Journal of Medicine and Life Science

Institute for Medical Science (제주대학교 의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Clinical outcomes and characteristics of acute myocardial infarction patients with developing fever after percutaneous coronary intervention

  • Jae-Geun Lee (Department of Internal Medicine, Jeju National University College of Medicine) ;
  • Yeekyoung Ko (Department of Cardiology, Cheju Halla General Hospital) ;
  • Joon Hyouk Choi (Department of Internal Medicine, Jeju National University College of Medicine) ;
  • Jeong Rae Yoo (Department of Internal Medicine, Jeju National University College of Medicine) ;
  • Misun Kim (Department of Internal Medicine, Jeju National University Hospital) ;
  • Ki Yung Boo (Department of Internal Medicine, Jeju National University Hospital) ;
  • Jong Wook Beom (Department of Internal Medicine, Jeju National University Hospital) ;
  • Song-Yi Kim (Department of Internal Medicine, Jeju National University College of Medicine) ;
  • Seung-Jae Joo (Department of Internal Medicine, Jeju National University College of Medicine)
  • Received : 2022.02.22
  • Accepted : 2022.05.20
  • Published : 2022.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

The incidence of fever complicating percutaneous coronary intervention (PCI) is rare. However, little is known regarding the cause of fever after PCI. Therefore, this study aimed to determine the clinical characteristics of patients with acute myocardial infarction (AMI), with or without fever, after PCI. We enrolled a total of 926 AMI patients who underwent PCI. Body temperature (BT) was measured every 4 hours or 8 hours for 5 days after PCI. Patients were divided into two groups according to BT as follows: BT<37.7℃ (no-fever group) and BT ≥37.7℃ (fever group). The 2 years clinical outcomes were compared subsequently. Fever after PCI was associated with higher incidence of major adverse cardiac events (MACE) (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.07-2.28; P=0.021), all-cause death (HR, 2.32; 95% CI, 1.18-4.45; P=0.014), cardiac death (CD) (HR, 2.57; 95% CI, 1.02-6.76; P=0.049), and any revascularization (HR, 1.69; 95% CI, 1.02-2.81; P=0.044) than without fever. In women, prior chronic kidney disease, lower left ventricular (LV) ejection fraction, higher LV wall motion score index, white blood cell count, peak creatine kinase-myocardial band level, and longer PCI duration were associated with fever after PCI. Procedures such as an intra-aortic balloon pump, extracorporeal membrane oxygenation, continuous renal replacement therapy, central and arterial line insertion, and cardiopulmonary resuscitation were related to fever after PCI. Fever after PCI in patients with AMI was associated with a higher incidence of MACE, all-cause death, CD, and any revascularization at the 2 years mark than in those without fever.

Keywords

Acknowledgement

This work was supported by a research grant from Jeju National University Hospital in 2017.

