• Molecules and Cells
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• v.39 no.6
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• pp.508-513
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• 2016

To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-1-${\beta}$ (IL-1-${\beta}$) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb induced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.

• Journal of the Korea Concrete Institute
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• v.17 no.2 s.86
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• pp.293-302
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• 2005

This study describes data from determination of the optimum mix proportion and site application of the mass concrete placed in bottom slab and side wall having a large depth and section as main structures of LNG in-ground tank. This concrete requires low heat hydration, excellent balance between workability and consistency because concreting work of LNG in-ground tank is usually classified by under-pumping, adaptation of longer vertical and horizontal pumping line than ordinary pumping condition. For this purpose, low heat Portland cement and lime stone powder as cementitious materials are selected and design factors including unit cement and water content, water-binder ratio, fine aggregate ratio and adiabatic temperature rising are tested in the laboratory and batch plant. As experimental results, the optimum unit cement and water content are selected under $270kg/m^3$ and $l55{\~}l60 kg/m^3$ separately to control adiabatic temperature rising below $30^{\circ}C$ and to improve properties of the fresh and hardened concrete. Also, considering test results of the confined water ratio($\beta$p) and deformable coefficient(Ep), $30\%$ of lime stone powder by cement weight is selected as the optimum replacement ratio. After mix proportions of 5cases are tested and compared the adiabatic temperature rising($Q^{\infty}$, r), tensile and compressive strength, modulus of elasticity, teases satisfied with the required performances are chosen as the optimum mix design proportions of the side wall and bottom slab concrete. $Q^{\infty}$ and r are proved smaller than those of another project. Before application in the site, properties of the fresh concrete and actual mixing time by its ampere load are checked in the batch plant. Based on the results of this study, the optimum mix proportions of the massive concrete are applied successfully to the bottom slab and side wall in LNG in-ground tank.

• Journal of KIISE:Databases
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• v.28 no.3
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• pp.395-405
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• 2001

In this paper, we analyze workflow management system in programming language aspects. Many workflow characteristics such as workflow relevant data, workflow control structures, and workflow application invocations are studied and compared with those of distributed parallel programs. Although there exist minor differences between them, we found that there exist surprisingly many analogies between them. Based on this observation, we suggest to view workflow management system as distributed parallel program development platform. This new view on workflow management system provides users consistent view on workflow and workflow management system and with this view workflow management system designer can cope with arbitrary requests from the users keeping design consistency. Moreover the analogy between workflow and program provides a basis to apply program analysis techniques to the analysis of workflow.

• The KIPS Transactions:PartA
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• v.14A no.4
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• pp.215-226
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• 2007

For past years, many distributed virtual shared-memory(DVSM) systems have been studied in order to develop a low-cost shared memory system with a fast interconnection network. But the DVSM needs a lot of data and control communication between distributed processing nodes in order to provide memory consistency in software, and this communication overhead significantly dominates the overall performance. In general, the communication overhead also increases as the number of processing nodes increase, so communication overhead is a very important performance factor for developing a large-scale DVSM system. In this paper, we study the performance scalability quantitatively and qualitatively for developing a large-scale DVSM system based on the next generation interconnection network, called the InfiniBand. Based on the study, we analyze a performance requirement of the next-coming interconnection network to be used for developing a performance-scalable DVSM system in the future.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2000.11a
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• pp.1-2
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• 2000

In chip plating, several parameters must be taken into consideration. Current density, solution concentration, pH, solution temperature, components volume, chip and media ratio, barrel geometrical shape were most likely found to have an effect to the process yields. The 3 types of barrels utilized in chip plating industry are the onventional rotating barrel, vibrational barrel(vibarrel), and the centrifugal type. Conventional rotating barrel is a close type and is commonly used. The components inside the barrel are circulated by the barrel's rotation at a horizontal axis. Process yield has known to have higher thickness deviation. The vibrational barrel is an open type which offers a wide exposure to electrolyte resulting to a stable thickness deviation. It rotates in a vertical axis coupled with multi-vibration action to facilitate mixed up and easy transportation of components. The centrifugal barrel has its plated work centrifugally compacted against the cathode ring for superior electrical contact with simultaneous rotary motion. This experiment has determined the effect of barrel vibration intensity to the plating thickness distribution. The procedures carried out in the experiment involved the overall plating process., cleaning, rinse, Nickel plating, Tin-Lead plating. Plating time was adjusted to meet the required specification. All other parameters were maintained constant. Two trials were performed to confirm the consistency of the result. The thickness data of the experiment conducted showed thatbthe average mean value obtained from higher vibrational intensity is nearer to the standard mean. The distribution curve shown has a narrower specification limits and it has a reduced variation around the target value. Generally, intensity control in vi-barrel facilitates mixed up and easy transportation of components. However, it is desirable to maintain an optimum vibration intensity to prevent solution intrusion into the chips' internal electrode. A cathodic reaction can occur in the interface of the external and internal electrode. 2H20 + e $\rightarrow$M/TEX> 20H + H2.. Hydrogen can penetrate into the body and create pressure which can cause cracks. At high intensity, the chip's motion becomes stronger, its contact between each other is delayed and so plating action is being controlled. However, the strong impact created by its collision can damage the external electrode's structure there by resulting to bad plating condition.

