• 한국의학물리학회지:의학물리
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• 제12권2호
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• pp.103-112
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• 2001

목적: 최근 국내의 핵의학 계측기기 및 감마카메라의 정도관리 수행현황을 파악하고, 핵의학 계측기기와 감마 카메라의 정도관리를 수행하고자 하였다. 방 법: 최근 국내의 핵의학 계측기기 및 감마 카메라의 정도관리 수행현황은 총 53개 병원을 대상으로 설문조사방법을 이용하여 수행하였다. 이들의 정도관리 연구는 Capintec의 CRC-15 기종의 dose calibrator와 Tc-99m 35.52 MBq을 사용하여 2분 간격으로 정밀도를 측정하였다. Nucleus사의 기종의 Thyroid Uptake system은 Tc-99m 5.14 MBq을 이용하여 1분 간격으로 10초동안 정밀도를 측정하였다. 지름이 15 cm이고 높이가 각각 12 cm, 30 cm인 원통형 팬텀과 TC-99m을 이용하여 저에너지 고해상도 조준기가 부착된 CeraSPECT$^{TM}$의 예민도를 측정하였다. CeraSPECT$^{TM}$와 일반 평면카메라와의 예민도에 대한 특성비교를 위하여 Varicam (Elscint Ltd, Israel) 감마 카메라로 영상을 얻었다. CeraSPECT$^{TM}$로 획득한 자료로 각 슬라이스에 대한 보정상수를 계산하였다. Elscint 사의 Varicam 감마 카메라의 정도관리를 위해 저에너지 고해상도 조준기를 부착하고 140 keV 중심20% 에너지창, 256$\times$256 또는 512$\times$512 메트릭스 크기를 이용하여 시스템의 평면 예민도, 균일도, 계수율 및 공기중과 산란매질에서의 공간 분해능을 측정하였다. 결 과: 핵의학 계측기기 및 감마 카메라의 정도관리 수행율은 dose calibrator와 well counter의 경우 매우 저조한 수행율을 나타내었으며 그 외 감마 카메라 등은 대체로 양호한 수행율을 나타내었다. dose calibrator의 정밀도 측정은 $\pm$1.4%(<$\pm$5%)의 결과를 얻었고, thyroid uptake system의 정밀도 측정은 chi^2=29.7(>16.92)의 결과를 얻었다. Varicam 감마 카메라의 경우 슬라이스들간에 전반적으로 균일한 민감도를 보여주었으나 CeraSPECT$^{TM}$ 의 경우는 위쪽과 아래쪽 부분의 슬라이스들은 민감도가 두드러지게 떨어져 있었고 팬텀의 중심부분 슬라이스들은 민감도가 매우 높은 것으로 나타났다. 계산한 보정 상수를 이용하여 CeraSPECT$^{TM}$로 얻은 환자 자료를 보정하였을 때 보정전에 비하여 전반적으로 균일한 영상을 얻을 수 있었다. 감마 카메라의 시스템 평면 예민도 측정 결과는 4.39 CPM/MBq 이었으며, 시스템 균일도는 첫 번째 검출기와 두번째 검출기가 각각 2.14%, 3.79%로 나타났다. 시스템 계수율 측정의 경우 입력 계수율 R_20%가 각각 102,407 counts/sec (head 1), 113,427 counts/sec (head 2)일 때 20% 계수율 손실이 발생했을 때의 측정된 계수율 C_20%는 각각 81,926 counts/sec (head 1), 90,741 counts/sec (head 2) 이었다. 공기 중에서의 시스템의 공간 분해능은 FWHM이 8.16 m, FWTM이 14.85 mm이었고, 산란매질에서는 시스템의 공간 분해능은 FWHM이 8.87 mm, FWTM이 18.87 mm이었다. 결 론: 정확하고 신뢰도 높은 검사를 위해 정도관리는 필수이며, 이에 대한 명확한 인식과 실질적인 수행이 반드시 뒤따라야 할 것으로 사료되었다

