• Korea Journal of Cosmetic Science
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• 제1권1호
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• pp.31-43
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• 2019

Melanosomes are specific melanin-containing intracellular organelles of epidermal melanocytes. In epidermal melanocytes, there are three kinds of key player proteins. Rab27a, melanophilin or Slac2-a and Myosin 5a form a tripartite complex connects the melanosome. Mature melanosomes make movements through the tripartite protein complex along actin filaments.In this study, we found that the haplamine (6-Methoxyflindersine) induced melanosome aggregation around the nucleus in epidermal melanocyte. In an attempt to elucidate the inhibitory effect of haplamine on melanosome transport, effect of haplamineon the expression level of Rab27a, melanophilin and Myosin 5a was measured. The results indicated that haplamine up to 5��M effectively suppressed mRNA and protein expression level of melanophilin.To determine the upstream regulator of melanophilin regulated by haplamine, we checked the level of MITF, c-JUN and USF1. Those are possible transcription factor of melanophilin. Among them,treatment of USF1 siRNA decreased mRNA and protein expression level of USF1 as well as melanophilin. Also, treatment of haplamine decreased mRNA and protein expression level of melanophilin as well as USF1 in a dose-dependent manner. Consequently, we found the inhibitory effect of haplamine on melanosome transport in melan-a melanocyte. Treatment of haplamine reduced melanophilin expression level which is a key protein of melanosome transport. We identified that USF1 could be a major transcription factor of melanophilin regulated by haplamine.

• 한국실내디자인학회논문집
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• 제40호
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• pp.26-33
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• 2003

Contemporary architecture has two different movements that one is the utilization of digital technology and the other is the inclination to nature. After deconstructivism in architecture, the tendency of design shows the fusion between digitalism and organicism and as a consequence the phenomena of 'skin expression' has emerged which can be thought as 'organic digitalism' or 'digital organicism'. The definition of skin tendency in environmental design is the design of nature based on the technology. As a result, the surface becomes the design issue compared to structure and the momentum for new aesthetic value. There are post-structuralism, complex system theory and the organic architecture as theoretical background for the tendency of skin expression. Specially the ideas of post-structural philosophy has effected deeply to the formation of its movement and also offered the theoretical nutrition for digital architecture. The characteristics of the skin tendency can be analyzed as topological transformation, smooth continuum, deterritorialization, ecological response system, and tactility. These design characteristics has combined with conventional material and design vocabulary to transform and develope new spatial conception.

• 디지털산업정보학회논문지
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• 제5권2호
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• pp.167-176
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• 2009

In this paper, a system that detects driver's drowsiness has been implemented based on the automatic extraction and the tracking of pupils. The research also focuses on the compensation of illumination and reduction of background noises that naturally exist in the driving condition. The system, that is based on the principle of Haar-like feature, automatically collects data from areas of driver's face and eyes among the complex background. Then, it makes decision of driver's drowsiness by using recognition of characteristics of pupils area, detection of pupils, and their movements. The implemented system has been evaluated and verified the practical uses for the prevention of driver's drowsiness.

• Journal of Electrical Engineering and Technology
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• 제10권2호
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• pp.676-687
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• 2015

Path planning algorithms are used to allow mobile robots to avoid obstacles and find ways from a start point to a target point. The general path planning algorithm focused on constructing of collision free path. However, a high continuous path can make smooth and efficiently movements. To improve the continuity of the path, the searched waypoints are connected by the proposed polynomial interpolation. The existing polynomial interpolation methods connect two points. In this paper, point groups are created with three points. The point groups have each polynomial. Polynomials are made by matching the differential values and simple matrix calculation. Membership functions are used to distribute the weight of each polynomial at overlapped sections. As a result, the path has $G^2$ continuity. In addition, the proposed method can analyze path numerically to obtain curvature and heading angle. Moreover, it does not require complex calculation and databases to save the created path.

