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Protective Effect of Monascus pilosus Mycelial Extract on Hepatic Damage in High-Fat Diet Induced-obese Rats (고지방식이로 유도한 비만 흰쥐에서 Monascus pilosus 균사체 추출물의 간 손상 예방효과)

  • Lee, Sang-Il;Kim, Jae-Won;Lee, Ye-Kyung;Yang, Seung-Hwan;Lee, In-Ae;Suh, Joo-Won;Kim, Soon-Dong
    • Journal of Applied Biological Chemistry
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    • v.54 no.3
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    • pp.206-213
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    • 2011
  • Hepatoprotective effects of Monascus pilosus mycelial ethanol extract (MPME) were examined in high-fat diet induced-obese rats. The rats were randomly divided into 2 groups; normal control (NC) and a high-fat and high cholesterol diet group (HFC). The HFC diet group was fed a 5L79 diet supplemented with 15% lard and 1% cholesterol for 3 weeks for induction of obesity. And then, the rats were divided into 4 groups (n=5); the NC, a HFC diet obesity control group (HF), 0.5% MPME supplemented HFC diet group (MPM), and 2% conjugated linoleic acid (CLA) supplemented HFC diet group for 7 weeks. Whereas the daily weight gain of NC and HFC groups were 3.48 g and 4.48 g, respectively, those of MPM and CLA were 3.09 g and 4.38 g, respectively. Furthermore, activity of serum alanine and aspartic aminotransferase in HF was markedly higher than those of NC group, but, the activity in MPM and CLA was significantly lower than HF. Hepatic reduced glutathione content in MPM and CLA was higher than HF. On the contrary, hepatic lipid peroxide content in MPM and CLA was significantly lower than HF. In conclusion, although the precise mechanisms of the hepatoprotective effects of the MPME in this study are unknown, our study provides experimental evidence that MPME may prevent obesity and hepatic damage by high-fat and high cholesterol diet via inhibition of lipid absorption and induction of reactive oxygen spices scavenging enzyme such as superoxide dismutase.

Changes of Serotype Distribution of Streptococcus pneumoniae Isolated from Children in Korea over a 15 Year-period(1991~2005) (15년간(1991~2005년) 우리나라 소아에서 분리된 폐구균의 혈청형 분포의 변화)

  • Kim, So-Hee;Song, Eun-Kyung;Lee, Jun-Ho;Kim, Nam-Hee;Lee, Jin-A;Choi, Eun-Hwa;Lee, Hoan-Jong
    • Pediatric Infection and Vaccine
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    • v.13 no.2
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    • pp.89-98
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    • 2006
  • Purpose : The prevalence of serotypes can be changed with respect to age of the patients, regions and times of the surveillance. The aim of this study is to analyze changes in serotype distribution of pneumococcal isolates from Korean pediatric patients. Methods : Four hundred and sixty five strains of S. pneumoniae were isolated from various clinical specimens at the Seoul National University Children's Hospital during a 15 year-period, from 1991 to 2005, were subjected to serotype and penicillin susceptibility. The study period was divided into three 5 year-periods, 1991~1995(period I), 1996~2000(period II), and 2001~2005(period III). Results : Common serotypes were 19F, 23F, 19A, 6B, 14, 6A and 9V in decreasing orders of frequency, and these 7 serotypes accounted for 79% of total 465 strains. In the serotype distribution of invasive infection isolates from children <60 months of age, similar serotypes accounted for 70% of 101 strains. In total strains, the proportion of serotype 19A and 6A increased, while that of serotype 19F and 14 decreased. The majority(75~92%) of vaccine types and cross-reactive types from invasive infection isolates was penicillin-resistant, whereas 34.4% of non-vaccine types was penicillin-resistant. Conclusion : Distribution of serotypes of S. pneuomoniae isolated from Korean children has changed significantly over the last 15 years. The surveillance for pneumococcal serotypes should be continued to monitor changes in serotype distribution which are essential for the establishment of pneumococcal vaccine policy.

