• Journal of Preventive Medicine and Public Health
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• 제50권5호
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• pp.303-310
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• 2017

Objectives: The aim of this study was to evaluate socioeconomic inequalities in the prevalence of dental caries among an urban population. Methods: This study was conducted among 2000 people 15-40 years of age living in Kurdistan, Iran in 2015. Using a questionnaire, data were collected by 4 trained dental students. The dependent variable was the decayed, missing, and filled teeth (DMF) index. Using principal component analysis, the socioeconomic status (SES) of families was determined based on their household assets. Inequality was measured using the concentration index; in addition, the Oaxaca analytical method was used to determine the contribution of various determinants to the observed inequality. Results: The concentration index for poor scores on the DMF index was -0.32 (95% confidence interval [CI], -0.40 to -0.36); thus, poor DMF indices had a greater concentration in groups with a low SES (p<0.001). Decomposition analysis showed that the mean prevalence of a poor DMF index was 43.7% (95% CI, 40.4 to 46.9%) in the least privileged group and 14.4% (95% CI, 9.5 to 9.2%) in the most privileged group. It was found that 85.8% of the gap observed between these groups was due to differences in sex, parents' education, and the district of residence. A poor DMF index was less prevalent among people with higher SES than among those with lower SES (odds ratio, 0.31; 95% CI, 0.19 to 0.52). Conclusions: An alarming degree of SES inequality in oral health status was found in the studied community. Hence, it is suggested that inequalities in oral health status be reduced via adopting appropriate policies such as the delivery of oral health services to poorer groups and covering such services in insurance programs.

• 약학회지
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• 제43권4호
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• pp.464-468
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• 1999

In order to find less toxic antiviral agents from basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (Pers.) Karst. Anti-encephalomyocarditis (EMC) virus activity of EA was examined in Vero cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with interferon (IFN) alpha and gamma were examined on the multiplication of EMC virus. EA exhibited a concentration-dependent reduction in the plaque formation of EMC virus with 50% effective concentration ($EC_{50}$) of 2.12 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha showed potent synergism with CI values of 0.40~0.60 for 50%, 70% and 90% effective levels, but that with IFN gamma showed antagonism with CI values of 2.16~2.83.

• 한국안전학회지
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• 제35권5호
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• pp.59-65
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• 2020

For monitoring the status of industrial accidents, many statistical indexes have been developed and applied such as fatal rate, frequency rate, and severity rate. These accident indexes are measured by frequency and loss time according to the accidents in the individual industry level. However, it is less considered to use the index of identifying the industrial concentration of accidents in the holistic view. Thus, this study aims to suggest the accident concentration level among domestic industries through index analysis. The concentration level of industrial accidents is calculated by the accident composition of sub-industries. This concentration level shows whether an industry is comprised of a few sub-industries generating more accidents or an industry consists of sub-industries having the similar number of accidents. To this end, the concentration rate (CR) and concentration index (CI) are proposed to take a look at the industry composition of accidents by embracing the concept of market concentration indexes such as Hirschman-Herfindahl Index. As for the case study, four industries of mining, manufacturing, transportation, and other business (usually service) are analyzed in terms of indexes of accident rate, death(fatality) rate, and CR and CI of accident and death. Finally, we illustrate the positioning map that the accident concentration level is compared with the traditional accident frequency level among industries.

• 한국콘텐츠학회논문지
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• 제20권1호
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• pp.530-538
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• 2020

최근 우리나라의 자살률 문제가 매우 심각한 상황에서 지방자치단체들은 자살률을 낮추는 것을 목표로 다양한 정책 노력을 추진하고 있다. 본 연구는 지역 간 자살률의 차이를 평가하고 집중지수(CI)를 산출하여 그 변화추이를 확인함으로써 지방자치단체의 노력에 근거를 제시하고자 한다. 주요 연구결과는 다음과 같다. 첫째, 지난 20년간 시군구 자살률은 군 지역 자살률이 가장 높고 구 지역이 가장 낮아서 도시 지역일수록 자살률이 낮은 현상이 지속되었다. 둘째, 시군구 자살률은 모든 지역에서 증가하고 있지만 구 지역과 군 지역의 자살률 격차는 감소하고 있었다. 즉, 도시와 농어촌 지역의 자살률 차이가 감소하고 있는 것이다. 셋째, 지역 간 자살률 차이를 지속적으로 모니터링하기 위해 산출한 집중지수 산출결과 20년 전체 자살률 집중지수가 모두 음(-)의 값으로 나타나서 인구밀도가 낮은 농어촌 지역의 자살률이 높았다. 넷째, 20년간 집중지수의 절대 값이 지속적으로 감소하고 있어서 농어촌과 도시 지역의 자살률 격차는 감소하고 있는 것으로 나타났다. 따라서 지역 간 자살률은 상향 평준화하고 있는 것으로 평가된다.

• Natural Product Sciences
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• 제5권2호
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• pp.107-111
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• 1999

To investigate less toxic antiviral agents from Basidiomycetes, EA, the water soluble substance, was isolated from the carpophores of Elfvingia applanata (pers.) Karst. Anti-varicella zoster virus (Oka strain; anti-VZV/Oka) activity of EA was examined in MRC-5 cells by plaque reduction assay in vitro. And the combined antiviral effects of EA with nucleoside anti-VZV agents, acyclovir and vidarabine, were examined on the multiplication of VZV/Oka. EA exhibited a concentration-dependent reduction in the plaque formation of VZV/Oka with a 50% effective concentration $(EC_{50})$ of $464.14\;{\mu}g/ml$. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combination of EA with acyclovir showed more potent synergism with CI values of $0.18{\sim}0.62$ for $50{\sim}90%$ effective levels than that of EA with vidarabine with CI values of $0.67{\sim}1.04$.

