• Journal of Korean Neurosurgical Society
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• 제66권1호
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• pp.95-104
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• 2023

Objective : Hypernatremia is a common complication encountered during the treatment of neurocritically ill patients. However, it is unclear whether clinical outcomes correlate with the severity of hypernatremia in such patients. Therefore, we investigated the impact of hypernatremia on mortality of these patients, depending on the degree of hypernatremia. Methods : Among neurosurgical patients admitted to the intensive care unit (ICU) in a tertiary hospital from January 2013 to December 2019, patients who were hospitalized in the ICU for more than 5 days and whose serum sodium levels were obtained during ICU admission were included. Hypernatremia was defined as the highest serum sodium level exceeding 150 mEq/L observed. We classified the patients into four subgroups according to the severity of hypernatremia and performed propensity score matching analysis. Results : Among 1146 patients, 353 patients (30.8%) showed hypernatremia. Based on propensity score matching, 290 pairs were included in the analysis. The hypernatremia group had higher rates of in-hospital mortality and 28-day mortality in both overall and matched population (both p<0.001 and p=0.001, respectively). In multivariable analysis of propensity score-matched population, moderate and severe hypernatremia were significantly associated with in-hospital mortality (adjusted odds ratio [OR], 4.58; 95% confidence interval [CI], 2.15-9.75 and adjusted OR, 6.93; 95% CI, 3.46-13.90, respectively) and 28-day mortality (adjusted OR, 3.51; 95% CI, 1.54-7.98 and adjusted OR, 10.60; 95% CI, 5.10-21.90, respectively) compared with the absence of hypernatremia. However, clinical outcomes, including in-hospital mortality and 28-day mortality, were not significantly different between the group without hypernatremia and the group with mild hypernatremia (p=0.720 and p=0.690, respectively). The mortality rates of patients with moderate and severe hypernatremia were significantly higher in both overall and matched population. Interestingly, the mild hypernatremia group of matched population showed the best survival rate. Conclusion : Moderate and severe hypernatremia were associated with poor clinical outcomes in neurocritically ill patients. However, the prognosis of patients with mild hypernatremia was similar with that of patients without hypernatremia. Therefore, mild hypernatremia may be allowed during treatment of intracranial hypertension using hyperosmolar therapy.

• 한국초지조사료학회지
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• 제43권1호
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• pp.56-61
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• 2023

The germination process is critical for plant growth and development and it is largely affected by environmental stress, especially salinity. Recently, hydrogen sulfide (H₂S) is well known to act as a signaling molecule in a defense mechanism against stress conditions but poorly understood regulating seed germination. In this study, the effects of NaHS (the H₂S donor) pretreatment on various biochemical (hydrogen peroxide (H₂O₂) content and amylase and protease activity) and physiological properties (germination rate) during seed germination of oilseed rape (Brassica napus L. cv. Mosa) were examined under salt stress. The seed germination and seedling growth of oilseed rape were inhibited by NaCl treatment but it was alleviated by NaHS pretreatment. The NaCl treatment increased H₂O₂ content leading to oxidative stress, but NaHS pre-treatments maintained much lower levels of H₂O₂ in germinating seeds under salt stress. Amylase activity, a starch degradation enzyme, significantly increased over 2-fold in control, NaHS pretreatment, and NaHS pretreatment under NaCl during seed germination compared to NaCl treatment. Protease activity was highly induced in NaHS-pretreated seeds compared to NaCl treatment, accompanied by a decrease in protein content. These results indicate that NaHS pretreatment could improve seed germination under salt stress conditions by decreasing H₂O₂ accumulation and activating the degradation of protein and starch to support seedling growth.