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The Studies on the Change of Lipid Phosphorus and Influence of Irradiation with the Origination of Silkworm Eggs (Bombyx mori L.) (가잠난 발생과정에서 Lipid Phosphorus의 변동과 방사선영향에 관한 연구(제일보))

  • 김원경;임영우
    • Journal of Sericultural and Entomological Science
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    • v.13 no.1
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    • pp.31-34
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    • 1971
  • The pupa (7th. day after mounting) were irradiated for foully minutes with 1,000${\gamma}$-ray and the copulation was done under the various conditions when the pupa grew to be imagos. The silkworm eggs that the imagos laid were divided into many groups by five, fifteen, foully-five, ninety, seven-hundred, twenty and twenty-four hundred minutes eggs respectively and the lipid phosphorus in the each group of eggs was analyzed as follows. 1. The quantity of 928${\gamma}$/100mg dry powder (D. P.) was shown in the group of the fourt-five minutes eggs whose ovum nucleus and sperm nucleus were not conjugate in the control C (male and female). The number of the greatest quantity of 944${\gamma}$/100mg D.P. after the syngamy of ovum nucleus and sperm nucleus while the smallest quantity was 768${\gamma}$/100mg D.P. in the group of ninety minutes eggs. 2. Not much difference could be seen the copulation group of female irradiation and male control and the copulation group of male irradiation and female control compared to the both male and female control group, but the influence could be seen in the group of irradiated female pupas. 3. The great difference could be seen in the group of irradiated male and female pupa compared to the control group. The five minutes eggs showed the smallest quantity of 536${\gamma}$/100mg D.P. and the quantity of lipid phosphorus rapidly began to increase from the fifteen minutes eggs. The quantity amounted to 1,082${\gamma}$/100 mg D.P. in the case of seven hundred and twenty minutes eggs while the quantity decreased in the twenty-four hundred minutes eggs which showed 912${\gamma}$/100 mg D.P. The general result obtained in the present study was that the irradiated male and female pupa were greatly influenced before and after the syngamy of gamete.

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Geochemical Characteristics of Granodiorite and Arenaceous Sedimentary Rocks in Chon-Ashuu Area, Kyrgyzstan (키르키스스탄 촌아슈 지역 화강섬록암질암 및 사질원 퇴적암의 지화학적 특징)

  • Kim, Soo-Young;Chi, Sei-Jung;Park, Sung-Won
    • Economic and Environmental Geology
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    • v.44 no.4
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    • pp.273-288
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    • 2011
  • Chon-Ashuu copper mining claim area is located, in terms of the geotectonic setting, in the northern part of the suture line which is bounded with the marginal part of Issik-kul micro-continent on the southern part of North Tien-Shan terrane. The geological blocks of Chon-Ashuu districts belong to the southern tip of Kazakhstan orocline. The rock formation of this area are composed of the continental crust or/and arc collage and the paleo-continental fragments-accretionary wedge complex of pre-Altaid orogenic materials. ASI(Alumina Saturation Index) of Paleozoic plutonic rocks in Chon-Ashuu area belong to the peraluminous and metaluminous rocks which were generated from fractional crystallization of Island and volcanic arc crusts in syn-post collisional plate. The geology of the ChonAshuu area consists of upper Proterozoic and Paleozoic rock formations. According to Harker variation diagrams for Chon-Ashuu arenaceous sedimentary rocks, the silty sandstone of Chon-Ashuu area showing the mineralogical immaturity were derived from Island arc or the marginal environments of active continent in Cambro-Carboniferous period. Numerous intrusive rocks of Chon-Ashuu area are distributed along north east trending tectonic structures and are bounded on four sides by the conjugate pattern. The most common type of the plutonic rocks are granodiorite and monzodiorite. According to the molecular normative An-Ab-Or composition (Barker, 1979), the plutonic rocks in Chon-Ashuu area are classified into tonalite - trondhjemite - granodiorite (TTG) series which are an aggregation of rocks which is the country rock of copper mineralization, that are formed by melting of hydrous mafic crust at high pressure.

Formation and Evolution of the Miocene Ipcheon Subbasin in Yangbuk-myeon, Gyeongju, SE Korea (한반도 남동부 경주시 양북면 마이오세 입천소분지의 형성과 발달사)

