• Journal of Trauma and Injury
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• 제34권4호
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• pp.299-304
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• 2021

Atypical hemolytic uremic syndrome (aHUS) is a rare, progressive, life-threatening condition of thrombotic microangiopathy characterized by thrombocytopenia, microangiopathic hemolytic anemia, and renal impairment. The mechanisms underlying aHUS remain unclear. Herein, we present the first case in the literature of aHUS after a traumatic injury. A 55-year-old male visited the emergency department after a traumatic injury caused by a tree limb. Abdominal computed tomography revealed a rectal wall defect with significant air density in the perirectal space and preperitoneum, implying rectal perforation. Due to the absence of intraperitoneal intestinal perforation, we performed diverting sigmoid loop colostomy. An additional intermittent simple repair was performed due to perianal and anal injuries. One day postoperatively, his urine output abruptly decreased and serum creatinine level increased. His platelet level decreased, and a spiking fever occurred after 2 days. The patient was diagnosed with acute renal failure secondary to aHUS and was treated with fresh frozen plasma replacement. Continuous renal replacement therapy (CRRT) was also started for oliguria and uremic symptoms. The patient received CRRT for 3 days and intermittent hemodialysis thereafter. After hemodialysis and subsequent supportive treatment, his urine output and renal function improved. The hemolytic anemia and thrombocytopenia also gradually improved. Dialysis was terminated on day 22 of admission and the patient was discharged after recovery. This case suggests that that a traumatic event can trigger aHUS, which should be considered in patients who have thrombocytopenia and acute renal failure with microangiopathic hemolytic anemia. Early diagnosis and appropriate management are critical for favorable outcomes.

• Archives of Plastic Surgery
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• 제49권1호
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• pp.115-120
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• 2022

Background In addition to vascular endothelial cells, vascular smooth muscle cells (VSMCs) are subject to continuous shear stress because of blood circulation. The angiogenic properties of VSMCs in extracranial arteriovenous malformations (AVMs) may exceed those of normal blood vessels if the body responds more sensitively to mechanical stimuli. This study was performed to investigate the hypothesis that rapid angiogenesis may be achieved by mechanical shear stress. Methods VSMCs were obtained from six patients who had AVMs and six normal controls. The target genes were set to angiopoietin-2 (AGP2), aquaporin-1 (AQP1), and transforming growth factor-beta receptor 1 (TGFBR1). Reverse-transcriptase polymerase chain reaction (RT-PCR) and real-time PCR were implemented to identify the expression levels for target genes. Immunofluorescence was also conducted. Results Under the shear stress condition, mean relative quantity values of AGP2, AQP1, and TGFBR1 in AVM tissues were 1.927±0.528, 1.291±0.031, and 2.284±1.461 when compared with neutral conditions. The expression levels of all three genes in AVMs were higher than those in normal tissue except for AQP1 under shear stress conditions. Immunofluorescence also revealed increased staining of shear stress-induced genes in the normal tissue and in AVM tissue. Conclusions Shear stress made the VSMCs of AVMs more sensitive. Although the pathogenesis of AVMs remains unclear, our study showed that biomechanical stimulation imposed by shear stress may aggravate angiogenesis in AVMs.

• 인간식물환경학회지
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• 제23권6호
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• pp.667-681
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• 2020

Background and objective: Recently, there has been an increasing need for relaxation and familiarity with nature in residential and living spaces faced daily by urban residents, leading to a growing social interest in urban gardens. The aim of this study was to determine how gardens in a city provide physical and social benefits, comparing cases in Korea and overseas. Methods: We used the keywords "garden" and "city" for Korea, and "urban," "garden," and "green" for overseas. We then determined the Korean and overseas research trends in urban gardens by analyzing 63 Korean and 90 overseas articles deemed suitable for this study. Results: As to the types of urban gardens, the most significant type was community gardens, both in Korea and overseas (30.2% and 48.6%, respectively), followed by rooftop gardens in Korea (22.2%) and kitchen gardens overseas (22.2%). Due to the narrow and complex urban structure in Korea, people focus on using rooftop, wall, and alley spaces, and tend to arrange container-type flexible gardens. Overseas there has been a focus on promoting health and reducing food inequality through allotment and kitchen gardens, and a tendency to use a larger area as a fixed form than Korea. In addition, it was found that gardens in urban areas had a positive effect on urban biodiversity. Conclusion: To sum up, gardens in Korea are close to living spaces, and gardens overseas influence the ecosystem with an emphasis on food production. Therefore, creating urban gardens is a method of urban regeneration with a high utility that goes beyond mere food production, both in Korea and overseas, providing comprehensive benefits for the environment (37.73%) and society (62.27%). As such, continuous research on this area of study is needed to create policy guidelines for Korea.

