• Journal of the Korean Wood Science and Technology
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• v.36 no.6
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• pp.59-68
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• 2008

This study was carried out to investigate the effects of the Inside end-taping (Inside-ET) and Outside end-taping (Outside-ET) treatments on prevention of drying defects during radiofrequency/vacuum (RF/V) drying domestic yellow poplar log cross section with size of 20~75 mm in thickness and 120~470 mm in diameter. The treatments of Inside-ET and Outside-ET were quite effective for producing sound log cross sections with thinner than 33 mm and smaller than 270 mm in diameter. Even the 60 mm- and 75 mm-thick log cross sections, if the diameter was smaller than 30 cm, it might expect preventing formation of border checks by appropriate end-taping treatments. The positions of the observed border checks differed in diameter ranging at a relative radius about 0.50~0.63 diameter, and it was estimated that it was necessary to select the border position of end-taping treatment properly according to the diameter of log cross sections. It was observed that the radius of 0.3 diameter was the critical location for pretreatment for preventing formation of border checks in the log cross section with middle diameter. There were severe border checks and V-shaped cracks in the log cross section with large diameter. This was because of the severe variation of moisture content along radial direction of natural characteristic of domestic yellow poplar.

• Journal of Periodontal and Implant Science
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• v.37 no.3
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• pp.497-509
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• 2007

Bone morphogenetic proteins(BMPs) are regarded as members of the transforming growth $factor-{\beta}$ superfamily with characteristic features in their amino acid sequences. A number of studies have demonstrated the biologic activities of BMPs, which include the induction of cartilage and bone formation. Recently there was a attempt to overcome a limitation of mass production, and economical efficieny of rh-BMPs. The method producing PTD by using bacteria have advantages of acquiry a mass of proteins. Hences, a new treatment which deliver protein employed by protein transduction domain(PTD) has been tried. The purpose of this study was to evaluate the bone regenerative effect of TATBMP-2 and TAT-HA2-BMP-2 employed by PTD from HlV-1 TAT protein for protein translocation in the rat calvarial model. An 8mm calvarial, critical size osteotomy defect was created in each of 32 male Spraque-Dawley rats(weight $250{\sim}300g$). The animals were divided into 4 groups of 32 animals each (4 animals/group/healing interval). The defect was treated with TATBMP-2/ACS(Absorbable collagen sponge) (TATBMP-2 0.1mg/ml), TAT-HA2-BMP-2/ACS(TAT-HA2-BMP-2 0.1mg/ml), ACS alone or left untreated for surgical control(negative control). The rats were sacrificed at 2 or 8 weeks postsurgery, and the results were evaluated histologically. The results were as follows: New bone formation were not significantly greater in the TATBMP-2/ACS group relative to negative, and positive control groups. New bone was evident at the defect sites in TAT-HA2-BMP-2/ACS group relative to negative, positive control and TATBMP-2 groups. There were a little bone regeneration in TATBMP-2 groups. While, enhanced local bone formation were observed in TAT-HA2-BMP-2 group. But, The results was not the same in all rat defects. Therefore, further investigations are required to develop a method. which disperse homogenously, and adhere to target cells.

• Journal of Periodontal and Implant Science
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• v.37 no.3
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• pp.511-522
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• 2007

Introduction : The purpose of this study was to evaluate the possibility of the acellular dermal matrix (ADM) as a barrier membrane for bone regeneration, and to evaluate the osteogenic effect of ADM as a carrier system for rhBMP-2 in the rat calvarial defect model. Materials and Methods: An 8-mm, calvarial, critical-size osteotomy defect was created in each of 60 male Spraque-Dawley rats(weight $250{\sim}300g$). Three groups of 20 animals, each received either rhBMP-2(0.025mg/ml) in an ADM carrier, ADM only, or negative surgical control. And each group was divided into 2- and 8-weeks healing intervals. The groups were evaluated by histologic and histomorphometric parameters(10 animals/group/healing intervals). Data were expressed as $means{\pm}standard$ deviations($m{\pm}SD$). Comparisons between experimental and control groups were made using two-way ANOVA and post hoc t-test. Comparisons between 2 weeks and 8 weeks were made using paired t-test. The level of statistical difference was defined as P< 0.05. Results : The ADM group and rhBMP-2/ADM group results in enhanced local bone formation in the rat calvarial defect at both 2 and 8 weeks. The amount of defect closure and new bone formation were significantly greater in the rhBMP-2/ADM group relative to ADM group(P<0.05). At 8 weeks, the majority of ADM in the defect was contracted, and integrated with surrounding host tissues. In addition, host cell infiltration and neovascularization of the ADM in the absence of an inflammatory response were observed, and the newly formed bone around ADM showed a continuous remodeling and consolidation. Conclusion : The results of the present study indicated that ADM may be used as a barrier membrane for bone regeneration and that may be employed as a delivery system for BMPs.

