• Radiation Oncology Journal
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• 제36권3호
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• pp.192-199
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• 2018

Purpose: Use of radiotherapy combined with chemotherapy is increasing in hypopharyngeal cancer. However, many show residual tumor after radiotherapy. Timing for treatment evaluation and salvage therapy is essential. However, optimal timing for salvage surgery has not been suggested. In this study, we tried to evaluate optimal timing for salvage surgery. Methods and Materials: Patients who were diagnosed with hypopharyngeal squamous cell carcinoma between 2006 and 2015 were retrospectively analyzed. All patients received definitive radiotherapy with or without chemotherapy. Response of all treated patients were analyzed at 1, 3, and 6 months after radiotherapy. Any patients with progression before 6 months were excluded. Results: A total of 54 patients were analyzed. Complete remission (CR) rates at 1 month (CR₁), 3 months (CR₃) and 6 months (CR₆) were 66.7%, 81.5%, and 90.7%, respectively. Non-CR at 1 month (NCR₁), 3 months (NCR₃), and 6 months (NCR₆) showed poor locoregional recurrence-free survival rates (1-year rates of 63.7%, 66.7%, and 0.0%, respectively) compared to CR₁, CR₃, and CR₆ (1-year rates 94.3%, 88.0%, and 91.5%, respectively). Particularly significant differences were seen between CR₆ and NCR₆ (p < 0.001). Of 10 patients with NCR₃, 5 showed CR at 6 months (NCR₃/CR₆). There was no statistical difference in locoregional recurrence-free survival between CR₃ and NCR₃/CR₆ group (p = 0.990). Conclusion: Our data suggest half of patients who did not show CR at 3 months eventually achieved CR at 6 months. Waiting until 6 months after radiotherapy may be appropriate for avoiding additional salvage therapy.

• 한국유기농업학회지
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• 제26권1호
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• pp.151-161
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• 2018

This study was designed to investigate the effects of multi-enzyme on diarrhea and immune responses of weaned pigs. A total 36 weaned pigs ($5.92{\pm}0.48kg\;BW$; 28 d old) were randomly allotted to 2 dietary treatments (3 pigs/pen, 6 replicates/treatment) in a randomized complete block design. The dietary treatments were a typical diet based on corn and soybean meal (CON) and CON with 0.1% multienzyme (Multi; mixture of ${\beta}-mannanase$, xylanase, ${\alpha}-amylase$, protease, ${\beta}-glucanase$, and pectinase). Pigs were fed their respective diets for 6 wk. Frequency of diarrhea, levels of packed cell volume (PCV), white blood cells (WBC), immunoglobulins, cortisol, tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), transforming growth $factor-{\beta}$ ($TGF-{\beta}$), and C-reactive protein (CRP) were measured. Multi group tended to decrease (p<0.1) diarrhea frequency than CON group during 2 wk after weaning. Lower values of PCV on d 3 (p<0.05) and d 7 (p<0.1) were found in Multi group compared with CON group. There were no significant differences on WBC number and immunoglobulin (Ig) M and A between Multi and CON groups. However, Multi group tended to increase (p<0.1) Ig G on d 7 than CON group. Moreover, Multi group showed modulated immune responses, indicated by decreased levels of cortisol (p<0.05) on d 7 and 14, $TNF-{\alpha}$ on d 3 (p<0.05) and d 7 (p<0.10), $TGF-{\beta}$ on d 2 (p<0.05) and d 7 (p<0.10), and CRP (p<0.10) on d 3 and 7 after weaning compared with CON group. Consequently, inclusion of multi-enzyme in diets for weaned pigs improved gut health and modulated immune responses of weaned pigs.