  • Seong, Changhun;Cheon, Youngbeom;Son, Moon;Sohn, Young Kwan;Kim, Jin-Seop
    • The Journal of the Petrological Society of Korea
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    • v.22 no.1
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    • pp.19-34
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    • 2013
  • The Ipcheon Subbasin is an isolated Miocene basin in SE Korea, which has the geometry of an asymmetric graben elongated in the NE-SW direction. It is in contact with basement rocks by faults and separated from adjacent Waup and Eoil basins by the basement. The strata of the basin fills have an overall homoclinal structure, dipping toward NW or WNW. The basin fills consist of Early Miocene sediments rich in dacitic volcanic and volcaniclastic deposits and Middle Miocene non-volcanic and nonmarine conglomerates intercalated with sand layers, which are distributed in the northeastern and southwestern parts of the basin, respectively. Kinematic analysis of syndepositional conjugate faults in the basin fills indicates WNW-ESE extension of the basin. These features are very similar to those of the adjacent Waup and Eoil basins, indicating that the basin extension was governed by the NE-trending northwestern border faults and that the basin experienced a propagating rifting from NE to SW. Basaltic materials, which occur abundantly in the Eoil Basin, are totally absent in the Ipcheon Subbasin. The observations of the dacitic tuff and tuffaceous mudstone in the subbasin, on slabs and under microscope, suggest that they have lithologies very similar to those of the Yondongri Tuff in the Waup Basin. The Middle Miocene non-volcanic sediments of the Waup and Eoil basins and the Ipcheon Subbasin are distributed consistently in the southwestern part of each basin. It is thus concluded that the extension of the Ipcheon Subbasin began at about 22 Ma together with the Waup Basin and was lulled during the main extension period of the Eoil Basin between 20-18 Ma. At about 17 Ma, the subbasin was re-extended due to the activation of the Yeonil Tectonic Line associated with the propagating rifting toward SW. This event is interpreted to have provided new sedimentation space for the Middle Miocene sediments in the southwestern parts of the Waup and Eoil basins and the Ipcheon Subbasin as well.

Radio location algorithm in microcellular wide-band CDMA environment (마이크로 셀룰라 Wide-band CDMA 환경에서의 위치 추정 알고리즘)

  • Chang, Jin-Weon;Han, Il;Sung, Dan-Keun;Shin, Bung-Chul;Hong, Een-Kee
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.23 no.8
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    • pp.2052-2063
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    • 1998
  • Various full-scale radio location systems have been developed since ground-based radio navigation systems appeared during World War II, and more recently global positioning systems (GPS) have been widely used as a representative location system. In addition, radio location systems based on cellular systems are intensively being studied as cellular services become more and more popular. However, these studies have been focused mainly on macrocellular systems of which based stations are mutually synchronized. There has been no study about systems of which based stations are asynchronous. In this paper, we proposed two radio location algorithms in microcellular CDMA systems of which base stations are asychronous. The one is to estimate the position of a personal station at the center of rectangular shaped area which approximates the realistic common area. The other, as a method based on road map, is to first find candidate positions, the centers of roads pseudo-range-distant from the base station which the personal station belongs to and then is to estimate the position by monitoring the pilot signal strengths of neighboring base stations. We compare these two algorithms with three wide-spread algorithms through computer simulations and investigate interference effect on measuring pseudo ranges. The proposed algorithms require no recursive calculations and yield smaller position error than the existing algorithms because of less affection of non-line-of-signt propagation in microcellular environments.

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The movement history of the southern part of the Yangsan Fault Zone interpreted from the geometric and kinematic characteristics of the Sinheung Fault, Eonyang, Gyeongsang Basin, Korea (언양 신흥단층의 기하학적.운동학적 특성으로부터 해석된 경상분지 양산단층대 남부의 단층운동사)

  • Kang, Ji-Hoon;Ryoo, Chung-Ryul
    • The Journal of the Petrological Society of Korea
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    • v.18 no.1
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    • pp.19-30
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    • 2009
  • The main fault of Yangsan Fault Zone (YFZ) and Quaternary fault were found in a trench section with NW-SE direction at an entrance of the Sinheung village in the northern Eonyang, Ulsan, Korea. We interpreted the movement history of the southern part of the YFZ from the geometric and kinematic characteristics of basement rock's fault of the YFZ (Sinheung Fault) and Quaternary fault (Quaternary Sinheung Fault) investigated at the trench section. The trench outcrop consists mainly of Cretaceous sedimentary rocks of Hayang Group and volcanic rocks of Yucheon Group which lie in fault contact and Quaternary deposits which unconformably overlie these basement rocks. This study suggests that the movement history of the southern part of the YFZ can be explained at least by two different strike-slip movements, named as D1 and D2 events, and then two different dip-slip movements, named as D3 and D4 events. (1) D1 event: a sinistral strike-slip movement which caused the bedding of sedimentary rocks to be high-angled toward the main fault of the YFZ. (2) D2 event: a dextral strike-slip movement slipped along the high-angled beddings as fault surfaces. The main characteristic structural elements are predominant sub-horizontal slickenlines and sub-vertical fault foliations which show a NNE trend. The event formed the main fault rocks of the YFZ. (3) D3 event: a conjugate reverse-slip movement slipped along fault surfaces which trend (E)NE and moderately dip (S)SE or (N)NW. The slickenlines, which plunge in the dip direction of fault surfaces, overprint the previous sub-horizontal slickenlines. The fault is characterized by S-C fabrics superimposed on the D2 fault gouges, fault surfaces showing ramp and flat geometry, asymmetric and drag folds and collapse structures accompanied with it. The event dispersed the orientation of the main fault surface of the YFZ. (4) D4 event: a Quaternary reverse-slip movement showing a displacement of several centimeters with S-C fabrics on the Quternary deposits. The D4 fault surfaces are developed along the extensions of the D3 fault surfaces of basement rocks, like the other Quaternary faults within the YFZ. This indicates that these faults were formed under the same compression of (N)NW-(S)SE direction.

