• Journal of Microbiology and Biotechnology
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• v.28 no.4
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• pp.645-651
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• 2018

The carcinogenicity of chemicals in the environment is a major concern. Recently, numerous studies have attempted to develop methods for predicting carcinogenicity, including rodent and cell-based approaches. However, rodent carcinogenicity tests for evaluating the carcinogenic potential of a chemical to humans are time-consuming and costly. This study focused on the development of an alternative method for predicting carcinogenicity using quantitative PCR (qPCR) and colon cancer stem cells. A toxicogenomic method, mRNA profiling, is useful for predicting carcinogenicity. Using microarray analysis, we optimized 16 predictive gene sets from five carcinogens (azoxymethane, 3,2'-dimethyl-4-aminobiphenyl, N-ethyl-n-nitrosourea, metronidazole, 4-(n-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone) used to treat colon cancer stem cell samples. The 16 genes were evaluated by qPCR using 23 positive and negative carcinogens in colon cancer stem cells. Among them, six genes could differentiate between positive and negative carcinogens with a p-value of ${\leq}0.05$. Our qPCR-based prediction system for colon carcinogenesis using colon cancer stem cells is cost- and time-efficient. Thus, this qPCR-based prediction system is an alternative to in vivo carcinogenicity screening assays.

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.12
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• pp.1734-1741
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• 2016

This study was conducted to examine the effects of adding phytoncide oil extracted from Korean pine nut cone by-product to the diet of dairy cows on milk yield and compositions, fatty acid characteristics, complete blood count and stress response. A total of 74 Holstein cows were used for 30 days and divided into two groups. Each group was given a basal diet (C) or an experimental diet containing phytoncide additives at 0.016% (T) in feed. The results showed that phytoncide feeding had no effect on milk yield. In addition, there were no observed effects on milk composition, but the ratio of fatty acid in milk was significantly affected by the phytoncide diet, and it showed a positive effect. Not only were the major functional fatty acids, conjugated linoleic acid and eicosapentaenoic acid increased, but also ${\omega}6:{\omega}3$ fatty acid ratio was reduced in milk of T group (p<0.05). In blood analysis, the complete blood count showed no significant difference between C and T group on all parameters. However, the cortisol concentration was significantly decreased in T group compared to control (p<0.05). Taken together, we suggest that phytoncide oil does not have a great influence on the physiological changes, but can be a potential feed additive that improves the milk fatty acid and stress resilience in dairy cows. In addition, it will contribute to the development of feed resource, a reduction in feed cost and a lessening of environmental pollution.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.11
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• pp.3246-3252
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• 2009

The interest on the recovery of thermal energy using the waste has been rising to solve the problems of continuous increase of waste generation and the depletion of the fossil fuel recently. The incineration has been used most popularly as a treatment process of the waste for the energy recovery. However, it is expected that incineration and design cost will increase in the treatment of air contaminant emitted from incinerator. This research has simulated the actual incinerator and the flue gas treatment system using the Aspen plus which is the software to simulate the chemical process. The incineration process is composed of the 1st and 2nd combustor to burn the waste, SNCR process to reduce the $NO_x$ using the urea, and the steam generation process to save the energy during incineration. The $Ca(OH)_2$ slurry was used as an acid gas (HCl, $SO_2$) treatment materials and the removal efficiency for the products from the neutralization of acid gas in SDA and combustion ash was simulated at the bag filter. The simulation result has been corresponded with the treatment efficiency of emitted gas from the actual industrial waste incinerator and it is presumed to be used to forecast the efficiencies of flue gas treatment system in the future.

• Journal of the Korean Association of Geographic Information Studies
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• v.21 no.3
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• pp.63-75
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• 2018

The purpose of this study is to analyze the effects of CCTV installation empirically in the economic and spatial aspects(crime displacement and diffusion effects of crime control benefits), targeting S city in Korea. In terms of economic effects, caused by CCTV installation(2012 and 2013), cost benefit analysis was conducted by means of CCTV installation costs, crime cases, and crime costs per case. The result shows that there is positive effect of 1.34(34%) in 2012. This is slightly higher than the previous study results in Korea(cost effectiveness 1.32), but a little lower than the USA cases(cost effectiveness 1.49). In the case areas in S city, the result proves that the new CCTV has gained economic profit through the crime reduction, compared to the installation expences. However, the cases in 2013 shows no economic profit effect. Secondly, an analysis was conducted in the spatial aspect(crime displacement and diffusion effects of crime control benefits) by using the analysis tool of crime displacement value called WDQ. The results are summarized as follows: The total crimes in three regions had crime diffusion effect but it was less than the direct effect, while in one region, displacement effect was found, but they were less than direct effect. In the case of theft and violence, CCTV had a positive effect, except for one region. The results of the analysis were totally different. Judging from this difference, it may conclude that the effects of CCTV are different by the types of crimes and the places of crimes. The results of this study is meaningful in that it examined and evaluated the effects of the CCTV by scientific and rational measurement tools where previous studies are not many. In addition, it has policy implication for the validity of CCTV and making effective installation plan for crime reduction and prevention.