• 벤처창업연구
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• 제16권4호
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• pp.179-193
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• 2021

개, 고양이 등과 같은 애완동물을 가족 구성원, 동반자의 개념으로 받아들이게 되어 반려동물로 부르는 일이 점점 보편화되게 되었다. 반려동물을 사람과 동일시하고 가족의 일원으로 대우하는 추세가 점점 확산되면서 사람들이 반려동물을 위한 음식, 건강, 여가 등에 더욱 신경 쓰게 되고 고가의 제품을 찾고 이와 연관된 비즈니스의 성장을 가속화시키고 있다. 본 연구는 반려동물 온라인 쇼핑몰을 방문한 고객들을 대상으로 온라인 설문을 진행하여 데이터를 수집하였다. 반려동물을 키우면서 반려동물 온라인 쇼핑몰에서 한 번이라도 구매해 본 사람들만을 대상으로 수집한 자료를 실증분석에 활용하였다. 205명의 설문지가 수집되었지만 불성실한 응답을 한 설문지를 제외하고 총 198부가 분석에 사용되었다. 본 연구를 통해 확인한 결과는 다음과 같다. 첫째, 탐색적 요인분석을 통해 반려동물 온라인 쇼핑몰의 서비스품질요인은 의사소통거래, 안전보안, 디자인, 정보제공의 4개 차원으로 구성됨을 확인할 수 있었다. 둘째, 반려동물 온라인 쇼핑몰 서비스품질요인인 의사소통거래, 정보제공, 디자인, 안전보안은 모두 고객만족에 유의한 정(+)의 영향을 주는 것으로 나타났다. 셋째, 반려동물 온라인 쇼핑몰의 고객만족은 충성도에 유의한 정(+)의 영향을 준다는 것을 확인하였다. 넷째, 반려동물 온라인 쇼핑몰의 서비스품질요인들(의사소통거래, 안전보안, 디자인, 정보제공)과 충성도 간의 관계에서 고객만족은 완전매개효과가 있음을 확인하였다.

• 한국산학기술학회논문지
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• 제22권4호
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• pp.25-36
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• 2021

본 연구는 도림천에서 발생한 고립 및 실족과 같은 수난사고의 근본적인 원인을 분석하고, 법·제도적인 개선방안을 제시하였다. 원인분석을 위하여 현장확인, 관계자 인터뷰, 관련자료 검토, 강우량과 하천 횡단면의 수위와의 관계, 자동경보 발령 기준수위의 적정성 및 진·출입 통제에 따른 대피시간 확보 가능여부 등을 평가 하였다. 도림천은 전형적인 도시하천의 특성을 띄고 있어 치수적으로 불리하며, 사망사고가 발생한 구간은 급만곡부를 형성하고 있는 등 고립사고 발생 위험이 높다. 고립 및 실족사고는 홍수주의·경보 발령 전 단계인 둔치주의·대피 단계에서 발생하고 둔치대피 발령은 둔치턱까지 수위가 상승해서야 발령되기 때문에 있기 때문에 강우예보에 따른 수위상승에 대한 즉각적인 대응이 중요하다. 또한, 수위 상승속도가 신림3교와 관악도림교에서 최대 2.62 cm/min임을 고려하였을 때 둔치경보 발령 후 충분한 대피시간을 확보하고 있지 못하다. 사망사고는 둔치주의 발령 기준수위보다 0.46 m이하에서 발생한 점을 보았을 때, 하천의 진·출입 등 통제가 사고 예방을 위해서는 매우 중요하다. 이러한 분석결과를 바탕으로 4건의 개선방안을 제시하였으며, 고립 및 실족과 같은 수난사고를 예방하는데 크게 기여할 수 있을 것으로 기대한다.

• Journal of Breast Cancer
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• 제21권4호
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• pp.433-4341
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• 2018

Purpose: This study aimed to evaluate the effects of sentinel lymph node biopsy (SLNB) on recurrence and survival after neoadjuvant chemotherapy (NAC) in breast cancer patients with cytology-proven axillary node metastasis. Methods: We selected patients who were diagnosed with invasive breast cancer and axillary lymph node metastasis and were treated with NAC followed by curative surgery between January 2007 and December 2014. We classified patients into three groups: group A, negative sentinel lymph node (SLN) status and no further dissection; group B, negative SLN status with backup axillary lymph node dissection (ALND); and group C, no residual axillary metastasis on pathology with standard ALND. Results: The median follow-up time was 51 months (range, 3-122 months) and the median number of retrieved SLNs was 5 (range, 2-9). The SLN identification rate was 98.3% (234/238 patients), and the false negative rate of SLNB after NAC was 7.5%. There was no significant difference in axillary recurrence-free survival (p=0.118), disease-free survival (DFS; p=0.578) or overall survival (OS; p=0.149) among groups A, B, and C. In the subgroup analysis of breast pathologic complete response (pCR) status, there was no significant difference in DFS (p=0.271, p=0.892) or OS (p=0.207, p=0.300) in the breast pCR and non-pCR patients. Conclusion: These results suggest that SLNB can be feasible and oncologically safe after NAC for cytology-determined axillary node metastasis patients and could help reduce arm morbidity and lymphedema by avoiding ALND in SLN-negative patients.

