• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.5
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• pp.1716-1729
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• 2010

In this paper, we deal with a hierarchical ring-mesh optical network design problem. The objective is to minimize the total cost of optical add-drop multiplexers (OADMs) handling intra-ring traffic, optical cross-connects (OXCs) handling inter-ring traffic, and cabling cost among OADMs and among OXCs, while satisfying intra-ring and inter-ring capacities. We develop an integer programming (IP) formulation for the problem and devise some cutting planes that partially break the symmetry of rings. Dealing with the inherent computational complexity of the problem, we devise an effective heuristic procedure that finds a good quality feasible solution within reasonable computing times. Computational results demonstrate the efficacy of the proposed solution procedure; the developed symmetry breaking inequalities significantly reduce the computing time to find an optimal solution for small size problems, and the heuristic procedure finds a better feasible solution than that CPLEX, a commercial optimization software, finds for large size problems.

• The Journal of Society for e-Business Studies
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• v.19 no.1
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• pp.15-42
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• 2014

Cloud storage service has the potential to be a core infrastructure for the future mobile and Internet service; thus related service providers have been investing in it and trying to attract as many users as possible. In addition, those need to find out what motivates the users to keep using their service not only to attract new customers but also to secure their subscribers. Therefore, this study will examine its relationship with user's motivation based on the extended TAM model with external variables for objective research about continuous use of cloud storage service. As a result, it was found that personal innovativeness, self efficacy, functional attributes, and psychological switching cost influence the continuous use of cloud storage service. Also, it is expected they can guide service providers to the right track when setting up their business strategy in the future.

• Journal of the Korea Institute of Building Construction
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• v.13 no.6
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• pp.585-593
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• 2013

For a successful construction project, systematic and objective decision-making is a prerequisite from the planning and designing stages. However, previous LCC analysis methods have focused only on simple cost savings and the accompanying economic efficacy while missing the environmental aspects of a structure. Although recently, a new approach of integrated $CO_2$ analysis has been introduced, which is more advanced than the existing simple LCC methods, it is difficult to collect all of the data necessary for each evaluation item since the product-specific cost is not presented under the LCC. In this research, cost evaluation items were selected by relatively high weights and items with heavy influence over a decision-making process in order to suggest an LCC-LCA integrated analysis model that is useful in comprehensively assessing the economic cost and environmental cost throughout the whole life cycle of a structure. The developed LCC-LCA integrated analysis model was applied to actual practices and compared with previous methods to test the model's effectiveness.

• The Korean Journal of Pesticide Science
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• v.2 no.3
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• pp.36-44
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• 1998

To develope cost-effective new granular formulation of mixture with 7.0% chlomethoxyfen and 3.5% butachlor, this study was conducted by investigation of floatability, dispersibility or collapsability and released concentration of active ingredients in water and bio-efficacies of the granules formulated by different formulation methods compared to commercial pellet-extruded granules. They were formulated by coating on or impregnation into extruded pellets, sands and zeolites with two active ingredients, binders, friction reducer, dispersing agents and bentonite. Pellet-coated method showed similar floatability, collapsability and bio-efficacy to the commercial pellet-extruded one or better than that but unstable patterns of released concentration of chlomethoxyfen because of easy isolation of coated technical particles from the surface of granules. Sand-coated methods showed similar physical properties, released pattern of two active ingredients, and bio-efficacy to the commercial one. Liquid binders and/or dispersing agents are more important than powdered ones to control released concentration of active ingredients from the granule mixtures, to improve the floatability and dispersibility, and to show good bio-efficacy. Sand-coated one might be a suitable method if types and amount of liquid binders and dispersing agents are selected.

• Applied Biological Chemistry
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• v.29 no.1
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• pp.90-95
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• 1986

A comparative study of chemical characteristics, efficacy and relative merits of extruded and coated granules, containing fungicide and insecticide, was conducted under laboratory and field conditions. Probenzole (3-allyloxy-1,2-benzisothiazole 1,1-dioxide) and carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methyl carbamate) were chosen as toxicants for rice blast(Pyricularia oryzae) and brown planthopper (Nilaparvata lugens) control, respectively. Stability of active ingredients in coated granule was superior to the extruded one under accelerated temperature. Active ingredient dissolution of coated one into distilled water showed slow release pattern. Pesticide residues in rice (Oryzae sativa, Chucheongbyeo) shoot applied with extruded one at the dosage of 3kg/10a retained higher levels than those with coated one on two days after application, while the residue levels were a reversed tendency on eight days after application. Efficacy on rice blast exhibited minute differences between the granules, on the other hand efficacy on brown planthopper by coated one was of higher rank than that by extruded one. Production cost of the combined pesticide granule by coating method could be cut down by 6% as compared to extrusion method.

