• Korean Journal of Pharmacognosy
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• v.14 no.1
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• pp.30-38
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• 1983

These studies were conducted in an attempt to investigate effects of 'Daeshiho-Tang' on the blood vessels, activities of liver enzyme and excretory action of bile juice in serum of $CCl_4-intoxicated$ rabbits, glucose and total cholesterol levels in serum of alloxan-induced diabetic rabbits. The result of these studies were summarized as follows; 1. Hypotensive ind vaso-dilatating actions due to vascular smooth muscle relaxation were noted in frogs, rabbits and dogs. 2. GOT, GPT and total cholesterol in serum of $CCl_4-intoxicated$ rabbits showed significant depressive effects. 3. Significantly increased biliary secretary effect was noted in $CCl_4-intoxicated$ rabbits. 4. Glucose and total cholesterol levels showed markedly decraese in alloxan-induced diabetic rabbits. Considering the experimental studies results, it is suggested that 'Daeshiho-Tang' has therapeutic efficacy to treat febrile diseses and metabolic diseases.

• Toxicological Research
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• v.13 no.3
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• pp.193-196
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• 1997

Matricaria Chammomillal L., Foemiculum Vulgare mill, and Plantago Psylium L. have been screened for their hepato protective activities against liver damge induced by $CCl_4$ intoxication in mice. Hydroalcoholic extractions (2:8) of herbal drugs were concentrated in vacuo and concentrated crude extracts of Matrica Chammomilla L. and Foeniculum Vulgare mill were orally administered at doses of 100 mg/kg, 200 mg/kg, 400 mg/kg, and 800 mg/kg. Plantago Psyllium was given at doses of 50 mg/kg, 100 mg/kg, 200 mg/kg, and 400 mg/kg. Liver protective activities of these herbs were determined after administration of $CCl_4$ Liver size, serum enzyme activities, sleeping time, and histopatology of the liver were examined one hour after administration of $CCl_4$. ALT and AST activities, liver weight and sleeping time decreased in groups that received 400 mg/kg of Matricaria Chammomilla L. or Foeniculum Vulgare. Histological investigation showed significant increase in hepatic cell regeneration and reduction in liver injury. The group that received 100 mg/kg Plantago Psylium showed liver protection but protection was not significant in other doses.

• Korean Journal of Pharmacognosy
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• v.27 no.3
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• pp.282-287
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• 1996

Cnidii rhizoma is one of the most important crude drugs used particularly for the treatment of female genital inflammatory diseases in traditional oriental medicine. In this study, its anti-inflammatory and analgesic activities were examined employing animal models. It was found that $H_2O$ extract and n-BuOH fraction inhibited significantly the edema formation after the subplantar injection of carrageenin at oral doses of 100 and 200 mg/kg in a dose-dependent fashion, where MeOH extract showed significant anti-inflammatory activity at a oral dose of 200 mg/kg. In Freund's complete adjuvant-induced arthritis, H2O extract and n-BuOH fraction exerted their significant inhibitory activity on the edema formation at oral doses of 100 and 200 mg/kg. The $H_2O$ extract and n-BuOH fraction also showed significant analgesic activity in a dose-dependent manner in acetic acid-induced writhing test.

• Korean Journal of Pharmacognosy
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• v.15 no.4
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• pp.179-187
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• 1984

To investigate the recorded efficacy in Oriental medical references and effects in clinics, experimental studies were undertaken to estimate 'Palmiwhan' to the diuretic effect in normal rats, rabbits and rats with $HgCl_2-induced$ acute renal failure and hypotensive effects on the nephrogenous hypertension in rabbits with $HgCl_2-induced$ acute renal failure. The results of this study were summarized as follows; Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly recognized in normal rats and rabbits. Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly shown in rats with 2mg/kg $HgCl_2-induced$ acute renal failure. Although plasma electrolyte and creatinine levels were little affected, plasma urea nitrogen levels were significantly elevated in normal rats and 2mg/kg $HgCl_2-induced$ acute renal failure of rats. Although the blood pressure was not affected in normal rabbits and cats, hypotensive actions due to the diuretic effect were recognized in rabbits $HgCl_2-induced$ acute renal failure.

• Korean Journal of Pharmacognosy
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• v.17 no.3
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• pp.223-231
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• 1986

Experimental studies were conducted to investigate for the effect of Mahaengkamsuk-tang on analgesic, antipyretic, antiinflammatory, secretion of respiratory tract, isolated ileum. Mahaengkamsuk-tang was composed of Ephedrae Herba, Armenicae Semen, Glycyrrhizae Radix, Gypsum Fibrosum. The following results has been obtained; analgesic and antipyretic actions were obtained. Anti-inflammatory effects in the paw edema induced by 1% dextran was significantly shown in rats. Spontaneous motilities of isolated ileum of mice were strongly suppressed, and contractions of isolated ileum of mice induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Expectorant effect was shown in rabbits. Continuous hypotensive action was seen.

