Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지
DOI QR코드

DOI QR Code

The treatment outcome of T2 laryngeal squamous cell carcinoma in one institution with long term follow-up: Radiotherapy alone vs Chemoradiotherapy

T2 후두 편평세포암종에서 단독 방사선치료와 항암방사선병합치료의 비교 연구

  • Jin, Seong-Min (Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital) ;
  • Kim, Jae-Gu (Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital) ;
  • Park, Kyeong-Suk (Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital) ;
  • Chung, Ik-Joo (Department of Internal Medicine, Chonnam National University Medical School and Hwasun Hospital) ;
  • Chung, Woong-Ki (Department of Radiation Oncology, Chonnam National University Medical School and Hwasun Hospital) ;
  • Lee, Dong-Hoon (Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital) ;
  • Lee, Joon-Kyoo (Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital) ;
  • Lim, Sang-Chul (Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital) ;
  • Yoon, Tae-Mi (Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital)
  • 진성민 (전남대학교 의과대학 화순전남대학교병원 이비인후-두경부외과학교실) ;
  • 김재구 (전남대학교 의과대학 화순전남대학교병원 이비인후-두경부외과학교실) ;
  • 박경석 (전남대학교 의과대학 화순전남대학교병원 이비인후-두경부외과학교실) ;
  • 정익주 (전남대학교 의과대학 화순전남대학교병원 내과학교실) ;
  • 정웅기 (전남대학교 의과대학 화순전남대학교병원 방사선종양학교실) ;
  • 이동훈 (전남대학교 의과대학 화순전남대학교병원 이비인후-두경부외과학교실) ;
  • 이준규 (전남대학교 의과대학 화순전남대학교병원 이비인후-두경부외과학교실) ;
  • 임상철 (전남대학교 의과대학 화순전남대학교병원 이비인후-두경부외과학교실) ;
  • 윤태미 (전남대학교 의과대학 화순전남대학교병원 이비인후-두경부외과학교실)
  • Received : 2018.05.13
  • Accepted : 2018.07.12
  • Published : 2018.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Background/Objectives: The efficacy of radiotherapy alone versus chemoradiotherapy has been studied in patients with T2N0M0 laryngeal squamous cell carcinoma. Materials & Methods: Thirty nine patients with newly diagnosed T2N0M0 laryngeal squamous cell carcinoma were treated with either radiotherapy(RT group, 66-70Gy) or chemoradiotherapy(CRT group, cisplatin based concurrent chemoradiation with or without 2 cycles induction chemotherapy including cisplatin, $5-FU{\pm}$ docetaxel / radiation therapy same with above mentioned). The mean follow-up was 73.5 months. Results: The overall survival (OS), disease specific survival (DSS), disease free survival (DFS), and larynx preservation survival (LPS) at 5 years were 70%, 79%, 67%, and 71%. The complete response rate was 82.4% in RT group, and was 95.5% in CRT group. OS (57% vs 80%), DSS (69% vs 86%), DFS (52% vs 77%), and LPS (63% vs 77%) at 5 years were higher in CRT group than RT group, but it was not statistically significant. In subsite analysis, CRT group tends to improve DFS, compared to RT group, in glottic cancer (p=0.06). The toxicities were tolerable and no fatal case was observed in both groups. Conclusion: Chemoradiotherapy is effective as primary therapy for T2 laryngeal squamous cell carcinoma and showed manageable treatment induced toxicity.

Keywords

References

  1. Ferlito A. The natural history of early vocal cord cancer. Acta Otolaryngol (Stockh). 1995;115:345-347. https://doi.org/10.3109/00016489509139326
  2. Groome PA, O'Sullivan B, Irish JC, Rothwell DM, Schulze K, Warde PR, et al. Management and outcome differences in supraglottic cancer between Ontario, Canada, and the Surveillance, Epidemiology, and End Results areas of the United States. Jpn J Clin Oncol. 2003;21:496-505. https://doi.org/10.1200/JCO.2003.10.106
  3. Mendenhall WM, Werning JW, Hinerman RW, Amdur RJ, Villaret DB. Management of T1-T2 Glottic carcinomas. Cancer. 2004;100:1786-1792. https://doi.org/10.1002/cncr.20181
  4. Jones AS, Fish B, Fenton JE, Husband DJ. The treatment of early laryngeal cancers (T1-T2 N0): Surgery or irradiation?. Head Neck. 2004;26:127-135. https://doi.org/10.1002/hed.10361
  5. Loughran S, Calder N, MacGregor FB, Carding P, MacKenzie K. Quality of life following endoscopic resection or radiotherapy for early glottic cancer. Clin Otolaryngol. 2005;30:42-47. https://doi.org/10.1111/j.1365-2273.2004.00919.x
  6. Lusinchi A, Dube P, Wibault P, Kunkler I, Luboinski B, Eschwege F. Radiation therapy in the treatment of early glottic carcinoma: The experience of Villejuif. Radiother Oncol. 1989;15:313-319. https://doi.org/10.1016/0167-8140(89)90076-5
  7. Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ, Ang KK, et al. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. Jpn J Clin Oncol. 2006;24:3693-3704. https://doi.org/10.1200/JCO.2006.07.4559
  8. Hirasawa N, Itoh Y, Ishihara S, Kubota S, Itoh J, Fujimoto Y, et al. Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: Retrospective analysis. Head Neck Oncol. 2010;2:20. https://doi.org/10.1186/1758-3284-2-20
  9. Furusaka T, Matuda H, Saito T, Katsura Y, Ikeda M. Long-term observations and salvage operations on patients with T2N0M0 squamous cell carcinoma of the glottic larynx treated with radiation therapy alone. Acta Otolaryngol (Stockh). 2012;132:546-551. https://doi.org/10.3109/00016489.2011.646008
  10. Arshad H, Jayaprakash V, Gupta V, Cohan DM, Ambujakshan D, Rigual NR, et al. Survival differences between organ preservation surgery and definitive radiotherapy in early supraglottic squamous cell carcinoma. Otolaryngol Head Neck Surg. 2014;150:237-244. https://doi.org/10.1177/0194599813512783
  11. Milas L, Mason KA, Liao Z, Ang KK. Chemoradiotherapy: Emerging treatment improvement strategies. Head Neck. 2003;25:152-167. https://doi.org/10.1002/hed.10232
  12. Nishimura G, Tsukuda M, Mikami Y, Matsuda H, Horiuchi C, Taguchi T, et al. Efficacy of concurrent chemoradiotherapy for T1 and T2 laryngeal squamous cell carcinoma regarding organ preservation. Anticancer Res. 2009;29:661-666.
  13. Akimoto T, Nonaka T, Kitamoto Y, Ishikawa H, Ninomiya H, Chikamatsu K, et al. Radiation therapy for T2N0 laryngeal cancer: A retrospective analysis for the impact of concurrent chemotherapy on local control. Int J Radiat Oncol Biol Phys. 2006;64:995-1001. https://doi.org/10.1016/j.ijrobp.2005.10.003