• International Journal of Highway Engineering
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• v.12 no.1
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• pp.21-27
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• 2010

Management of driver hours of service (HOS) for commercial vehicle operators has been a continual safety challenge. One of the more critical issues to government and motor carriers is fatigue and fatigue-related accidents. To reduce truck drivers’fatigue-related accident risk in other countries, the government issued the HOS regulations. However, korea government does not have any HOS regulations. The objective of this research gives the clues that korea should have the HOS regulation to reduce truck drivers’fatigue-related accident risk. This study examines the HOS regulation over other countries and conducts relative accident risk analysis using the real data from 3 freight companies. The data set includes 231 accident involved drivers and 462 non-accident drivers. Therefore, the size of the total data set is 693 drivers. One of the most important aspects of early studies of safety and HOS was the need to characterize continuous driving by using the notion of "survival". Subsequent research used a data replication scheme and logistic regression to capture the survival effect. This study uses time-dependent logistic regression. The test of significance between parameters indicates that the first three hours are almost the same risk. In the 10th hour of driving, the risk was more than 2.2times that in the baseline first hour. In conclusion, as driving time goes on, the crash risk increases.

• Journal of Korean Tunnelling and Underground Space Association
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• v.15 no.6
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• pp.585-597
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• 2013

In this study, in order to evaluate stability of the room-and-pillar underground structure, a series of preliminary numerical analyses were performed. Design concept and procedure of an underground structure for obtaining a space are proposed, which should be different from structural design for the room-and-pillar in mine. With assumed material properties, a series of numerical analyses were performed by varying size ratios of room and pillar and then the failure modes and location at yielding initiation were investigated. From the results, relationship between the ratio of pillar width to the roof span (w/s) and overburden pressure at failure initiation shows a relatively linear relation, and the effect of w/s on structural stability is much more critical than the ratio of pillar width and height (w/H) which is a crucial parameter in design of the room-and-pillar mining. It means that roof tensile failure and shear failure at shoulder and pillar are necessary to be considered together for confirming overall structural stability of the room-and-pillar structure, rather than considering the pillar stability only in mining. Failure modes and location at failure initiation were varied with respect to the ratio of room and pillar widths. Therefore, it is necessary to simultaneously consider stability of both roof span and pillar for design of underground structure by the room-and-pillar method.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.5
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• pp.153-164
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• 2016

It is critical for adolescents to foster self-efficacy, creativity, and adventurous spirit as well as plans for appropriate career path in order to become good members of society. During this adolescent period, newspapers will be a good learning material as they deliver various and timely information in refined language. In this paper, we analyzed the impact of NIE on development of self-efficacy, awareness of career path, and entrepreneurship through comparing adolescents who regularly read newspapers with those who do not. We came up with the following result after analysis of surveys (with a sample size of 283) that targeted middle school and higher grade elementary school students across Korea. We confirmed that reading newspapers has a positive impact on development of self-efficacy, awareness of career path, and entrepreneurship. More specifically, reading newspapers regularly has a positive impact on development of self-efficacy that subsequently has a positive impact on development of awareness of career path and entrepreneurship. Therefore, we found that simply reading newspapers regularly has a positive impact on development of self-efficacy, awareness of career path, and entrepreneurship with no special programs utilizing the newspapers. This is because various information and opinions in newspapers help adolescents to develop their own views, improve understanding and awareness of career, and development of sociality including creativity and adventurous spirit. There is the meaning as the first research that this research checks what the NIE of the adolescents affects the positive impact to not only the self-efficacy and career awareness but also entrepreneurship.

• Korean Journal of Ichthyology
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• v.19 no.2
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• pp.154-159
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• 2007

The oblong rockfish, Sebastes oblongus has recently drawn attention from aquaculturists because of its marketable value and tolerance against winter water temperature in the southern coastal waters of the Korean peninsula. In the study of temperature effect on growth, water temperature $16^{\circ}C$ showed best growth. The upper temperature of the fish showed feeding activity was $27^{\circ}C$ over which the fish showed no longer feeding activity. Stocking density was also a critical factor affecting the growth and survival of the juvenile fish. The best growth was in the density of 200 juveniles/L, while the highest survival was in the density of 100 juveniles/L. A feeding experiment was conducted to determine the effects of feeding frequency on growth and survival. A feeding scheme of twice a day was good enough in the sense of growth, survival, and economy. These results indicate that parameters such as water temperature, density, tank size and feeding frequency are consideration for best seed production of the fish.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.11 no.3
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• pp.85-93
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• 1991