• Journal of Animal Science and Technology
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• 제65권3호
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• pp.479-489
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• 2023

Livestock production depends on the utilization of nutrients, and when this is accomplished, there is accelerated momentum toward growth with a low cost-to-feed ratio. Public concern over the consumption of pork with antibiotic residues in animals fed antibiotic growth promoters (AGP) has paved the way for using other natural additives to antibiotics, such as herbs and their products, probiotics, prebiotics, etc. Numerous feed additives are trending to achieve this goal, and a classic example is vitamins and minerals. Vitamins and minerals represent a relatively small percentage of the diet, but they are critical to animal health, well-being, and performance; both play a well-defined role in metabolism, and their requirements can vary depending on the physiological stage of the animals. At the same time, the absence of these vitamins and minerals in animal feed can impair the growth and development of muscles and bones. Most commercial feeds contain vitamins and trace minerals that meet nutrient requirements recommended by National Research Council and animal feeding standards. However, the potential variability and bioavailability of vitamins and trace elements in animal feeds remain controversial because daily feed intake varies, and vitamins are degraded by transportation, storage, and processing. Accordingly, the requirement for vitamins and minerals may need to be adjusted to reflect increased production levels, yet the information presented on this topic is still limited. Therefore, this review focuses on the role and function of different sources of minerals, the mode of action, the general need for micro and macro minerals in non-ruminant diets, and how they improve animal performance.

• 감성과학
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• 제25권4호
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• pp.21-32
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• 2022

최근 주목받고 있는 미니멀리즘은 더 적은 소유에 대해 심사숙고하는 삶의 방식이다. 그러나 지금까지 미니멀리즘의 이득에 대해 학문적으로 검증한 연구가 거의 수행되지 않았다. 본 연구에서는 미니멀리즘에서 소유를 줄이는 방식이 사회적 가치 및 주관적 행복감과 어떤 관계에 있는지를 분석하려 한다. 연구 1에서는 참가자들에게 비대칭 도형 사진을 제시하고, 버리기 또는 추가의 방식으로 안정감있는 대칭구조로 변환하는 과제를 수행하도록 하였다. 그 결과 버리기의 방식을 많이 사용한 참가자일수록 주관적 행복감이 더 높게 나타났다. 또한 주관적 행복감이 높을수록 내면적 가치추구경향이 더 높게 나타났다. 연구 2에서는 소비지향 또는 미니멀리즘과 연관된 자극을 제시한 후, 물질주의 추구경향, 주관적 행복감 및 사회적 봉사활동의 참여의향을 측정하였다. 그 결과 미니멀리즘이 유도된 조건에서 소비지향의 조건보다 물질주의 추구경향이 더 낮게 나타났다. 또한 버리기의 방식을 자주 사용할수록 주관적 행복감 및 사회적 활동의 참여의향이 더 높게 나타났다. 이 결과는 적게 소유하는 미니멀리즘이 사회적 삶과 행복감을 변화시키는 대안적 삶의 방식이 될 수 있음을 시사한다. 논의에서는 연구의 한계 및 후속연구의 방향을 다루었다.

• 대한간호학회지
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• 제53권3호
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• pp.275-294
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• 2023

Purpose: This study aimed to develop an evidence-based extracorporeal membrane oxygenation (ECMO) nursing protocol for critically ill patients receiving ECMO treatment by using an adaptation process, and to verify the effects of the protocol. Methods: The protocol was developed according to the adaptation guidelines. A non-randomized controlled trial was conducted to test the protocol's effects. Data were collected between April 2019 and March 2021. The differences in physiological indicators and complication rates between the two groups were investigated using a chart review to evaluate patient outcomes. The nurses' outcome variables were evaluated using a questionnaire. Results: First, after reviewing 11 guidelines by appraisal of the guidelines for research and evaluation collaboration II, 5 guidelines with a standardization grade of over 50 points were selected. An ECMO nursing protocol was developed based on these guidelines. Second, there were no statistically significant differences in physiological indicators between the two groups of patients. However, the experimental group showed a statistically significant decrease in the infection rate (p = .026) and pressure injury rates (p = .041). The levels of satisfaction with ECMO nursing care, and empowerment and performance of the nurses who used the ECMO nursing protocol were higher than those of nurses who did not (p < .001). Conclusion: This protocol may help prevent infections and pressure injuries in patients, and improve nurses' satisfaction and empowerment. The nursing protocol developed for critically ill patients receiving ECMO treatment can be utilized in evidence-based nursing practice.