• Journal of Korean society of Dental Hygiene
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• v.15 no.2
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• pp.319-324
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• 2015

Objectives: The purpose of this study was to verify the oral environmental change in using the natural oral cleaner containing propolis and prevention effect of oral disease. Methods: The subjects were 60 university students in Gangwon province. The groups consisted of 30 students of experimental group and 30 students of control group. The subjects were those who did not take the antipsychotic, diuretic, antihistamine, and anesthetic. The students rinsed their mouth with propolis mixture of oral cleanser for 4 weeks after receiving informed consent from October 1 to November 2, 2012. Collected saliva was measured for amount, salivary consistency, pH, plague index, gingival index, and halitosis. Results: The amount of salivary in propolis mixture of oral cleansing group remarkably increased (t=2.16, p<0.05). pH was alkaline in the group with oral cleaner containing the propolis (t=2.80, p<0.01). The bad breath remarkably decreased in the group with oral cleaner containing the propolis (t=-5.77, p<0.001). Conclusions: The use of the oral cleaner containing the propolis increased the amount of salivary and pH. The use of oral cleaner containing the propolis reduces halitosis and maintains good quality of oral hygiene.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.2
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• pp.672-677
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• 2014

The purpose of this study is to analyze the advertising regulations for juvenile protection, find their problems and suggest the alternatives for their improvements. All media products harmful to juveniles including advertising are regulated by the Juvenile Protection Act. The regulations related with advertising for juvenile protection of the Special Act on Safety Control of Children's Dietary Life, the Broadcasting Advertising Review Regulations and the National Health Improvement Act were analyzed. The results were: 1)the weaknesses of the implementation of the regulations with lack a little consistency and a lack of objectivity; 2)the necessity of the newly established articles with the times; and 3) the urgency of the establishment of alcohol advertising regulations. In conclusion, it has been suggested that the integrated advertising regulations or guidelines by the unitary review board should be implemented.

• Proceedings of the Korea Society of Poultry Science Conference
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• 2003.11a
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• pp.105-106
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• 2003

This study was conducted to investigate the effects of supplemental Lactobacillus with drinking water on growing performance, nutrients digestibility, intestinal microflora, fecal NH3-N and VFA of broiler chicks. Four hundreds and eighty one day broiler chicks were divided into no supplement (none) and three drinking water, 10$^{6}$ (T1), 10$^4$(T2) and 10$^2$ cfu/ml water(T3) with Lactobacillus reuteri for five week. Weight gain of T2 was the highest in all treatments(P＜0.05), and other supplements also tended to increase but there were not significantly difference compared to the none. Feed intake and feed conversion were not statistically different of all treatments. Dry Matter digestibility of Lactobacillus treatments was tended to improve compared to that of none, but was not significantly different. Protein and fat digestibility were also tended to Improve In Lactobacillus treatments relative that of control(P＜0.05), whereas ash digestibility was not consistency. Total Lactobacillus spp. of birds fed Lactobacillus was significantly higher in cecum at five weeks(P＜0.05), but was not different at ileum. E. coli and Salmonella were not difference by treatments. In conclusion, feeding Lactobacillus increase performance and nutrients digestibility of broiler chicks and Improve environments of house.

• Korean Journal of Veterinary Research
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• v.51 no.2
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• pp.151-158
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• 2011

The study evaluated whether a transgenic carrot vaccine could induce a K88-specific immune response in sows and whether the resultant maternal antibody could protect piglets against enterotoxigenic Escherichia coli (ETEC) K88ac infection. Sows (n = 15) selected randomly from a farm in Korea were assigned to three groups (n = 5 per group: control [untreated]), group A (orally inoculated with a nontransgenic and transgenic carrot vaccines at 2 and 4 weeks ante partum, respectively), and group B (conventionally vaccinated according to the manufacturer's instructions). After 7 days of lactation, 5 piglets selected randomly from each group were challenged with $1{\times}10^{10}$ colony forming units/mL ETEC K88ac. Group C had the lowest mean fecal consistency score on post-challenge days 1 and 7. Histiologically, On post-challenge day 7, group C showed an increased duodenum and ileum villus:crypt ratio, compared to group A in the duodenum, with group B displaying the highest ratio. Groups B and C had more increased villus width than group A in the jejunum. Group C displayed the greatest increase in villus width in the ileum. The colostrums and serum from groups B and C displayed higher concentrations of IgA and IgG against ETEC K88, compared to group A. Based on the results, it was concluded that the transgenic carrot vaccine in sow per oral may have an effect on preventing piglet diarrhea as good as commercial recombinant vaccine.

• Journal of the Korean Society of Food Culture
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• v.29 no.4
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• pp.355-363
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• 2014

The purpose of this study was to investigate the rheological characteristics of medium wheat flour mixed with bamboo leaf and lotus leaf powders. Rheological properties of the mixed flours were tested based on falling number, color, RVA, farinogram, and rheofermentometer analyses. Falling numbers increased with addition of bamboo leaf and lotus leaf powders. The L values of all mixed flours were less than that of control. The 1% mixed flour sample containing bamboo leaf and lotus leaf powders was not significantly different from 3% mixed flour. The a values of the mixed flour decreased as bamboo and lotus powders increased, whereas b values increased. Addition of bamboo leaf and lotus leaf powders to flour reduced peak viscosity, holding strength, and final viscosity. The set back values of mixed wheat flour containing bamboo leaf powder were lower than those of mixed wheat flour containing lotus leaf powder, suggesting that bamboo leaf powder suppressed retrogradation of flour compared to lotus leaf powder. In the farinogram, the water absorption and consistency of the flours containing bamboo and lotus leaf powders increased, whereas development time and stability decreased. The fermentation time of dough with lotus leaf powder was less than that of dough with bamboo leaf powder.