Browse > Article

Effect of Samryungbaikchul-san on Astrocyte Activation and Apoptosis in Mouse Model of Alzheimer Disease  

Lee, Sang-Ryong (Department of Neuropsychiatry, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.2, 2009 , pp. 374-380 More about this Journal
Abstract
Samryungbaikchul-san(SRBCS) has been used in oriental medicine for the treatments of gastrointestinal and neurological disorders. Here, potential protective function of SRBCS was investigated in neural tissues in Alzheimer's disease(AD) mouse model. In primary cultured cells from the spinal cord of newborn rats, treatment of ${\beta}$-amyloid peptide elevated cell counts positive to glial fibrillary acidic protein(GFAP) or caspase 3 immunoreactivity, but the co-treatment of SRBCS reduced positive cell counts. In vivo administration of scopolamine, an inhibitor of muscarinic receptor, resulted in increases in the number of glial fibrillary acidic protein(GFAP) and caspase 3-positive cells in hippocampal subfields, which was then decreased by the treatment of SRBCS or acetylcholinesterase inhibitor galathamine. The present data suggest that SRBCS may play a protective role in damaged neural tissues caused by scopolamine treatments in mice.
Keywords
alzheimer's disease; samryungbaikchul-san(SRBCS); GFAP; caspase 3;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Leung, L.W., Yim, C.Y. Intrinsic membrane potential oscillations in hippocampal neurons in vitro. Brain Res. 553(2):261-274, 1991   DOI   ScienceOn
2 Selkoe, D.J., Schenk, D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol. 43: 545-584, 2003   DOI   ScienceOn
3 朱震亨. 金櫃鉤玄. 서울, 鼎談出版社 pp 306-307, 1992
4 張介賓. 張氏景岳全書. 서울, 翰成社, pp 610-611, 1978
5 대한한방신경정신과학회편. 한방신경정신의학. 서울, 집문당, pp 311-320, 324-333, 2007
6 신재용 편저. 方藥合編解說. 서울, 성보사, p 37, 1988
7 유종호, 이상택, 한윤승, 김근우, 구병수, 김헌일. 황련청심음(黃連淸心飮)의 항산화 및 AChE 억제 효과에 관한 연구. 동의신경정신과학회지 17(1):1-16, 2006   과학기술학회마을
8 최강욱, 정인철. 天王補心丹 열수추출물, 초미세분말제형이 Alzheimer's Disease 병태 모델에 미치는 영향. 동의생리병리학회지 19(2):77-93, 2008
9 송대섭. 蔘笭白朮散의 효능에 관한 실험적 연구, 경희대학교 대학원, 1993
10 acquevel, M., Lebeurrier, N., Cheenne, S., Vivien, D. Cytokines in neuroinflammation and Alzheimer's disease, Current Drug Targets. 5(6):529-534, 2004   DOI   ScienceOn
11 Mhatre, M., Floyd, R.A., Hensley, K. Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets, Journal of Alzheimers disease. 6(2):147-157, 2004.   DOI
12 de Vente, J., Markerink-van Ittersum, M., van Abeelen, J., Emson, P.C., Axer, H., Steinbusch, H.W. NO-mediated cGMP synthesis in cholinergic neurons in the rat forebrain , effects of lesioning dopaminergic or serotonergic pathways on nNOS and cGMP synthesis, Eur J Neurosci. 12(2):507-519, 2000   DOI   ScienceOn
13 江克明, 包明蕙. 簡明方劑辭典. 上海, 上海科學技術出版社, p 699, 1989
14 이향중 외 4인. 중의방제적약리급임상응용, 북경, 人民衛生出版社, pp 232-235, 1992
15 Rich, T., Watson, C.J., Wyllie, A. Apoptosis: the germs of death. Nat Cell Biol. 1(3):69-71, 1999   DOI   ScienceOn
16 Weiss, C., Preston, A.R., Matthew, M. Oh, Roy D., Schwarz, Devin Welty and John F. Disterhoft. The M1 Muscarinic Agonist CI-1017 Facilitates Trace Eyeblink Conditioning in Aging Rabbits and Increases the Excitability of CA1 Pyramidal Neurons. J. Neurosci. 20: 783-790, 2000   ScienceOn
17 During, M.J., Symes, C.W., Lawlor, P.A., Lin, J., Dunning, J., Fitzsimons, H.L., Poulsen, D., Leone, P., Xu, R., Dicker, B.L., Lipski, J., Young, D. An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy. Science. 287(5457):1453-1460, 2000   DOI   PUBMED   ScienceOn
18 Yee, A.S., Longacher, J.M., Staley, K.J. Convulsant and anticonvulsant effects on spontaneous CA3 population bursts. J Neurophysiol. 89(1):427-441, 2003   DOI   ScienceOn
19 Wallenstein, G.V., Hasselmo, M.E. Functional transitions between epileptiform-like activity and associative memory in hippocampal region CA3. Brain Res Bull. 43(5):485-493, 1997   DOI   ScienceOn
20 Kobayashi, K., Hayashi, M., Nakano, H., Shimazaki, M., Sugimori, K., Koshino, Y. Correlation between astrocyte apoptosis and Alzheimer changes in gray matter lesions in Alzheimer's disease. J Alzheimers Dis. 6(6):623-632, 673-681, 2004
21 Okada, S., Nakamura, M., Katoh, H., Miyao, T., Shimazaki, T., Ishii, K., Yamane, J., Yoshimura, A., Iwamoto, Y., Toyama, Y., Okano, H. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury, Nat Med, 12(7):829-834, 2006   DOI   ScienceOn
22 House,r C.R. Interneurons of the dentate gyrus: an overview of cell types, terminal fields and neurochemical identity. Prog Brain Res. 163: 217-232, 2007   DOI   PUBMED
23 洪元植. 精校黃帝內經素問. 서울, 東洋醫學硏究院, pp 37, 124, 196, 229, 217-218, .229, 1985
24 안준익, 이용성. Beta-amyloid의 분자생물학. 한양의대학술지, 21(1):11-16, 2001
25 錢鏡湖, 辨證奇問全書. 台北, 甘地出版社, pp 222-225, 233-235, 1990.
