• 한국의류학회지
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• 제32권7호
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• pp.1034-1045
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• 2008

The objectives of this study were to group female consumer types according to cosmetics benefits sought at online and off-line cosmetic shopping malls, and to investigate the differences in consumer values, cosmetic purchase behaviors, and demographic variables according to the consumer types. Subjects were 451 females residing in Seoul, of whom 212 were online shoppers and 239 were off-line shoppers. Five dimensions of cosmetics benefits sought were derived by factor analysis. These were functionality, economy, brand, fashion, and practicality. The female consumers were classified into four benefits sought types by cluster analysis of the five dimensions: T.1 'practicality sought type', T.2 'economy sought type', T.3 'brand function sought type', and T.4 'economic function sought type'. Economy sought consumers purchased cosmetics much more from online shopping malls than from off-line. The cosmetics expenses of practicality sought online consumers were low and many of them were in their 20's and middle-class. Economy sought online consumers preferred domestic brand, their cosmetics expenses were low, and many of them were career women. Practicality sought off-line consumers were high in independent value. Economy sought off-line consumers were low in independent value and social approval value, preferred domestic brand, and distributed more in college students than in career women. Brand function sought off-line consumers purchased cosmetics at department store and regarded social approval value as important. Economic function sought off-line consumers were distributed in middle-class and in diverse age range.

• 융합정보논문지
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• 제10권11호
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• pp.279-287
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• 2020

본 연구는 갈조류 중 하나인 회초리말의 기능성 화장품 원료로서 기능성을 알아보기 위하여, 항산화 실험 및 세포실험을 실시하였다. 항산화능 측정을 위해 회초리말을 70% 에탄올로 추출물을 제조하였다. 항산화 측정에는 DPPH와 ABTS 법을 사용하였으며, 각 실험에서 EC50값이 2.040과 2.182 mg/mL로 나타났다. 폴리페놀 함량과 환원능 측정에서는 103 mg gallic acid/g extract의 폴리페놀 함량과 134 mg ascorbic acid/g extract의 환원능이 나타났다. 세포실험에서는 MTT 법을 사용하여 해당 추출물이 세포독성이 없음을 나타내었으며, 100 ㎍/mL 농도에서 항염능과 미백능을 나타내었다. 결과적으로 수송나물 추출물은 미백 및 항염능을 가진 화장품 소재로서 사용가능함을 확인하였다.

• 한국포장학회지
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• 제28권3호
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• pp.171-174
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• 2022

화장품용 펌프는 복합재질의 내부 부품들과 복잡한 구조로 인하여 소비자들이 재질별로 분리 배출할 수 없는 구조를 이루고 있으며, 특히 금속 스프링을 사용하고 있어 재활용률이 현저히 떨어졌다. 하지만 최근 국내·외에서 환경오염으로 인한 다양한 규제 및 소비자의 인식 변화로 친환경적인 제품의 수요도 급격히 증가하고 있으며, 이에 따라 화장품 업계에서도 재활용률을 높이기 위해 다양한 시도가 진행되고 있다. 또한 아직 국내·외 플라스틱 화장품 용기의 재활용률이 20% 내외로 낮은 상황에서 친환경 화장품 용기 세계시장 선점과 국내 포장산업 활성화를 위해서는 기술적 차별화와 동시에 선진기업 수준의 품질 성능을 갖춘 화장품용 고성능 펌프의 개발이 필요하다. 따라서, 본 연구에서는 단일재질(PP)로 구성된 0.2 ml 고성능 펌프를 개발하였으며, 실험을 통해 감압 시 내용물의 누수와 용기 변형이 없으며, 누름강도 14.8~17.5N, 토출량 편차 2.3~8.8%, 초기 공타 4회로 기존 금속재 스프링을 사용한 복합소재펌프와 대등한 수준의 품질 성능을 확인할 수 있었다. 또한, 단일소재를 사용하였기 때문에, 향후 국내·외 친환경 화장품 용기 시장 점유율 확대와 함께 플라스틱 재활용률 향상에 기여할 것으로 기대된다.

• KSBB Journal
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• 제25권3호
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• pp.223-229
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• 2010

Fucoidans, polysaccharides that are composed of fucose, uronic acids, galactose and xylose, are one of the main constituents of brown seaweeds. For the past decade algal fucoidans have been extensively studied due to their biological activities including anticoagulant, antiinflammatory, antitumor, contraceptive and antiviral activities. Even though fucoidan is known as a highly functionality derivative, its industrial applications have been limited because of low inclusion efficiency and high cost of manufacturing. Furthermore the sea-weed smell of fucoidan has been a limiting factor for the application especially in food and cosmetic area. The potential application of various extraction technology and deodorization of sea-weed smell is highly required for a wider application of fucoidan. As an alternative extraction process, enzymatic hydrolysis process or ultra-high pressure treatment has been investigated for the improvement of production yield and bioefficacy of fucoidan. More intensive research on the fucoidan production technology and its application in nutraceutical and cosmoceutical area is needed.