• 한국수학사학회지
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• 제29권6호
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• pp.353-363
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• 2016

In mathematical population ecology which is an academic field that studies how populations of biological species change as times flows at specific locations in their habitats, PDE models have been studied in many aspects and found to have different properties from the classical ODE models. And different approaches to PDE type models in mathematical biology are still being tried currently. This article investigate various forms to express diffusion effects and review the history of PDE models involving diffusion terms in mathematical ecology. Semi-linear systems representing the spatial movements of each individual as random simple diffusion and quasi-linear systems describing more complex diffusions reflecting interspecific interactions are studied. Also it introduce a few of important problems to be solved in this field.

• 한국공작기계학회논문집
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• 제17권1호
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• pp.150-157
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• 2008

Bellows are commonly used in piping systems to absorb expansion and contraction in order to reduce stress. Unlike most piping components, bellows consist of a thin-walled shell of revolution with a corrugated meridian, in order to provide the flexibility needed to absorb mechanical movements. It is a composite shell structure consisting of at least one toroidal shell, an annular plate or conical shell. It is difficult to analyze the behavior of bellows because of its complex geometry. Simplified formulas for variable mechanical behaviors of bellows are provided by a standard called EJMA. An automatic design software for bellows is programming by using VBA(Visual Basic for Application) based on EJMA. Bellows engineers can effectively make a decision for bellows geometries because this software provides graphically design results in its post-processor. Bellows design software is expected to give quite a good guidance to practical design. The characteristics of bellows are also investigated through the automatic design process in bellows design software.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1883-1884
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• 2008

This paper presents a framework for decentralized control of self-organizing swarm agents based on the artificial potential functions (APFs). The framework explores the benefits by associating agents based on position information to realize complex swarming behaviors. A key development is the introduction of a set of association rules by APFs that effectively deal with a host of swarming issues such as flexible and agile formation. In particular, this paper presents an association rule for swarming that requires less movements for each agent and compact formation among agents. Extensive simulations are presented to illustrate the viability of the proposed framework.

• 한국농공학회지
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• 제40권5호
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• pp.80-90
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• 1998

The EPS construction method-one kind of the load reducing methods-utilizes the EPS blocks, ultra-light materials whose unit weight is about 1/100 of soils and has been applied to many soft ground sites. It needed 3,000 days to get the 90% degree of the consolidation for the case of 12m high soil embankments on the 30m thick soft clayey foundations. The N value of SPT at this deposit was less than 5. The pack drain was installed to promote the radial consolidations. Although staged embankments were planned, designers failed to get a sufficient stability of the foundation ground. Therefore, the EPS fill method was selected to reduce the load and the construction period. EPS blocks(D-20 model) replaced the upper part of the soil embankments. These complex embankments reduced the ground settlement and the construction period. The possibility of lateral movements of the bridge abutments was checked and the design scheme was reviewed.

• Safety and Health at Work
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• 제6권1호
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• pp.9-17
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• 2015

The human hand is a complex structure that performs various functions for activities of daily living and occupations. This paper presents a literature review on the methodologies used to evaluate hand functions from a biomechanics standpoint, including anthropometry, kinematics, kinetics, and electromyography (EMG). Anthropometry describes the dimensions and measurements of the hand. Kinematics includes hand movements and the range of motion of finger joints. Kinetics includes hand models for tendon and joint force analysis. EMG is used on hand muscles associated with hand functions and with signal-processing technology.

• 한국습지학회지
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• 제5권1호
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• pp.53-66
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• 2003

The subject of sediment transport has been studied for centuries by engineers and river morpohologists. Many of the complex aspects of sediment transport are yet to be understood, and remain among the challenging subject for future studies. In this study, the finite element model is applied to various hypothetical channels. On the basis of the flow analysis results, sediment transport analysis is conducted using 3-different optional equations, and the results are compared with experimental results. For the purpose of predicting the sediment movements in natural river, RMA model is applied to Geum-River. It turned out to be very effective tool to predict various aspects of river evolution and the effects of hydraulic structures. The simulation results are also linked to the Geographic Information Systems (GIS).