References

  1. Tavakol M, Ashraf S, Brener SJ. Risks and complications of coronary angiography: a comprehensive review. Glob J Health Sci 2012;4:65-93. 
  2. Alkan M, Cristal N, Paran E. Infectious complications of acute myocardial infarction. Infect Control 1986;7:220-2. 
  3. Alfonso F, Moreno R, Vergas J. Fatal infection after rapamycin eluting coronary stent implantation. Heart 2005;91:e51. 
  4. Lofmark R, Nordlander R, Orinius E. The temperature course in acute myocardial infarction. Am Heart J 1978;96:153-6. 
  5. Herlitz J, Bengtson A, Hjalmarson A, Wilhelmsen L. Body temperature in acute myocardial infarction and its relation to early intervention with metoprolol. Int J Cardiol 1988;20:65-71. 
  6. Risoe C, Kirkeby OJ, Grottum P, Sederholm M, Kjekshus JK. Fever after acute myocardial infarction in patients treated with intravenous timolol or placebo. Br Heart J 1987;57:28-31. 
  7. Cho HO, Nam CW, Lee HM, Shin HW, Cho YK, Yoon HJ, et al. Fever after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction is associated with adverse outcomes. Int J Cardiol 2014;170:376-80. 
  8. Kuchinskiĭ AP. Fever in myocardial infarction, its relation with catecholamine excretion and disorders of heart rhythm. Ter Arkh 1982;54:53-6. 
  9. Ben-Dor I, Haim M, Rechavia E, Murininkas D, Nahon M, Harell D, et al. Body temperature - a marker of infarct size in the era of early reperfusion. Cardiology 2005;103:169-73. 
  10. Geppert A, Steiner A, Zorn G, Delle-Karth G, Koreny M, Haumer M, et al. Multiple organ failure in patients with cardiogenic shock is associated with high plasma levels of interleukin-6. Crit Care Med 2002;30:1987-94. 
  11. Jeger RV, Assmann SF, Yehudai L, Ramanathan K, Farkouh ME, Hochman JS. Causes of death and re-hospitalization in cardiogenic shock. Acute Card Care 2007;9:25-33. 
  12. Hochman JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation 2003;107:2998-3002. 
  13. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD. Third universal definition of myocardial infarction. Glob Heart 2012;7:275-95. 
  14. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD. Third universal definition of myocardial infarction. Nat Rev Cardiol 2012;9:620-33. 
  15. Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;130:2354-94. 
  16. Newby LK, Jesse RL, Babb JD, Christenson RH, De Fer TM, Diamond GA, et al. ACCF 2012 expert consensus document on practical clinical considerations in the interpretation of troponin elevations: a report of the American College of Cardiology Foundation task force on Clinical Expert Consensus Documents. J Am Coll Cardiol 2012;60:2427-63. 
  17. Grech ED. ABC of interventional cardiology: percutaneous coronary intervention. II: the procedure. BMJ 2003;326:1137-40. 
  18. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002;105:539-42. 
  19. Naito K, Anzai T, Yoshikawa T, Maekawa Y, Sugano Y, Kohno T, et al. Increased body temperature after reperfused acute myocardial infarction is associated with adverse left ventricular remodeling. J Card Fail 2007;13:25-33. 
  20. Palmerini T, Coller BS, Cervi V, Tomasi L, Marzocchi A, Marrozzini C, et al. Monocyte-derived tissue factor contributes to stent thrombosis in an in vitro system. J Am Coll Cardiol 2004;44:1570-7. 
  21. Goel MS, Diamond SL. Neutrophil enhancement of fibrin deposition under flow through platelet-dependent and -independent mechanisms. Arterioscler Thromb Vasc Biol 2001;21:2093-8. 
  22. Palmerini T, Nedelman MA, Scudder LE, Nakada MT, Jordan RE, Smyth S, et al. Effects of abciximab on the acute pathology of blood vessels after arterial stenting in nonhuman primates. J Am Coll Cardiol 2002;40:360-6. 
  23. Palmerini T, Mehran R, Dangas G, Nikolsky E, Witzenbichler B, Guagliumi G, et al. Impact of leukocyte count on mortality and bleeding in patients with myocardial infarction undergoing primary percutaneous coronary interventions: analysis from the harmonizing outcome with revascularization and stent in acute myocardial infarction trial. Circulation 2011;123:2829-37. 
  24. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135-43. 
  25. Lindahl B, Toss H, Siegbahn A, Venge P, Wallentin L. Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease. N Engl J Med 2000;343:1139-47. 
  26. Tomoda H, Aoki N. Prognostic value of C-reactive protein levels within six hours after the onset of acute myocardial infarction. Am Heart J 2000;140:324-8. 
  27. Celik T, Iyisoy A, Kursaklioglu H, Turhan H, Kilic S, Kose S, et al. The impact of admission C-reactive protein levels on the development of poor myocardial perfusion after primary percutaneous intervention in patients with acute myocardial infarction. Coron Artery Dis 2005;16:293-9. 
  28. Banai S, Selitser V, Keren A, Benhorin J, Shitrit OB, Yalon S, et al. Prospective study of bacteremia after cardiac catheterization. Am J Cardiol 2003;92:1004-7. 
  29. van Werkum JW, ten Berg JM, Thijs Plokker HW, Kelder JC, Suttorp MJ, Rensing BJ, et al. Staphylococcus aureus infection complicating percutaneous coronary interventions. Int J Cardiol 2008;128:201-6.