• 한국임상수의학회지
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• 제27권1호
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• pp.66-70
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• 2010

Reference interval is critical for interpreting laboratory results, monitoring response to therapy and predicting the prognosis of the patients in clinical settings. The aim of the present study was to update established reference intervals for routine hematologic and serum chemistry values for a population of clinically healthy dogs (range, 1-8 years) seen in an animal hospital. Blood was obtained by venipuncture while animals were physically restrained, and samples were analyzed for 9 chemistries on MS9-5H (Melot Schloesing Lab, France) and 6 hematology on Vet Test 8008 (IDEXX, USA). Data from 105 dogs (52 males and 53 females) for hematology and 113 dogs (37 males and 76 females) for chemistry were used to determine reference intervals using the parametric, nonparametric and bootstrap methods. Prior to analysis, all parameters were tested for normal distribution using Anderson-Darling criterion. Of the 9 biochemical analytes, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, creatinine, total protein, and glucose concentrations did not fit normal distribution for both original and transformed data. All but eosinophil count satisfied normal distribution for either original or transformed data. Parametric method can be used for original cholesterol concentrations, RBC, WBC, and neutrophil counts. This technique can also be used for power-transformed values of blood urea nitrogen concentrations and for logarithm of lymphocyte and monocyte counts. Non-parametric or bootstrap method was the preferred choice for the remaining 7 biochemical parameters and eosinophil count as they did not follow normal distributions. All three statistical techniques performed in similar reference intervals. When establishing reference intervals for clinical laboratory data, it is essential to assess the distribution of the original data to increase the accuracy of the interval, and non-parametric or bootstrap methods are of alternative for the data that do not fit normal distribution.

• 품질경영학회지
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• 제26권4호
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• pp.111-123
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• 1998

We consider the problem of modeling count data where the observation period is determined by the life time of the system under study. We assume random effects or a frailty model to allow for a possible association between the death times and the counts. We assume that, given a random effect or a frailty, the death times follow a Weibull distribution with a hazard rate. For the counts, given a frailty, a Poisson process is assumed with the intensity depending on time. A gamma distribution is assumed for the frailty model. Maximum likelihood estimators of the model parameters are obtained. A model for the time to death and the number of failures system received is constructed and consequences of the model are examined.

• 한국해양공학회지
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• 제16권5호
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• pp.66-72
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• 2002

Fracture behaviors of pipes with local wall thinning are very important for the integrity of nuclear power plant. However, effects of local wall thinning on strength and fracture behaviors of piping system were not well studied. Acoustic emission(AE) has been widely used in various fields because of its extreme sensitivity, dynamic detection ability and location of growing defects. In this study, we investigated failure modes of locally wall thinned pipes and AE signals by bending test. From test results, we could be divided four types of failure modes of ovalization, crack initiation after ovalization, local buckling and crack initiation after local buckling. And fracture behaviors such as elastic region, yielding region, plastic deformation region and crack progress region could be evaluated by AE counts, accumulative counts and time-frequency analysis during bending test. The result of the frequency range is expected to be basic data that can inspect plants in real-time.

• 동의생리병리학회지
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• 제23권2호
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• pp.374-380
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• 2009

Samryungbaikchul-san(SRBCS) has been used in oriental medicine for the treatments of gastrointestinal and neurological disorders. Here, potential protective function of SRBCS was investigated in neural tissues in Alzheimer's disease(AD) mouse model. In primary cultured cells from the spinal cord of newborn rats, treatment of ${\beta}$-amyloid peptide elevated cell counts positive to glial fibrillary acidic protein(GFAP) or caspase 3 immunoreactivity, but the co-treatment of SRBCS reduced positive cell counts. In vivo administration of scopolamine, an inhibitor of muscarinic receptor, resulted in increases in the number of glial fibrillary acidic protein(GFAP) and caspase 3-positive cells in hippocampal subfields, which was then decreased by the treatment of SRBCS or acetylcholinesterase inhibitor galathamine. The present data suggest that SRBCS may play a protective role in damaged neural tissues caused by scopolamine treatments in mice.