• Information Systems Review
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• v.25 no.4
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• pp.27-45
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• 2023

The importance of information security has grown alongside the development of information and communication technology. However, companies struggle to select suitable countermeasures within their limited budgets. Sönmez and Kılıç (2021) proposed a model using AHP and mixed integer programming to determine the optimal investment combination for mitigating information security breaches. However, their model had limitations: 1) a lack of objective measurement for countermeasure efficacy against security threats, 2) unrealistic scenarios where risk reduction surpassed pre-investment levels, and 3) cost duplication when using a single countermeasure for multiple threats. This paper enhances the model by objectively quantifying countermeasure efficacy using the beta probability distribution. It also resolves unrealistic scenarios and the issue of duplicating investments for a single countermeasure. An empirical analysis was conducted on domestic SMEs to determine investment budgets and risk levels. The improved model outperformed Sönmez and Kılıç's (2021) optimization model. By employing the proposed effectiveness measurement approach, difficulty to evaluate countermeasures can be quantified. Utilizing the improved optimization model allows for deriving an optimal investment portfolio for each countermeasure within a fixed budget, considering information security costs, quantities, and effectiveness. This aids in securing the information security budget and effectively addressing information security threats.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.11a
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• pp.51-66
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• 2006

The field of cytochrome P450 pharmacogenomics has progressed rapidly during the past 25 years. Recently, conjugating enzymes including sulfotransferase, acetyltransferase, glucuronosyltransferase and glutathione transferase have been also extensively studied. All the major human drug-metabolizing P450 enzymes and some conjugating enzymes have been identified and cloned, and the major gene variants that cause inter-individual variability in drug response and are related to adverse drug reactions have been identified. This information now provides the basis for the use of predictive pharmacogenomics to yield drug therapies that are more efficient and safer. Today, we understand which drugs warrant dosing based on pharmacogenomics to improve drug treatment. It is anticipated that genotyping could be used to personalize drug treatment for vast numbers of subjects, decreasing the cost of drug treatment and increasing the efficacy of drugs and health in general. It is assumed that such personalized P450 gene-based treatment which is so-called tailor(order)-made drug therapy would be relevant for 10-20% of all drug therapy in the future.

• Bulletin of the Korean Chemical Society
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• v.33 no.5
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• pp.1593-1596
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• 2012

A new enzyme immobilization method based on hydrophobic interaction between supporting material and enzyme has been successfully developed. The efficacy of the new technique has been investigated by loading a horse radish peroxidase (HRP) enzyme on the surface of conducting polymer-silica composites and by measuring the enzyme activity and leaching property of HRP loaded within polymer-silica composites. The immobilized HRP enzyme showed activity profiles similar to that of free HRP in phosphate buffer (pH 6). Above all, HRP adsorbed on the polymer-silica composites has showed excellent stability over 10 days, compared to HRP adsorbed on the pristine silica. It is thought that with appropriate optimization works, the present method would be used as a cost-effective and facile route for the immobilization of biomolecules.

• Structural Engineering and Mechanics
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• v.11 no.5
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• pp.535-546
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• 2001

A new p-adaptive analysis scheme for hp-clouds method is presented. In the scheme, refined global equations are resolved into two parts, one of them being related to the newly appended dof's. The solution obtained in previous analysis step is reflected in the force vector. The size of the p-adaptive equation consisting of the newly appended dof's is much smaller than the original equation. Consequently, the computational cost is drastically decreased. Through numerical examples, the efficiency and efficacy of the method in comparison with the existing p-refinement scheme of the hp-clouds have been demonstrated.

• Korean Journal of Biological Psychiatry
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• v.1 no.1
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• pp.7-16
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• 1994

I will try to serve as the basis for the development of a clinical therapeutic guideline of antipsychotic drugs. Knowing that many patients fail standard treatment recommendations, either because of insufficient efficacy or intolerance to adverse effects, led us to emphasize the importance of the guideline. The clinicians continually assimilate new information about recent advances, including : novel agents targeted to impact specific components of various neurotransmitter systems ; combination strategies ; alternative uses of existing agents ; and specialized requirements of a growing number of identified diagnostic subtypes. The cost to benefit ratio must always be considered when developing a therapeutic guideline.