• Journal of Applied Biological Chemistry
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• 제64권3호
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• pp.205-211
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• 2021

In order to test the functionality of Panax ginseng thioredoxin 1 (PgTRX1) isolated from fermented wild ginseng roots, a transient effect on physiological activity were performed over a short time frame using the Agrobacterium infiltration technique. The PgTRX1 gene isolated from fermented wild ginseng was confirmed to have a size of 579 bp, and the expression of PgTRX1 was the highest in the sample after 6 h of fermentation. As a result of constructing this gene and confirming the infiltration reaction mediated by Agrobacterium in tobacco leaves, it was found that the expression of the NbHSR203j gene was also induced as PgTRX1 expression increased. As a result of measuring the biological activity of the infiltration samples, the total phenol content increased by 35.45±1.84 to 49.01±1.84 ㎍ GAE/mL compared to the control, and the total flavonoid amount of 9.52±0.41 to 9.82±0.25 ㎍ QE/mL was slightly high. From these results, Agrobacterium-mediated PgTRX1 appears to be related to the hypersensitive response induction mechanism of plants and the production of secondary metabolites such as phenolic substances.

• 생명과학회지
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• 제26권5호
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• pp.608-613
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• 2016

최근 화장품에 쓰이는 방부제에 대한 피부 부작용이 보고되고 있다. 그 중에서 1,2-hexanediol (HD)는 방부기능과 보습기능을 가지고 있는 물질로 알려져 있는데, 본 연구에서는 보다 안전한 화장품용 소재를 개발하기 위하여 β-galactosidase (β-gal)을 함유하고 있는 대장균 세포를 이용한 transgalactosylation 반응을 통하여 1,2-hexanediol galactoside (HD-G)을 합성하는 연구를 수행하였다. 이 반응은 높은 농도의 lactose (300 g/l) 조건에서 24시간 동안 수행되었으며, 반응 시간이 12시간 지난 후부터 새로운 spot이 TLC 분석으로 확인되었다. 이 spot을 잠정적으로 HD-G로 추정한 후, 이 물질을 silica gel chromatography로 정제한 후, mass spectrometry 분석을 통하여, 이 물질이 HD-G의 sodium adduct ion ([M+Na]⁺, m/z=303.1423)임을 확인하였다. 추가적으로 정제된 HD-G를 시판되는 β-gal을 이용하여 가수분해하고, 유리된 단당류를 TLC로 분석하여 보았다. 이 때, galactose 한 분자가 HD-G로부터 유리 되는 것을 확인하였다. 결론적으로, 재조합 대장균 β-gal을 이용하여 HD로부터 HD-G이 합성되었음을 확인할 수 있었으며, 앞으로 추가연구를 통하여 항균력의 변화와 피부세포에 대한 세포독성 변화를 조사할 예정이며, 기능성에 변화가 없는 보다 안전한 화장품용 방부제가 개발되기를 기대하고 있다.

• 대한화장품학회지
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• 제43권3호
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• pp.239-245
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• 2017

노화는 생리학적으로 비가역적으로 일어나는 과정으로 노화가 진행됨에 따라 단백질의 산화화학반응 등으로 노화징후가 축적된다. 활성산소와 당화된 최종 당화산물(advanced glycation endproducts, AGEs 최종 당화산물)은 생체 조직과 세포를 공격하여 노화를 촉진한다고 알려져 있다. 본 연구에서는 항산화 물질로 알려진 aminoguanidine을 양성 대조군으로 anti-glycation 효과를 확인하였으며, methoxy PEG-45 thioctate(LA-PEG)를 농도별로 처리하여 anti-glycation 효과를 평가하였다. 실험결과 LA-PEG는 매우 우수한 anti-glycation 효과로 최종 당화산물(AGEs) 생성억제 활성이 매우 우수하게 나타났으며, 항산화 효과와 밀접한 연관을 나타냈다. 또, 세포노화 지표물질인 senescence-associated ${\beta}$-galactosidase ($SA-{\beta}-gal$) 활성을 사람 섬유아세포(HDF)를 이용하여 확인한 결과, LA-PEG를 처리하였을 때 염색된 세포의 수가 감소하여 세포의 senescence를 억제하는 것을 확인할 수 있었다. 본 연구결과, LA-PEG의 anti-glycation 효과 및 산화로 인한 단백질 손상에 대한 보호 효과가 우수하게 나타났으며, 항노화 화장품에 적용 시 효과적으로 적용할 수 있을 것으로 사료된다.

