• Title/Summary/Keyword: Cox regression model

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Developing the Sarcopenia Risk Assessment Model in Korean Adults (한국 성인의 근감소증 위험도 평가점수 모형 개발)

  • Eun-Jung, Bae;Il-Su, Park
    • The Journal of Korean Society for School & Community Health Education
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    • v.23 no.4
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    • pp.81-93
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    • 2022
  • Objectives: The purpose of this study was to develop a model for comprehensively evaluating the risk of sarcopenia in Korean adults and to generate the sarcopenia risk scorecard model based on the results. Methods: The participants of the study were 7,118 adults without sarcopenia in the first basic survey, and a longitudinal analysis was conducted using data from the 1st to 8th survey (2006-2020) of the Korean Longitudinal Study of Aging (KLoSA). The data were analyzed using Rao-Scott chi-square test and weighted Cox proportional hazards regression of complex sampling design. The sarcopenia risk scorecard model was developed by Cox proportional hazards regression using points to double the odds (PDO) method. Results: The findings show that the risk factors for sarcopenia in Korean adults were gender, age, marital status, socioeconomic status, body mass index (BMI), regular exercise, diabetes and arthritis diagnosis. In the scorecard results, the case of exposure to the highest risk level was 100 points. The highest score range were given in the order of age over 65, low BMI, and low socioeconomic status. Conclusions: The significance of this study is that the causal relationship between various factors and the occurrence of sarcopenia in Korean adults was identified. Also, the model developed in this study is expected to be useful in detecting participants with risk of sarcopenia in the community early and preventing and managing sarcopenia through appropriate health education.

Comparative Study on Statistical Packages Analyzing Survival Model - SAS, SPSS, STATA -

  • Cho, Mi-Soon;Kim, Soon-Kwi
    • Journal of the Korean Data and Information Science Society
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    • v.19 no.2
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    • pp.487-496
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    • 2008
  • Recently survival analysis becomes popular in a variety of fields so that a number of statistical packages are developed for analyzing the survival model. In this paper, several types of survival models are introduced and considered briefly. In addition, widely used three packages(SAS, SPSS, and STATA) for survival data are reviewed and their characteristics are investigated.

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Determinant of Married Women′s New Entry in Labor Market after the First Child Birth (첫 자녀 출산 후 노동시장 신규진입의 결정요인)

    • Journal of the Korean Home Economics Association
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    • v.42 no.1
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    • pp.69-79
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    • 2004
  • This study has examined factors of young married women's new entry in labor market after the birth of their first child. For the dynamic analysis, the Cox Regression Hazard Model is applied. The following results are obtained: First, about 33% of married women who did not have a job at the pre-birth enter in labor market at the post-birth. Second, compared to those out of the labor force, women who succeeded in finding their first jobs after the birth of their first child are more likely to be younger, have baby-sitters, have working experiences in the past, and have lower level of household income. Third, age, having baby-sitter and the experience of job transition are vital factors in entering the labor market after the first child birth.

Cox Model Improvement Using Residual Blocks in Neural Networks: A Study on the Predictive Model of Cervical Cancer Mortality (신경망 내 잔여 블록을 활용한 콕스 모델 개선: 자궁경부암 사망률 예측모형 연구)

  • Nang Kyeong Lee;Joo Young Kim;Ji Soo Tak;Hyeong Rok Lee;Hyun Ji Jeon;Jee Myung Yang;Seung Won Lee
    • The Transactions of the Korea Information Processing Society
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    • v.13 no.6
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    • pp.260-268
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    • 2024
  • Cervical cancer is the fourth most common cancer in women worldwide, and more than 604,000 new cases were reported in 2020 alone, resulting in approximately 341,831 deaths. The Cox regression model is a major model widely adopted in cancer research, but considering the existence of nonlinear associations, it faces limitations due to linear assumptions. To address this problem, this paper proposes ResSurvNet, a new model that improves the accuracy of cervical cancer mortality prediction using ResNet's residual learning framework. This model showed accuracy that outperforms the DNN, CPH, CoxLasso, Cox Gradient Boost, and RSF models compared in this study. As this model showed accuracy that outperformed the DNN, CPH, CoxLasso, Cox Gradient Boost, and RSF models compared in this study, this excellent predictive performance demonstrates great value in early diagnosis and treatment strategy establishment in the management of cervical cancer patients and represents significant progress in the field of survival analysis.

Estimation of lapse rate of variable annuities by using Cox proportional hazard model (Cox 비례위험모형을 이용한 변액연금 해지율의 추정)

  • Kim, Yumi;Lee, Hangsuck
    • Journal of the Korean Data and Information Science Society
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    • v.24 no.4
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    • pp.723-736
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    • 2013
  • The importance of lapse rate is highly increasing due to the introduction of Cash Flow Pricing system, non-refund-of-reserve insurance policy, and IFRS (International Financial Reporting System) to the Korean insurance market. Researches on lapse rate have mainly focused on simple data analysis and regression analysis, etc. However, lapse rate can be analyzed by survival analysis and can be well explained in terms of several covariates with Cox proportional hazard model. Guaranteed minimum benefits embedded in variable annuities require more elegant statistical analysis of lapse rate. Hence, this paper analyzes data of policyholders with variable annuities by using Cox proportional hazard model. The key variables of policy holder that influences the lapse rate are payment method, premium, lapse insured to term insured, reserve-GMXB ratio, and age.

