paper, comparison of human security controls shown in ISO27001, COBIT, NIST 800-53, K-ISMS, Cyber Security Framework such as the main information security management systems was analyzed, and proposed of the security implications about effective controls of human resources security issues.

A Study on the Development of Educational Software for Web-based Visual Effects Interactive Environment (Web 기반 VE(Visual Effects) 인터랙티브 환경 교육용 소프트웨어 개발에 관한 연구)

  • Na, Wonshik
    • Journal of Convergence for Information Technology
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    • v.7 no.5
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    • pp.89-93
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    • 2017
  • As the cost of installing and maintaining software on large organizations such as recent companies and schools has increased, software installation and maintenance costs are low, system management is easy, demand for ease of use software solutions has increased. In the reality that special education for service center engineers is required along with the release of various products, training of the software and solution industry is regarded as important. Building Web-based user and system interactive environment, strengthened usability and educational ability effect suitable for engineer level. In the future, research that is familiar with specific software, not successfully combining multiple frameworks, rather than developers, will be increasingly important for research that can achieve optimal performance.

Azimuth Accuracy Test of Phase Comparison Direction Finding Method Using F-16 Fighter Scale-down Model (F-16 전투기 축소모델을 사용한 위상비교 방향 탐지 기법의 방위각 정확도 시험)

  • Lim, Joong-Soo;Chae, Gyoo-Soo;Kim, Young-Ho;Kim, Kichul
    • Journal of Convergence for Information Technology
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    • v.7 no.5
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    • pp.83-88
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    • 2017
  • This paper describes the azimuth accuracy test of phase comparison direction finding method using F-16 fighter scale-down model. When the antennas are placed on the bottom of a fighter, reflection signals caused by an aircraft structure arises and an azimuth error occurs. In this research, the F-16 fighter scale-down model was made to 5:1, and five antennas were placed on the bottom of the model, then the radio waves of emitters were received by the antennas in the $0-360^{\circ}$ azimuth angles. The accuracy test was performed by numerically analyzing the phases of the radio waves received by the five antennas. The azimuth error of the phase comparison direction finding with scale-down model was measured to be less than $0.5^{\circ}$ when the signal noise ratio was larger then 0dB, and it could be very useful for the design of the phase comparison direction finding method of the fighter.

Growth of Amorphous SiOx Nanowires by Thermal Chemical Vapor Deposition Method (열화학 기상 증착법에 의한 비정질 SiOx 나노와이어의 성장)

  • Kim, Ki-Chul
    • Journal of Convergence for Information Technology
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    • v.7 no.5
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    • pp.123-128
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    • 2017
  • Nanostructured materials have received attention due to their unique electronic, optical, optoelectrical, and magnetic properties as a results of their large surface-to-volume ratio and quantum confinement effects. Thermal chemical vapor deposition process has attracted much attention due to the synthesis capability of various structured nanomaterials during the growth of nanostructures. In this study, silicon oxide nanowires were grown on Si\$SiO_2$(300 nm)\Pt(5~40 nm) substrates by two-zone thermal chemical vapor deposition with the source material $TiO_2$ powder via vapor-liquid-solid process. The morphology and crystallographic properties of the grown silicon oxide nanowires were characterized by field-emission scanning electron microscope and transmission electron microscope. As results of analysis, the morphology, diameter and length, of the grown silicon oxide nanowires are depend on the thickness of the catalyst films. The grown silicon oxide nanowires exhibit amorphous phase.