• 생명과학회지
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• 제33권7호
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• pp.586-592
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• 2023

돼지 정액을 저장하는 동안 산화스트레스의 발생은 정자의 질과 생존에 영향을 미치는 중요한 인자이다. 정액의 저장은 온도 변화, 동결보호제 등의 다양한 스트레스 인자에 노출되어 있다. 이러한 정자 내에서의 산화스트레스는 활성산소종의 생성에 의해 발생되며, 이는 지질, 단백질, DNA와 같은 세포를 구성하는 물질에 산화적으로 손상을 일으킨다. 활성산소종과 항산화물질의 균형있는 체계는 정자의 생존과 그 기능을 유지하는 데 중요한 역할을 한다. 정액을 장기간 보존하게 되면 활성산소종의 수준이 증가하여 정자의 운동성, 막 온전성, DNA 온전성에 영향을 미치게 된다. 또한, 활성산소종에 의해 유도된 지질과산화 반응은 정자막의 유동성과 안정성에 영향을 미쳐 정자의 운동성을 감소시킨다. 그리고, DNA의 산화적 손상은 DNA 단편화를 일으켜 정자의 DNA 온전성을 손상시킬 수 있다. 결론적으로, 정액을 보관하는 동안 발생되는 산화스트레스는 정자의 질과 기능을 유지하는 데 중요하다. 따라서, 산화스트레스의 기본적인 메커니즘과 정자의 기능에 미치는 영향을 이해하는 것은 산화스트레스로부터의 손상을 최소화하고, 효율적이고 기능적인 정자의 저장 방법을 개선하기 위한 효과적인 전략과 연구 개발을 위해 중요할 것으로 판단된다.

• 영어영문학
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• 제56권1호
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• pp.25-45
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• 2010

While environmental ethics, a relatively new field of philosophy, has gained its practical power in the contemporary world, the ethics of ecological poetry has not been studied well and the relationship between poetry and ethics has also been troubled for a long time. How can it be probed, interrogated, and constructed in ecological criticism? Attempting to steer some critical focus to the topic of ethics and poetic language, this essay is to elucidate these questions within the ecological traits of Mary Oliver's poems. In the process of revisiting Oliver's poems, this essay tries to rescue the poet Oliver, one of the most gifted poets in contemporary American poetic landscape, but a long-neglected one, and questions of ethics which have been evaded for a long time in ecological criticism. Oliver's ecological imagination at once invites readers to become other in the outer world in a most spontaneous way and re-questions the fundamental distance between the self and the other in the process of becoming other. Challenging the humanistic view of nature, she opens the various layers of becoming other: from the possible state of perfect merging to the sad recognition of the impossibility of merging, from the happy moment of rebirth beyond death, to the conflicting moment of being-together. In the different cycles and levels of becoming other, Oliver's poetry completes the poetics of relation in the components of 'self-in-relation.' In those different layers of relations, the ethics of ecological poetry is newly explored rather than residing in the safe net of goodness or sympathy between the self and the other, or the stark division between the two. Oliver's witty, sensitive, sometimes sad eyes toward others, therefore, entice readers to move from the established view of nature to the extraordinary moment of encountering it, thus accomplishing the ethics of beings, not just of ecological poetry.

• 의정연구
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• 제15권1호
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• pp.5-38
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• 2009