• 한국환경보건학회지
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• 제5권1호
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• pp.51-57
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• 1978

Antibiotics susceptibilities of Staphylococci were tested to get useful data for prevention food contamination and treatment of food poisoning. Tested were colony counts, isolation of Staphylococci, identification for the Staphylococcus aureus and resistant patterns to antimcrobial agents. The colonies and Staphylococci isolated from the atmosphere of 37 home kitchens in the morning (07:00-08:00) on Nov. 19, 1977 in Busan. The findings are as follows: 1. The average of colony counts was shown to be 9.6 ranging from 47 to 1 at mean temperature of 18$\circ$C (the highest 21$\circ$C, the lowest 15$\circ$C) 2. Out of total 37 kitchens, 18 Staphylococci were isolated from 15 kitchens with 40.5 per cent, and 4 Staphylococcus aureus were identified with 22.2 per cent from 18 Staphylococci. 3. Isolated Staphylococci were resistant to penicillin(100%), dihydrostreptomycin(93.3%), tetracycline (93.3%) and oleandomycin(66.6%), while the strains were sensitive to sulfonamide(88.6%) and colistin(83.3%). 4. Staphylococcus aureus identified were resistant to dihydrostreptomycin, penicillin and tetracycline, while the strains were sensitive to sulfonamide and colistin.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2008년도 춘계학술대회
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• pp.185-196
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• 2008

The objective of this study is to evaluate the mechanical behaviors and structural integrity of the weldment of high strength steel by using an acoustic emission (AE) techniques. Simple tension and AE tests were conducted against the 3 kind of welding test specimens. In order to analysis the effectiveness of weldability, joinability and structural integrity, we used K-means clustering method as a unsupervised learning pattern recognition algorithm for obtained multivariate AE main data sets, such as AE counts, energy, amplitude, hits, risetime, duration, counts to peak and rms signals. Through the experimental results, the effectiveness of the proposed method is discussed.

• 대한안전경영과학회지
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• 제10권4호
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• pp.127-134
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• 2008

The objective of this study is to evaluate the mechanical behaviors and structural integrity of the weldment of high strength steel by using an acoustic emission (AE) techniques. Monotonic simple tension and AE tests were conducted against the 3 kinds of welded specimen. In order to analysis the effectiveness of weldability, joinability and structural integrity, we used K-means clustering method as a unsupervised learning pattern recognition algorithm for obtained multi-variate AE main data sets, such as AE counts, energy, amplitude, hits, risetime, duration, counts to peak and rms signals. Through the experimental results, the effectiveness of the proposed method is discussed.

• 통합자연과학논문집
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• 제1권1호
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• pp.1-4
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• 2008

We developed quantification method based on the concept of candela in physics. The measurement of fluorescence signal from a nude mouse in the research of molecular biology. In the measurement of the optical signal with CCD, the quantification method for photon counts based on bio-luminescence imaging technique can provide comparative reference data. In this paper, we described theoretical derivation of our proposed concept. We hope this method could be a useful standard reference for quantitative date analysis in optical imaging.

• 한국항해학회지
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• 제4권1호
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• pp.1-18
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• 1980

As the NNSS system calculates ship's position by the doppler shift of the NNSS radio waves caused by the change of the distance between Transit Satellite and the ship, ship's speed error inevitably results in the position error, and moreover this kind of erroris most dominant compared with other errors especially in high speed ships and airplanes. Most NNSS receivers now in use have adoptedsuccessive short doppler counts as positioning data and by investigating the dispersion of serval successive positions calculated and by neglecting the mean position having dispersion of over certain threshold level, more accurate adn safe position is to be achieved. This paper proposes the method of finding ship's true speed by selecting a speed having least position dispersion for given successive doppler counts. And by computer simulation it was verified that the method proposed here is reasonable in finding the ship's desired correct speed together with the correct ship's position.