• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2003년도 제27회 추계학술대회
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• pp.49-49
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• 2003

목적 : 심초음파는 비침습적이므로 반복적으로 정확히 심질환의 경과를 관찰하여 치료효과 및 수술시기를 정할 수 있는 검사로서 임상적으로 매우 유용하다. 실시간 심근조영심초음파에 의한 time intensity 평가는 부위별로 수행됨으로 연속적으로 위치하는 관심영역이 intensity에 있어 심장의 움직임 변화에 영향을 받는다. Time intensity 곡선의 최적의 곡선맞춤을 위해 주기적인 심장 운동 매개변수를 조합해 기존의 모델을 보정한 안정적인 측정방법을 제시한다. 방법 : 심장의 운동에 의한 특징적인 정보를 설명하기 위해 기존의 문헌에 제시된 지수 함수에 주어진 심박수로 만들어진 시간에 관한 일반적인 정형파 함수를 추가한다. C(t) = A[1 - exp($\beta$t)] + Dsine(2$\pi$ft + $\theta$) C(t): videointensity A: plateau videointensity (blood volume) $\beta$: capillary blood velocity (rate constant of rise in videointensity) t: pulsing interval (ms) D: displacement from the periodic variance of the curve (estimated motion field from the ejection point for the ratio between systole and diastole) f: heart rate $\theta$: transit time issue A $\times$ $\beta$ : myocardial blood flow 관상동맥의 관류 데이터에 대한 실험이 펄스간격에 대한 비디오 세기로 수행되었다. 그리고 이러한 결과들이 the sum of squares due to error, R square, root mean squared error로 평가되었다. 결과 : 실험결과, 주기적인 심장의 움직임과 심박출 시점으로부터의 변위를 잘 기술하고 곡선에서의 측정 점들이 예측된 심장 움직임에 따라 성공적으로 표시되었다. 뿐만 아니라 보정된 모델이 현저한 적합도의 향상을 보여주었다. 결론 : 제시된 접근방법은 각각의 측정에서 심장 운동 영역의 변화에 독립적이며 측정 시점에 의해 영향받지 않고 심근 관류의 안정적인 측정이 가능하다. 심장의 움직임에 관한 매개변수를 조합한 모델로 곡선접합을 수행함으로써 관류의 정량적 정보를 좀더 정확하게 얻을 수 있으며 임상적 이용을 가능하게 할 것으로 기대된다.

• 한국임상약학회지
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• 제21권2호
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• pp.74-80
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• 2011

Population pharmacokinetics for gentamicin were compared with 20 Korean patients (14 male and 6 female) and 25 Caucasian appendicitis patients (16 male and 9 female). Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion. Nonparametric expected maximum(NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant(K), the slope(KS) of the relationship between K versus creatinine clearance(Ccr), the apparent volume of distribution (V), the slope(VS) of the relationship between V versus weight, gentamicin clearance(CL) and the slope(CS) of the relationship between CL versus Ccr and the V. The output includes two marginal probability density function(PDF), means, medians, modes, variance, skewness, kurtosis, and CV%. The mean K(KS) were$0.402{\pm}0.129hr^{-1}$ ($0.00486{\pm}0.00197[hr{\cdot}mL/min/1.73m^2]^{-1}$) and $0.425{\pm}0.137hr^{-1}$($0.00432{\pm}0.00168[hr{\cdot}mL/min/1.73m^2]^{-1}$) for Korean and Caucasian populations, respectively. The mean V(VS) were not different at $14.3{\pm}3.69L$($0.241{\pm}0.0511L/kg$) and $15.8{\pm}4.81L$($0.236{\pm}0.0531L/kg$) for Korean and Caucasian populations, respectively (P>0.2). The mean CL(CS) were $5.68{\pm}1.69L/hr$ ($0.0714{\pm}0.0222L/kg[hr{\cdot}mL/min/1.73m^2]$) and $6.29{\pm}1.84L/hr$ ($0.0629{\pm}0.0189L/kg[hr{\cdot}mL/min/1.73m^2]$) for Korean and Caucasian populations, respectively. There are no differences in gentamicin pharmacokinetics between Korean and Caucasian appendicitis patients.

• 한국초지조사료학회지
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• 제8권2호
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• pp.68-76
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• 1988

The variation of rumination response in steers fed a same amount of orcharograss hay was investigated. With three steers (6, 12, 24 months) of the Japanese Black Breed, rumination behaviour was measured continuously during a 5 days period by masseter EMG telemetry system. The results are summarized as follows: 1. The average daily ruminatio time of respective animals were 438,447 and 433 min. with small daily variation both within and among animal. But the rumination time per DM kg of hay consumed varied from 66 to 138 min., and calf spent longer than older calf. 2. Actural chewing time showed small variation, and percentage of actural chewing time spent in rumination time was from 88 to 93% on individual average. 3. The daily number of chewing in rumination was approximately 25,000 to 30,000 with large individual differences. The chews per DM kg intake varied from 3,800 to 9,600, and calf chewed more than older calf. 4. The average rate of chewing per 100 sec. (chewing speed), there was a large difference between animals I.e. 104, 114, 131 respectively, but very little variance between days in individual. 5. No relation between day to day variations in eating time and rumination behavior, but significantly positive correlation was observed in the relation among rumination time, chewing time, No. of boluses and No. of chews. 6. Active time of day in rumination altered considerably day to day, but variation in the amount of rumination per day as expressed by the rumination time was relatively small.

