• 한방안이비인후피부과학회지
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• 제21권2호
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• pp.19-27
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• 2008

Objective : The side effect of prolonged use of topical corticosteroids to skin is well-known. Moreover, resent studies have shown that prolonged use of systemic corticosteroids also negatively impacts skin barrier function. Corticosteroids have a major role in the practical management of many variable conditions. So, it is important to find the drug or the method which could protect the skin from the damage caused by corticosteroids. At former study, we investigated that Insamyangyoung-tang has some effect on skin barrier function of DNCB induced contact dermatitis hairless mice. So, this study was performed to research the effect of Insamyangyoung-tang on the TEWL with high dose steroid injected hairless mice. Method : Hairless mice were divided into 4 groups ; Control group, Group A, Group B and Group C. All groups were injected triamcinolone O.4mg for 10 times. Control group was medicated distilled water during the experimental period. Group A was medicated distilled water for 5 days before the $1^{st}$ injection day, and then medicated Insamyangyoung-tang extract during the experimental period. Group B was medicated Insamyangyoung-tang extract for 5 days before the $1^{st}$ injection day, and then medicated distilled water during the experimental period. Group C was medicated Insamyangyoung-tang extract for 5 days before the $1^{st}$ injection day, and then medicated Insamyangyoung-tang extract during the experimental period. TEWL of each group was measured for 5 times. After the $10^{th}$ injection, the tissue sample was made and the damage of epithelial cell was examined. Statistical significance was set at p<0.05 by using non parametric methods and repeated-anova.. Results : Group C showed significant effect on TEWL change of hairless mice evoked by triamcinolone injection. Group A and Group B also showed some effect, but there was no statistical significance.

• Journal of Pharmaceutical Investigation
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• 제32권2호
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• pp.73-80
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• 2002

Cefuroxime axetil is a cephalosporin antibiotic having a high activity against a wide spectrum of Grampositive and Gram-negative microorganisms. It is a cephalosporin antibiotic which exist as 2 diastereoisomers: diastereoisomer A and B. It shows polymorphism of three forms: a crystalline form having a melting point of about $180^{\circ}C$, a substantially amorphous form having a high melting point of about $135^{\circ}C$ and a substantially amorphous form having a low melting point of about 70^{\circ}C$. The crystalline form of cefuroxime axetil is slightly soluble in water because diastereoisomer A has lower solubility than B in water. Substantially amorphous form of which there are no difference in solubility between diastereoisomer A and B has better solubility than crystalline form, but it forms a thicker gel than crystalline form upon contact with an aqueous medium. Based on this reason, cefuroxime axetil is not readily absorbable in the gastrointestinal tract, rendering its bioavailability on oral administration very low. The object of this study was to develop an improved non-crystalline cefuroxime axetil composition having a high physicochemical stability and bioavailability. A non-crystalline cefuroxime axetil solid dispersant showing no peak on a Differential Scanning Calorimetry (DSC) scan is prepared by dissolving cefuroxime axetil and a surfactant in an organic solvent; suspending a water-insoluble inorganic carrier in the resulting solution; and spray drying the resulting suspension to remove the organic solvent, said solid dispersant having an enhanced dissolution and stability of cefuroxime axetil and being useful for the preparation of a pharmaceutical composition for oral administration. Tablet was formulated with this cefuroxime axetil solid dispersant, disintegrants and other ingredients. It disintegrated and dissolved easily and dynamically in dissolution medium, so showed a good dissolution profile.

• 농약과학회지
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• 제17권4호
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• pp.343-349
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• 2013

식물추출물 후추 추출물과 카시아 오일, 라벤더 오일을 이용하여 친환경유기농자재로 개발 중인 제품으로 배추좀나방 방제에 이용할 수 있는 후추 추출물+카시아 오일 57.5% (후보제형 A), 후추 추출물+카시아 오일 57% (후보제형 B), 후추 추출물+라벤더 오일 50% (후보제형 C) 유제의 생태에 대한 급성독성을 평가하여 친환경농자재 시제품으로서의 활용가능성을 확인하고자 하였다. 물벼룩 급성독성을 실시한 결과 후보제형 A 및 C 유제의 $EC_{50}$은 각 0.46, 0.25 mg $L^{-1}$로 EPA 기준으로 강한 독성이었고, 후보제형 B 유제의 $EC_{50}$는 1.9 mg $L^{-1}$로 보통독성이었다. 잉어 급성독성 시험의 경우, 후보제형 A 유제의 $LC_{50}$가 1.9 mg $L^{-1}$으로 농촌진흥청 고시에 따라 어독성 II급 농약이었으며 후보제형 B, C 유제는 2.9, 3.8 mg $L^{-1}$로 어독성 III급 농약으로 구분되었다. 꿀벌 급성독성시험은 접촉과 섭식 시험으로 나누어서 실시하였고, 후보 3종 모두 접촉과 섭식독성 $LD_{50}$가 100 ${\mu}g$ a.i $bee^{-1}$ 이상으로 나타나 독성이 낮은 것으로 판단되었다. 지렁이 급성독성시험의 경우, 후보제형 A, B 및 C 유제의 $LC_{50}$가 각각 887, 988, 564 mg $kg^{-1}$이었다. 후추 추출물+카시아 오일 57% (후보제형 B), 후추 추출물+라벤더 오일 50% (후보제형 C) 유제는 어독성 및 꿀벌 급성독성이 낮아 친환경 농자재로서 활용이 가능할 것으로 사료되었다.