• 생약학회지
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• 제30권2호
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• pp.151-157
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• 1999

In order to find less toxic antiherpetic agents, the effect of natural quercetin on the plaque formation of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) was studied in vitro in cell culture monolayers employing the technique of viral plaque reduction assay. Quercetin caused a concentration-dependent reduction in the plaque formation of herpesviruses. It also exhibited more potent antiherpetic activity on HSV-1 with effective concentration $(EC_{50})$ of $18.7\;{\mu}g/ml$ than on HSV-2 with $EC_{50}$ of $24.5\;{\mu}g/ml$. The combined antiherpetic effects of quercetin with nucleoside antiherpetic agents, acyclovir and vidarabine, were examined on the multiplication of these two strains of herpesviruses in Vero cells by the combination assay. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combinations of quercetin with acyclovir on HSV-1 and HSV-2 showed more potent synergism with CI values of $0.19{\sim}0.89$ for 50%, 70%, 90% effective levels than those with vidarabine with CI values of $0.43{\sim}1.46$.

• Biomolecules & Therapeutics
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• 제7권2호
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• pp.158-163
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• 1999

In order to find less toxic antiherpetic agents, antiviral activities of quercitrin against two strains of pathogenic viruses such as herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) were determined in Vero cells using plaque reduction assay in vitro. Quercitrin showed a concentration-dependent decrease in plaque formation of HSV-1 and HSV-2. It also exhibited more potent antiherpetic activity on HSV-1 with 50% effective concentration (EC$_{50}$) of 20.4 $\mu$g/ml than on HSV-2 with EC$_{50}$ of 30.4 $\mu$g/ml. The combined antiherpetic effects of quercitrin with nucleoside antiherpetic agents, acyclovir and vidarabine, were examined on the multiplication of these two strains of herpesviruses in Vero cells by the combination assay. The results of combination assay were evaluated by the combination index (CI) that was calculated by the multiple drug effect analysis. The combinations of quercitrin with acyclovir and vidarabine on HSV-1 showed more potent synergism with CI values of 0.27-0.81 for 50%, 70%, 90% effective levels than those on HSV-2 with CI values of 1.03~2.20..20.

• 약학회지
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• 제43권4호
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• pp.469-473
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• 1999

EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers). Karst. Anti-influenza A virus (anti-Flu A) activity of EA was examined of Vero cells by plaque reduction assay in vitro. And the combined antiviral effects fo EA with interferon (IFN) alpha and gamma were examined on the multiplication of Flu A with 50% effective concentration ($EC_50$) of 1.50 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha on Flu A showed more potent synergism with CI values of 0.50~0.52 of 50%, 70%, 90% effective levels than that with IFN gamma with CI values of 0.82~0.99.

• 한국인터넷방송통신학회논문지
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• 제19권3호
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• pp.83-90
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• 2019

최근 들어 노년기의 인지기능장애에 대한 예방 또는 치료의 필요성이 대두되고 있다. 특히 알츠하이머 치매의 전단계로서 경도인지장애(Mild Cognitive Impairment) 여부를 조기에 진단하고, 인지기능 훈련을 통하여 치매로의 진행을 지연시키고자 노력하고 있다. 대부분의 인지기능 훈련은 여러 가지 인지능력과 관련한 게임 콘텐츠로 제작되지만, 피험자들이 인지기능 훈련에 집중하고 있는 지에 대한 정량적 검증이 필요하다. 그래서 본 논문에서는 제작된 주의력 훈련 게임 콘텐츠를 수행하는 동안 뇌 활성화에 대한 EEG 신호를 측정하여 분석하였다. 분석 방법으로는 게임 콘텐츠에 얼마나 집중하고 있는 지를 나타내는 주의집중 지표(Concentration Index)와 휴식 상태에서의 안정을 나타내는 이완 지표(Relaxation Index)를 사용하였다. 이에 대한 본 연구에서의 결과는 피험자들의 CI는 모두 증가하는 것으로 나타났으며, 이것은 피험자들이 집중하여 게임 콘텐츠를 수행하였다고 볼 수 있는 것이다.

• 디지털융복합연구
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• 제16권5호
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• pp.75-84
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• 2018

본 연구는 인구 10만명 당 사회복지시설수의 지역분포를 집중지수(CI)를 활용하여 시계열로 분석하고 지역복지환경과의 관계를 평가하여 균등한 복지자원 분포를 위한 근거자료로 활용하기 위해 수행되었다. 분석결과와 함의는 다음과 같다. 첫째, 도시와 농어촌간 사회복지시설의 분포차이를 시계열적으로 분석한 결과 농어촌지역에 사회복지시설이 많이 분포하고 있었으며, 농어촌 집중현상은 점차 감소하고 있었다. 둘째, 인구밀도 지역구분에 따른 사회복지시설 집중지수를 산출한 결과 집중지수가 10년간 꾸준히 음(-)의 값으로 나타나서 농어촌 지역에 사회복지시설이 집중된 것으로 나타났다. 그러나 집중지수 절대 값이 감소추세를 보이고 있어서 집중현상은 줄어들고 있었다. 끝으로 지역복지환경과의 관계분석결과 경제여건이 나쁜 지역, 저소득층이 많은 지역, 복지예산 투입이 적은 지역, 사회해체 관련 지표가 나쁜 지역에 사회복지시설이 많이 분포하고 있었다. 대체로 지역복지환경을 고려한 사회복지시설 분포가 이루어지고 있는 것으로 평가된다. 향후 복지자원 지역분포의 불평등과 지역복지환경과의 관계를 지속적으로 모니터링하여 사회복지자원이 지역별로 균형있게 배분될 수 있도록 하여야 할 것이다.