• Journal of Korean Neurosurgical Society
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• 제40권3호
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• pp.180-185
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• 2006

Objective : Middle cerebral artery occlusion[MCAO] has widely been used to produce ischemic brain lesions. The lesions induced by MCAO tend to be variable in size because of the variance in the collateral blood supply found in the mouse brain. To establish a less invasive and reproducible focal ischemia model in mice, we modified the technique used for rat photo thrombosis model. Methods : Male C57BL/6 mice were subjected to focal cerebral ischemia by photothrombosis of cortical microvessels. Cerebral infarction was produced by intraperitoneal injection of Rose Bengal, a photosensitive dye and by focal illumination through the skull. Motor impairment was assessed by the accelerating rotarod and staircase tests. The brain was perfusion-fixed for histological determination of infarct volume four weeks after stroke. Results : The lesion was located in the frontal and parietal cortex and the underlying white matter was partly affected. A relatively constant infarct volume was achieved one month after photothrombosis. The presence of the photothrombotic lesion was associated with severe impairment of the motor performance measured by the rotarod and staircase tests. Conclusion : Photothrombotic infarction in mice is highly reproducible in size and location. This procedure can provide a simple method to produce cerebral infarction in a unilateral motor cortex lesion. In addition, it can provide a suitable model for study of potential neuroprotective and therapeutic agents in human stroke.

• 한국주거학회논문집
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• 제23권5호
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• pp.95-102
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• 2012

We studied in order to find out suitable amounts of board by visual effects to establish indoor boards and human psychological effects by several board designs. Thirty students of C university were tested in constant temperature/humidity room and interviewed after tests. The experimental visual images were projected from 54' TV. As a result, the board length that showed high preference and satisfaction was the 90cm both horizontal and vertical direction. We found that vertical board gave an impression of a linear and narrow shape and the horizontal board gave wide space and cool feeling from psychological analytical study. The factors affecting satisfaction in horizontal direction were refreshing, intimacy, beauty, area, splendor and those in vertical direction were a sense of security, beauty, texture, intimacy, continuity, extensity, natural feeling. We got 5 factors from the result of factor analysis in order to get psychological factor axis. Those were pleasantness, artificiality, openness, dynamics, refinement. By multiple regression analysis, the factor pleasantness had the highest impact on visual satisfaction on scenary. The study on psychological factor difference by analysis of variance showed that psychologically feeling amount about pleasantness, artificiality, dynamics, refinement, and openness had statistically meaningful difference despite of board direction. We found that the 90cm had a tendency as a changing point leading image change by the investigative analysis of board direction based on factor points.

• Transactions on Electrical and Electronic Materials
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• 제8권1호
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• pp.5-10
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• 2007

Using a reference slurry, ammonium dodecyl sulfate (ADS), an anionic and environmentally friendly surfactant, was investigated as an alternative to BTA for its inhibition and lubrication characteristics. Results demonstrated that the inhibition efficiency of ADS was superior to that of BTA. Coefficient of friction (COF) was the lowest when the slurry contained ADS. This suggested that adsorbed ADS on the surface provided lubricating action thereby reducing the wear between the contacting surfaces. Temperature results were consistent with the COF and removal rate data. ADS showed the lowest temperature rise again confirming the softening effect of the adsorbed surfactant layer and less energy dissipation due to friction. Spectral analysis of shear force showed that increasing the pad-wafer sliding velocity at constant wafer pressure shifted the high frequency spectral peaks to lower frequencies while increasing the variance of the frictional force. Addition of ADS reduced the fluctuating component of the shear force and the extent of the pre-existing stick-slip phenomena caused by the kinematics of the process and collision event between pad asperities with the wafer. By contrast, in the case of BTA, there were no such observed benefits but instead undesirable effects were seen at some polishing conditions. This work underscored the importance of real-time force spectroscopy in elucidating the adsorption, lubrication and inhibition of additives in slurries in CMP.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제29권2호
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• pp.47-53
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• 2018