• Journal of Medicine and Life Science
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• 제19권2호
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• pp.46-56
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• 2022

The incidence of fever complicating percutaneous coronary intervention (PCI) is rare. However, little is known regarding the cause of fever after PCI. Therefore, this study aimed to determine the clinical characteristics of patients with acute myocardial infarction (AMI), with or without fever, after PCI. We enrolled a total of 926 AMI patients who underwent PCI. Body temperature (BT) was measured every 4 hours or 8 hours for 5 days after PCI. Patients were divided into two groups according to BT as follows: BT<37.7℃ (no-fever group) and BT ≥37.7℃ (fever group). The 2 years clinical outcomes were compared subsequently. Fever after PCI was associated with higher incidence of major adverse cardiac events (MACE) (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.07-2.28; P=0.021), all-cause death (HR, 2.32; 95% CI, 1.18-4.45; P=0.014), cardiac death (CD) (HR, 2.57; 95% CI, 1.02-6.76; P=0.049), and any revascularization (HR, 1.69; 95% CI, 1.02-2.81; P=0.044) than without fever. In women, prior chronic kidney disease, lower left ventricular (LV) ejection fraction, higher LV wall motion score index, white blood cell count, peak creatine kinase-myocardial band level, and longer PCI duration were associated with fever after PCI. Procedures such as an intra-aortic balloon pump, extracorporeal membrane oxygenation, continuous renal replacement therapy, central and arterial line insertion, and cardiopulmonary resuscitation were related to fever after PCI. Fever after PCI in patients with AMI was associated with a higher incidence of MACE, all-cause death, CD, and any revascularization at the 2 years mark than in those without fever.

• Nuclear Engineering and Technology
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• 제55권1호
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• pp.71-79
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• 2023

Air ingress incidents are major safety accidents in very-high-temperature reactors (VHTRs). Air containing a high volume fraction of oxygen may cause severe oxidation of core components at the VHTR, especially for the significantly thin alloy tube wall in the intermediate heat exchanger (IHE). The research objects of this study are Inconel 617 and Incoloy 800H, two candidate alloys for IHE in VHTR. The air ingress accident scenario is simulated with high-temperature air flow at 950 ℃. A continuous oxide scale was formed on the surfaces of both the alloys after the experiment. Because the oxide scale of Inconel 617 has a loose structure, whereas that of Incoloy 800H is denser, Inconel 617 exhibited significantly more severe internal oxidation than Incoloy 800H. Further, Inconel 617 showed a significant decrease in ultimate tensile strength and plasticity after aging for 200 h, whereas Incoloy 800H maintained its tensile properties satisfactorily. Through control experiment under vacuum, we preliminarily concluded that serious internal oxidation is the primary reason for the decline in the tensile properties of Inconel 617.