• Korean Journal of Pharmacognosy
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• v.17 no.3
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• pp.215-222
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• 1986

Although the 'Insamyangwee-tang' has been widely used in clinical purposes in the oriental medicine, its clinical efficacy is only documentated for the cases of gastritis, gastric ulcer and enteritis, but the experimental study on these has not been undertaken. So, to investigate the clinical efficacy of 'Insamyangwee-tang' comparing with animal experiments, This study was carried out. The results showed that relaxing action was shown on the isolated ileum in mice and that strong antagonistic actions were seen on $BaCl_2$, acetylcholine and histamine induced contraction of the ileum in mice, rats, rabbits and guinea-pigs that the relaxing effect of the intestinal smooth muscle was recognized. Inhibitory effects on transport rate in the small intestine of mice. Strong antagonistic actions were seen on acetylcholine induced contraction of duodenum in rats and remarkably inhibiting actions were seen of duodenum in rats. Inhibitory action on the secretion of gastric juice and pepsin, anti-ulceration effect was recognized.

• Korean Journal of Pharmacognosy
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• v.26 no.2
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• pp.154-158
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• 1995

Twentyfive plant crude drugs with traditional reputation were selected for the antithrombotic screening. MeOH (80%) extract of each plant was given (500 mg/Kg, p.o.) to mice 1 hr prior to the thrombotic challenge (1.8 mg collagen plus 180 ug epinephrine/Kg, i.v.). Seven extracts (1, 2, 8, 10, 18, 22 and 23) showed either comparable or better recovery than aspirin (50 mg/Kg, p.o.) from paralysis caused by the pulmonary thrombosis. 1, 2, 8, 10, 18, 22 and 23 were fractionated to $CH_2Cl_2$ soluble (fr I) and $H_2O$ soluble (fr II) fractions and each fraction (100 mg/Kg, p.o.) was also tested. Mice treated with fr I of 2 (Angelica koreana), 10 (Corydalis spp.) or 23 (Schizonepeta tenuifolia) showed higher recovery and lower mortality rates than aspirin (50 mg/Kg, p.o.) treated mice.

• Korean Journal of Pharmacognosy
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• v.14 no.4
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• pp.161-169
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• 1983

Although the 'Samulanshin-Tang' has been widely used in clinical purposes in the -oriental medicine, its clinical efficacy is only documented for the case of palpitation in the Oriental medical reference. The present experiments were undertaken to investigate the clinical efficacy of 'Samulanshin-Tang' comparing effects with animal experiments and to validate its oriental medicine description. Following results were obtained; 1)Suppressive action was shown on convulsion due to cerebrocortical and diencephalic causes in Fraction I and II, but no such action was noted myelic causes in mice. 2)Sedative, analgesic and antipyretic actions were noted by Fraction III. 3)Relaxing action was shown on the isolated ileum in mice and antagonistic action was seen on acetylcholine and $BaCl_2$-induced contractions of the ilem that the direct action of the intestinal smooth muscle was recognized in mice and rats.

• Korean Journal of Pharmacognosy
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• v.18 no.4
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• pp.233-240
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• 1987

In order to investigate experimentally the clinical effects of Chungsimjeongchun-Tang that have been widely used for cardiac asthma, dyspnea and coughs secondary to the appoplexy and cardiac diseases, the water extract of Chungsimjeongchun-Tang was conducted to the effects on the anti-histamine action and respiratory system in mice, guinea-pigs, rabbits and cats. The following results of Chungsimieongchun-Tang were obtained. Spontaneous motility of the isolated ileum of mice and rabbits was strongly suppressed and contractions of the isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Anti-histamine action was noted. Antitussive action on the mechanically irritative cough in cats was recognized. Expectorant action on the leakage of dye in the respiratory tract of rabbits was also shown.

• YAKHAK HOEJI
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• v.41 no.5
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• pp.565-570
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• 1997

High levels of extracellular phospholipase $A_2$ (Plase $A_2$) associated with inflammatory process in man and animal models have been extensively reported elsew here. Thus, a logical approach to the treatment of inflammatory diseases should involve the inhibitors of Plase $A_2$. To develop new Plase $A_2$ inhibitors from natural products, two hundred crude drugs were screened using group II PLA$A_2$ inhibitory activity. Among them, methanol extract of 5 medicinal plants such as, Raphani Semen, Moutan cortex radicis, Arecae semen, Caryophylli Cortex and Betulae Cortex inhibited more than 90% of PLase $A_2$ activity at a concentration 2.5${\mu}g/ml$. Then, 10 methanol extracts sample were transferred into organic solvents, PLase $A_2$ inhibitory effects were found mainly in CHCl3 and EtoAc fractions.