• 산업경영시스템학회지
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• 제43권2호
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• pp.72-78
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• 2020

Demand for cosmetics with functionality and eco-friendliness has increased dramatically due to recent aging, well-being trends, and increased interest in beauty. Cosmetics production in 2014 was 8,970.4 billion won, an increase of about 50% compared to 6,014.6 billion won in 2010. In the midst of this, similar companies in intense competition are pursuing differentiated strategies and innovation activities to solve quality, price and delivery problems. In particular, cosmetics packaging work is getting more difficult due to the increasing bill of materials (BOM) and difficult assembly methods. Therefore, in this study, the following problems were identified and suggestions for the improvement of the packaging Many research laboratories such as biotechnology, chemistry, and pharmaceuticals, which are undergoing various studies, are equipped with ready-made laboratory safety equipments such as bio-safety workbenches, aseptic bases, and exhaust workbenches. However, most researchers are disadvantaged in using existing safety equipment. This is because existing safety equipment can not take into account all of the unique characteristics of the research. For this reason, researchers are demanding the development of customized safety equipment that is well suited to their research needs. process of Company C, which is facing difficult situation to respond to the customer 's delivery due to the 52 - hour work week. First, we used the stopwatch to find the difficulty process in the packaging process and show ways to improve it. Second, to improve the efficiency of line balancing in the packaging process, we integrate processes, improve work methods, and perform simple automation. As a result, the prepare loss for replacement was reduced by 1 minute from 5 minutes, resulting in a 23% increase in productivity from 112 ea./hour to 137ea./ hour per person. At this time, the LOB of the packaging process was improved from 70% to 82% by operating one more production line through one person per line, total 9 people saving.

• Archives of Plastic Surgery
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• 제44권1호
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• pp.48-52
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• 2017

Background The ideal vaginoplasty must be successful functionally as well as have a natural appearance, and also must retain its functionality and appearance over the long term. Conventional vaginoplasty techniques have functional limitations and are associated with recurrent complications, but rectosigmoid vaginoplasty is known to have a high satisfaction rate due to its functional similarity with the vagina. We conducted the present study to assess the usability of rectosigmoid vaginoplasty over the course of long-term follow-up. Methods From March 1992 to February 2014, 84 patients were treated with rectosigmoid vaginoplasty; 44 had gender identity disorder, 29 had vaginal agenesis, 8 had female pseudohermaphroditism, and 3 had gynecologic malignancies after radical pelvic surgery. This retrospective study was based on a review of the patients' records, clinical examinations, complications, and questionnaires about appearance, function, and sexual intercourse. Results All patients who underwent rectosigmoid vaginoplasty were discharged within 2 weeks without surgical flap loss. The early complications were partial flap necrosis, difficulty in defecation, mucous hypersecretion, and postoperative ileus. The late complications were vaginal introitus contracture, vaginal prolapse, and difficulty in urination. The mean length and diameter of the neovagina 3.4 years after rectosigmoid vaginoplasty were 13.2 cm and 3.8 cm, respectively. On questionnaires about satisfaction, 70% of patients reported excellent satisfaction, 11% good, 12% fair, and 7% poor. Conclusions Rectosigmoid vaginoplasty is useful, safe, and well-accepted operative method with good functional and cosmetic results, such as natural lubrication and adequate vaginal length and width obtained without requiring the use of a dilator.

• 한국약용작물학회지
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• 제25권3호
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• pp.152-159
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• 2017

Background: In this study, examined the effects of an extract of a mixture of Angelica gigas, Cnidium officinale, Paeonia lactiflora, and Rehmannia glutinosa fermented by Leuconostoc mesenteroides, with enhanced value and functionality. In oriental medicine, a mixture of these herbs is called Samultang. Methods and Results: In this study, we evaluated the effects of a fermented extract of Samultang on oxidative stress, procollagen type I expression, and melanin production. Samultang was extracted with 70% ethanol, followed by inoculation with Leuconostoc mesenteroides to obtain the fermented extract. The evaluation of viability of B16F10 cells and human foreskin fibroblast (HHF) revealed that both ethanol and fermented extracts of Samultang were non-toxic. The results of 1,1-diphenyl-2-picrylhydrazyl (DPPH) test showed that the fermented extract of Samultang ($SC_{50}value=100{\mu}g/m{\ell}$) was a more effective DPPH free radical scavenger than its ethanol extract. In addition, procollagen type I expression was higher in cells treated with the fermented extract of Samultang than in cells treated with ethanol. In the non-toxic concentration range, the fermented extract of Samultang showed strong inhibitory effect on melanin production in ${\alpha}-melanocyte$ stimulatin hormone-stimulated B16F10 cells ($IC_{50}=37.9{\mu}g/m{\ell}$). Conclusions: These results suggest that the fermented extract of Samultang has considerable protential as a cosmetic ingredient owing to its antioxidant, anti-wrinkle, and whitening effects.