A study on Scalable Video Coding Signals Transmission using inter-layer Differential OVSF code allocation scheme in MC-CDMA (MC-CDMA 기반의 SVC 전송 시스템에서 계층 간 차등 OVSF코드 할당 기법에 관한 연구)

  • Shin, Hyung-Song;Kim, Kyun-Tak;Lee, Kyu-Jin;Lee, Kye-San
    • Journal of Convergence Society for SMB
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    • v.6 no.3
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    • pp.49-55
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    • 2016
  • This paper proposes an adaptive video signal transmission scheme in order to ensure the QoS (Quality of Service) of user requirements. SVC (Scalable Video Coding) is an effective transmission scheme, because that can transmit video signal according to the video layer's weight. However, in previous works, those adaptive transmission systems which are considered about the various channel environments and user requirements have not been insufficiently studied. So, we propose the SVC signal transmission using inter-layer differential OVSF code allocation scheme in MC-CDMA. The proposed scheme is able to obtain each layer signal's protection order and control the sub-block of MC-CDMA by feedback information from receiver. Therefore, our proposed scheme is possible to provide the video quality for each users according to variable channel environments. The simulation results demonstrate the enhancement of proposed system in terms of BER performance.

The Effects of Accounting Service Worker's Professionalism and Accounting Information System's Level on the Quality of Customer's Accounting Information (회계서비스종사자 전문성과 회계정보시스템 수준이 고객사 회계정보의 질에 미치는 영향)

  • Lee, Ji-Young;Kim, Kyung-Ihl
    • Journal of Convergence Society for SMB
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    • v.6 no.3
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    • pp.1-6
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    • 2016
  • The purpose of this study is to verify mainly qualitative characteristics impact on the quality of customer's accounting information to analyze the expertise and the level of accounting system, accounting service worker. This method was conducted in empirical research by the hypothesis based on the survey after examining theoretical background founded on the literature search. As a result, by accounting information systems needed Accounting services worker's professionalism, customer to be served most satisfies faithful representation among the qualitative characteristics and it showed timeliness is low satisfaction. This study will contribute to enhance the recognition and improvement of expertise of the accounting service workers, in the future for improving the quality of accounting information system, discussion will be needed about the contents and method for education and training.

The Effects of Parenting Attitudes on Peer Attachment in Early Adolescents : Focusing on Moderating Effects of Gender in Convergence Era (부모의 양육태도가 초기 청소년의 또래애착에 미치는 영향 : 융복합 시대에 성별 조절효과를 중심으로)

  • Lee, Eun-Hee;Yang, Yi-Jung
    • Journal of Convergence for Information Technology
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    • v.8 no.2
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    • pp.37-44
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    • 2018
  • This study examined the moderating effects of gender on the influences of parental parenting attitudes on peer attachment in early adolescents. Data analysis was conducted over 1,912 respondents who met the purpose of this study among Korean Youth Panel KCYPS 7th year data of 1st grade in elementary school. The research methods examined the influence of variables on dependent variable, with difference of gender influences. As a result, it was found that gender, the control variable, and overall grade satisfaction affected peer attachment. Second, positive and negative parenting attitudes have confirmed positive and negative effects on peer attachment. Third, moderating effect was confirmed as parenting attitudes by gender show the difference of impact on peer attachment. Therefore, this study suggest to apply it to practical and theoretical implications and basic data for the program development to improve youth peer relations.

The Effects of Entrepreneurship on Employability of the College Student -Focusing on the Moderating Effects of Gender- (대학생의 기업가정신이 취업가능성에 미치는 영향 -성별의 조절효과를 중심으로-)

  • Baek, Yu-Mi
    • Journal of Convergence for Information Technology
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    • v.8 no.2
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    • pp.113-120
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    • 2018
  • The purpose of this study is to examine if entrepreneurship that can influence entrepreneurial intention affects job-getting possibility. Particularly, this author has questingly investigated if the entrepreneurship of undergraduates who are supposed to get a job influences job-getting possibility and if sex has regulating effects on job-getting possibility. According to the results, first, undergraduates' entrepreneurship influences job-getting possibility. Second, according to sex, there is difference found in the effects of entrepreneurship on job-seeking skills and job-getting possibility. In other words, sex has significant regulating effects on job-seeking skills and job-getting possibility. Third, according to the results of comparing the mean values of two groups, upper and lower groups of entrepreneurship, regarding their job-getting possibility(work ethic, occupational exploration, & job-seeking skills) in accordance with moderating variables, female undergraduates gained significantly higher mean values than male undergraduates. Based on the results, this author suggests implications and presents proposals for follow-up research.