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검색결과 2,385건 처리시간 0.031초

Molecular and Functional Characterization of Monocot-specific Pex5p Splicing Variants, Using OsPex5pL and OsPex5pS from Rice (Oryza sativa)

  • Lee, Jung Ro;Jung, Ji Hyun;Kang, Jae Sook;Kim, Jong Cheol;Jung, In Jung;Seok, Min Sook;Kim, Ji Hye;Kim, Woe Yeon;Kim, Min Gab;Kim, Jae-Yean;Lim, Chae Oh;Lee, Kyun Oh;Lee, Sang Yeol
    • Molecules and Cells
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    • 제23권2호
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    • pp.161-169
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    • 2007

  • We identified two alternatively spliced variants of the peroxisomal targeting signal 1 (PTS1) receptor protein Pex5ps in monocot (rice, wheat, and barley) but not in dicot (Arabidopsis and tobacco) plants. We characterized the molecular and functional differences between the rice (Oryza sativa) Pex5 splicing variants OsPex5pL and OsPex5pS. There is only a single-copy of OsPEX5 in the rice genome and RT-PCR analysis points to alternative splicing of the transcripts. Putative light-responsive cis-elements were identified in the 5' region flanking OsPEX5L and Northern blot analysis demonstrated that this region affected light-dependent expression of OsPEX5 transcription. Using the pex5-deficient yeast mutant Scpex5, we showed that OsPex5pL and OsPex5pS are able to restore translocation of a model PTS1 protein (GFP-SKL) into peroxisomes. OsPex5pL and OsPex5pS formed homo-complexes via specific interaction domains, and interacted with each other and OsPex14p to form hetero-complexes. Although overexpression of OsPex5pL in the Arabidopsis pex5 mutant (Atpex5) rescued the mutant phenotype, overexpression of OsPex5pS only resulted in partial recovery.

  • KSCI

잔류자속을 고려한 변압기 보호용 수정 전류차동 계전방식 (A Modified Current Differential Relaying Algorithm for Transformer Protection Considered by a Remanent Flux)

  • 강용철;김은숙;원성호;임의재;강상희
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2003년도 추계학술대회 논문집 전력기술부문
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    • pp.262-265
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    • 2003

  • During magnetic inrush or over-excitation saturation of the core in a transformer draws a large exciting current. This can cause mal-operation of a differential relay. This paper proposes a modified current differential relay for transformer protection. In order to cope with the remanent flux at the beginning. the start of saturation of the core is detected and the core flux at the instant is estimated by inserting the differential current into a magnetization curve. Then, this core flux value can be used to calculate the core flux. The proposed relay calculates the core-loss current from the induced voltage and the core-loss resistance; the relay calculates the magnetizing current from the core flux and the magnetization curve. Finally, the relay obtains the modified differential current by subtracting the core-loss current and the magnetizing current from the conventional differential current. The proposed technique not only discriminates magnetic inrush and over-excitation from an internal fault, but also improves the speed of the conventional relay.

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TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G1- to S-phase transition

  • Wang, Yi-Dong;Bian, Guo-Hui;Lv, Xiao-Yan;Zheng, Rong;Sun, Huan;Zhang, Zheng;Chen, Ye;Li, Qin-Wei;Xiao, Yan;Yang, Qiu-Tan;Ai, Jian-Zhong;Wei, Yu-Quan;Zhou, Qin
    • BMB Reports
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    • 제41권10호
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    • pp.733-738
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    • 2008

  • Although previous studies have implicated a role for TC1 (C8orf4) in cancer cell proliferation, the molecular mechanism of its action is still largely unclear. In this study, we showed, for the first time, that the mRNA levels of TC1 were upregulated by mitogens (FBS/thrombin) and at least partially, through the ERK1/2 signaling pathway. Interestingly, the over-expression of TC1 promoted the $G_1$- to S-phase transition of the cell cycle, which was delayed by the deficiency of ERK1/2 signaling in fibroblast cells. Furthermore, the luciferase reporter assay indicated that the over-expression of TC1 significantly increased Cyclin D1 promoter-driven luciferase activity. Taken together, our findings revealed that TC1 was involved in the mitogen-activated ERK1/2 signaling pathway and positively regulated $G_1$- to S-phase transition of the cell cycle. Our results may provide a novel mechanism of the role of TC1 in the regulation of cell proliferation.

  • https://doi.org/10.5483/BMBRep.2008.41.10.733 인용 PDF

OCBT 멀티캐스트 프로토콜에서 core 노드의 분산 계층 위치 결정 (Distributed Hierarchical Location Placement of Core Nodes in the OCBT Multicast Protocol)

  • 황경호;조동호
    • 한국통신학회논문지
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    • 제25권1A호
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    • pp.90-95
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    • 2000

  • Ordered Core Based Tree (OCBT) 프로토콜에서 core 스위치의 위치는 성능에 영향을 끼치는 가장 중요한 요소이다. 본 논문에서는 여러 level의 core 스위치를 어디에 둘 것인가에 대한 방법을 연구한다. 제안된 알고리즘은 전체 네트워크는 3개의 논리적 계층-Small, Medium, Large-으로 나누어, 네트워크의 각 노드(라우터)들은 자기 이와의 다른 노드들로부터 자신의 노드까지의 최단경로 비용의 합을 계산한다. S지역에서 최소의 비용을 가지는 노드를 core노드로 만들고, 같은 M지역에 속한 S지역의 core 노드들은 다른 core 노드들로부터의 최단 경로 합을 계산해서 그 값이 가장 작은 노드가 레벨이 하나 높은 core 노드가 된다. 그리고 M지역에서의 core노드에서 같은 방법으로 가장 높은 레벨을 가지는 core노드를 정한다. 제안한 방법을 네트워크에서 core 노드를 정하는 두 가지 일반적인 방법과 비교한다. 첫 번째 방법은 random 방법으로 같은 수의 core 노드를 random하게 선정하는 방법이다. 두 번째 방법은 center 방법으로 각각의 S지역에서 중심에 가까운 노드를 core 노드로 만들고, M지역이나 L 지역에서의 core는 하위 레벨 core 중에서 해당 熾だ\ulcorner중심에 가까운 core로 결정한다. 시뮬레이션을 통하여 제안한 방법이 mean tree cost와 join latency관점에서 비교된 다른 방법들 보다 우월한 성능을 가지는 것을 확인할 수 있었다.

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