• Journal of Ginseng Research
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• 제48권2호
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• pp.229-235
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• 2024

Background: Plant health is directly related to the change in native microbial diversity and changes in soil health have been implicated as one of the main cause of root rot. However, scarce information is present regarding allelopathic relationship of Panax notoginseng root exudates and pathogenic fungi Fusarium oxysporum in a continuous cropping system. Methods: We analyzed P. notoginseng root exudate in the planting soil for three successive years to determine phenolic acid concentration using GC-MS and HPLC followed by effect on the microbial community assembly. Antioxidant enzymes were checked in the roots to confirm possible resistance in P. notoginseng. Results: Total 29 allelochemicals in the planting soil extract was found with highest concentration (10.54 %) of p-hydroxybenzoic acid. The HPLC showing a year-by-year decrease in p-hydroxybenzoic acid content in soil of different planting years, and an increase in population of F. oxysporum. Moreover, community analysis displayed negative correlation with 2.22 mmol. L^-1 of p-hydroxybenzoic acid correspond to an 18.1 % population of F. oxysporum. Furthermore, in vitro plate assay indicates that medium dose of p-hydroxybenzoic acid (2.5-5 mmol. L^-1) can stimulate the growth of F. oxysporum colonies and the production of macroconidia, as well as cell wall-degrading enzymes. We found that 2-3 mmol. L^-1 of p-hydroxybenzoic acid significantly increased the population of F. oxysporum. Conclusion: In conclusion, our study suggested that p-hydroxybenzoic acid have negative effect on the root system and modified the rhizosphere microbiome so that the host plant became more susceptible to root rot disease.

• Journal of Chest Surgery
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• 제57권3호
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• pp.291-299
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• 2024

Background: Postoperative pain management following minimally invasive repair of pectus excavatum (MIRPE) remains a critical concern due to severe post-procedural pain. Promising results have been reported for cryoanalgesia following MIRPE; however, its invasiveness, single-lung ventilation, and additional instrumentation requirements remain obstacles. Serratus anterior plane block (SAPB) is a regional block technique capable of covering the anterior chest wall at the T2-9 levels, which are affected by MIRPE. We hypothesized that SAPB would be a superior alternative pain control modality that reduces postoperative pain more effectively than conventional methods. Methods: We conducted a retrospective study of patients who underwent MIRPE between March 2022 and August 2023. The efficacy of pain control was compared between group N (conventional pain management, n=24) and group S (SAPB, n=26). Group N received intravenous patient-controlled analgesia (IV-PCA) and subcutaneous local anesthetic infusion. Group S received bilateral continuous SAPB with 0.3% ropivacaine after a bilateral bolus injection of 30 mL of 0.25% ropivacaine with baseline IV-PCA. Pain levels were evaluated using a Visual Analog Scale (VAS) at 1, 3, 6, 12, 24, 48, and 72 hours postoperatively and total intravenous rescue analgesic consumption by morphine milligram equivalents (MME). Results: Mean VAS scores were significantly lower in group S than in group N throughout the 72-hour postoperative period (p<0.01). Group S showed significantly lower MME at postoperative 72 hours (group N: 108.53, group S: 16.61; p<0.01). Conclusion: SAPB improved immediate postoperative pain control in both the resting and dynamic states and reduced opioid consumption compared to conventional management.

• 생명과학회지
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• 제16권3호
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• pp.534-539
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• 2006

