• BMB Reports
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• v.46 no.11
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• pp.550-554
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• 2013

The platelet-derived growth factor (PDGF) signaling pathway is essential for inducing a dedifferentiated state of vascular smooth muscle cells (VSMCs). Activation of PDGF inhibits smooth muscle cell (SMC)-specific gene expression and increases the rate of proliferation and migration, leading to dedifferentiation of VSMCs. Recently, microRNAs have been shown to play a critical role in the modulation of the VSMC phenotype in response to extracellular signals. However, little is known about microRNAs regulated by PDGF in VSMCs. Herein, we identify microRNA- 15b (miR-15b) as a mediator of VSMC phenotype regulation upon PDGF signaling. We demonstrate that miR-15b is induced by PDGF in pulmonary artery smooth muscle cells and is critical for PDGF-mediated repression of SMC-specific genes. In addition, we show that miR-15b promotes cell proliferation. These results indicate that PDGF signaling regulates SMC-specific gene expression and cell proliferation by modulating the expression of miR-15b to induce a dedifferentiated state in the VSMCs.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.12 no.5
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• pp.380-388
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• 2002

This paper describes the optimum design for low-pressure steam turbine rotor of 1,000 MW nuclear power plant by using a combined genetic algorithm, which uses both a genetic algorithm and a local concentrate search algorithm (e.g. simplex method). This algorithm is not only faster than the standard genetic algorithm but also supplies a more accurate solution. In addition, this algorithm can find the global and local optimum solutions. The objective is to minimize the resonance response (Q factor) and total weight of the shaft, and to separate the critical speeds as far from the operating speed as possible. These factors play very important roles in designing a rotor-bearing system under the dynamic behavior constraint. In the present work, the shaft diameter, the bearing length, and clearance are used as the design variables. The results show that the proposed algorithm can improve the Q factor and reduce the weight of the shaft and the 1st critical speed.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.15 no.2
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• pp.1-8
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• 2019

The integrity of the Reactor Pressure Vessel (RPV) is affected by the neutrons bombarding the vessel wall leading to embrittlement. This irradiation-induced embrittlement leads to reduction in the fracture toughness of RPV materials. This paper presents a comparative study of typical Optimized Power Reactor (OPR)1000 reactor pressure-temperature (P-T) limit curves using the pre-2006 American Society of Mechanical Engineers (ASME) editions used in the power plant and the current ASME edition of 2010. The current ASME Code utilizes critical reference stress intensity factor based on the lower bound of static, while the Pre-2006 ASME editions are based the critical reference stress intensity factor based on the lower bound of static, dynamic and crack arrest. Model-Based Systems Engineering approach was used to evaluate ASME Code Section XI Appendix G for generating the P-T limit curves. The results obtained from this analysis indicate decrease in conservatism in P-T limit curves constructed using the current 2017 ASME code, which can potentially increase operational flexibility and plant safety. Hence it is recommended to use ASME code edition after 2006 be used in all operating nuclear power plants (NPPs) to establish P-T limit curve.

• Korean Journal of Health Education and Promotion
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• v.30 no.5
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• pp.177-188
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• 2013

Objectives: The purpose of this study was to evaluate the feeling of distance of social work practitioners for people living with HIV/AIDS(PLWHA) and to identify related factors. Methods: A total of 409 data were collected as convenience sampling from social welfare service providers. Independent variables were socio-demographic data, AIDS related knowledge, authoritarian personality, prejudice for minority(handicapped, women, foreigner, old aged), cultural competency. Data were analyzed by t-test, ANOVA, multiple regression analysis were conducted. Results: Multiple regression model was developed by integrating the significant variables from univariate analysis. Significant factors of physical distance were social prejudice against handicapped, knowledge about AIDS and critical awareness/knowledge about other culture. And significant factors of social distance were social prejudice against handicapped, knowledge about AIDS, authoritarian personality, critical awareness/knowledge about other culture. At last, we found that social prejudice against handicapped was the biggest factor for physical distance and authoritarian personality was the biggest factor for social distance of social work practitioners. Conclusions: The area of social services for PLWHA have to be expanded. Physical and social distance of professionals to provide services to PLWHA and factors affecting it is necessary to continue research. In addition, on the basis of these findings, specific training programs is need to be developed.

