Studies on the Efficacy of Combined Preparation of Crude Drugs (XIII) -Effects of ‘Daeshiho-Tang’ on the Blood Vessels, Activities of the Liver Enzyme, Biliary Secretory and Anti-Diabetic Actions-

생약복합제제(生藥複合製劑)의 약효연구(藥效硏究) 제13보(第13報) -대시호탕(大柴胡湯)이 혈관(血管), 간독성(肝毒性), 이담(利膽) 및 항당뇨효과(抗糖尿效果)에 대(對)하여-

These studies were conducted in an attempt to investigate effects of 'Daeshiho-Tang' on the blood vessels, activities of liver enzyme and excretory action of bile juice in serum of $CCl_4-intoxicated$ rabbits, glucose and total cholesterol levels in serum of alloxan-induced diabetic rabbits. The result of these studies were summarized as follows; 1. Hypotensive ind vaso-dilatating actions due to vascular smooth muscle relaxation were noted in frogs, rabbits and dogs. 2. GOT, GPT and total cholesterol in serum of $CCl_4-intoxicated$ rabbits showed significant depressive effects. 3. Significantly increased biliary secretary effect was noted in $CCl_4-intoxicated$ rabbits. 4. Glucose and total cholesterol levels showed markedly decraese in alloxan-induced diabetic rabbits. Considering the experimental studies results, it is suggested that 'Daeshiho-Tang' has therapeutic efficacy to treat febrile diseses and metabolic diseases.