• The Korean Journal of Physiology and Pharmacology
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• v.25 no.5
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• pp.459-466
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• 2021

Cardiovascular disease (CVD) and its complications are the leading cause of morbidity and mortality in the world. Because of the side effects and incomplete recovery from current therapy, stem cell therapy emerges as a potential therapy for CVD treatment, and endothelial progenitor cell (EPC) is one of the key stem cells used for therapeutic applications. The effect of this therapy required the expansion of EPC function. To enhance the EPC activation, proliferation, and angiogenesis using dronedarone hydrochloride (DH) is the purpose of this study. DH received approval for atrial fibrillation treatment and its cardiovascular protective effects were already reported. In this study, DH significantly increased EPC proliferation, tube formation, migration, and maintained EPCs surface marker expression. In addition, DH treatment up-regulated the phosphorylation of AKT and reduced the reactive oxygen species production. In summary, the cell priming by DH considerably improved the functional activity of EPCs, and the use of which might be a novel strategy for CVD treatment.

• BMB Reports
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• v.57 no.1
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• pp.60-65
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• 2024

The CRISPR-Cas9 system has significantly advanced regenerative medicine research by enabling genome editing in stem cells. Due to their desirable properties, mesenchymal stem cells (MSCs) have recently emerged as highly promising therapeutic agents, which properties include differentiation ability and cytokine production. While CRISPR-Cas9 technology is applied to develop MSC-based therapeutics, MSCs exhibit inefficient genome editing, and susceptibility to plasmid DNA. In this study, we compared and optimized plasmid DNA and RNP approaches for efficient genome engineering in MSCs. The RNP-mediated approach enabled genome editing with high indel frequency and low cytotoxicity in MSCs. By utilizing Cas9 RNPs, we successfully generated B2M-knockout MSCs, which reduced T-cell differentiation, and improved MSC survival. Furthermore, this approach enhanced the immunomodulatory effect of IFN-r priming. These findings indicate that the RNP-mediated engineering of MSC genomes can achieve high efficiency, and engineered MSCs offer potential as a promising therapeutic strategy.

• Polymer Science and Technology
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• v.20 no.4
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• pp.328-337
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• 2009

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.382-383
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• 2013

Gate-controlled spin-orbit interaction parameter is a key factor for developing spin-Field Effect Transistor (Spin-FET) in a quantum well structure because the strength of the spin-orbit interaction parameter decides the spin precession angle [1]. Many researches show the control of spin-orbit interaction parameter in n-type quantum channels, however, for the complementary logic device p-type quantum channel should be also necessary. We have calculated the spin-orbit interaction parameter and the effective mass using the Shubnikov-de Haas (SdH) oscillation measurement in a GaSb two-dimensional hole gas (2DHG) structure as shown in Fig 1. The inset illustrates the device geometry. The spin-orbit interaction parameter of $1.71{\times}10^{11}$ eVm and effective mass of 0.98 $m^0$ are obtained at T=1.8 K, respectively. Fig. 2 shows the gate dependence of the spin-orbit interaction parameter and the hole concentration at 1.8 K, which indicates the spin-orbit interaction parameter increases with the carrier concentration in p-type channel. On the order hand, opposite gate dependence was found in n-type channel [1,2]. Therefore, the combined device of p- and n-type channel spin transistor would be a good candidate for the complimentary logic device.

• The Pure and Applied Mathematics
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• v.3 no.1
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• pp.33-40
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• 1996

A convergence structure defined by Kent [4] is a correspondence between the filters on a given set X and the subsets of X which specifies which filters converge to points of X. This concept is defined to include types of convergence which are more general than that defined by specifying a topology on X. Thus, a convergence structure may be regarded as a generalization of a topology. With a given convergence structure q on a set X, Kent [4] introduced associated convergence structures which are called a topological modification and a pretopological modification. (omitted)

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.451-451
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• 2012

Instead of a highly toxic CdSe and ZnScore-shell,InP/ZnSecore-shell quantum dots [1,2] were investigated as an active material for quantum dot light emitting diode (QD-LED). In this paper, aquantum dot light-emitting diode (QDLED), consisting of a InP/ZnS core-shell type materials, with the device structure of glass/indium-tin-oxide (ITO)/PEDOT:PSS/Poly-TPD/InP-ZnS core-shell quantum dot/Cesium carbonate(CsCO3)/Al was fabricated through a simple spin coating technique. The resulting InP/ZnS core-shell QDs, emitting near blue green wavelength, were more efficient than the above CdSe QDs, and their luminescent properties were comparable to those of CdSe QDs.Thebrightness ofInP/ZnS QDLED was maximumof 179cd/m2.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.11a
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• pp.702-704
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• 2020

연구자의 R&D활동은 연구기획에서부터 과제제안, 과제수행 및 실험, 연구자간 공유와 협업, 결과해석, 성과확산 및 성과관리 등에 이르기까지 다양한 영역에서 이루어지고 있다. 그러나 이러한 활동을 지원하는 통합서비스가 존재하지 않아 각각의 서비스를 찾아서 융·복합적으로 활용하기는 쉽지 않다. 본 연구에서는 R&D활동에 필요한 정보와 데이터, 서비스, 고성능 컴퓨팅 인프라를 연계·융합 활용할 수 있는 통합서비스 개발을 위한 방법을 제시한다. 그리고 통합서비스 개발 사례로 ScienceON을 소개한다.

