• 한국산업융합학회 논문집
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• 제4권4호
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• pp.395-401
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• 2001

The characteristics of heat transfer and pressure drop through tubes has been investigated experimentally for a compound heat transfer enhancement. The test tubes were spirally indented tubes with wire coil inserts which had a various combinations of pitch and helix angles. Pure water was used as working fluids for the experiments, Heat transfer coefficients and friction factors of the test tubes were evaluated from the values of measured temperatures, flow rates and pressure drops. An performance evaluation was performed to find an optimal combination of spirally indented tubes with wire coil inserts. When the helix angle of wire coil insert are $71^{\circ}-72^{\circ}$, the best heat transfer enhancement was shown. The friction factor was 9 - 13 times higher than those in smooth tubes, and the heat transfer was enhanced a maximum of 500%.

• Asian Journal of Innovation and Policy
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• 제5권2호
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• pp.197-207
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• 2016

This paper seeks to measure the monetary value of technical development in the deep seabed manganese nodule mining by applying the compound option model (COM). The COM is appropriate for the project in terms of its decision-making structure and embedded uncertainty. The estimation results show that the deep seabed mining project has more economic potential than shown by the previously obtained results from the discounted cash flow (DCF) analysis. In addition, it is reasonable to invest in the project taking the various uncertainty factors into consideration, because the ratio of the value to the cost of the project is far higher than one. This information can be utilized in national ocean policy decision-making.

• 한국의류학회지
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• 제42권5호
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• pp.855-870
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• 2018

This study analyzes and categorize the types of digital signage content using the case study method as well as explores the moderating effects of digital signage content in the relationship between digital signage attributes and consumer's flow using the empirical study method. For a case study, the total of 38 fashion brands, including 10 designer brands, 14 sports and outdoor brands, 6 casual brands and 8 SPA brands were investigated. For an empirical study, the virtual store with two types of digital signage contents was developed. Then, the online survey was conducted with 20s to 40s respondents and a total of 544 responses were analyzed using SPSS 24.0. The study results were as follows. First, digital signage in fashion store were categorized into four types by its content; brand-centric type, product-centric type, compound type, and promotional type. Second, digital signage consists of three attributes such as attractiveness, informativity, and entertainment. Third, the results showed that attractiveness and entertainment had a significant effect on consumer's flow. The type of digital signage content was also shown to moderate the influence of attractiveness and consumer's flow.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2003년도 춘계학술대회 논문집
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• pp.32-36
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• 2003

This paper deals with a theoretical method for the design of a biased asymmetric preswirl stator propulsion system which has been used to increase efficiency by the recovery of a propeller slipstream rotational energy by the counter rotating flow of a stator. In the case of full slow-speed ship, the upward flow is generated at the propeller plane by the after body hull form. The generated upward flow cancells the rotating flow of the propeller at the starboard part while it increases at port part. A biased asymmetric preswirl stator propulsion system consists of three blades at the port and one blade at the starboard which can recover the biased rotating flow effectively. This paper provides the design concept which gives more simple and a high degree of efficiency. The model tests for the designed compound propulsion system will be carried out later.

• 한국습지학회지
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• 제18권3호
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• pp.267-274
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• 2016

농촌 지역 하수도 보급은 하천, 호소 및 습지와 같은 수계 수질 보호를 위해서 반드시 필요하다. 또한 안정적인 소규모 하수처리장 운영을 위해서는 유입 유량과 농도의 변화가 큰 소규모 하수도 특성을 고려해야 한다. 본 연구에서는 봉화군 18개의 소규모 하수처리장 운전 결과를 통해 유입유량비 (유입 유량 / 설계 유량) 특성, 소규모 하수처리장 처리 효율에 미치는 영향과 적정 유입유량비 산정에 관한 연구를 수행하였다. 분석 결과 유입유량비는 여름철에 가장 높은 것으로 나타난 반면, 유입 하수 농도는 가을철과 겨울철에 높은 것으로 나타났다. 유입유량비가 증가할수록 처리 효율이 증가하는 경향을 보였으며, 영양염류 처리 효율이 유기물과 부유물질 처리 효율에 비해 민감한 영향을 받는 것으로 나타났다. 안정적인 소규모 하수처리장 처리 효율을 위해서는 유입유량비 0.8 이상을 유지해야 할 것으로 판단된다.

• Journal of Ginseng Research
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• 제37권1호
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• pp.135-141
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• 2013

A rapid, sensitive and selective analytical method was developed and validated for the determination of compound K, a major intestinal bacterial metabolite of ginsenosides in human plasma. Liquid-liquid extraction was used for sample preparation and analysis, followed by liquid chromatography tandem spectrometric analysis and an electrospray-ionization interface. Compound K was analyzed on a Phenomenex Luna C18 column ($100{\times}2.00$ mm, 3 ${\mu}m$) with the mobile phase run isocratically with 10 mM ammonium acetate-methanol-acetonitrile (5:47.5:47.5, v/v/v) at a flow rate of 0.5 mL/min. The method was validated for accuracy (relative error <12.63%), precision (coefficient of variation <9.14%), linearity, and recovery. The assay was linear over the entire range of calibration standards i.e., a concentration range of 1 ng/mL to 1,000 ng/mL ($r^2$ >0.9968). The recoveries of compound K after liquid-liquid extraction at 1, 2, 400, and 800 ng/mL were $106.00{\pm}0.08%$, $103.50{\pm}0.19%$, $111.45{\pm}5.21%$, and $89.62{\pm}34.46%$ for intra-day and $85.40{\pm}0.08%$, $94.50{\pm}0.09%$, $112.50{\pm}5.21%$, and $95.87{\pm}34.46%$ for inter-day, respectively. The lower limit of quantification of the analytical method of compound K was 1 ng/mL in human plasma. The developed method was successfully applied to a pharmacokinetic study of compound K after oral administration in ten of healthy human subjects.