• Journal of Breast Cancer
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• 제21권4호
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• pp.382-390
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• 2018

Purpose: PIK3CA mutation is considered to be a possible cause for resistance to neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. We investigated the association between PIK3CA mutations and the outcome of NAC in HER2-positive breast cancers. Methods: A total of 100 HER2-positive breast cancer patients who had undergone NAC and surgery between 2004 and 2016 were examined. Mutation status was sequentially assessed in pre-NAC, post-NAC, and recurrent specimens taken from these patients. Results: PIK3CA mutations were identified in the sequential specimens of 17 patients (17.0%). These 17 patients experienced shorter disease-free survival (DFS) than the rest of the patients (58.3 months vs. 119.3 months, p=0.020); however, there was no significant difference in pathologic complete response (pCR) and overall survival (OS) (pCR, 17.6% vs. 33.7%, p=0.191; OS, 84.5 months vs. 118.0 months, p=0.984). While there was no difference in pCR between the wild-type and mutant PIK3CA groups in pre-NAC specimens (25.0% vs. 31.8%, p=0.199), PIK3CA mutations correlated with lower pCR in postNAC specimens (0.0% vs. 24.3%, p<0.001). Multivariate analysis revealed significantly worse DFS in the mutant PIK3CA group than in the wild-type group (hazard ratio, 3.540; 95% confidence interval, 1.001-12.589; p=0.050). Moreover, the DFS curves of the change of PIK3CA mutation status in sequential specimens were significantly different (p=0.016). Conclusion: PIK3CA mutation in HER2-positive breast cancer was correlated with a lower pCR rate and shorter DFS. These results suggest that PIK3CA mutation is a prognostic marker for NAC in HER2-positive breast cancer, especially in post-NAC specimens.

• 대한두경부종양학회지
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• 제34권2호
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• pp.11-15
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• 2018

Background/Objectives: The efficacy of radiotherapy alone versus chemoradiotherapy has been studied in patients with T2N0M0 laryngeal squamous cell carcinoma. Materials & Methods: Thirty nine patients with newly diagnosed T2N0M0 laryngeal squamous cell carcinoma were treated with either radiotherapy(RT group, 66-70Gy) or chemoradiotherapy(CRT group, cisplatin based concurrent chemoradiation with or without 2 cycles induction chemotherapy including cisplatin, $5-FU{\pm}$ docetaxel / radiation therapy same with above mentioned). The mean follow-up was 73.5 months. Results: The overall survival (OS), disease specific survival (DSS), disease free survival (DFS), and larynx preservation survival (LPS) at 5 years were 70%, 79%, 67%, and 71%. The complete response rate was 82.4% in RT group, and was 95.5% in CRT group. OS (57% vs 80%), DSS (69% vs 86%), DFS (52% vs 77%), and LPS (63% vs 77%) at 5 years were higher in CRT group than RT group, but it was not statistically significant. In subsite analysis, CRT group tends to improve DFS, compared to RT group, in glottic cancer (p=0.06). The toxicities were tolerable and no fatal case was observed in both groups. Conclusion: Chemoradiotherapy is effective as primary therapy for T2 laryngeal squamous cell carcinoma and showed manageable treatment induced toxicity.

• Journal of Animal Science and Technology
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• 제61권2호
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• pp.77-86
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• 2019