• Korean journal of applied entomology
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• v.52 no.2
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• pp.115-123
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• 2013

A microbial insecticide "Bt-Plus" has been developed to enhance an insecticidal efficacy of an entomopathogenic bacterium, Bacillus thuringiensis (Bt). However, its wettable powder formulation is not preferred by farmers and industry producers due to relatively high cost. This study aimed to develop a soluble concentrate formulation of Bt-Plus. To this end, an optimal mixture ratio of two bacterial culture broths was determined to be 5:4 (v/v) of Bt and Xenorhabdus nematophila (Xn) along with 10% ethanol preservative. In addition, Bt broth was concentrated by 10 times to apply the mixture at 1,000 times fold dilution. The resulting liquid formulation was sprayed on cabbage crop field infested by late instar larvae of the diamondback moth, Plutella xylostella. The field assay showed about 77% control efficacy at 7 days after treatment, which was comparable to those of current commercial biopesticides targeting P. xylostella. For storage test in both low and room temperatures, the liquid formation showed a relatively stable control efficacy at least for a month. To develop a quality control technique to exhibit a stable control efficacy of Bt-Plus, Bt spore density ($5{\times}10^{11}$ spores/mL) and eight active component concentrations of Xn bacterial metabolites in the formulation products have been proposed in this study.

• Aerospace Engineering and Technology
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• v.4 no.1
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• pp.211-220
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• 2005

The purpose of this study is to examine the image-based atmospheric correction models using the data from Landsat Enhanced Thermal Mapper Plus (ETM+) that have quite similar spectral characteristics to the forthcoming KOrea Multi-Purpose SATellite (KOMPSAT)-2 Multi-Spectral Camera (MSC), and the in-situ measured surface reflectance data during satellite overflight. The main advantage of this type of correction is that it does not require in-situ measurements during each satellite overflight. While substantial differences are present between Top-Of-the Atmosphere (TOA) reflectance and in-situmeasurements, the results showed that Case 1 based on COST model gives most accurate results among three cases. The accuracy of Case 2_1 is very close to Case 1 and its values are smaller than in-situ data. No notable features appear between some bands in the Case 3_1 and in-situ data. It is expected from this study that if the current methods are applied to the IKONOS high resolution data, we will be able to develop the suitable atmospheric correction methods for MSC data.

• Journal of Environmental Policy
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• v.9 no.2
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• pp.135-155
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• 2010

The purposes of the paper are to estimate welfare change from water quality degradation by using contingent valuation method in Namdae stream of Gangrung and identify what factors of Namdae stream are important to Gangrun citizens. The study results show their total WTP per year and per household, \117,040 to improve Namdae stream quality from grade 3 to grade 1, including monetary WTP \87,502 plus opportunity cost of volunteering time for protection campaign, \29,538. The amount of total welfare change from water quality degradation based on the total WTP estimated above is calculated to be \27 billion of which the amount, as a sort of damage cost from water quality degraded, is so huge. All projects and policies related to natural environments, therefore, should consider both indirect and direct effects from them because natural environments have the irreversibility once degraded or deteriorated and would ultimately be influential on humans, both current and future generations, with tremendous amounts of time and costs beyond our imagination.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.8
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• pp.3777-3784
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• 2011

This paper examines into the influence of the public servants' perception of tourism industry on their understanding of importance of the tourism industry. For a study, the positive analysis was carried out which the public servants' perception of tourism industry was different in accordance with the satisfaction of tourism policy. The result of the analysis showed that the benevolent influence of the public servants' perception of tourism industry had a significant effect on the satisfaction of tourism policy and the cost of tourist influence had no significance of itself. It has been shown that both the influence of the public servants' perception of tourism effect on their understanding of importance of the tourism industry and that of the benevolence of the tourist influence on the understanding for the importance of tourism industry showed had plus(+) effects. Especially, it has been shown that the influence of the cost of tourist effect on the understanding for the importance of tourism industry had a minus(-) effect.

• Journal of KIISE:Computer Systems and Theory
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• v.31 no.7
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• pp.402-413
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• 2004

This paper presents an Implementation of Korean standard 128-bit block cipher SEED for the small (8 or 16-bits) embedded system using a low-cost FPGA(Field Programmable Gate Array) chip. Due to their limited computing and storage capacities most of the 8-bits/16-bits small embedded systems require a separate and dedicated cryptography processor for data encryption and decryption process which require relatively heavy computation job. So, in order to integrate the SEED with other logic circuit block in a single chip we need to invent a design which minimizes the area demand while maintaining the proper performance. But, the straight-forward mapping of the SEED specification into hardware design results in exceedingly large circuit area for a low-cost FPGA capacity. Therefore, in this paper we present a design which maximize the resource sharing and utilizing the modern FPGA features to reduce the area demand resulting in the successful implementation of the SEED plus interface logic with single low-cost FPGA. We achieved 66% area accupation by our SEED design for the XC2S100 (a Spartan-II series FPGA from Xilinx) and data throughput more than 66Mbps. This Performance is sufficient for the small scale embedded system while achieving tight area requirement.

• Journal of Korean Society of Transportation
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• v.25 no.3
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• pp.145-154
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• 2007

Determining stop spacing is a very important process in transit system planning. This study is involved in an analytical approach to decide the transit stop spacing. Transit stop spacing should be longer as 1) user access speed, 2) user travel time, and 3) dwell time increase, and shorter as 1) passengers (boardings and alightings) and 2) headway increase. In this study, a methodology is proposed to determine transit stop spacing to minimize total cost (user cost plus operator cost) with irregular passenger distribution (boardings and alightings) Without considering in-vehicle passengers, the transit stop spacing should be shorter in the concentrated sections of the passenger distribution than in others to minimize total cost. Through the conceptual analysis, it is verified that the transit stop spacing could be longer as the in-vehicle passengers increase in certain sections. This study proposes a simple practical method to determine transit stop spacing and locations instead of a dynamic programming method which generally includes a complex and difficult calculation. If the space axis is changed to a time axis. the methodology of this study could be expanded to analyze a solution for the transit service (or headway) schedule problem.