• 한국산학기술학회논문지
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• 제11권8호
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• pp.2935-2941
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• 2010

본 논문은 SLS의 함유정도를 다르게 한 A(0%), B(1.1%), C(2.2%)의 세가지 실험세치제를 제작하여 구취변화를 실험하였다. 대상은 전신질환이 없는 20대 성인 150명이었으며 50명씩 세 그룹(A, B, C )으로 나누어 진행되었다. SLS함량에 따른 세치제의 4주간사용 후 3집단의 구취변화를 황화물가스와 암모니아 양의 변화로 측정한 결과 3집단 모두 집단내의 변화는 있는 것으로 나타났지만 SLS함량에 따른 상관관계를 본 결과에서는 구강황(r=0.412)과 호기황(r=0.285)에서만 상관관계가 있는 것으로 나타났다. 이는 잇솔질의 개선으로 인한 변화라고 볼 수 있으며 SLS의 함량이 높을수록 타액분비율을 저하시켜, 구강건조를 유발하므로 구강 황화합물과 호기 황화합물의 수치가 높게 나온 것으로 생각된다.

• 대한기계학회논문집B
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• 제35권9호
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• pp.903-913
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• 2011

본 연구에서는 가스터빈 블레이드의 냉각을 위해 사용되는 막냉각 홀을 대상으로 다양한 형상변수들이 막냉각 효율에 미치는 영향을 평가하기 위한 수치적 연구를 수행하였다. 삼차원 압축성 Reynolds-averaged Navier-Stokes 해석을 수행하였으며, 난류모델로는 shear stress transport 모델이 사용되었다. 해석을 통해 홀의 형상, 측면 방향 분사각, 홀의 주기 및 분사율이 막냉각 효율에 미치는 영향이 평가되었다. 해석결과, 원통형홀의 경우 측면 방향 분사각이 존재할 때 월등히 향상된 막냉각 효율을 보여주었으며, 홴형상 홀의 경우 측면 방향 분사각이 $20^{\circ}{\sim}30^{\circ}$일 때 가장 높은 막냉각 효율을 보여주었다. 또한 홀의 주기의 변화에 따른 성능평가 결과 높은 분사율일 때가 낮은 분사율의 경우보다 홀의 주기에 의존하는 경향을 보였다.

• Archives of Pharmacal Research
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• 제19권6호
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• pp.554-558
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• 1996

High-performance liquid chromatographic method was developed for the determination or LB 20304 (compound 1) in the plasma of rats and dogs. The analyte was deproteinized with 1 volume of methanol and 1/2 volume of 10% zinc sulfate, and the supernatant was injected onto a reversed-phase HPLC column. The mobile phase was a mixture of 24 parts of acetonitrile and 76 parts of 0.1% trifluoroacetic acid. The flow rate was 1 ml/min, and the effluent was monitored by fluorescence detector at an excitation wavelength of 337 nm and an emission wavelength of 460 nm. The retention time of compound 1 was 6.3 min. The assay of compound 1 was linear over the concentration range of 0.2-100.mu.g/ml in the plasma of rats and dogs. The lower limit of quantification was 0.2.mu.g/ml using 100.mu.l of plasma with a 97-99% accuracy and a 12-14% precision. In the 0.5, 5, and 50.mu.g/ml quality control samples, the intra- and inter-day accuracy were 88-95% and 88-97%, whereas intra- and interday precision were 0.5-6.6% and 0.2-9.3%, respectively, in the plasma of rats and dogs. The recoveries were 68-71% independent of concentration and species in the plasma. No interferences from endogenous substances were observed. Taken together, the above HPLC assay method by deproteinization and fluorescence detection was suitable for the determination of compound 1 in the preclinical pharmacokinetics.

• Journal of Ginseng Research
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• 제43권4호
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• pp.692-698
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• 2019

Background: Breast cancer is a severe disease and the second leading cause of cancer death in women worldwide. To surmount this, various diagnosis and treatment options for breast cancer have been developed. One of the most effective strategies for cancer treatment is to induce apoptosis using naturally occurring compounds. Compound K (CK) is a ginseng saponin metabolite generated by human intestinal bacteria. CK has been studied for its cardioprotective, antiinflammatory, and liver-protective effects; however, the role of CK in breast cancer is not fully understood. Methods: To investigate the anticancer effects of CK in SKBR3 and MDA-MB-231 cells, cell viability assays and flow cytometry analysis were used. In addition, the direct targets of CK anticancer activity were identified using immunoblotting analysis and overexpression experiments. Invasion, migration, and clonogenic assays were carried out to determine the effects of CK on cancer metastasis. Results: CK-induced cell apoptosis in SKBR3 cells as determined through 3-(4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide assays, propidium iodide (PI) and annexin V staining, and morphological changes. CK increased the cleaved forms of caspase-7, caspase-8, and caspase-9, whereas the expression of Bcl-2 was reduced by CK. In assays probing the cell survival pathway, CK activated only AKT1 and not AKT2. Moreover, CK inhibited breast cancer cell invasion, migration, and colony formation. Through regulation of AKT1 activity, CK exerts anticancer effects by inducing apoptosis. Conclusion: Our results suggest that CK could be used as a therapeutic compound for breast cancer.