The supplementation level of barley was limited because of high contents of fiber in monogastric animals. Barley contained high soluble fiber, thus it could prevent to diarrhea of weaning pigs. Moreover, as the barley break down by enzymes, free sugars come out from the barley, which could be used as an energy source in weaning pigs and replace milk by-products in weaning pig's diet. Therefore, present study was conducted to investigate the influence of barley to replace milk by-product in weaning pig's diet on growth performance, blood profile, nutrient digestibility, diarrhea incidence, and economic analysis in weaning pigs. A total of 112 crossbred ($[Yorkshire{\times}Landrace]{\times}Duroc$, weaned at 28 days of age) piglets were allotted to 4 treatments in a randomized complete block (RCB) design. Each treatment has 7 replications with 4 pigs per pen. Pigs were fed each treatment diet which containing different levels of barley (0%, 10%, 20%, and 30%) at the expense of whey powder and lactose. Three phase feeding programs were used for 6 weeks of growth trial (phase 1: 0-2 weeks; phase 2: 3-4 weeks; phase 3: 5-6 weeks). During 0-2 week, body weight (BW), average daily gain (ADG) and G:F ratio were decreased as barley level increased in the diet (linear response, p < 0.01). In blood profile, blood urea nitrogen was decreased as the barley level increased in the diet (linear, p < 0.01). However, no significant differences were observed in blood glucose level. In nutrient digestibility, crude fat digestibility was linearly increased as barley increased (linear, p < 0.01). The incidence of diarrhea was improved as increasing barley contents in all phases (linear, p < 0.01). These results demonstrated that supplementation of barley to replace milk by-product influenced negatively on growth performance during 0-2 week. However, the incidence of diarrhea and later growth performance from 3 week postweaning were improved as dietary barley level increased.

• 해양환경안전학회지
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• 제25권2호
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• pp.159-168
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• 2019

본 연구는 수중활동에서 나타나는 인체의 생리적 변화와 알코올 섭취로 인한 생리적 변화를 살펴보고 알코올 섭취가 스쿠버다이버에게 미치는 영향을 규명하는데 그 목적이 있다. 미국 내부통제연구소위원회의 내부통제 프레임워크를 기초로 본 연구에 적합하도록 새롭게 정립한 '리스크 평가 및 분석(RAA, risk assessment and analysis)' 기법을 활용하여 알코올 섭취 전과 후의 리스크 분석을 실시하였다. RAA기법은 리스크 간 상관관계를 분석하는 1단계, 리스크를 정량화하고 리스크 데이터베이스를 구축하는 2단계, 그리고 이를 도식화하여 리스크맵을 분석하는 3단계로 이루어져 있다. RAA기법을 통해 알코올 섭취로 인한 수중활동의 리스크수준이 전반적으로 증가하여 고위험군의 비율이 높아진 것을 확인하였고 리스크수준의 정량화와 고위험군 분류를 통해 리스크관리 측면에서 우선통제대상을 지정할 수 있었다. 본 연구 결과는 알코올 섭취 후 행해지는 스쿠버다이빙의 위험성을 명확하게 알리고 이에 대한 스쿠버다이버들의 의식 개선을 도모하여 보다 안전한 스쿠버다이빙 환경을 제시할 수 있을 것으로 기대한다.

• 대한족부족관절학회지
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• 제23권1호
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• pp.12-17
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• 2019

Purpose: This study examined the clinical outcomes and usefulness of triamcinolone acetonide (TA) injections as an option in the conservative treatment of patients with lateral malleolar bursitis of the ankle. Materials and Methods: A total of 27 patients (27 ankles), in whom TA injection had been performed between March 2016 and June 2017, were reviewed retrospectively. After the aspiration of fluid in the lateral malleolar bursal sac, 1 mL (40 mg) of TA was injected into the malleolar bursal sac. After the injection, the ankle was compressed with an elastic cohesive bandage for 2 to 4 weeks. The clinical outcomes and side effects were evaluated at the following time points: 2 weeks, 4 weeks, 3 months, 6 months, and 1 year after TA injection therapy. The responses to treatment were assessed according to the degree of fluctuation, shrinkage of the bursal sac, and soft tissue swelling. Results: The mean age was 62.1 years (range, 41~81 years); there were 19 males and 8 females. Complete resolution was observed in 26 patients (96.3%) after the first or second application of a TA injection, and a partial response was observed in 1 patient (3.7%) after the first TA injection. The physical component scores of Medical Outcomes Study 36-item Short-Form Health Survey improved from 71.1 to 76.0 at the last follow-up (p=0.001). Associated complications were 1 patient (3.7%) with skin atrophy and 3 patients (11.1%) with transient hyperglycemia in diabetes mellitus. Conclusion: TA injection is a useful and safe procedure for patients not responding to the usual conservative treatment of lateral malleolar bursitis of the ankle.