• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-1
• /
• pp.92-92
• /
• 2003

The drug discovery landscape is changing rapidly in the post-genomic era. Mapping of the human genome has led to an abundance of potential drug targets. Drug discovery times and costs can be significantly reduced by developing methods for high throughput target identification/ validation, multiplexed assay development and high efficient combinatorial chemistry. (omitted)

• Korean Journal of Mathematics
• /
• 제26권4호
• /
• pp.675-681
• /
• 2018

In the paper, by virtue of techniques in combinatorial analysis, the authors simplify three families of nonlinear ordinary differential equations in terms of the Stirling numbers of the first kind and establish a new family of nonlinear ordinary differential equations in terms of the Stirling numbers of the second kind.

• East Asian mathematical journal
• /
• 제25권4호
• /
• pp.469-479
• /
• 2009

Temperley-Lieb algebras had been generalized to web spaces for rank 2 simple Lie algebras which led us to link invariants for these Lie algebras as a generalization of Jones polynomial. Recently, Geer found a new generalization of Jones polynomial for some Lie superalgebras. In this paper, we study the quantum sl(1|1) representation theory using the web space and find a finite presentation of the representation category (for generic q) of the quantum sl(1|1).

• 접착 및 계면
• /
• 제10권3호
• /
• pp.127-133
• /
• 2009

아크릴 점착제는 고내구성 및 분자량 조절, 관능기의 도입 등이 용이하여 반도체, 디스플레이, 모바일 기기, 자동차 등의 첨단 산업에서 매우 다양하게 활용되고 있다. 점착제의 점착물성은 산업에서의 적용, 공정관리, 제품의 신뢰성에 지대한 영향을 미치기에 그 중요성이 날로 더해가고 있다. 본 연구에서는 조합기법을 이용하여 아크릴 점착제의 물성 영향인자 가운데 두께의 변화에 따른 점착물성 변화를 살펴보고자 한다. 아크릴 점착제는 2-ethylhexyl acrylate와 acrylic acid로 구성된 기본점착제만을 활용하여 샘플을 제작하였으며, 두께 구배가 가능한 micro applicator를 활용하여 thickness-gradient acrylic PSA 샘플을 제작하였으며, 이를 기존의 코팅법으로 제작한 샘플과 비교함으로써 조합기법의 재현성을 평가하였다.

• 한국세라믹학회지
• /
• 제42권6호
• /
• pp.391-398
• /
• 2005

It is known that $BaMgAl_{10}O_{17}:Eu^{2+}(BAM)$ phosphors currently used have a serious thermal degradation problem. We screened $SrO-B_2O_3-P_2O_5$ system by a solution combinatorial chemistry technique in an attempt to search for a thermally stable blue phosphor for PDPs. A Quantitative Structure Activity Relationship (QSAR) was also obtained using an artificial neural network trained by the result fiom the combinatorial screening. As a result, we proposed a promising composition range in the $SrO-B_2O_3-P_2O_5$ ternary library. These compositions crystallized into a single major phase, $Sr_6BP_5O_{20}:Eu^{2+}$. The structure of $Sr_6BP_5O_{20}:Eu^{2+}$ was clearly determined by ab initio calculation. The luminescent efficiency of $Sr_6BP_5O_{20}:Eu^{2+}$ was 2.8 times of BAM at Vacuum Ultra Violet (VUV) excitation. The thermal stability was also good but the CIE color chromaticity was slightly poor.

• Biomolecules & Therapeutics
• /
• 제26권6호
• /
• pp.591-598
• /
• 2018

Epigenetic silencing is considered to be a major mechanism for loss of activity in tumor suppressors. Reversal of epigenetic silencing by using inhibitors of DNA methyltransferase (DNMT) or histone deacetylases (HDACs) such as 5-Aza-CdR and FK228 has shown to enhance cytotoxic activities of several anticancer agents. This study aims to assess the combinatorial effects of genesilencing reversal agents (5-Aza-CdR and FK228) and oxaliplatin in gastric cancer cells, i.e., Epstein-Barr virus (EBV)-negative SNU-638 and EBV-positive SNU-719 cells. The doublet combinatorial treatment of 5-Aza-CdR and FK228 exhibited synergistic effects in both cell lines, and this was further corroborated by Zta expression induction in SNU-719 cells. Three drug combinations as 5-Aza-CdR/FK228 followed by oxaliplatin, however, resulted in antagonistic effects in both cell lines. Simultaneous treatment with FK228 and oxaliplatin induced synergistic and additive effects in SNU-638 and SNU-719 cells, respectively. Three drug combinations as 5-Aza-CdR prior to FK228/oxaliplatin, however, again resulted in antagonistic effects in both cell lines. This work demonstrated that efficacy of doublet synergistic combination using DNMT or HDACs inhibitors can be compromised by adding the third drug in pre- or post-treatment approach in gastric cancer cells. This implies that the development of clinical trial protocols for triplet combinations using gene-silencing reversal agents should be carefully evaluated in light of their potential antagonistic effects.