• Journal of Distribution Science
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• v.16 no.6
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• pp.77-84
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• 2018

Purpose - The aim of this study was to analyze the educational needs of distribution company salespeople in core competencies for convergence and their general perception of convergence education. Furthermore, this study provides basic data on core competencies for convergence needed by them. Research design, data, and methodology - A survey was conducted on 104 distribution company salespeople who worked near Seoul, Korea to analyze the perceptions of their educational needs in core competencies for convergence education, according to their socio-demographic characteristics. The socio-demographic characteristics were gender, age, workplace size, education background, work experience and business category. The questionnaire consisted of demographic factors (7 questions), general perception of convergence education (5 questions), perception of importance of core competency for distribution company salespeople (9 questions), and current perception of distribution company salespeople on core competency of convergence workers (9 questions). Park et al.(2014)'s categorization of convergence core competencies was used: Cognitive convergence (creative thinking, critical thinking and understanding of convergence knowledge), convergence performance (problem solving, communications, collaboration and application of convergence tools) and attitude toward convergence (empathy and responsibility). Data was collected through an independent sample of t-tests and a one-way analysis of variance and the Borich Needs Assessment Model was used to identify the educational needs of distribution company salespeople in the core competencies of convergence education. Results- The results show that the subjects recognized the need for convergence education to be high among the general perceptions. The perception scores for workers of different backgrounds only varied according to the size of the business. Moreover, the results of the educational needs analysis and the ranks of the required core competencies of convergence workers by the subjects were as follows: 1. convergence knowledge understanding competency, 2. creative thinking competency, 3. convergence tool application competency, 3. communications competency, 4. problem solving competency, 5. collaboration competency, 6. critical thinking competency, 7. empathy competency, 8. responsibility competency. Conclusions - This study highlights the necessity of developing university curriculum that can nurture the core competencies of conversion education reflecting distribution company salespeople's requests as well as cultivating qualified convergence workers required by distribution company workers.

• Korean Journal of Agricultural Science
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• v.48 no.3
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• pp.367-375
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• 2021

The aim of this study was to identify the factors contributing to the auction price and total price of carcasses by using squared semi-partial correlation of carcass traits. The data used in this study were the carcass grades assigned to 7,145 head of Hanwoo slaughtered from 2013 to 2018 in Gyeonggi province and 106,779 head of Hanwoo slaughtered from 2013 to 2018 outside of Gyeonggi province. The rankings of the carcass traits contributing to the auction price were in the order of marbling score (86.70%), backfat thickness (10.42%), eye muscle area (1.40%), and carcass weight (0.92%) in Gyeonggi province. In Hanwoo slaughtered outside of Gyeonggi province, the rankings were in the order of marbling score (88.53%), backfat thickness (9.06%), eye muscle area (1.24%), and carcass weight (0.99%). The rankings of carcass traits contributing to the total price were in the order of marbling score (45.95%), carcass weight (45.60%), backfat thickness (6.49%) and eye muscle area (0.77%) in Gyeonggi province. In Hanwoo slaughtered outside Gyeonggi province, the rankings were in the order of marbling score (49.64%), carcass weight (43%), backfat thickness (5.86%), and eye muscle area (0.66%). Gyeonggi province Hanwoo had thinner backfat thickness than Hanwoo outside Gyeonggi, and it had a higher contribution to auction price and total price. Collectively, Hanwoo in Gyeonggi province showed higher contribution scores for backfat thickness. This study aimed to provide basic information to guide Hanwoo breeding and increase profits for Hanwoo farms through the analysis of each traits according to environmental factors.

• Journal of Science Education
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• v.38 no.2
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• pp.376-400
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• 2014

This study aims to examine the current status of Korean and overseas science and arts convergence programs in and out of schools to apply them in school education settings and to learn about the characteristics of overseas programs through case studies. In addition, it explores implications of the current domestic and overseas for implementation in schools. For this study, we selected 193 domestic in-school science and arts convergence programs and 106 domestic out-of-school programs. For the overseas programs, we selected those conducted by the government, research institutes, science halls, and art galleries. We also analyzed the domestic in-school programs by type of students, operation hours, areas of convergence, and the function and role of arts activities. We analyzed domestic out-of-school programs by operation time, operation method, areas of convergence, and type of activities. Moreover, we examined the overseas programs in terms of their program developers, goals, and characteristics. These findings suggest that in order for science and arts convergence education to become well established in Korean schools, it is necessary to develop programs that can be incorporated into the present science education curriculum, rather than individual content or a single class on science and arts convergence, and to diversify the range of programs. In addition, out-of-school programs should be actively considered, and intense discussions on the use of program activities and teaching materials are needed. Finally, research institutes and educational institutions should be closely linked to achieve a common goal.