• 대한치과보철학회지
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• 제43권4호
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• pp.544-561
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• 2005

Purpose : This study was to assess the loading distributing characteristics of implant systems with internal connection or external connection under vertical and inclined loading using finite element analysis. Materials and methods : Two finite element models were designed according to type of internal connection or external connection The crown for mandibular first molar was made using cemented abutment. Each three-dimensional finite element model was created with the physical properties of the implant and surrounding bone This study simulated loads of 200N at the central fossa in a vertical direction (loading condition A), 200N at the centric cusp tip in a 15$^{\circ}$ inward inclined direction (loading condition B), or 200N at the centric cusp tip in a 30$^{\circ}$ outward inclined direction (loading condition C) respectively. Von Mises stresses were recorded and compared in the supporting bone, fixture, abutment and abutment screw. Results : 1. In comparison with the whole stress or the model 1 and model 2, the stress pattern was shown through th contact of the abutment and the implant fixture in the model 1, while the stress pattern was shown through the abutment screw mainly in the model 2. 2. Without regard to the loading condition, greater stress was taken at the cortical bone, and lower stress was taken at the cancellous bone. The stress taken at the cortical bone was greater at the model 1 than at the model 2, but the stress taken at the cortical bone was much less than the stress taken at the abutment, the implant fixture, and the abutment screw in case of both model 1 and model 2. 3. Without regard to the loading condition, the stress pattern of the abutment was greater at the model 1 than at the model 2. 4. In comparison with the stress distribution of model 1 and model 2, the maximum stress was taken at the abutment in the model 1. while the maximum stress was taken at the abutment screw in the model 2. 5. The magnitude of the maximum stress taken at the supporting bone, the implant fixture, the abutment, and the abutment screw was greater in the order of loading condition A, B and C. Conclusion : The stress distribution pattern of the internal connection system was mostly distributed widely to the lower part along the inner surface of the implant fixture contacting the abutment core through its contact portion because of the intimate contact of the abutment and the implant fixture and so the less stress was taken at the abutment screw, while the abutment screw can be the weakest portion clinically because the greater stress was taken at the abutment screw in case of the external connection system, and therefore the further clinical study about this problem is needed.

• KIEE International Transactions on Electrophysics and Applications
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• 제12C권4호
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• pp.220-224
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• 2002

The electromagnetic properties and thermal behavior of Mn-Zn ferrite cores for the blocking filter of PLC application were investigated as the function of additives. The highest density and permeability were 4.98 g/㎤ and 8,221, respectively and were obtained to the specimen with composition of MnO 24 mol%, ZnO 25 mol% and Fe$_2$O$_3$51 mol%, added MoO$_3$ of 400 ppm, SiO$_2$ of 100 ppm, and CaO of 200 ppm. The uniform grains were organized, and the microstructures were compacted due to reduction of pores in the specimen. The permeability was increased up to 13,904 as the temperature of specimen increased to 110。C. However, it was decreased precipitously under 100 over 110。C. The exothermic behavior was observed in the frequency range from 1 kHz to 1 MHz, and the maximum temperature of specimen was 102。C at 1 MHz. In the consequence, the Mn-Zn ferrite core developed in this research will maintain the stable electromagnetic properties since the temperature of ferrite core rose to 93 。C in the range of 100 kHz to 450 kHz bandwidth qualified for PLC. The blocking filters were designed for single phase and three phases using the in-line and non-contact core. The best attenuation ratios of -46.46 dB and -73.9 dB were measured in the range of 100 kHz to 450 kHz bandwidth, respectively.