To investigate the effect of the initial sediment concentration ($C_o$) and bed shear stress (${\tau}_b$) on the settling properties of silty mud, deposition experiments were conducted in a recirculating flume using silty mud sediment taken from the Youngkwang coast which is located in the eastern Yellow Sea. The relative concentration, $C/C_o$ (C=depth averaged concentration), and the relative equilibrium concentration, $C_{eq}/C_o$ ($C_{eq}$=depth averaged concentration in the equilibrium state), have been found to depend much more strongly on the bed shear stress than initial concentration, and to increase with increasing bed shear stress. The minimum value. ${\tau}_{bmin}$, and maximum value. ${\tau}_{bmax}$, of critical bed shear stress for deposition of the Youngkwang sediment were deduced to be $0.017N/m^2$ and $1.25N/m^2$, respectively, and these values depend strongly on the properties of sediment (grain size and mineralogy). Formulas for the relative concentration and apparent median settling velocity in the range of ${\tau}_b{\geq}{\tau}_{bmin}$ were deduced. The apparent median settling velocity was found to depend much more strongly on the bed shear stress than the initial concentration and to decrease exponentially with increasing bed shear stress.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.851-856
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• 2012

Objective: NBS1 plays a key role in the repair of DNA double-strand break (DSB). We conducted this study to investigate the effect of two critical polymorphisms (rs1805794 and rs13312840) in NBS1 on treatment response and prognosis of advanced non-small cell lung cancer (NSCLC) patients with platinum-based chemotherapy. Methods: Using TaqMan methods, we genotyped the two polymorphisms in 147 NSCLC patients. Odds ratios (ORs) and their 95% confidential intervals (CIs) were calculated as a measure of difference in the response rate of platinum-based chemotherapy using logistic regression analysis. The Kaplan-Meier and log-rank tests were used to assess the differences in progression-free survival (PFS) and overall survival (OS). Cox proportional hazards model was applied to assess the hazard ratios (HRs) for PFS and OS. Results: Neither of the two polymorphisms was significantly associated with treatment response of platinum-based chemotherapy. However, patients carrying the rs1805794 CC variant genotype had a significantly improved PFS compared to those with GG genotype (16.0 vs. 8.0 months, P = 0.040). Multivariable cox regression analysis further showed that rs1805974 was a significantly favorable prognostic factor for PFS [CC/CG vs. GG: Adjusted HR = 0.62, 95% CI: 0.39-0.99; CC vs. CG/GG: Adjusted HR = 0.56, 95% CI: 0.32-0.97). Similarly, rs13312840 with a small sample size also showed a significant association with PFS (CC vs. CT/TT: Adjusted HR = 25.62, 95% CI: 1.53-428.39). Conclusions: Our findings suggest that NBS1 polymorphisms may be genetic biomarkers for NSCLC prognosis especially PFS with platinum-based chemotherapy in the Chinese population.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2009.06a
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• pp.187-187
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• 2009

Opening of fractures induced by shear dilation or normal deformation can be a significant source of fracture permeability change in fractured rock, which is important for the performance assessment of geological repositories for spent nuclear fuel. As the repository generates heat and later cools the fluid-carrying ability of the rocks becomes a dynamic variable during the lifespan of the repository. Heating causes expansion of the rock close to the repository and, at the same time, contraction close to the surface. During the cooling phase of the repository, the opposite takes place. Heating and cooling together with the, virgin stress can induce shear dilation of fractures and deformation zones and change the flow field around the repository. The objectives of this work are to examine the contribution of thermal stress to the shear slip of fracture in mid- and far-field around a KBS-3 type of repository and to investigate the effect of evolution of stress on the rock mass permeability. In the first part of this study, zones of fracture shear slip were examined by conducting a three-dimensional, thermo-mechanical analysis of a spent fuel repository model in the size of 2 km $\times$ 2 km $\times$ 800 m. Stress evolutions of importance for fracture shear slip are: (1) comparatively high horizontal compressive thermal stress at the repository level, (2) generation of vertical tensile thermal stress right above the repository, (3) horizontal tensile stress near the surface, which can induce tensile failure, and generation of shear stresses at the comers of the repository. In the second part of the study, fracture data from Forsmark, Sweden is used to establish fracture network models (DFN). Stress paths obtained from the thermo-mechanical analysis were used as boundary conditions in DFN-DEM (Discrete Element Method) analysis of six DFN models at the repository level. Increases of permeability up to a factor of four were observed during thermal loading history and shear dilation of fractures was not recovered after cooling of the repository. An understanding of the stress path and potential areas of slip induced shear dilation and related permeability changes during the lifetime of a repository for spent nuclear fuel is of utmost importance for analysing long-term safety. The result of this study will assist in identifying critical areas around a repository where fracture shear slip is likely to develop. The presentation also includes a brief introduction to the ongoing site investigation on two candidate sites for geological repository in Sweden.