이 연구는 민주화 이후 국회-대통령-정당관계를 역사적으로 살펴봄으로써 이를 상생적인 관계로 이끌어가기 위한 조건들에 대하여 고찰하고자 하였다. 연구자는 정당 내부의 권력집중도와 정당기율의 정도가 국회-대통령관계의 상생성에 결정적 영향을 미친다고 보고 이를 분석의 중심틀로 적용하였다. 2002년 이전까지 한국 정당은 권력집중형에 강한 기율이 특징이었다. 대통령 정당은 그의 의제실현을 목적으로 한 입법도구였고, 야당은 반대자로만 존재하는 집단적 대립과 교착의 시대였다. 2002-4년이후 정당정치에서 권력을 분산시키고 기율을 약화시키는 미국식 원내정당화를 포함하여 다양한 제도 개혁이 이루어졌으나 현재까지는 상생정치가 별로 진전되지 않고 있다. 개혁의 결과는 의원들 개인보다는 파벌의 중요도를 증진하였다. 그런데 파벌정치가 (잠재적)대권후보를 중심으로 강하게 응집함으로써 국회는 여전히 정당간의 당론들만이 격돌하는 입법전쟁터로 존재할 뿐이다. 분석을 토대로 연구자는 상생정치 발전을 위해서 현재 정당 및 하위 파벌들의 집단적 행태를 더욱 해체하는 방향으로의 제도 개선을 제안하였다.

• Journal of Microbiology and Biotechnology
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• 제33권10호
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• pp.1281-1291
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• 2023

Infectious diseases caused by drug-resistant Escherichia coli (E. coli) pose a critical concern for medical institutions as they can lead to high morbidity and mortality rates. In this study, amygdalin exhibited anti-inflammatory and antioxidant activities, as well as other potentials. However, whether it could influence the drug-resistant E. coli-infected cells remained unanswered. Amygdalin was therefore tested in a cellular model in which human macrophages were exposed to resistant E. coli. Apoptosis was measured by flow cytometry and the lactate dehydrogenase (LDH) assay. Western immunoblotting and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) were used to quantify interleukin-18 (IL-18), interleukin-1β (IL-1β), and interleukin-6 (IL-6). The production of reactive oxygen species (ROS) in macrophages was detected by ROS kit. The expression of pan-apoptotic proteins in macrophages was measured by qRT-PCR and Western immunoblotting. Drug-Resistant E. coli inhibited cell viability and enhanced apoptosis in the cellular model. In cells treated with amygdalin, this compound can inhibit cell apoptosis and reduce the expression of pro - inflammatory cytokines such as IL-1β, IL-18 and IL-6. Additionally, it decreases the production of PANoptosis proteins, Furthermore, amygdalin lowered the levels of reactive oxygen species induced by drug-resistant E. coli, in cells, demonstrating its antioxidant effects. Amygdalin, a drug with a protective role, alleviated cell damage caused by drug-resistant E. coli in human macrophages by inhibiting the PANoptosis signaling pathway.

• Journal of Preventive Medicine and Public Health
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• 제56권6호
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• pp.573-582
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• 2023

Objectives: For students with epilepsy, schools are a critical environment for managing the disease properly. This study examined awareness of epilepsy, attitudes toward epilepsy, and health literacy among school teachers in Turkey. Methods: This study was conducted in a city in Turkey with 1408 public school teachers from June 2021 to September 2021. Results: The median scores of the scales were 5, 29, and 32 for epilepsy awareness, epilepsy attitudes, and health literacy, respectively. Epilepsy awareness was higher in women, and epilepsy attitudes were more positive in women than men (p<0.05). While epilepsy awareness was higher in primary school teachers, epilepsy attitudes were more positive in secondary school teachers (p<0.05). Epilepsy awareness was lower in secondary school teachers (odds ratio [OR], 1.27; p<0.05), those who did not have an individual with epilepsy in their family/social environment (OR, 1.57; p<0.001), those who did not have a student with epilepsy in their class (OR, 1.45; p<0.05), and in those who had not witnessed an epilepsy seizure (OR,1.19; p<0.05). Compared to those with positive attitudes regarding epilepsy, epilepsy awareness was 1.36 times lower in those with negative attitudes (p<0.001). Epilepsy awareness was 1.92 times lower in those with limited health literacy than those with adequate health literacy (p<0.001). Conclusions: In this study, low epilepsy awareness, negative epilepsy attitudes, and limited health literacy were common among teachers. The findings from this study suggest that panels, workshops, and health training on epilepsy should be organized for school teachers and included at regular intervals in certified first-aid practices.