• Bulletin of the Korean Chemical Society
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• 제25권6호
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• pp.823-828
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• 2004

The crystal structures of sparteinium tetrachlorocuprate monohydrate $[(C_{15}H_{28}N_2)CuCl_4{\cdot}H_2O]$, 1 and sparteinium tetrabromocuprate monohydrate $[(C_{15}H_{28}N_2)CBr_4{\cdot}H_2O]$, 2, were determined. The structures of 1 [orthorhombic, $P2_12_12_1$, a = 8.3080(10) ${\AA}$, b = 14.6797(19) ${\AA}$ and c = 16.4731(17) ${\AA}$], and 2 [orthorhombic, $P2_12_12_1$, a = 8.4769(7) ${\AA}$, b = 15.166(3) ${\AA}$ and c = 16.679(3) ${\AA}$], are composed of a doubly protonated sparteinium cation, $[C_{15}H_{28}N_2]^{2+}$, a discrete $CuX_4^{2-}$ anion $(X=Cl^-\;or\;Br^-)$, and one water molecule. These monomeric compounds are stabilized through various types of hydrogen bonding interaction in their packing structures. Crystal 2 exhibits weak anti-ferromagnetism (J = -3.24 $cm^{-1}$) as opposed to the magnetically isolated paramagnetism observed for 1. The results of comparative magneto-structural investigations of 1 and 2 suggest that the pathway for the weak anti-ferromagnetic super-exchange in 2 might be through a Cu-Br${\cdots}$Br-Cu contact.

• 대한기계학회논문집A
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• 제32권7호
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• pp.597-601
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• 2008

Currently knowledge of strain in welds has mainly been obtained from strain gaging method: that is directly attaching most of the material to the gage. The very few non-contact methods are still in the early stage. One of the non-contact methods is by the use of the laser that has high-level of the accuracy for the measurement, and this laser also has excellent characteristics on which many studies for its applications are focused throughout the many fields. A method of study is on the measurement of the strain caused by the characteristics of the spot welded zone which is used with 3-D ESPI system that is functionally modified through the laser ESPI(Electronic Speckle Pattern Interferometry) system. This system employed the SGCC 1.2t which are mainly used for the steel plate such as automobile, structure, building material and electronic appliances.

• 한국운동역학회지
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• 제28권3호
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• pp.165-173
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• 2018

Objective: The purpose of this study is to provide biomechanical basis data for the analysis of the maximum vertical ground reaction force, the maximum plantar pressure, the average plantar pressure, and the contact area according to the type of the insole through the insole insertion type foot pressure gauge. Method: In the treadmill, the slope was set at 10%, the first type A was worn at a walking speed of 3.5 km / h, and then walking was carried out using B, C, and D types. Data from 20 boots with consistent walking were extracted and plantar pressure data were collected and analyzed. Results: Functional insole was more effective than conventional insole for maximum vertical ground reaction force, maximum plantar pressure, average plantar pressure, and contact area at 10% of treadmill ramps. Conclusion: In this study, D-type insole supports the cushion in the middle part and supports the heel cup with hardness in the hind part, so that it is the most effective insole by lowering the plantar pressure and dispersing it more widely.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1995년도 추계학술대회 논문집 학회본부
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• pp.475-478
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• 1995

The variations of cold gas properties such as density, pressure, temperature and velocity which are dependent each other are closely related with the dielectric recovery of an interrupter. So, the pressure-rises at no-load in the puffer cylinder and in front of fixed arcing contact of 800kV model interrupter were measured experimentally using pressure transducers of strain gage type and semiconducting type, respectively. The maximum value of pressure-rise in the puffer cylinder increased almost linearly from 7.6 bar at the minimum operated pressure to 9.7 bar at the maximum operated pressure, while the pressure-rise in front of fixed arcing contact was independent with the operated pressure. The measured values will be utilized in verifying the self-developed cold flow analysis program and as an input of commercialized CFD program package.

• 소성∙가공
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• 제19권4호
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• pp.253-262
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• 2010

For multi-stage deep drawing process including ironing operation and biaxial forming in this study, tool developments are achieved, and the developed tool sets are applied to experimental investigations. In process and tool designs, a contact condition between intermediate blank and lower die is considered as the sequential one. In this study, the material used is cold-rolled thin sheet (SPCE) with the initial thickness of 0.4mm. From the experimental approaches, several failures such as tearing, localized thickening and thinning, are observed. To solve these failures, the contact surface on the lower die is modified. As the experimental results by applying the modified lower die, it is investigated that the failures are not occurred, and the excessive deformation behavior due to the thinning and thickening effects are decreased. Furthermore, the thickness distributions on the major axis and the minor axis of each intermediate blank are investigated to be already satisfied the target (ironing) thickness, respectively. By this systematic approach, it is confirmed that the experimental results show good agreements with the designed and required configuration of each deformed and final products.