• 한국정보처리학회논문지
• /
• 제4권6호
• /
• pp.1550-1556
• /
• 1997

본 논문에서는 진화 알고리즘에 기반하여 조합 최적화 문제를 해결하고자 한다. 진화 알고리즘은 대규모 문제 공간에서 최적화 문제를 해결하는데 적합한 알고리즘이다. 본 논문의 조합 최적화의 예는 경수로 원자로로부터 나온 폐연료를 중수로에서 재사용하는데 필요한 폐연료의 조합 문제이다. 이와 같은 조합 최적화 문제는 0/1 knapsack 문제와 같이 NP-Comprete 문제에 해당한다. 이러한 문제를 해결하기 위해서는 고전적인 진화 알고리즘의 전략에 기반하여 랜덤 연산자를 이용하여 평가 함수 값이 좋은 방향으로만 탐색을 수행하는 방법, 그리고 벡터 연산자를 이용하여 최적의 해를 보다 빨리 얻을 수 있는 휴리스틱을 사용하는 방법이 있다. 본 논문에서는 중수로 연료 조합 문제 영역의 모든 지식을 벡터화하여 벡터의 연산만으로 가능성 검사, 해를 평가하는 방법을 소개한다. 또한 벡터 휴리스틱이 고전적인 진화 알고리즘에 비해 어느 정도의 성능을 보이는지 비교한다.

• Molecules and Cells
• /
• 제27권3호
• /
• pp.313-319
• /
• 2009

The dual-vector system-II (DVS-II), which allows efficient display of Fab antibodies on phage, has been reported previously, but its practical applicability in a phage-displayed antibody library has not been verified. To resolve this issue, we created two small combinatorial human Fab antibody libraries using the DVS-II, and isolation of target-specific antibodies was attempted. Biopanning of one antibody library, termed DVFAB-1L library, which has a $1.3{\times}10^7$ combinatorial antibody complexity, against fluorescein-BSA resulted in successful isolation of human Fab clones specific for the antigen despite the presence of only a single light chain in the library. By using the unique feature of the DVS-II, an antibody library of a larger size, named DVFAB-131L, which has a $1.5{\times}10^9$ combinatorial antibody complexity, was also generated in a rapid manner by combining $1.3{\times}10^7$ heavy chains and 131 light chains and more diverse anti-fluorescein-BSA Fab antibody clones were successfully obtained. Our results demonstrate that the DVS-II can be applied readily in creating phage-displayed antibody libraries with much less effort, and target-specific antibody clones can be isolated reliably via light chain promiscuity of antibody molecules.

• 한국분말재료학회지
• /
• 제23권2호
• /
• pp.143-148
• /
• 2016

A microfluidic reactor with computer-controlled programmable isocratic pumps and online detectors is employed as a combinatorial synthesis system to synthesize and analyze materials for fabricating CdSe quantum dots for various applications. Four reaction condition parameters, namely, the reaction temperature, reaction time, Cd/Se compositional ratio, and precursor concentration, are combined in synthesis condition sets, and the size of the synthesized CdSe quantum dots is determined for each condition. The average time corresponding to each reaction condition for obtaining the ultraviolet-visible absorbance and photoluminescence spectra is approximately 10 min. Using the data from the combinatorial synthesis system, the effects of the reaction conditions on the synthesized CdSe quantum dots are determined. Further, the data is used to determine the relationships between the reaction conditions and the CdSe particle size. This method should aid in determining and selecting the optimal conditions for synthesizing nanoparticles for diverse applications.

• 한국컴퓨터정보학회논문지
• /
• 제26권10호
• /
• pp.27-35
• /
• 2021

지역 탐색은 다양한 조합 최적화 문제들을 해결하기 위해 활용되어 왔다. 지역 탐색에 있어서 가장 중요한 요소 중 하나가 이웃해를 생성하는 방법이다. 본 논문에서는 순열 기반 조합 최적화를 위한 지역 탐색의 이웃해 생성 전략들을 제안하고, 순회 외판원 문제를 대상으로 각 전략들의 성능을 비교한다. 본 논문에서는 총 10가지 이웃해 생성 전략을 제안한다. 기본적으로 기존에 많이 사용했던 Swap 등 4가지 전략 이외에 Rotation 등 4가지 기법을 새롭게 제안한다. 이외에 기본 이웃해 생성 전략들을 결합하여 만든 Combined1과 Combined2가 있다. 실험은 기본적인 지역 탐색을 적용하되 이웃해 생성 전략만 변경하여 수행하였다. 실험 결과, 이웃해 생성 전략에 따라 성능 차이가 큰 것을 확인하였으며 아울러 Combined2의 성능이 가장 좋음을 확인하였다. 뿐만 아니라 Combined2는 기존의 지역 탐색 기법들보다 더 좋은 성능을 발휘함을 확인하였다.