Survival Function Estimation for the Proportional Hazards Regression Model

  • Cha, Young Joon
    • Journal of Korean Society for Quality Management
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    • v.18 no.1
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    • pp.9-20
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    • 1990
  • The purpose of this paper is to propose the modified semiparametric estimators for survival function in the Cox's regression model with randomly censored data based on Tsiatis and Breslow estimators, and present their asymptotic variances estimates. The proposed estimators are compared to Tsiatis, Breslow, and Kaplan-Meier estimators through a small-sample Monte Carlo study. The simulation results show that the proposed estimators are preferred for small sample sizes.

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Test of Linearity in Panel Regression Model (패널회귀모형에서 선형성검정)

  • 송석헌;최충돈
    • The Korean Journal of Applied Statistics
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    • v.16 no.2
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    • pp.351-364
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    • 2003
  • This paper derives Lagrange multiplier tests based on Double-Length Artificial Regression and Outer-Product Gradient for testing linear and log-linear panel regressions against Box-Cox alternatives. The proposed DLR based LM tests are easy to implement in an error component model. From the Monte Carlo study, the DLR based LM tests are recommended for testing functiona forms.

Some Remarks on the Likelihood Inference for the Ratios of Regression Coefficients in Linear Model

  • Kim, Yeong-Hwa;Yang, Wan-Yeon;Kim, M.J.;Park, C.G.
    • Journal of the Korean Data and Information Science Society
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    • v.15 no.1
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    • pp.251-261
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    • 2004
  • The paper focuses primarily on the standard linear multiple regression model where the parameter of interest is a ratio of two regression coefficients. The general model includes the calibration model, the Fieller-Creasy problem, slope-ratio assays, parallel-line assays, and bioequivalence. We provide an orthogonal transformation (cf. Cox and Reid (1987)) of the original parameter vector. Also, we give some remarks on the difficulties associated with likelihood based confidence interval.

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Survival Prognostic Factors of Male Breast Cancer in Southern Iran: a LASSO-Cox Regression Approach

  • Shahraki, Hadi Raeisi;Salehi, Alireza;Zare, Najaf
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.15
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    • pp.6773-6777
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    • 2015
  • We used to LASSO-Cox method for determining prognostic factors of male breast cancer survival and showed the superiority of this method compared to Cox proportional hazard model in low sample size setting. In order to identify and estimate exactly the relative hazard of the most important factors effective for the survival duration of male breast cancer, the LASSO-Cox method has been used. Our data includes the information of male breast cancer patients in Fars province, south of Iran, from 1989 to 2008. Cox proportional hazard and LASSO-Cox models were fitted for 20 classified variables. To reduce the impact of missing data, the multiple imputation method was used 20 times through the Markov chain Mont Carlo method and the results were combined with Rubin's rules. In 50 patients, the age at diagnosis was 59.6 (SD=12.8) years with a minimum of 34 and maximum of 84 years and the mean of survival time was 62 months. Three, 5 and 10 year survival were 92%, 77% and 26%, respectively. Using the LASSO-Cox method led to eliminating 8 low effect variables and also decreased the standard error by 2.5 to 7 times. The relative efficiency of LASSO-Cox method compared with the Cox proportional hazard method was calculated as 22.39. The19 years follow of male breast cancer patients show that the age, having a history of alcohol use, nipple discharge, laterality, histological grade and duration of symptoms were the most important variables that have played an effective role in the patient's survival. In such situations, estimating the coefficients by LASSO-Cox method will be more efficient than the Cox's proportional hazard method.

Regression models for interval-censored semi-competing risks data with missing intermediate transition status (중간 사건이 결측되었거나 구간 중도절단된 준 경쟁 위험 자료에 대한 회귀모형)

  • Kim, Jinheum;Kim, Jayoun
    • The Korean Journal of Applied Statistics
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    • v.29 no.7
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    • pp.1311-1327
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    • 2016
  • We propose a multi-state model for analyzing semi-competing risks data with interval-censored or missing intermediate events. This model is an extension of the 'illness-death model', which composes three states, such as 'healthy', 'diseased', and 'dead'. The state of 'diseased' can be considered as an intermediate event. Two more states are added into the illness-death model to describe missing events caused by a loss of follow-up before the end of the study. One of them is a state of 'LTF', representing a lost-to-follow-up, and the other is an unobservable state that represents the intermediate event experienced after LTF occurred. Given covariates, we employ the Cox proportional hazards model with a normal frailty and construct a full likelihood to estimate transition intensities between states in the multi-state model. Marginalization of the full likelihood is completed using the adaptive Gaussian quadrature, and the optimal solution of the regression parameters is achieved through the iterative Newton-Raphson algorithm. Simulation studies are carried out to investigate the finite-sample performance of the proposed estimation procedure in terms of the empirical coverage probability of the true regression parameter. Our proposed method is also illustrated with the dataset adapted from Helmer et al. (2001).