• Journal of the Korean Society for Library and Information Science
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• v.50 no.2
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• pp.271-287
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• 2016

This study intends to review the quality factors of library service for the disabled using user-centered approach. For the empirical review of quality factors, Nine quality factors were drawn after analyzing the current library service quality factors and the standards of library service for the disabled. Using these factors, The survey for identifying importance of factors and the qualitative evaluation of service cases were performed in this study. As a result of this survey, the most critical but relatively weak quality factors were facility, collection and staff factors. And the qualitative evaluation results of service cases indicated that the reading culture program and the information service factors were critical.

• Journal of Ocean Engineering and Technology
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• v.31 no.4
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• pp.299-307
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• 2017

The design of the mooring line to maintain the position of an offshore structure in rough marine environments is recognized as a very important consideration. Conventional fatigue evaluation of a mooring line was performed by considering the tensile force acting on the mooring line, but the mooring line broke after 238 days in the girassol area even though the expected fatigue life was expected to be longer. The causes of this event are known to be due to OPB/IPB (out-of-plane bending/in-plane bending) caused by chain link friction due to the excessive tensile strength of the mooring line. In this study, three models with different boundary conditions were proposed for fatigue analysis of a mooring line considering OPB/IPB. Interlink stiffness was calculated by nonlinear structure analysis and a stress concentration factor was derived. In addition, the sensitivity of interlink stiffness according to the magnitude of tensile force, large deformation effect, and coefficient of friction was analyzed, and the effect of critical elastic slip and bending moment calculation position on interlink stiffness was confirmed.

• Journal of the Korea Institute of Military Science and Technology
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• v.21 no.2
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• pp.217-224
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• 2018

The purpose of this study is to evaluate the future potential value of CTE(Critical Technology Element)s that are evaluated to be low in TRA(Technology Readiness Assesment) and to present investment prioritization technologies in defense R&D(Research and Development) based on them. To do this, we used the DEA(Data Envelopment Analysis) method, which is useful in evaluating the efficiency of the organization. Specifically, we suggest a systematic framework to evaluate the future value of CTEs by setting the CTEs derived from the TRA process to DMU(Decision Making Unit)s, the cost and time required to develop each CTE as the input factor of the DEA and the effects of the development of each CTE as the output factor of the DEA respectively. We also conducted an illustrative case study on radar technologies to demonstrate the usefulness of the proposed approach.

• Journal of Satellite, Information and Communications
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• v.8 no.2
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• pp.36-43
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• 2013

In this study, the high current behaviors and double snapback mechanism of gate grounded_extended drain n-type MOSFET(GG_EDNMOS) device were analyzed in order to realize the robust electrostatic discharge(ESD) protection performances of high voltage operating display driver IC(DDIC) chips. Both the transmission line pulse(TLP) data and the thermal incorporated 2-dimensional simulation analysis as a function of ion implant conditions demonstrate a characteristic double snapback phenomenon after triggering of bipolar junction transistor(BJT) operation. Also, the background carrier density is proven to be a critical factor to affect the high current behavior of the GG_EDNMOS devices.

• Journal of Construction Engineering and Project Management
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• v.6 no.4
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• pp.24-34
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• 2016

Disputes seem to be synonymous with large-scale construction projects in Ethiopia. The purpose of this study is to determine the factors responsible for impacting the performance of Ethiopian public construction projects. To this end, 35 success and failure attributes responsible for impacting the performance of the projects were identified and presented to Ethiopian construction professionals in the form of a structured questionnaire, and responses were collected. The factor analysis conducted on the success and failure attributes influencing no-dispute performance separately resulted in six success factors and five failure factors. Further analysis using stepwise multiple regression indicates that owner competence and interaction among project participants have a positive impact on no-dispute performance. However, conflict among project participants has a negative impact on the no-dispute performance of Ethiopian public construction projects. Although Ethiopia-specific, the results reflect construction management problems common to both developed and developing countries. The findings are expected to help researchers and practitioners gain a better understanding of critical success and failure factors and to help them take proactive measures to avoid disputes in public construction projects.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.21 no.1
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• pp.49-55
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• 2022

Recently, the automobile industry has continued to demand lighter materials owing to international environmental regulations and increased convenience. To address this demand, aluminum parts have increased in popularity and are mainly developed and produced through hot forging and cold pressing. However, because this method has low yield and low production efficiency, a new manufacturing method is desirable. In this study, the water capacity efficiency of an aluminum inner tie rod socket was investigated using cold forging that provided a high yield and excellent production efficiency. Mechanical properties were derived through tensile testing of 6110A aluminum materials, and critical fracture factor and process analysis based on experimental data were carried out. The optimized process was applied as a prototype using cold multi-stage forging, and based on the derived results, the formability, productivity, and material efficiency of aluminum inner tie rod socket parts using this cold forging process was verified.