Three-Dimensional High-Frequency Electromagnetic Modeling Using Vector Finite Elements (벡터 유한 요소를 이용한 고주파 3차원 전자탐사 모델링)

  • Son Jeong-Sul;Song Yoonho;Chung Seung-Hwan;Suh Jung Hee
    • Geophysics and Geophysical Exploration
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    • v.5 no.4
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    • pp.280-290
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    • 2002
  • Three-dimensional (3-D) electromagnetic (EM) modeling algorithm has been developed using finite element method (FEM) to acquire more efficient interpretation techniques of EM data. When FEM based on nodal elements is applied to EM problem, spurious solutions, so called 'vector parasite', are occurred due to the discontinuity of normal electric fields and may lead the completely erroneous results. Among the methods curing the spurious problem, this study adopts vector element of which basis function has the amplitude and direction. To reduce computational cost and required core memory, complex bi-conjugate gradient (CBCG) method is applied to solving complex symmetric matrix of FEM and point Jacobi method is used to accelerate convergence rate. To verify the developed 3-D EM modeling algorithm, its electric and magnetic field for a layered-earth model are compared with those of layered-earth solution. As we expected, the vector based FEM developed in this study does not cause ny vector parasite problem, while conventional nodal based FEM causes lots of errors due to the discontinuity of field variables. For testing the applicability to high frequencies 100 MHz is used as an operating frequency for the layer structure. Modeled fields calculated from developed code are also well matched with the layered-earth ones for a model with dielectric anomaly as well as conductive anomaly. In a vertical electric dipole source case, however, the discontinuity of field variables causes the conventional nodal based FEM to include a lot of errors due to the vector parasite. Even for the case, the vector based FEM gave almost the same results as the layered-earth solution. The magnetic fields induced by a dielectric anomaly at high frequencies show unique behaviors different from those by a conductive anomaly. Since our 3-D EM modeling code can reflect the effect from a dielectric anomaly as well as a conductive anomaly, it may be a groundwork not only to apply high frequency EM method to the field survey but also to analyze the fold data obtained by high frequency EM method.

Thermal Behavior and Leaf Temperature in a High Pressure Sodium Lamp Supplemented Greenhouse (고압나트륨등 보광 온실의 열적 거동 및 엽온 분석)

  • Seungri Yoon;Jin Hyun Kim;Minju Shin;Dongpil Kim;Ji Wong Bang;Ho Jeong Jeong;Tae In Ahn
    • Journal of Bio-Environment Control
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    • v.32 no.1
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    • pp.48-56
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    • 2023
  • High-pressure sodium (HPS) lamps have been widely used as a useful supplemental light source to emit sufficient photosynthetically active radiation and provide a radiant heat, which contribute the heat requirement in greenhouses. The objective of this study to analyze the thermal characteristics of HPS lamp and thermal behavior in supplemented greenhouse, and evaluate the performance of a horizontal leaf temperature of sweet pepper plants using computational fluid dynamics (CFD) simulation. We simulated horizontal leaf temperature on upper canopy according to three growth stage scenarios, which represented 1.0, 1.6, and 2.2 plant height, respectively. We also measured vertical leaf and air temperature accompanied by heat generation of HPS lamps. There was large leaf to air temperature differential due to non-uniformity in temperature. In our numerical calculation, thermal energy of HPS lamps contributed of 50.1% the total heat requirement on Dec. 2022. The CFD model was validated by comparing measured and simulated data at the same operating condition. Mean absolute error and root mean square error were below 0.5, which means the CFD simulation values were highly accurate. Our result about vertical leaf and air temperature can be used in decision making for efficient thermal energy management and crop growth.