크립토스포리디움은 염소내성이 매우 강해 일반적인 표준정수처리공정의 소독으로는 제거가 불가능하다. 따라서 본 연구에서는 오존 및 UV를 이용한 단위소독공정에서 DAPI/PI 및 in vitro excystation을 이용하여 크립토스포리디움 불활성화를 평가하였으며, 또한 오존을 이용한 고도산화처리 파일럿에서는 세포배양법을 이용하여 크립토스포리디움 불활성화를 평가하였다. 오존 소독연구는 50 mL 용량의 piston type batch reactor에서 용존오존을 자동적으로 측정해주는 flow injection analysis (FIA) 시스템을 이용하여 실험한 결과, 1 log 제거에 필요한 CT값은 $25^{\circ}C$에서 DAPI/PI 및 in vitro excystation에 의해 각각 약 1.8, 2.2 $mg/L{\cdot}min$으로 나타났으며, 2 log 제거에 필요한 CT값은 각각 약 3.2, 3.8 $mg/L{\cdot}min$으로 나타났다. 또한 $5^{\circ}C$에서 크립토스포리디움 1 log 제거에 필요한 CT값은 DAPI/PI 방법에 의해 약 9.1 $mg/L{\cdot}min$으로 나타났으며, 2 log제거에 필요한 CT값은 14.8 $mg/L{\cdot}min$로 나타나, 같은 소독효과를 나타내기 위해서 저온에서는 상온에서보다 요존 요구량이 약 $4{\sim}5$배 정도 증가하여야 함을 확인하였다. 40 L규모의 오존 반응조를 이용한 파일럿 실험에서는 정수처리공정상 모래여과를 거친 물에 살아있는 크립토스포리디움을 접종한 것을 시료로 하여 연속적으로 흐르게 한 다음, 오존량을 변화시키고 체류시간은 5분으로 고정하여 불활성화를 평가하였다. 실험결과, 8 $mg/L{\cdot}min$의 CT값에서 DAPI/PI 및 excystation과 같은 생사판별법을 이용하였을 경우에는 약 0.2 log정도의 불활성화를 나타내었으며, 세포감염시험법을 이용하였을 경우에는 약 1.2 log정도의 불활성화를 나타냈다. 오존에 의한 크립토스포리디움의 소독능 평가에 단위공정 및 파일럿 실험 모두 2가지 생사판별법(DAPI/PI와 excystation) 사이에는 큰 차이를 나타내지 않았으나, 생사판별법과 세포감염시험법 사이에는 현저한 차이를 나타내었는데, 이는 세포감염시험법으로 측정하는 sporozoite 및 merozoite로의 분화과정이 생사판별법이 근거한 세포벽의 구조와 기능 유지 보다 더 오존 소독에 더 민감함을 알 수 있었다. 파일럿 실험에서의 CT값이 piston batch reactor에서의 CT값 보다 낮게 나타난 것은 파일럿 실험에서 수작업으로 인한 용존 오존 측정이 정밀하지 못하여 IOD가 농도에 반영되지 않았고, 반응조 규모(50 mL vs 40 L) 및 형태(회분식 vs 연속식)의 차이에 기인하는 것으로 여겨진다. 한편, UV를 이용한 단위공정에서는 크립토스포리디움 1, 2 log 제거에 필요한 IT값은 $25^{\circ}C$에서 각각 DAPI/PI 방법에 의해 약 25, 50 $mWs/cm^2$로 나타났으며, $5^{\circ}C$에서의 크립토스포리디움 1, 2 log제거에 필요한 IT값은 약 40, 80 $mWs/cm^2$로 나타났다. 온도 $20^{\circ}C$ 감소 시 약 60% 정도의 IT값이 더 필요한데, 이것은 저온에서는 약한 자외선을 발산하는 저압저출력 UV 램프의 특성 때문인 것으로 사료되었다.

• 한국전통조경학회지
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• 제33권4호
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• pp.38-51
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• 2015

고지도를 보면 한양에 동지, 서지, 남지 등 큰 연못이 표기되었는데, 이는 궁궐이나 공해시설, 일반 민간 저택 내 원지들과는 달리 국가 소유의 필지였으나 공공에게 개방된 연못이었다. 동지, 서지, 남지는 한양도성과 연결된 연지로, 본 연구는 여러 지도 및 도면 자료와 회화 자료, 고문헌, 문학작품을 수집해 종합 분석하여 물리적 차원에서의 연지의 조영 경위와 이후의 운영상황, 연지의 입지 및 공간 특성을 고찰하고자 했다. 연구 결과, 첫째, 서지와 남지는 비보, 명당수 확보, 화기 진압, 방화수, 수경시설로의 목적 하에 조영되었고 동지는 비보, 명당수 확보 외에도 수구막이로서의 기능이 중시되었다. 둘째, 주변 지형과 연지의 수원을 보았을 때 서지는 계류와, 동지, 남지는 구거와 연결되어 연못의 수량 확보에 차이가 있었다. 셋째, 서지와 남지는 도시지역에, 동지는 전원지역에 위치하였는데 이 같은 입지적 특성은 연지를 이용하는 방식에 영향을 미쳤다. 넷째, 연지의 형태는 모서리가 둥근 방형이나 자유로운 형상으로 궁궐이나 공해시설의 원지와 구분된다. 다섯째, 연지는 지속적인 유지 관리를 통해서만 유지될 수 있었고, 조선시대 매몰과 수축의 과정이 반복되었다. 길게는 오백 년 이상 동안 유지되었던 조선시대 한양도성의 연지들은 개국 초기에는 비보풍수적 의미가 강조되면서 조성되었지만, 점차 도시에서 넓은 수공간이라는 공공 오픈스페이스로서의 가치를 인정받아 거주민과 행락객들이 애착을 갖는 문화공간으로 운영되었던 것으로 판단된다.