26 National Institute on Aging. National Institute on Health, Progress Report on Alzheimer's Disease, 1999
27 김영진. 蔘笭白朮散의 Indomethacin 유도 위점막손상에 미치는 抗酸化效果, 동국대학교 대학원, 1998
28 Kuhl, D.E., Koeppe, R.A., Minoshima, S., Snyder, S.E., Ficaro, E.P., Foster, N.L., Frey, K.A., Kilbourn, M.R. In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease. Neurology. 52(4):691-699, 1999   DOI   PUBMED   ScienceOn
29 李尙仁 외. 방제학. 서울, 영림사, p 278, 1999.
30 陳士鐸. 石室秘錄. 北京, 中國中醫藥出版社, p 125, 1991
31 Villarroya, M., Garc$\a, A.G., Marco-Contelles, J., L$\pez, M.G. An update on the pharmacology of galantamine. Expert Opin Investig Drugs. 16(12):1987-1998, 2007   DOI   ScienceOn
32 北京中醫學院中藥方劑敎硏組, 湯頭歌訣白話解, 北京, 人民衛生出版社, pp 56-57, 1995
33 이광우. 임상신경학. 서울, 고려의학, pp 203-208, 2002
34 Selkoe, D.J. Deciphering the genesis and fate of amyloid β-protein yields novel therapies for Alzheimer disease. J Clin Invest. 110(10):1375-1381, 2002.   DOI
35 서규태. 鹿茸大補湯이 $\beta$-amyloid로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響. 대구한의대학교 대학원, 2007
36 대한치매학회. 치매 임상적 접근. 서울, 아카데미아, pp23-24, 30-34, 201, 233-236, 2006
37 이병훈, 박선영, 최철홍, 이은경, 정대규. 紫河車 藥鍼이 $\beta$A로 유도된 Alzheimer's Disease 병태 모델에 미치는 영향. 동의생리병리학회지 19(2):41-64, 2008
38 Vassar, R. Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer's disease, Neuron, 54(5):671-673, 2007   DOI   PUBMED   ScienceOn
39 Leung, L.S., Shen, B., Nagalingam, N. and Ma, J. Cholinergic Activity Enhances Hippocampal Long-Term Potentiation in CA1 during Walking in Rats J. Neurosci.. 23: 9297-9304, 2003
40 Raschetti, R., Albanese, E., Vanacore, N., Maggini, M. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials. PLoS Med. 4(11):338, 2007   DOI   ScienceOn
41 Paradis, S., Sacchetti, B., Balduzzi, M., Gaudi, S., Malchiodi-Albedi, F. Astrocyte modulation of in vitro $\beta$-amyloid neurotoxicity. Glia. 46(3):252-260, 2004   DOI   ScienceOn
42 김현주, 이상룡. 加味補陽還五湯과 八味合聰明湯의 microglia 보호, 항산화 및 acetylcholinesterase 억제 효과. 동의신경정신과학회지 19(2):65-75, 2008
43 Blennow, K., de Leon, M.J., Zetterberg H. Alzheimer's disease. Lancet. 368(9533):387-403, 2006   DOI   ScienceOn
44 陳師文. 中醫學大系, 太平惠民和劑局方. 서울, 도서출판 鼎談, 9(147):537, 1990.
45 Downey, D. Pharmacologic management of Alzheimer disease. J Neurosci Nurs. 40(1):55-59, 2008   DOI
46 Banker G., Goslin, K. Culturing nerve cells, second edition. MIT Press, Cambridge, USA, 2002
47 Oh, M.M., Power, J.M., Lucien, T., Thompson, Pamela, L., Moriearty, John F. Disterhoft. Metrifonate Increases Neuronal Excitability in CA1 Pyramidal Neurons from Both Young and Aging Rabbit Hippocampus. J. Neurosci.. 19: 1814-1823, 1999   DOI
48 許浚. 東醫寶鑑. 서울, 법인문화사, p 1158, 1999
49 徐㚆霖 외 2인. 脾胃理論與臨床, 湖南, 湖南科學技術出版社, pp 28-36, 69-85, 121, 127-147, 1990
50 Bierer, L.M., Haroutunian, V., Gabriel, S., Knott, P.J., Carlin, L.S., Purohit, D.P., Perl, D., Dchmeridler, J., Kanof, P. and Davis, K.L. Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. Journal of Neurochemistry. 64: 749-760, 1995   DOI   PUBMED
51 Trabace, L., Cassano, T., Steardo, L., Pietra, C., Villetti, G., Kendrick, K.M., Cuomo, V. Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease, J Pharmacol Exp Ther. 294(1):187-194, 2000
52 송호철, 김성훈. 加味蔘笭白朮散 hexane세분획의 抗轉移 및 혈관형성억제작용에 대한 연구. 동의생리병리학회지. 15(6):967-974, 2001