Objectives: This study aimed to develop the attention-deficit hyperactivity disorder (ADHD)-After School Checklist (ASK) to evaluate the severity of ADHD symptoms and self-management ability in children and adolescents in South Korea. Additionally, we evaluated the reliability and validity of the scale. Methods: We developed the ASK to evaluate the effect of ADHD psychopathologies on self-management and interpersonal impulsivity. We investigated the reliability and validity of the scale with 1349 parents (male 56.9%; 1202 parents of non-ADHD children, 147 parents of children with ADHD) in Seoul and Gyeonggi Province, Korea. Results: According to the construct validity test using principal constant analysis with the varimax rotation method, two factors explained 60.7% of the cumulative variance in ASK scores. Cronbach's alpha for the whole scale was 0.71. There was no statistical difference between mean ASK scores at test and retest. Mean total ASK scores of the ADHD group were significantly higher than those of the non-ADHD group (p<0.001). Conclusion: The ASK can be used as a reliable and valid tool to evaluate not only self-management capability of children and adolescents with ADHD in their academic and everyday life, but also their impulsiveness in interpersonal relationships.

• Asian-Australasian Journal of Animal Sciences
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• 제33권9호
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• pp.1387-1399
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• 2020

Objective: The objective of this study was to estimate the genetic parameters and trends for milk, fat, and protein yields in the first three lactations of Thai dairy cattle using a 3-trait,-3-lactation random regression test-day model. Methods: Data included 168,996, 63,388, and 27,145 test-day records from the first, second, and third lactations, respectively. Records were from 19,068 cows calving from 1993 to 2013 in 124 herds. (Co) variance components were estimated by Bayesian methods. Gibbs sampling was used to obtain posterior distributions. The model included herd-year-month of testing, breed group-season of calving-month in tested milk group, linear and quadratic age at calving as fixed effects, and random regression coefficients for additive genetic and permanent environmental effects, which were defined as modified constant, linear, quadratic, cubic and quartic Legendre coefficients. Results: Average daily heritabilities ranged from 0.36 to 0.48 for milk, 0.33 to 0.44 for fat and 0.37 to 0.48 for protein yields; they were higher in the third lactation for all traits. Heritabilities of test-day milk and protein yields for selected days in milk were higher in the middle than at the beginning or end of lactation, whereas those for test-day fat yields were high at the beginning and end of lactation. Genetics correlations (305-d yield) among production yields within lactations (0.44 to 0.69) were higher than those across lactations (0.36 to 0.68). The largest genetic correlation was observed between the first and second lactation. The genetic trends of 305-d milk, fat and protein yields were 230 to 250, 25 to 29, and 30 to 35 kg per year, respectively. Conclusion: A random regression model seems to be a flexible and reliable procedure for the genetic evaluation of production yields. It can be used to perform breeding value estimation for national genetic evaluation in the Thai dairy cattle population.

• 한국정보통신학회논문지
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• 제19권10호
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• pp.2263-2268
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• 2015

본 논문은 멀티미디어 환경하에서 WPAN 시스템에 미치는 WLAN 시스템의 간섭신호 경감을 위한 MAC schedule 기법에 대해 연구한다. 본 연구에서 고려하는 파라미터는 간섭신호평가와 주장치 지연정책을 고려한다. 제안된 스케쥴링 기법은 패킷 전송손실과 다중 슬롯 패킷의 경우 전송지연시간을 감소시키는데 효과적임을 알 수 있었다. 또 다른 장점은 채널 상태가 나쁠 경우 패킷의 전송이 이루어지지 않기 때문에 전송 전력의 낭비를 막을 수 있다는 것이다. 더욱이 다른 장치에 의해 차지하고 있는 채널을 피함으로 인해 같은 주파수 대역을 사용하고 있는 다른 시스템으로의 간섭의 영향을 줄일 수 있었다. 음성 패킷은 고정된 기간에 보내지기 때문에 스케쥴링 정책은 데이터 트래픽에 한하여 적용된다. 그러나 지연분산이 일정하고 한 슬롯내로 제한된다면 음성을 위한 DM패킷에도 적용 가능 할 것이다.

• 한국수자원학회논문집
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• 제34권5호
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• pp.499-509
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• 2001

자연하천에서의 이송-확산 과정의 모의를 위하여 입자위치의 이산확률분포에 기초한 2차원 수송 모형을 개발하였다. 제안된 모형에서는 단위 시간간격동안 격자간의 질량이송을 예측하기 위하여 평균과 분산의 함수로 나타내어진 확률분포를 사용하였다. 개발된 모형은 유속, 확산계수, 단면적이 일정한 단순영역에 대하여 수치확산이 없는 해를 구하였고, 양의 확률을 만족시키는 안정조건이 성립한다면, 해석해와 다른 유한차분법과 비교하였을 때, 좋은 결과를 나타내었다. 본 모형의 현장적용성을 검토하기 위하여 캐나다에 위치한 Grand River를 대상을 얻은 수치실험 결과를 정상상태의 색소실험 결과와 비교하였다. 그 결과로서 본 모형은 자연하천에서의 2차원 이송-확산을 잘 모의할 수 있는 것으로 나타났다.