• 생물환경조절학회지
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• 제11권1호
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• pp.5-11
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• 2002

본 연구는 여름 같은 고온기나 외부온도가 높지 않아도 시설내 온도가 많이 상승하는 봄 .가을 같은 시기에 온실내 고온 공기를 외부로 신속하게 유출시켜 강제환기를 사용하지 않고도 온실내부의 환경을 조절 할 수 있는 새로운 자연 환기창을 개발하는데 목적을 두고 수행하였다 패널굴절방식 측창은 지면에 가까운 쪽의 패널 하부에 절점을 두고 패널 상부가 측고 부위로부터 가이드 레일을 따라 하향하도록 구성하여 창이 개방되게 하였고, 천창은 측고 부위에 절점을 두고 용마루 쪽의 패널 상부가 가이드 레일을 따라 경사진 지붕면을 따라 하향하도록 구성하여 고온 공기층이 정체되어 있는 온실 상부인 측고 부위와 용마루 부위가 개방되도록 하였다. 굴절 패널의 상부 개방거리는 X=L(1-cos$\theta$)로 나타낼 수 있고 측면 개방 거리는 Y=L/2$\times$sin$\theta$로 나타낼 수 있다. 천창 개방시간은 4분 20초 소요되었으며 개방 시작한 2분 후부터 온도가 하강하기 시작하였고, 완전 개방 2분 후부터는 외기온과의 온도차 3~4$^{\circ}C$정도를 유지하면서 평형상태를 유지하였다. 패널굴절방식 환기창 온실의 환기성능은 체적환기량이 22.3-94.3m$^3$.m$^{-2}$ .h$^{-1}$이었으며, 환기 횟수는 15.2~39.3회.h$^{-1}$로 나타나 일반적인 연속형 천창의 10~15회.h$^{-1}$ 정도에 비해 환기효과가 높은 것으로 나타났다. 그리고 벤로형 온실과의 천창개폐시 온도하강을 비교하였을 때 환기효과가 2배 이상 높은 것으로 판단되었다.$_{r}$", $\mu$$_{r}$′) and the dielectric loss ($\varepsilon$$_{r}$"/$\varepsilon$$_{r}$′) were increased. It was caused that the absorption characteristics of the absorber were improved. The conduction loss and magnetic loss were expected to be occurred together because two matching frequencies were shown with carbon addition. It was confirmed that the matching frequency of the microwave absorber could be controlled by controlling heat-treatment temperatures and carbon additions.ons.tions.加的)으로 되거나 과가황(過加黃)이 될 우려가 있는 제조공정(製造工程)에서는 흔히들 이 방법(方法)을 무시(無視)하고 있다. 여기서 강조(强調)해 두어야 할 것은 항상 제품(製品)의 외부(外部)를 완전(完全)히 가황(加黃)시킬 필요(必要)는 없다는 것이다. 다공성(多孔性)이나 기포생성(氣泡生成)을 조장(助長)하는 불량가황상태(不良加黃狀態)와 표면(表面)에서의 과가황상태간(過加黃狀態間)의 균형(均衡)을 취(取)해 줘야 하는데 물론(勿論) 이때는 가황시간(加黃時間)을 단축(短縮)시켜야 한다는 경제적(經濟的)인 측면(側面)도 아울러 고려(考慮)해야 한다